LOCUS       NM_008451               2907 bp    mRNA    linear   ROD 27-JUL-2024
DEFINITION  Mus musculus kinesin light chain 2 (Klc2), transcript variant 1,
            mRNA.
ACCESSION   NM_008451
VERSION     NM_008451.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2907)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2907)
  AUTHORS   Fu,X., An,Y., Wang,H., Li,P., Lin,J., Yuan,J., Yue,R., Jin,Y.,
            Gao,J. and Chai,R.
  TITLE     Deficiency of Klc2 Induces Low-Frequency Sensorineural Hearing Loss
            in C57BL/6 J Mice and Human
  JOURNAL   Mol Neurobiol 58 (9), 4376-4391 (2021)
   PUBMED   34014435
  REMARK    GeneRIF: Deficiency of Klc2 Induces Low-Frequency Sensorineural
            Hearing Loss in C57BL/6 J Mice and Human.
REFERENCE   3  (bases 1 to 2907)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2907)
  AUTHORS   Nguyen,T.Q., Chenon,M., Vilela,F., Velours,C., Aumont-Nicaise,M.,
            Andreani,J., Varela,P.F., Llinas,P. and Menetrey,J.
  TITLE     Structural plasticity of the N-terminal capping helix of the TPR
            domain of kinesin light chain
  JOURNAL   PLoS One 12 (10), e0186354 (2017)
   PUBMED   29036226
  REMARK    GeneRIF: structural plasticity of the N-terminal capping helix
            might represent a structural determinant for TPR domain structural
            versatility in cargo binding
            Erratum:[PLoS One. 2018 May 7;13(5):e0197193. doi:
            10.1371/journal.pone.0197193. PMID: 29734375]
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2907)
  AUTHORS   Pernigo,S., Lamprecht,A., Steiner,R.A. and Dodding,M.P.
  TITLE     Structural basis for kinesin-1:cargo recognition
  JOURNAL   Science 340 (6130), 356-359 (2013)
   PUBMED   23519214
REFERENCE   6  (bases 1 to 2907)
  AUTHORS   Frederikse,P.H., Yun,E., Kao,H.T., Zigler,J.S. Jr., Sun,Q. and
            Qazi,A.S.
  TITLE     Synapsin and synaptic vesicle protein expression during embryonic
            and post-natal lens fiber cell differentiation
  JOURNAL   Mol Vis 10, 794-804 (2004)
   PUBMED   15529118
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 2907)
  AUTHORS   Bowman,A.B., Kamal,A., Ritchings,B.W., Philp,A.V., McGrail,M.,
            Gindhart,J.G. and Goldstein,L.S.
  TITLE     Kinesin-dependent axonal transport is mediated by the sunday driver
            (SYD) protein
  JOURNAL   Cell 103 (4), 583-594 (2000)
   PUBMED   11106729
REFERENCE   8  (bases 1 to 2907)
  AUTHORS   Deussing,J., Tisljar,K., Papazoglou,A. and Peters,C.
  TITLE     Mouse cathepsin F: cDNA cloning, genomic organization and
            chromosomal assignment of the gene
  JOURNAL   Gene 251 (2), 165-173 (2000)
   PUBMED   10876093
REFERENCE   9  (bases 1 to 2907)
  AUTHORS   Rahman,A., Friedman,D.S. and Goldstein,L.S.
  TITLE     Two kinesin light chain genes in mice. Identification and
            characterization of the encoded proteins
  JOURNAL   J Biol Chem 273 (25), 15395-15403 (1998)
   PUBMED   9624122
  REMARK    Erratum:[J Biol Chem 1998 Sep 11;273(37):24280]
REFERENCE   10 (bases 1 to 2907)
  AUTHORS   Lamerdin,J.E., Stilwagen,S.A., Ramirez,M.H., Stubbs,L. and
            Carrano,A.V.
  TITLE     Sequence analysis of the ERCC2 gene regions in human, mouse, and
            hamster reveals three linked genes
  JOURNAL   Genomics 34 (3), 399-409 (1996)
   PUBMED   8786141
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC124502.4.
            
            On Apr 5, 2019 this sequence version replaced NM_008451.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC014845.1, SRR11927934.8116008.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164138, SAMN01164139
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-177               AC124502.4         5290-5466
            178-416             AC124502.4         6156-6394
            417-647             AC124502.4         9417-9647
            648-717             AC124502.4         9738-9807
            718-940             AC124502.4         10648-10870
            941-1028            AC124502.4         11675-11762
            1029-1130           AC124502.4         11868-11969
            1131-1304           AC124502.4         12050-12223
            1305-1404           AC124502.4         12351-12450
            1405-1454           AC124502.4         13172-13221
            1455-1522           AC124502.4         13324-13391
            1523-1631           AC124502.4         13747-13855
            1632-1781           AC124502.4         13946-14095
            1782-1906           AC124502.4         14163-14287
            1907-1964           AC124502.4         14428-14485
            1965-2907           AC124502.4         14900-15842
FEATURES             Location/Qualifiers
     source          1..2907
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 4.25 cM"
     gene            1..2907
                     /gene="Klc2"
                     /gene_synonym="8030455F02Rik; KLC 2; KLC-2"
                     /note="kinesin light chain 2"
                     /db_xref="GeneID:16594"
                     /db_xref="MGI:MGI:107953"
     exon            1..177
                     /gene="Klc2"
                     /gene_synonym="8030455F02Rik; KLC 2; KLC-2"
                     /inference="alignment:Splign:2.1.0"
     exon            178..416
                     /gene="Klc2"
                     /gene_synonym="8030455F02Rik; KLC 2; KLC-2"
                     /inference="alignment:Splign:2.1.0"
     exon            417..647
                     /gene="Klc2"
                     /gene_synonym="8030455F02Rik; KLC 2; KLC-2"
                     /inference="alignment:Splign:2.1.0"
     exon            648..717
                     /gene="Klc2"
                     /gene_synonym="8030455F02Rik; KLC 2; KLC-2"
                     /inference="alignment:Splign:2.1.0"
     exon            718..940
                     /gene="Klc2"
                     /gene_synonym="8030455F02Rik; KLC 2; KLC-2"
                     /inference="alignment:Splign:2.1.0"
     exon            941..1028
                     /gene="Klc2"
                     /gene_synonym="8030455F02Rik; KLC 2; KLC-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1029..1130
                     /gene="Klc2"
                     /gene_synonym="8030455F02Rik; KLC 2; KLC-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1131..1304
                     /gene="Klc2"
                     /gene_synonym="8030455F02Rik; KLC 2; KLC-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1305..1404
                     /gene="Klc2"
                     /gene_synonym="8030455F02Rik; KLC 2; KLC-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1405..1454
                     /gene="Klc2"
                     /gene_synonym="8030455F02Rik; KLC 2; KLC-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1455..1522
                     /gene="Klc2"
                     /gene_synonym="8030455F02Rik; KLC 2; KLC-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1523..1631
                     /gene="Klc2"
                     /gene_synonym="8030455F02Rik; KLC 2; KLC-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1632..1781
                     /gene="Klc2"
                     /gene_synonym="8030455F02Rik; KLC 2; KLC-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1782..1906
                     /gene="Klc2"
                     /gene_synonym="8030455F02Rik; KLC 2; KLC-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1907..1964
                     /gene="Klc2"
                     /gene_synonym="8030455F02Rik; KLC 2; KLC-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1965..2907
                     /gene="Klc2"
                     /gene_synonym="8030455F02Rik; KLC 2; KLC-2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2885..2890
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Klc2"
                     /gene_synonym="8030455F02Rik; KLC 2; KLC-2"
                     /note="hexamer: AATAAA"
     polyA_site      2907
                     /gene="Klc2"
                     /gene_synonym="8030455F02Rik; KLC 2; KLC-2"
                     /note="major polyA site"
ORIGIN      
        1 ggggactgct gggaaggccg gcgggatgga ggcagcgaga cgagctcacg gtcgaggatc
       61 cgggtgaagc gggacaggag caggagccgg agccgggcca aagcagaagg tgcaggtcgg
      121 cgccggccgg ttgggccggg agacccagtc aagccggaca gtgaggagcg gttgcagacg
      181 gcacgaccat ggccacgatg gtgcttcctc gagaggagaa gctgagtcag gacgagatag
      241 tgctgggcac caaggcggtg atccagggtt tagagaccct gagaggggag catcgtgccc
      301 tgctagctcc cctagcttct catgaagcag gcgaggccga gccgggctca caggagcgct
      361 gcctcctcct gcgccgctcc ctggaggcca tcgagctggg gcttggggag gctcaggtga
      421 tcctggcatt atcaagccat ctgggggctg tggagtcaga gaagcagaag ctgcgggctc
      481 aggtgcggcg cctggtacaa gagaaccagt ggttgcgtga ggagctggca gggacacagc
      541 agaagctgca gcgcagtgaa caggcggtgg ctcagctgga ggaagagaag cagcacctgc
      601 tattcatgag tcagatccga aagctggatg aggatgcttc cccaaatgag gagaagggtg
      661 atgtccccaa agactccctg gatgacctgt ttcccaatga agatgaacag agcccagccc
      721 ccagccctgg aggaggagat gtagctgcac agcatggggg ctatgagatc ccagcacggc
      781 tacggaccct ccacaacctg gtaatccagt atgcttcaca aggccgctat gaggtggccg
      841 tgcccctctg caagcaggca ctggaagatt tggagaagac atcaggccat gaccaccctg
      901 atgtggccac catgctgaac atcctggcac tggtttatcg ggaccagaat aagtacaagg
      961 atgctgctca cctgctcaat gatgccctgg ctatccggga aaagacactg ggcaaggacc
     1021 acccagctgt ggctgcgacc ctcaacaatc tggctgttct ctacggcaaa cggggcaagt
     1081 acaaagaggc tgagccactg tgcaagagag cactggagat ccgggagaag gtcctgggca
     1141 agtttcaccc agatgtggcc aagcagctca gcaacctggc cttgctgtgc cagaaccagg
     1201 gcaaagctga ggaggtggaa tactactacc ggagagccct ggagatctat gccacacgcc
     1261 ttggtcctga tgaccccaat gtggcgaaga ccaagaacaa cctggcttcc tgctacctga
     1321 aacagggcaa gtaccaggat gcagagaccc tgtacaagga gatccttacc cgtgcgcacg
     1381 agaaggagtt tggctcagtc aatggagaga acaagcccat ctggatgcac gcagaggagc
     1441 gcgaggagag caaggataag cgccgggaca gcgcccccta tggggagtat ggcagctggt
     1501 acaaagcctg taaagttgac agtcccacag tcaacaccac tctgcgaagc ttgggcgccc
     1561 tgtaccggcg ccagggcaag ctggaagccg cacacacact ggaagactgt gccagccgca
     1621 gccgcaaaca gggcctggat cctgccagcc agaccaaggt ggtagaactg ttaaaagatg
     1681 gcagtggtgg acgaggacac cgccgtggca gcagagatgt ggctgggcct caatctgagt
     1741 cggacctgga ggagtcaggg cctgcagctg agtggagtgg ggacggcagc ggctctctgc
     1801 ggcgcagtgg ctcctttggg aagctccggg atgctctgag acgcagcagt gagatgctgg
     1861 tgaggaagct gcagggaggg ggcccacagg agccccctaa ctctaggatg aagagggcca
     1921 gctctcttaa cttccttaac aagagtgtgg aagagccagt ccagcctgga ggcacgggtc
     1981 tttctgacag ccgcactttg agctccagct ccatggacct ctctcgaaga agctccctgg
     2041 tgggctaaag ctgaaggggc agccagtcac cagagcctcc atccgacatg gtcccttccc
     2101 ccagccctgc gcatgggcct gctgcttgtc ctgcctgccc ctcccaagga cccctgtctt
     2161 ttctgttcaa tctcagggta acttcctccc ttgtcatctc agccatggcc ctggaggacg
     2221 gtcctgccgg ctccagctct gctccttatt tattcttcca gcagggggcc tttcttccct
     2281 gagttcaggg cctgtgggag tggtggcctg tctacccagc cccaaagcca agaacactaa
     2341 gtacttgctg tcccctcagc acctttgccc tccactcccg gccgttgctt ctgtatatag
     2401 agaaataagt tattggccgt gtgtcatcct ctcagccctc ctctcagtcc acggtattcc
     2461 cgggccacca cctgcctctc tcttatccag tggtaccgcc caggccttaa atcaccccgt
     2521 tcccagtggt ggtatctccc aagcttcaag ttctgggacc agagcctccc aaaaggggtc
     2581 cctagacctc ttcgcctggt cttggaggga ttcgttccac tccatcttgc aaatgcccag
     2641 accctcacac cacagggccc tgtgctgctt ccggggactt aatgcactgt cctcccccac
     2701 cccgccccca ccccagcccc tcccaggcat ggcctgaccc caccctgggc acagcccatt
     2761 gagccatcct gccacgccat ccttgcctca gcttctgatg tcccccttcc tcccacacag
     2821 taggaggggc taccccattt gttgggtaag gcagtcactc tctattttca gatgttgctg
     2881 tagaaataaa gacgatttga atctgaa
//
