LOCUS       NM_001361609            2373 bp    mRNA    linear   ROD 27-JUL-2024
DEFINITION  Mus musculus kinesin light chain 1 (Klc1), transcript variant j,
            mRNA.
ACCESSION   NM_001361609 XM_006515492
VERSION     NM_001361609.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2373)
  AUTHORS   Qu,Z., Shi,L., Wu,Z., Lin,P., Zhang,G., Cong,X., Zhao,X., Ge,H.,
            Yan,S., Jiang,L. and Wu,H.
  TITLE     Kinesin light chain 1 stabilizes insulin receptor substrate 1 to
            regulate the IGF-1-AKT signaling pathway during myoblast
            differentiation
  JOURNAL   FASEB J 38 (3), e23432 (2024)
   PUBMED   38300173
  REMARK    GeneRIF: Kinesin light chain 1 stabilizes insulin receptor
            substrate 1 to regulate the IGF-1-AKT signaling pathway during
            myoblast differentiation.
REFERENCE   2  (bases 1 to 2373)
  AUTHORS   Chassefeyre,R., Chaiamarit,T., Verhelle,A., Novak,S.W.,
            Andrade,L.R., Leitao,A.D.G., Manor,U. and Encalada,S.E.
  TITLE     Endosomal sorting drives the formation of axonal prion protein
            endoggresomes
  JOURNAL   Sci Adv 7 (52), eabg3693 (2021)
   PUBMED   34936461
REFERENCE   3  (bases 1 to 2373)
  AUTHORS   Doron-Mandel,E., Koppel,I., Abraham,O., Rishal,I., Smith,T.P.,
            Buchanan,C.N., Sahoo,P.K., Kadlec,J., Oses-Prieto,J.A.,
            Kawaguchi,R., Alber,S., Zahavi,E.E., Di Matteo,P., Di Pizio,A.,
            Song,D.A., Okladnikov,N., Gordon,D., Ben-Dor,S., Haffner-Krausz,R.,
            Coppola,G., Burlingame,A.L., Jungwirth,P., Twiss,J.L. and
            Fainzilber,M.
  TITLE     The glycine arginine-rich domain of the RNA-binding protein
            nucleolin regulates its subcellular localization
  JOURNAL   EMBO J 40 (20), e107158 (2021)
   PUBMED   34515347
  REMARK    GeneRIF: The glycine arginine-rich domain of the RNA-binding
            protein nucleolin regulates its subcellular localization.
REFERENCE   4  (bases 1 to 2373)
  AUTHORS   Chen,X.Q., Das,U., Park,G. and Mobley,W.C.
  TITLE     Normal levels of KIF5 but reduced KLC1 levels in both Alzheimer
            disease and Alzheimer disease in Down syndrome: evidence suggesting
            defects in anterograde transport
  JOURNAL   Alzheimers Res Ther 13 (1), 59 (2021)
   PUBMED   33691783
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2373)
  AUTHORS   Saez,T.M.M., Fernandez Bessone,I., Rodriguez,M.S., Alloatti,M.,
            Otero,M.G., Cromberg,L.E., Pozo Devoto,V.M., Oubina,G., Sosa,L.,
            Buffone,M.G., Gelman,D.M. and Falzone,T.L.
  TITLE     Kinesin-1-mediated axonal transport of CB1 receptors is required
            for cannabinoid-dependent axonal growth and guidance
  JOURNAL   Development 147 (8) (2020)
   PUBMED   32265198
  REMARK    GeneRIF: Kinesin-1-mediated axonal transport of CB1 receptors is
            required for cannabinoid-dependent axonal growth and guidance.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2373)
  AUTHORS   Bowman,A.B., Kamal,A., Ritchings,B.W., Philp,A.V., McGrail,M.,
            Gindhart,J.G. and Goldstein,L.S.
  TITLE     Kinesin-dependent axonal transport is mediated by the sunday driver
            (SYD) protein
  JOURNAL   Cell 103 (4), 583-594 (2000)
   PUBMED   11106729
REFERENCE   7  (bases 1 to 2373)
  AUTHORS   Kelkar,N., Gupta,S., Dickens,M. and Davis,R.J.
  TITLE     Interaction of a mitogen-activated protein kinase signaling module
            with the neuronal protein JIP3
  JOURNAL   Mol Cell Biol 20 (3), 1030-1043 (2000)
   PUBMED   10629060
REFERENCE   8  (bases 1 to 2373)
  AUTHORS   Rahman,A., Kamal,A., Roberts,E.A. and Goldstein,L.S.
  TITLE     Defective kinesin heavy chain behavior in mouse kinesin light chain
            mutants
  JOURNAL   J Cell Biol 146 (6), 1277-1288 (1999)
   PUBMED   10491391
REFERENCE   9  (bases 1 to 2373)
  AUTHORS   Rahman,A., Friedman,D.S. and Goldstein,L.S.
  TITLE     Two kinesin light chain genes in mice. Identification and
            characterization of the encoded proteins
  JOURNAL   J Biol Chem 273 (25), 15395-15403 (1998)
   PUBMED   9624122
  REMARK    Erratum:[J Biol Chem 1998 Sep 11;273(37):24280]
REFERENCE   10 (bases 1 to 2373)
  AUTHORS   Lan,Y., Jiang,R., Shawber,C., Weinmaster,G. and Gridley,T.
  TITLE     The Jagged2 gene maps to chromosome 12 and is a candidate for the
            lgl and sm mutations
  JOURNAL   Mamm Genome 8 (11), 875-876 (1997)
   PUBMED   9341252
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC152065.4, BY783968.1,
            BC055744.1, AY753300.1 and AK031309.1.
            
            On Mar 29, 2018 this sequence version replaced XM_006515492.2.
            
            Summary: Conventional kinesin is a tetrameric molecule composed of
            two heavy chains and two light chains, and transports various
            cargos along microtubules toward their plus ends. The heavy chains
            provide the motor activity, while the light chains bind to various
            cargos. This gene encodes a member of the kinesin light chain
            family. It associates with kinesin heavy chain through an
            N-terminal domain, and six tetratricopeptide repeat (TPR) motifs
            are thought to be involved in binding of cargos such as vesicles,
            mitochondria, and the Golgi complex. Thus, kinesin light chains
            function as adapter molecules and not motors per se. Although
            previously named 'kinesin 2', this gene is not a member of the
            kinesin-2 / kinesin heavy chain subfamily of kinesin motor
            proteins. Extensive alternative splicing produces isoforms with
            different C-termini that are proposed to bind to different cargos;
            however, the full-length nature of some of these variants has not
            been determined. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660813.224787.1,
                                           SRR7345562.1117360.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-8                 AC152065.4         148445-148452       c
            9-164               BY783968.1         3-158
            165-195             BC055744.1         1-31
            196-1819            AY753300.1         1-1624
            1820-1845           BC055744.1         1632-1657
            1846-2312           BC055744.1         1789-2255
            2313-2373           AK031309.1         2416-2476
FEATURES             Location/Qualifiers
     source          1..2373
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 61.13 cM"
     gene            1..2373
                     /gene="Klc1"
                     /gene_synonym="Kns2"
                     /note="kinesin light chain 1"
                     /db_xref="GeneID:16593"
                     /db_xref="MGI:MGI:107978"
     exon            1..194
                     /gene="Klc1"
                     /gene_synonym="Kns2"
                     /inference="alignment:Splign:2.1.0"
     exon            195..456
                     /gene="Klc1"
                     /gene_synonym="Kns2"
                     /inference="alignment:Splign:2.1.0"
     CDS             196..1905
                     /gene="Klc1"
                     /gene_synonym="Kns2"
                     /EC_number="2.7.1.21"
                     /note="isoform 1J is encoded by transcript variant j;
                     kinesin 2 60/70kDa; KLC 1"
                     /codon_start=1
                     /product="kinesin light chain 1 isoform 1J"
                     /protein_id="NP_001348538.1"
                     /db_xref="GeneID:16593"
                     /db_xref="MGI:MGI:107978"
                     /translation="MYDNMSTMVYIKEEKLEKLTQDEIISKTKQVIQGLEALKNEHNS
                     ILQSLLETLKCLKKDDESNLVEEKSSMIRKSLEMLELGLSEAQVMMALSNHLNAVESE
                     KQKLRAQVRRLCQENQWLRDELANTQQKLQKSEQSVAQLEEEKKHLEFMNQLKKYDDD
                     ISPSEDKDSDSSKEPLDDLFPNDEDEPGQGIQQQHSSAAAAAQQGGYEIPARLRTLHN
                     LVIQYASQGRYEVAVPLCKQALEDLEKTSGHDHPDVATMLNILALVYRDQNKYKDAAN
                     LLNDALAIREKTLGRDHPAVAATLNNLAVLYGKRGKYKEAEPLCKRALEIREKVLGKD
                     HPDVAKQLNNLALLCQNQGKYEEVEYYYQRALGIYQTKLGPDDPNVAKTKNNLASCYL
                     KQGKFKQAETLYKEILTRAHEREFGSVDDENKPIWMHAEEREECKGKQKDGSAFGEYG
                     GWYKACKVDSPTVTTTLKNLGALYRRQGKFEAAETLEEAAMRSRKQGLDNVHKQRVAE
                     VLNDPESMEKRRSRESLNMDVVKYESGPDGGEEVSMSVEWNGGIPRRASLCGKRQQQP
                     RRR"
     exon            457..687
                     /gene="Klc1"
                     /gene_synonym="Kns2"
                     /inference="alignment:Splign:2.1.0"
     exon            688..766
                     /gene="Klc1"
                     /gene_synonym="Kns2"
                     /inference="alignment:Splign:2.1.0"
     exon            767..992
                     /gene="Klc1"
                     /gene_synonym="Kns2"
                     /inference="alignment:Splign:2.1.0"
     exon            993..1080
                     /gene="Klc1"
                     /gene_synonym="Kns2"
                     /inference="alignment:Splign:2.1.0"
     exon            1081..1182
                     /gene="Klc1"
                     /gene_synonym="Kns2"
                     /inference="alignment:Splign:2.1.0"
     exon            1183..1356
                     /gene="Klc1"
                     /gene_synonym="Kns2"
                     /inference="alignment:Splign:2.1.0"
     exon            1357..1456
                     /gene="Klc1"
                     /gene_synonym="Kns2"
                     /inference="alignment:Splign:2.1.0"
     exon            1457..1506
                     /gene="Klc1"
                     /gene_synonym="Kns2"
                     /inference="alignment:Splign:2.1.0"
     exon            1507..1574
                     /gene="Klc1"
                     /gene_synonym="Kns2"
                     /inference="alignment:Splign:2.1.0"
     exon            1575..1683
                     /gene="Klc1"
                     /gene_synonym="Kns2"
                     /inference="alignment:Splign:2.1.0"
     exon            1684..1845
                     /gene="Klc1"
                     /gene_synonym="Kns2"
                     /inference="alignment:Splign:2.1.0"
     exon            1846..1912
                     /gene="Klc1"
                     /gene_synonym="Kns2"
                     /inference="alignment:Splign:2.1.0"
     exon            1913..2373
                     /gene="Klc1"
                     /gene_synonym="Kns2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2287..2292
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Klc1"
                     /gene_synonym="Kns2"
                     /note="hexamer: ATTAAA"
     polyA_site      2310
                     /gene="Klc1"
                     /gene_synonym="Kns2"
                     /note="major polyA site"
ORIGIN      
        1 acagcattgt ggggcgggcg cggcgccggc gacgccattt tcggcggcgg agggtggcgc
       61 gaggctgcgg agcgcgggtc agggtgagga tgctgcgggg cggctgcgga ggcgccgctt
      121 gctgctgagg cggctgggct ctgcgcggcc tcggcctgtg acagcgcgac gagcgcgact
      181 ctcccgatcg gacggatgta tgacaacatg tccaccatgg tgtacataaa ggaagagaag
      241 ctggagaagc tcacgcagga tgagatcatc tctaagacca agcaagtgat ccaggggctg
      301 gaagccctga agaatgagca caactccatc ctgcagagtt tgctggagac gctgaagtgc
      361 ttgaagaagg atgacgagag caacctggtg gaagagaaat ccagcatgat ccgcaagtcc
      421 ctggagatgc tggagcttgg cctgagcgag gcgcaggtga tgatggcgct gtccaatcac
      481 ctgaatgctg tggagtccga gaagcaaaag ctccgcgctc aggttcgacg gctgtgccag
      541 gagaaccagt ggctgcggga tgagctggcc aacacgcagc agaagttgca gaagagcgag
      601 cagtcggtgg cgcagctgga ggaggagaag aaacacctgg agttcatgaa ccagctgaag
      661 aagtacgacg acgacatctc cccctcggag gacaaagact ctgattcttc caaagagccg
      721 ttggatgatc tcttcccaaa tgacgaggac gaaccaggac aaggaatcca gcagcagcac
      781 agtagtgctg cggccgccgc ccagcagggc ggctacgaga tccctgcaag gctgcgcacg
      841 ctccacaact tggtgatcca gtatgcttca caggggcgtt acgaggtggc ggtgccactc
      901 tgcaagcagg ccctggagga tctggagaag acttccggcc acgaccaccc cgatgtggct
      961 accatgctca acatcttggc cctggtgtac agggatcaga acaagtataa agatgcagct
     1021 aacctcctga acgacgccct ggctatccgc gagaaaaccc tgggcagaga tcaccccgcg
     1081 gtggcagcga ctctgaacaa cctagcagta ctgtacggta agcgagggaa gtacaaggag
     1141 gcggagccgc tgtgtaaacg agccctggag atcagggaga aggttctggg aaaggatcat
     1201 cctgatgttg ccaaacagtt aaataacctg gccctgctgt gccagaacca gggcaagtac
     1261 gaggaggtgg agtattatta ccagagggcc ctgggcatct accagacgaa gctggggccc
     1321 gacgatccca acgtggccaa gaccaagaac aacctggcct cctgttatct gaaacaaggg
     1381 aagttcaagc aggcagaaac gctgtacaag gagattctca cccgcgcaca cgagcgggag
     1441 tttggatctg tggacgacga gaacaagccc atctggatgc acgctgaaga gagagaggag
     1501 tgcaaaggca agcagaagga cgggtcggct tttggagagt atggcggctg gtataaagcc
     1561 tgcaaagtgg acagtcccac cgtcacaacc accttgaaaa accttggagc actttaccga
     1621 cggcagggga agtttgaagc tgcagagaca ttggaagaag ccgccatgag gtcacgtaag
     1681 cagggtcttg acaatgttca caaacagaga gtggctgaag tgctaaatga ccctgagagc
     1741 atggagaagc ggaggagccg ggagagtctc aatatggacg tggtcaagta cgagagtggc
     1801 cctgacggag gggaggaagt gagtatgagc gtagagtgga atgggggcat cccccgcaga
     1861 gcctctttgt gtggaaaacg acagcagcag cctagaagac gctagcacta actgacctgg
     1921 gcctggtcct ttagacacca tgctgctgct gctgctgctg ctgctgagca cggctccgga
     1981 gctggccctg tgaaggccag ggtggggctg ggagggccct cggctgggag cccgcagtgc
     2041 taacttagtt cccttgccca tgtgctgtgg agcgtatact aacaactaca cctctagtag
     2101 ggtcttggag agccactctc agtcagcaag ggtggtgacc tggtcctgtc cccttcctgg
     2161 gaggcctacg agcaggacac gtctggctct tgctgcttct gcctggcctc tttgtggcac
     2221 ttctcatgtg tttagttctg tgtcgtgtgt gataatgtat ttttattgta cattttttaa
     2281 aaaaaaatta aaagtttata tgccatacca tctaccagaa tgaaagcctg ttcataacta
     2341 ttttttaaaa attaaatttt tttattatca tgc
//
