LOCUS       NM_001369360            2944 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Mus musculus kinesin light chain 2 (Klc2), transcript variant 3,
            mRNA.
ACCESSION   NM_001369360 XM_011248603
VERSION     NM_001369360.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2944)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2944)
  AUTHORS   Fu,X., An,Y., Wang,H., Li,P., Lin,J., Yuan,J., Yue,R., Jin,Y.,
            Gao,J. and Chai,R.
  TITLE     Deficiency of Klc2 Induces Low-Frequency Sensorineural Hearing Loss
            in C57BL/6 J Mice and Human
  JOURNAL   Mol Neurobiol 58 (9), 4376-4391 (2021)
   PUBMED   34014435
  REMARK    GeneRIF: Deficiency of Klc2 Induces Low-Frequency Sensorineural
            Hearing Loss in C57BL/6 J Mice and Human.
REFERENCE   3  (bases 1 to 2944)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2944)
  AUTHORS   Nguyen,T.Q., Chenon,M., Vilela,F., Velours,C., Aumont-Nicaise,M.,
            Andreani,J., Varela,P.F., Llinas,P. and Menetrey,J.
  TITLE     Structural plasticity of the N-terminal capping helix of the TPR
            domain of kinesin light chain
  JOURNAL   PLoS One 12 (10), e0186354 (2017)
   PUBMED   29036226
  REMARK    GeneRIF: structural plasticity of the N-terminal capping helix
            might represent a structural determinant for TPR domain structural
            versatility in cargo binding
            Erratum:[PLoS One. 2018 May 7;13(5):e0197193. doi:
            10.1371/journal.pone.0197193.. PMID: 29734375]
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2944)
  AUTHORS   Pernigo,S., Lamprecht,A., Steiner,R.A. and Dodding,M.P.
  TITLE     Structural basis for kinesin-1:cargo recognition
  JOURNAL   Science 340 (6130), 356-359 (2013)
   PUBMED   23519214
REFERENCE   6  (bases 1 to 2944)
  AUTHORS   Frederikse,P.H., Yun,E., Kao,H.T., Zigler,J.S. Jr., Sun,Q. and
            Qazi,A.S.
  TITLE     Synapsin and synaptic vesicle protein expression during embryonic
            and post-natal lens fiber cell differentiation
  JOURNAL   Mol Vis 10, 794-804 (2004)
   PUBMED   15529118
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 2944)
  AUTHORS   Bowman,A.B., Kamal,A., Ritchings,B.W., Philp,A.V., McGrail,M.,
            Gindhart,J.G. and Goldstein,L.S.
  TITLE     Kinesin-dependent axonal transport is mediated by the sunday driver
            (SYD) protein
  JOURNAL   Cell 103 (4), 583-594 (2000)
   PUBMED   11106729
REFERENCE   8  (bases 1 to 2944)
  AUTHORS   Deussing,J., Tisljar,K., Papazoglou,A. and Peters,C.
  TITLE     Mouse cathepsin F: cDNA cloning, genomic organization and
            chromosomal assignment of the gene
  JOURNAL   Gene 251 (2), 165-173 (2000)
   PUBMED   10876093
REFERENCE   9  (bases 1 to 2944)
  AUTHORS   Rahman,A., Friedman,D.S. and Goldstein,L.S.
  TITLE     Two kinesin light chain genes in mice. Identification and
            characterization of the encoded proteins
  JOURNAL   J Biol Chem 273 (25), 15395-15403 (1998)
   PUBMED   9624122
  REMARK    Erratum:[J Biol Chem 1998 Sep 11;273(37):24280]
REFERENCE   10 (bases 1 to 2944)
  AUTHORS   Lamerdin,J.E., Stilwagen,S.A., Ramirez,M.H., Stubbs,L. and
            Carrano,A.V.
  TITLE     Sequence analysis of the ERCC2 gene regions in human, mouse, and
            hamster reveals three linked genes
  JOURNAL   Genomics 34 (3), 399-409 (1996)
   PUBMED   8786141
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC124502.4.
            
            On Apr 5, 2019 this sequence version replaced XM_011248603.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7345562.3303110.1,
                                           ERR3363658.5735375.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164138
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-177               AC124502.4         5290-5466
            178-453             AC124502.4         6119-6394
            454-684             AC124502.4         9417-9647
            685-754             AC124502.4         9738-9807
            755-977             AC124502.4         10648-10870
            978-1065            AC124502.4         11675-11762
            1066-1167           AC124502.4         11868-11969
            1168-1341           AC124502.4         12050-12223
            1342-1441           AC124502.4         12351-12450
            1442-1491           AC124502.4         13172-13221
            1492-1559           AC124502.4         13324-13391
            1560-1668           AC124502.4         13747-13855
            1669-1818           AC124502.4         13946-14095
            1819-1943           AC124502.4         14163-14287
            1944-2001           AC124502.4         14428-14485
            2002-2944           AC124502.4         14900-15842
FEATURES             Location/Qualifiers
     source          1..2944
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 4.25 cM"
     gene            1..2944
                     /gene="Klc2"
                     /gene_synonym="8030455F02Rik; KLC 2; KLC-2"
                     /note="kinesin light chain 2"
                     /db_xref="GeneID:16594"
                     /db_xref="MGI:MGI:107953"
     exon            1..177
                     /gene="Klc2"
                     /gene_synonym="8030455F02Rik; KLC 2; KLC-2"
                     /inference="alignment:Splign:2.1.0"
     exon            178..453
                     /gene="Klc2"
                     /gene_synonym="8030455F02Rik; KLC 2; KLC-2"
                     /inference="alignment:Splign:2.1.0"
     CDS             226..2085
                     /gene="Klc2"
                     /gene_synonym="8030455F02Rik; KLC 2; KLC-2"
                     /note="isoform 1 is encoded by transcript variant 3"
                     /codon_start=1
                     /product="kinesin light chain 2 isoform 1"
                     /protein_id="NP_001356289.1"
                     /db_xref="CCDS:CCDS37889.1"
                     /db_xref="GeneID:16594"
                     /db_xref="MGI:MGI:107953"
                     /translation="MATMVLPREEKLSQDEIVLGTKAVIQGLETLRGEHRALLAPLAS
                     HEAGEAEPGSQERCLLLRRSLEAIELGLGEAQVILALSSHLGAVESEKQKLRAQVRRL
                     VQENQWLREELAGTQQKLQRSEQAVAQLEEEKQHLLFMSQIRKLDEDASPNEEKGDVP
                     KDSLDDLFPNEDEQSPAPSPGGGDVAAQHGGYEIPARLRTLHNLVIQYASQGRYEVAV
                     PLCKQALEDLEKTSGHDHPDVATMLNILALVYRDQNKYKDAAHLLNDALAIREKTLGK
                     DHPAVAATLNNLAVLYGKRGKYKEAEPLCKRALEIREKVLGKFHPDVAKQLSNLALLC
                     QNQGKAEEVEYYYRRALEIYATRLGPDDPNVAKTKNNLASCYLKQGKYQDAETLYKEI
                     LTRAHEKEFGSVNGENKPIWMHAEEREESKDKRRDSAPYGEYGSWYKACKVDSPTVNT
                     TLRSLGALYRRQGKLEAAHTLEDCASRSRKQGLDPASQTKVVELLKDGSGGRGHRRGS
                     RDVAGPQSESDLEESGPAAEWSGDGSGSLRRSGSFGKLRDALRRSSEMLVRKLQGGGP
                     QEPPNSRMKRASSLNFLNKSVEEPVQPGGTGLSDSRTLSSSSMDLSRRSSLVG"
     exon            454..684
                     /gene="Klc2"
                     /gene_synonym="8030455F02Rik; KLC 2; KLC-2"
                     /inference="alignment:Splign:2.1.0"
     exon            685..754
                     /gene="Klc2"
                     /gene_synonym="8030455F02Rik; KLC 2; KLC-2"
                     /inference="alignment:Splign:2.1.0"
     exon            755..977
                     /gene="Klc2"
                     /gene_synonym="8030455F02Rik; KLC 2; KLC-2"
                     /inference="alignment:Splign:2.1.0"
     exon            978..1065
                     /gene="Klc2"
                     /gene_synonym="8030455F02Rik; KLC 2; KLC-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1066..1167
                     /gene="Klc2"
                     /gene_synonym="8030455F02Rik; KLC 2; KLC-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1168..1341
                     /gene="Klc2"
                     /gene_synonym="8030455F02Rik; KLC 2; KLC-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1342..1441
                     /gene="Klc2"
                     /gene_synonym="8030455F02Rik; KLC 2; KLC-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1442..1491
                     /gene="Klc2"
                     /gene_synonym="8030455F02Rik; KLC 2; KLC-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1492..1559
                     /gene="Klc2"
                     /gene_synonym="8030455F02Rik; KLC 2; KLC-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1560..1668
                     /gene="Klc2"
                     /gene_synonym="8030455F02Rik; KLC 2; KLC-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1669..1818
                     /gene="Klc2"
                     /gene_synonym="8030455F02Rik; KLC 2; KLC-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1819..1943
                     /gene="Klc2"
                     /gene_synonym="8030455F02Rik; KLC 2; KLC-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1944..2001
                     /gene="Klc2"
                     /gene_synonym="8030455F02Rik; KLC 2; KLC-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2002..2944
                     /gene="Klc2"
                     /gene_synonym="8030455F02Rik; KLC 2; KLC-2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2922..2927
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Klc2"
                     /gene_synonym="8030455F02Rik; KLC 2; KLC-2"
                     /note="hexamer: AATAAA"
     polyA_site      2944
                     /gene="Klc2"
                     /gene_synonym="8030455F02Rik; KLC 2; KLC-2"
                     /note="major polyA site"
ORIGIN      
        1 ggggactgct gggaaggccg gcgggatgga ggcagcgaga cgagctcacg gtcgaggatc
       61 cgggtgaagc gggacaggag caggagccgg agccgggcca aagcagaagg tgcaggtcgg
      121 cgccggccgg ttgggccggg agacccagtc aagccggaca gtgaggagcg gttgcaggcc
      181 tggcgtccgc ctgccccacc ccttgcctcc acagacggca cgaccatggc cacgatggtg
      241 cttcctcgag aggagaagct gagtcaggac gagatagtgc tgggcaccaa ggcggtgatc
      301 cagggtttag agaccctgag aggggagcat cgtgccctgc tagctcccct agcttctcat
      361 gaagcaggcg aggccgagcc gggctcacag gagcgctgcc tcctcctgcg ccgctccctg
      421 gaggccatcg agctggggct tggggaggct caggtgatcc tggcattatc aagccatctg
      481 ggggctgtgg agtcagagaa gcagaagctg cgggctcagg tgcggcgcct ggtacaagag
      541 aaccagtggt tgcgtgagga gctggcaggg acacagcaga agctgcagcg cagtgaacag
      601 gcggtggctc agctggagga agagaagcag cacctgctat tcatgagtca gatccgaaag
      661 ctggatgagg atgcttcccc aaatgaggag aagggtgatg tccccaaaga ctccctggat
      721 gacctgtttc ccaatgaaga tgaacagagc ccagccccca gccctggagg aggagatgta
      781 gctgcacagc atgggggcta tgagatccca gcacggctac ggaccctcca caacctggta
      841 atccagtatg cttcacaagg ccgctatgag gtggccgtgc ccctctgcaa gcaggcactg
      901 gaagatttgg agaagacatc aggccatgac caccctgatg tggccaccat gctgaacatc
      961 ctggcactgg tttatcggga ccagaataag tacaaggatg ctgctcacct gctcaatgat
     1021 gccctggcta tccgggaaaa gacactgggc aaggaccacc cagctgtggc tgcgaccctc
     1081 aacaatctgg ctgttctcta cggcaaacgg ggcaagtaca aagaggctga gccactgtgc
     1141 aagagagcac tggagatccg ggagaaggtc ctgggcaagt ttcacccaga tgtggccaag
     1201 cagctcagca acctggcctt gctgtgccag aaccagggca aagctgagga ggtggaatac
     1261 tactaccgga gagccctgga gatctatgcc acacgccttg gtcctgatga ccccaatgtg
     1321 gcgaagacca agaacaacct ggcttcctgc tacctgaaac agggcaagta ccaggatgca
     1381 gagaccctgt acaaggagat ccttacccgt gcgcacgaga aggagtttgg ctcagtcaat
     1441 ggagagaaca agcccatctg gatgcacgca gaggagcgcg aggagagcaa ggataagcgc
     1501 cgggacagcg ccccctatgg ggagtatggc agctggtaca aagcctgtaa agttgacagt
     1561 cccacagtca acaccactct gcgaagcttg ggcgccctgt accggcgcca gggcaagctg
     1621 gaagccgcac acacactgga agactgtgcc agccgcagcc gcaaacaggg cctggatcct
     1681 gccagccaga ccaaggtggt agaactgtta aaagatggca gtggtggacg aggacaccgc
     1741 cgtggcagca gagatgtggc tgggcctcaa tctgagtcgg acctggagga gtcagggcct
     1801 gcagctgagt ggagtgggga cggcagcggc tctctgcggc gcagtggctc ctttgggaag
     1861 ctccgggatg ctctgagacg cagcagtgag atgctggtga ggaagctgca gggagggggc
     1921 ccacaggagc cccctaactc taggatgaag agggccagct ctcttaactt ccttaacaag
     1981 agtgtggaag agccagtcca gcctggaggc acgggtcttt ctgacagccg cactttgagc
     2041 tccagctcca tggacctctc tcgaagaagc tccctggtgg gctaaagctg aaggggcagc
     2101 cagtcaccag agcctccatc cgacatggtc ccttccccca gccctgcgca tgggcctgct
     2161 gcttgtcctg cctgcccctc ccaaggaccc ctgtcttttc tgttcaatct cagggtaact
     2221 tcctcccttg tcatctcagc catggccctg gaggacggtc ctgccggctc cagctctgct
     2281 ccttatttat tcttccagca gggggccttt cttccctgag ttcagggcct gtgggagtgg
     2341 tggcctgtct acccagcccc aaagccaaga acactaagta cttgctgtcc cctcagcacc
     2401 tttgccctcc actcccggcc gttgcttctg tatatagaga aataagttat tggccgtgtg
     2461 tcatcctctc agccctcctc tcagtccacg gtattcccgg gccaccacct gcctctctct
     2521 tatccagtgg taccgcccag gccttaaatc accccgttcc cagtggtggt atctcccaag
     2581 cttcaagttc tgggaccaga gcctcccaaa aggggtccct agacctcttc gcctggtctt
     2641 ggagggattc gttccactcc atcttgcaaa tgcccagacc ctcacaccac agggccctgt
     2701 gctgcttccg gggacttaat gcactgtcct cccccacccc gcccccaccc cagcccctcc
     2761 caggcatggc ctgaccccac cctgggcaca gcccattgag ccatcctgcc acgccatcct
     2821 tgcctcagct tctgatgtcc cccttcctcc cacacagtag gaggggctac cccatttgtt
     2881 gggtaaggca gtcactctct attttcagat gttgctgtag aaataaagac gatttgaatc
     2941 tgaa
//
