LOCUS       NM_010635               1476 bp    mRNA    linear   ROD 20-AUG-2024
DEFINITION  Mus musculus Kruppel-like transcription factor 1 (erythroid)
            (Klf1), mRNA.
ACCESSION   NM_010635 XM_987384
VERSION     NM_010635.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1476)
  AUTHORS   Huang,S., Reed,C., Ilsley,M., Magor,G., Tallack,M., Landsberg,M.,
            Mitchell,H., Gillinder,K. and Perkins,A.
  TITLE     Mutations in linker-2 of KLF1 impair expression of membrane
            transporters and cytoskeletal proteins causing hemolysis
  JOURNAL   Nat Commun 15 (1), 7019 (2024)
   PUBMED   39147774
  REMARK    GeneRIF: Mutations in linker-2 of KLF1 impair expression of
            membrane transporters and cytoskeletal proteins causing hemolysis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1476)
  AUTHORS   Cardarelli,S., Biglietto,M., Orsini,T., Fustaino,V., Monaco,L., de
            Oliveira do Rego,A.G., Liccardo,F., Masciarelli,S., Fazi,F.,
            Naro,F., De Angelis,L. and Pellegrini,M.
  TITLE     Modulation of cAMP/cGMP signaling as prevention of congenital heart
            defects in Pde2A deficient embryos: a matter of oxidative stress
  JOURNAL   Cell Death Dis 15 (2), 169 (2024)
   PUBMED   38395995
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1476)
  AUTHORS   Mukherjee,K. and Bieker,J.J.
  TITLE     EKLF/Klf1 regulates erythroid transcription by its pioneering
            activity and selective control of RNA Pol II pause-release
  JOURNAL   Cell Rep 41 (12), 111830 (2022)
   PUBMED   36543143
  REMARK    GeneRIF: EKLF/Klf1 regulates erythroid transcription by its
            pioneering activity and selective control of RNA Pol II
            pause-release.
REFERENCE   4  (bases 1 to 1476)
  AUTHORS   Kulczynska-Figurny,K., Bieker,J.J. and Siatecka,M.
  TITLE     Severe anemia caused by dominant mutations in Kruppel-like factor 1
            (KLF1)
  JOURNAL   Mutat Res Rev Mutat Res 786, 108336 (2020)
   PUBMED   33339573
  REMARK    Review article
REFERENCE   5  (bases 1 to 1476)
  AUTHORS   Cantu,I., van de Werken,H.J.G., Gillemans,N., Stadhouders,R.,
            Heshusius,S., Maas,A., Esteghamat,F., Ozgur,Z., van IJcken,W.F.J.,
            Grosveld,F., von Lindern,M., Philipsen,S. and van Dijk,T.B.
  TITLE     The mouse KLF1 Nan variant impairs nuclear condensation and
            erythroid maturation
  JOURNAL   PLoS One 14 (3), e0208659 (2019)
   PUBMED   30921348
  REMARK    GeneRIF: Study shows that embryos from KLF1 Nan variant have
            defects in erythroid maturation.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1476)
  AUTHORS   Waye,J.S. and Eng,B.
  TITLE     Kruppel-like factor 1: hematologic phenotypes associated with KLF1
            gene mutations
  JOURNAL   Int J Lab Hematol 37 Suppl 1, 78-84 (2015)
   PUBMED   25976964
  REMARK    Review article
REFERENCE   7  (bases 1 to 1476)
  AUTHORS   Yien,Y.Y. and Bieker,J.J.
  TITLE     EKLF/KLF1, a tissue-restricted integrator of transcriptional
            control, chromatin remodeling, and lineage determination
  JOURNAL   Mol Cell Biol 33 (1), 4-13 (2013)
   PUBMED   23090966
  REMARK    Review article
REFERENCE   8  (bases 1 to 1476)
  AUTHORS   Anderson,K.P., Kern,C.B., Crable,S.C. and Lingrel,J.B.
  TITLE     Isolation of a gene encoding a functional zinc finger protein
            homologous to erythroid Kruppel-like factor: identification of a
            new multigene family
  JOURNAL   Mol Cell Biol 15 (11), 5957-5965 (1995)
   PUBMED   7565748
REFERENCE   9  (bases 1 to 1476)
  AUTHORS   Nuez,B., Michalovich,D., Bygrave,A., Ploemacher,R. and Grosveld,F.
  TITLE     Defective haematopoiesis in fetal liver resulting from inactivation
            of the EKLF gene
  JOURNAL   Nature 375 (6529), 316-318 (1995)
   PUBMED   7753194
REFERENCE   10 (bases 1 to 1476)
  AUTHORS   Miller,I.J. and Bieker,J.J.
  TITLE     A novel, erythroid cell-specific murine transcription factor that
            binds to the CACCC element and is related to the Kruppel family of
            nuclear proteins
  JOURNAL   Mol Cell Biol 13 (5), 2776-2786 (1993)
   PUBMED   7682653
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC161765.5.
            
            On Feb 25, 2019 this sequence version replaced NM_010635.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M97200.1, BC114978.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849385
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-134               AC161765.5         169348-169481
            135-948             AC161765.5         170055-170868
            949-1476            AC161765.5         172130-172657
FEATURES             Location/Qualifiers
     source          1..1476
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 41.3 cM"
     gene            1..1476
                     /gene="Klf1"
                     /gene_synonym="Eklf; Nan"
                     /note="Kruppel-like transcription factor 1 (erythroid)"
                     /db_xref="GeneID:16596"
                     /db_xref="MGI:MGI:1342771"
     exon            1..134
                     /gene="Klf1"
                     /gene_synonym="Eklf; Nan"
                     /inference="alignment:Splign:2.1.0"
     CDS             48..1124
                     /gene="Klf1"
                     /gene_synonym="Eklf; Nan"
                     /note="erythroid transcription factor; erythroid
                     krueppel-like transcription factor; neonatal anemia;
                     Kruppel-like factor 1 (erythroid)"
                     /codon_start=1
                     /product="Krueppel-like factor 1"
                     /protein_id="NP_034765.3"
                     /db_xref="CCDS:CCDS22483.1"
                     /db_xref="GeneID:16596"
                     /db_xref="MGI:MGI:1342771"
                     /translation="MASAETVLPSISTLTTLGQFLDTQEDFLKWWRSEETQDLGPGPP
                     NPTGPSHHVSLKSEDPSGEDDERDVTCAWDPDLFLTNFPGSESPGTSRTCALAPSVGP
                     VAQFEPPESLGAYAGGPGLVTGPLGSEEHTSWAHPTPRPPAPEPFVAPALAPGLAPKA
                     QPSYSDSRAGSVGGFFPRAGLAVPAAPGAPYGLLSGYPALYPAPQYQGHFQLFRGLAA
                     PSAGPTAPPSFLNCLGPGTVATELGATAIAGDAGLSPGTAPPKRSRRTLAPKRQAAHT
                     CGHEGCGKSYTKSSHLKAHLRTHTGEKPYACSWDGCDWRFARSDELTRHYRKHTGHRP
                     FCCGLCPRAFSRSDHLALHMKRHL"
     exon            135..948
                     /gene="Klf1"
                     /gene_synonym="Eklf; Nan"
                     /inference="alignment:Splign:2.1.0"
     exon            949..1476
                     /gene="Klf1"
                     /gene_synonym="Eklf; Nan"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1455..1460
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Klf1"
                     /gene_synonym="Eklf; Nan"
                     /note="hexamer: TATAAA"
     polyA_site      1476
                     /gene="Klf1"
                     /gene_synonym="Eklf; Nan"
                     /note="major polyA site"
ORIGIN      
        1 agaagagaga gaggaggcct gaggtccagg gtggacacca gccagccatg gcctcagctg
       61 agactgtctt accctccatc agtacactca ccaccctggg acagttcctg gacacccagg
      121 aggacttcct caagtggtgg cggtctgagg agacgcagga tttggggccg gggcccccga
      181 atcccacggg gccgtcccat cacgtgagtc tgaaatcgga ggacccttcc ggagaggacg
      241 atgagaggga cgtgacctgt gcgtgggacc cggatctttt ccttacaaac tttccaggtt
      301 ccgagtctcc cggcacttcc cggacctgtg ccctggcgcc cagcgtgggg ccagtggcac
      361 agttcgagcc gcctgagtct ctgggcgcct atgcgggtgg cccagggttg gtgactgggc
      421 ctttgggctc cgaggagcac acaagctggg cgcacccgac tccgagaccc ccagcccctg
      481 aacccttcgt ggcccctgcc ctggccccgg gactcgctcc caaggctcag ccctcgtact
      541 ccgactcgcg agcgggctcc gtagggggct tcttcccgcg ggcggggctt gcggtgcccg
      601 cagctccagg cgccccctat gggctgctgt cgggataccc cgcgctgtac cccgcgccac
      661 agtaccaagg ccacttccag ctctttcgcg ggctcgcggc gccttctgct ggtcccacgg
      721 cgcccccttc cttcttgaat tgtctgggac ctgggactgt ggccacagaa ctcggggcca
      781 ctgcgatcgc cggagacgca ggcttgtccc cgggaactgc gccgcccaaa cgcagccggc
      841 gaactttggc acctaagagg caggcggcac atacgtgcgg gcacgaaggc tgcgggaaga
      901 gctacaccaa gagctcgcac ctcaaggcgc acctgcgcac gcacacggga gagaagcctt
      961 atgcctgctc ctgggacggc tgtgactgga ggttcgctcg ctcagacgaa ctgacgcgcc
     1021 actaccggaa gcacactgga catcgtccct tctgctgtgg cctctgccca cgtgcttttt
     1081 cacgctctga ccacttagct ctgcacatga agcgtcacct ctgagtgatc ctgcacaagg
     1141 actggggatg aaataagagt ggatccaagg accgtatccc aaaagatggg ccattatata
     1201 gtcctaccca gatcaaaaac tgaccagaag accatacaaa ggagccttca ggacaaacct
     1261 cacatgtcct cagggagccc cacacatggc cccacagacc cagcaatata gaccaccaga
     1321 taaatcaact caaatggacc cctagaccag aggagtgacc ctgtgtcctg gacgcagatg
     1381 gactggggtg agatttccta agatctagaa gggagcttca cactgtgccc atctgctagg
     1441 attgttgtcg ttactataaa aatttcccat ataaaa
//
