LOCUS       NM_001403685            1781 bp    mRNA    linear   ROD 12-NOV-2024
DEFINITION  Mus musculus kinesin light chain 3 (Klc3), transcript variant 4,
            mRNA.
ACCESSION   NM_001403685 XM_030242433
VERSION     NM_001403685.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1781)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1781)
  AUTHORS   Daniel-Carlier,N., Castille,J., Passet,B., Vilotte,M., Le
            Danvic,C., Jaffrezic,F., Beauvallet,C., Pechoux,C., Capitan,A. and
            Vilotte,J.L.
  TITLE     Targeted mutation and inactivation of the kinesin light chain 3
            protein-encoding gene have no impact on mouse fertilitydagger
  JOURNAL   Biol Reprod 110 (1), 78-89 (2024)
   PUBMED   37776549
  REMARK    GeneRIF: Targeted mutation and inactivation of the kinesin light
            chain 3 protein-encoding gene have no impact on mouse
            fertilitydagger.
REFERENCE   3  (bases 1 to 1781)
  AUTHORS   Rah,G., Cha,H., Kim,J., Song,J., Kim,H., Oh,Y.K., Ahn,C., Kang,M.,
            Kim,J., Yoo,K.H., Kim,M.J., Ko,H.W., Ko,J.Y. and Park,J.H.
  TITLE     KLC3 Regulates Ciliary Trafficking and Cyst Progression in CILK1
            Deficiency-Related Polycystic Kidney Disease
  JOURNAL   J Am Soc Nephrol 33 (9), 1726-1741 (2022)
   PUBMED   35961787
  REMARK    GeneRIF: KLC3 Regulates Ciliary Trafficking and Cyst Progression in
            CILK1 Deficiency-Related Polycystic Kidney Disease.
REFERENCE   4  (bases 1 to 1781)
  AUTHORS   Zhang,Y., Ou,Y., Cheng,M., Saadi,H.S., Thundathil,J.C. and van der
            Hoorn,F.A.
  TITLE     KLC3 is involved in sperm tail midpiece formation and sperm
            function
  JOURNAL   Dev Biol 366 (2), 101-110 (2012)
   PUBMED   22561200
  REMARK    GeneRIF: KLC3 plays a role during spermiogenesis in the development
            of the midpiece and in the normal function of spermatozoa
REFERENCE   5  (bases 1 to 1781)
  AUTHORS   Chung,S.H., Marzban,H., Aldinger,K., Dixit,R., Millen,K.,
            Schuurmans,C. and Hawkes,R.
  TITLE     Zac1 plays a key role in the development of specific neuronal
            subsets in the mouse cerebellum
  JOURNAL   Neural Dev 6, 25 (2011)
   PUBMED   21592321
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1781)
  AUTHORS   Yang,J., Liu,X., Yue,G., Adamian,M., Bulgakov,O. and Li,T.
  TITLE     Rootletin, a novel coiled-coil protein, is a structural component
            of the ciliary rootlet
  JOURNAL   J Cell Biol 159 (3), 431-440 (2002)
   PUBMED   12427867
REFERENCE   7  (bases 1 to 1781)
  AUTHORS   Junco,A., Bhullar,B., Tarnasky,H.A. and van der Hoorn,F.A.
  TITLE     Kinesin light-chain KLC3 expression in testis is restricted to
            spermatids
  JOURNAL   Biol Reprod 64 (5), 1320-1330 (2001)
   PUBMED   11319135
REFERENCE   8  (bases 1 to 1781)
  AUTHORS   Rahman,A., Friedman,D.S. and Goldstein,L.S.
  TITLE     Two kinesin light chain genes in mice. Identification and
            characterization of the encoded proteins
  JOURNAL   J Biol Chem 273 (25), 15395-15403 (1998)
   PUBMED   9624122
  REMARK    Erratum:[J Biol Chem 1998 Sep 11;273(37):24280]
REFERENCE   9  (bases 1 to 1781)
  AUTHORS   de Boer,J., Donker,I., de Wit,J., Hoeijmakers,J.H. and Weeda,G.
  TITLE     Disruption of the mouse xeroderma pigmentosum group D DNA
            repair/basal transcription gene results in preimplantation
            lethality
  JOURNAL   Cancer Res 58 (1), 89-94 (1998)
   PUBMED   9426063
REFERENCE   10 (bases 1 to 1781)
  AUTHORS   Lamerdin,J.E., Stilwagen,S.A., Ramirez,M.H., Stubbs,L. and
            Carrano,A.V.
  TITLE     Sequence analysis of the ERCC2 gene regions in human, mouse, and
            hamster reveals three linked genes
  JOURNAL   Genomics 34 (3), 399-409 (1996)
   PUBMED   8786141
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC118017.15.
            
            On Apr 3, 2022 this sequence version replaced XM_030242433.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR17784648.527648.1,
                                           SRR17784651.1327248.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849383 [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-45                AC118017.15        50716-50760
            46-311              AC118017.15        54966-55231
            312-542             AC118017.15        56323-56553
            543-612             AC118017.15        57045-57114
            613-832             AC118017.15        57424-57643
            833-920             AC118017.15        57921-58008
            921-1022            AC118017.15        58132-58233
            1023-1196           AC118017.15        58542-58715
            1197-1287           AC118017.15        59060-59150
            1288-1328           AC118017.15        59236-59276
            1329-1435           AC118017.15        59348-59454
            1436-1499           AC118017.15        59567-59630
            1500-1781           AC118017.15        59794-60075
FEATURES             Location/Qualifiers
     source          1..1781
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 9.62 cM"
     gene            1..1781
                     /gene="Klc3"
                     /gene_synonym="Klct"
                     /note="kinesin light chain 3"
                     /db_xref="GeneID:232943"
                     /db_xref="MGI:MGI:1277971"
     exon            1..45
                     /gene="Klc3"
                     /gene_synonym="Klct"
                     /inference="alignment:Splign:2.1.0"
     CDS             39..1580
                     /gene="Klc3"
                     /gene_synonym="Klct"
                     /note="isoform b is encoded by transcript variant 4"
                     /codon_start=1
                     /product="kinesin light chain 3 isoform b"
                     /protein_id="NP_001390614.1"
                     /db_xref="GeneID:232943"
                     /db_xref="MGI:MGI:1277971"
                     /translation="MHGAAMSVQVAAPGSTGLGPERLNPEELVRQTRQVVQGLEALRA
                     EHHSLAGHLAEALAGPGPVAGVELLEEKQQVVNHSLEAIELGLGEAQVLLALSAHVSV
                     LEAEKQRLRAQARRLAQENTWLREELEETQRRLRASEEAVAQLEEEKSHLQFLGQLRQ
                     YDPPEESQRPESPPRRDSLASLFPSEEEEKKGPEAAGAAAAQQGGYEIPARLRTLHNL
                     VIQYAGQGRYEVAVPLCRQALEDLERSSGHCHPDVATMLNILALVYRDQNKYKEATEL
                     LHDALQIREQTLGPEHPAVAATLNNLAVLYGKRGRYREAEPLCQRALEIREKVLGADH
                     PDVAKQLNNLALLCQNQGKFQDVERHYARALSIYEALGGPQDPNVAKTKNNLASAYLK
                     QNKYQQAEELYKEILSQEALPAPLGAPQGGTAGDTQQQVLRRSSSFSKLRESIRRGSE
                     KLVSRLRGEGMAGAAGMKRAMSLNMLNVDGPRAARTQLSQLSTRHLSEAPRTLSISTQ
                     DLSPR"
     exon            46..311
                     /gene="Klc3"
                     /gene_synonym="Klct"
                     /inference="alignment:Splign:2.1.0"
     exon            312..542
                     /gene="Klc3"
                     /gene_synonym="Klct"
                     /inference="alignment:Splign:2.1.0"
     exon            543..612
                     /gene="Klc3"
                     /gene_synonym="Klct"
                     /inference="alignment:Splign:2.1.0"
     exon            613..832
                     /gene="Klc3"
                     /gene_synonym="Klct"
                     /inference="alignment:Splign:2.1.0"
     exon            833..920
                     /gene="Klc3"
                     /gene_synonym="Klct"
                     /inference="alignment:Splign:2.1.0"
     exon            921..1022
                     /gene="Klc3"
                     /gene_synonym="Klct"
                     /inference="alignment:Splign:2.1.0"
     exon            1023..1196
                     /gene="Klc3"
                     /gene_synonym="Klct"
                     /inference="alignment:Splign:2.1.0"
     exon            1197..1287
                     /gene="Klc3"
                     /gene_synonym="Klct"
                     /inference="alignment:Splign:2.1.0"
     exon            1288..1328
                     /gene="Klc3"
                     /gene_synonym="Klct"
                     /inference="alignment:Splign:2.1.0"
     exon            1329..1435
                     /gene="Klc3"
                     /gene_synonym="Klct"
                     /inference="alignment:Splign:2.1.0"
     exon            1436..1499
                     /gene="Klc3"
                     /gene_synonym="Klct"
                     /inference="alignment:Splign:2.1.0"
     exon            1500..1781
                     /gene="Klc3"
                     /gene_synonym="Klct"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1679..1684
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Klc3"
                     /gene_synonym="Klct"
                     /note="hexamer: ATTAAA"
     polyA_site      1699
                     /gene="Klc3"
                     /gene_synonym="Klct"
                     /note="major polyA site"
     polyA_site      1781
                     /gene="Klc3"
                     /gene_synonym="Klct"
                     /note="major polyA site"
ORIGIN      
        1 gtcggagggt cccccgctgc agcctgaggg tgcaagacat gcatggagca gccatgtctg
       61 tgcaggtggc agcccctgga agcacagggc tgggcccaga acgcctgaac cccgaggagc
      121 tggtgcggca gacacgacag gttgtacagg gactggaggc cctgcgggcc gagcaccata
      181 gtctggctgg gcacctggcg gaggccctgg ctggaccagg ccctgtggct ggtgtggagc
      241 tgctggaaga gaagcaacag gtggtgaacc actcgctgga ggccatcgag ctggggctgg
      301 gtgaggccca ggtgctgctg gccctgtccg cacacgtgag tgtgttggag gctgagaagc
      361 agaggctacg ggcacaggca cggaggctag cccaagagaa cacatggctt cgagaggagc
      421 tggaggagac acagaggcga ctgcgggcca gcgaggaggc tgtggcccag ctggaagagg
      481 agaagagcca cctccagttc ctggggcagc tgaggcagta tgacccgccc gaggagagcc
      541 agaggcccga gtccccccct cgccgagaca gcttggcatc tctgttcccc agtgaagagg
      601 aggaaaagaa aggtcctgag gcagcaggag cagcagccgc gcagcagggt ggctatgaga
      661 tcccagctcg tctgcggacc ctgcacaacc tggtgatcca gtatgctggc cagggccgct
      721 atgaggtggc agttccccta tgtcgccagg ctctggagga cctggagcgg agctcgggcc
      781 actgccatcc tgacgtggcc accatgctca acatcctggc actcgtgtac agggaccaga
      841 acaaatacaa ggaagctacg gagcttcttc acgacgccct gcagatccgg gaacagacgc
      901 tgggtcctga acaccctgca gtggctgcca ccctcaacaa cctggctgtc ctctatggaa
      961 aacgtggacg ttaccgggag gcagaacccc tctgccagcg tgctctggag atccgtgaga
     1021 aggtcctggg tgcagaccac cctgatgtgg ccaagcagct caacaacctg gccctactgt
     1081 gccagaacca gggcaagttt caggacgtgg agcggcacta tgcgcgggcc ctgagcatct
     1141 acgaggccct gggcgggcca caggacccaa atgtggccaa gactaagaac aacctggcct
     1201 cagcctacct gaaacagaac aagtatcagc aggcagagga gctatacaag gagatcctca
     1261 gccaggaggc cctgcccgcc ccacttggag ccccccaggg aggcacagca ggcgatacac
     1321 agcagcaggt cctgcgcagg agcagttcct tctctaagct ccgggaatcc atcaggcgag
     1381 gaagcgagaa gctggtctcc cgcctccgag gagagggcat ggcaggggct gccgggatga
     1441 agagagccat gtcactcaat atgctgaacg tggatggtcc cagggctgcc cggacgcagc
     1501 tctcccagct ctcaacccgg cacctgagtg aggcccctcg gaccctgagc atcagcacac
     1561 aagatctgag cccgcgctaa gtggactggc tgcagaggcc acagcttctc aaggatcagg
     1621 aagggtgggt ggtcaccctg caccctgcct gggcagctct tgtagatcgc tccctgcaat
     1681 taaaggcggt gcactggtac tgggtgtttg ccgagggccc tgggaccttc cagcacctcc
     1741 caggagccac aggcggtcac cccacagccc cgctgttcag a
//
