LOCUS       NM_031180               3439 bp    mRNA    linear   ROD 17-JUL-2024
DEFINITION  Mus musculus klotho beta (Klb), mRNA.
ACCESSION   NM_031180
VERSION     NM_031180.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3439)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3439)
  AUTHORS   Tzur,Y., Winek,K., Madrer,N., Dubnov,S., Bennett,E.R.,
            Greenberg,D.S., Hanin,G., Gammal,A., Tam,J., Arkin,I.T., Paldor,I.
            and Soreq,H.
  TITLE     Lysine tRNA fragments and miR-194-5p co-regulate hepatic steatosis
            via beta-Klotho and perilipin 2
  JOURNAL   Mol Metab 79, 101856 (2024)
   PUBMED   38141848
  REMARK    GeneRIF: Lysine tRNA fragments and miR-194-5p co-regulate hepatic
            steatosis via beta-Klotho and perilipin 2.
REFERENCE   3  (bases 1 to 3439)
  AUTHORS   Kobayashi,K., Iwasa,K., Azuma-Suzuki,R., Kawauchi,T. and
            Nabeshima,Y.I.
  TITLE     Feto-maternal cholesterol transport regulated by beta-Klotho-FGF15
            axis is essential for fetal growth
  JOURNAL   Life Sci Alliance 6 (10), e202301916 (2023)
   PUBMED   37541847
  REMARK    GeneRIF: Feto-maternal cholesterol transport regulated by
            beta-Klotho-FGF15 axis is essential for fetal growth.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3439)
  AUTHORS   Sarkar,A., Jin,Y., DeFelice,B.C., Logan,C.Y., Yang,Y.,
            Anbarchian,T., Wu,P., Morri,M., Neff,N.F., Nguyen,H., Rulifson,E.,
            Fish,M., Kaye,A.G., Martinez Jaimes,A.M. and Nusse,R.
  TITLE     Intermittent fasting induces rapid hepatocyte proliferation to
            restore the hepatostat in the mouse liver
  JOURNAL   Elife 12, e82311 (2023)
   PUBMED   36719070
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3439)
  AUTHORS   Jin,L., Geng,L., Ying,L., Shu,L., Ye,K., Yang,R., Liu,Y., Wang,Y.,
            Cai,Y., Jiang,X., Wang,Q., Yan,X., Liao,B., Liu,J., Duan,F.,
            Sweeney,G., Woo,C.W.H., Wang,Y., Xia,Z., Lian,Q. and Xu,A.
  TITLE     FGF21-Sirtuin 3 Axis Confers the Protective Effects of Exercise
            Against Diabetic Cardiomyopathy by Governing Mitochondrial
            Integrity
  JOURNAL   Circulation 146 (20), 1537-1557 (2022)
   PUBMED   36134579
REFERENCE   6  (bases 1 to 3439)
  AUTHORS   Ogawa,Y., Kurosu,H., Yamamoto,M., Nandi,A., Rosenblatt,K.P.,
            Goetz,R., Eliseenkova,A.V., Mohammadi,M. and Kuro-o,M.
  TITLE     BetaKlotho is required for metabolic activity of fibroblast growth
            factor 21
  JOURNAL   Proc Natl Acad Sci U S A 104 (18), 7432-7437 (2007)
   PUBMED   17452648
  REMARK    GeneRIF: betaKlotho functions as a cofactor essential for
            fibroblast growth factor 21 activity
REFERENCE   7  (bases 1 to 3439)
  AUTHORS   Chang,Q., Hoefs,S., van der Kemp,A.W., Topala,C.N., Bindels,R.J.
            and Hoenderop,J.G.
  TITLE     The beta-glucuronidase klotho hydrolyzes and activates the TRPV5
            channel
  JOURNAL   Science 310 (5747), 490-493 (2005)
   PUBMED   16239475
REFERENCE   8  (bases 1 to 3439)
  AUTHORS   Ito,S., Fujimori,T., Furuya,A., Satoh,J., Nabeshima,Y. and
            Nabeshima,Y.
  TITLE     Impaired negative feedback suppression of bile acid synthesis in
            mice lacking betaKlotho
  JOURNAL   J Clin Invest 115 (8), 2202-2208 (2005)
   PUBMED   16075061
REFERENCE   9  (bases 1 to 3439)
  AUTHORS   Ito,S., Kinoshita,S., Shiraishi,N., Nakagawa,S., Sekine,S.,
            Fujimori,T. and Nabeshima,Y.I.
  TITLE     Molecular cloning and expression analyses of mouse betaklotho,
            which encodes a novel Klotho family protein
  JOURNAL   Mech Dev 98 (1-2), 115-119 (2000)
   PUBMED   11044614
REFERENCE   10 (bases 1 to 3439)
  AUTHORS   Shiraki-Iida,T., Aizawa,H., Matsumura,Y., Sekine,S., Iida,A.,
            Anazawa,H., Nagai,R., Kuro-o,M. and Nabeshima,Y.
  TITLE     Structure of the mouse klotho gene and its two transcripts encoding
            membrane and secreted protein
  JOURNAL   FEBS Lett 424 (1-2), 6-10 (1998)
   PUBMED   9537505
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AC138654.4 and
            AC136513.2.
            
            [WARNING] On Aug 3, 2024 this sequence was replaced by NM_031180.3.
            
            On Nov 17, 2006 this sequence version replaced NM_031180.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF165170.1, AK133823.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849379
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-826               AC138654.4         180138-180963
            827-1331            AC136513.2         169562-170066       c
            1332-1600           AC136513.2         166074-166342       c
            1601-2744           AC136513.2         161951-163094       c
            2745-3439           AC136513.2         158019-158713       c
FEATURES             Location/Qualifiers
     source          1..3439
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 33.64 cM"
     gene            1..3439
                     /gene="Klb"
                     /gene_synonym="betaKlotho"
                     /note="klotho beta"
                     /db_xref="GeneID:83379"
                     /db_xref="MGI:MGI:1932466"
     exon            1..826
                     /gene="Klb"
                     /gene_synonym="betaKlotho"
                     /inference="alignment:Splign:2.1.0"
     CDS             2..3133
                     /gene="Klb"
                     /gene_synonym="betaKlotho"
                     /note="BKL; klotho beta-like protein"
                     /codon_start=1
                     /product="beta-klotho"
                     /protein_id="NP_112457.1"
                     /db_xref="CCDS:CCDS19306.1"
                     /db_xref="GeneID:83379"
                     /db_xref="MGI:MGI:1932466"
                     /translation="MKTGCAAGSPGNEWIFFSSDERNTRSRKTMSNRALQRSAVLSAF
                     VLLRAVTGFSGDGKAIWDKKQYVSPVNPSQLFLYDTFPKNFSWGVGTGAFQVEGSWKT
                     DGRGPSIWDRYVYSHLRGVNGTDRSTDSYIFLEKDLLALDFLGVSFYQFSISWPRLFP
                     NGTVAAVNAQGLRYYRALLDSLVLRNIEPIVTLYHWDLPLTLQEEYGGWKNATMIDLF
                     NDYATYCFQTFGDRVKYWITIHNPYLVAWHGFGTGMHAPGEKGNLTAVYTVGHNLIKA
                     HSKVWHNYDKNFRPHQKGWLSITLGSHWIEPNRTDNMEDVINCQHSMSSVLGWFANPI
                     HGDGDYPEFMKTGAMIPEFSEAEKEEVRGTADFFAFSFGPNNFRPSNTVVKMGQNVSL
                     NLRQVLNWIKLEYDDPQILISENGWFTDSYIKTEDTTAIYMMKNFLNQVLQAIKFDEI
                     RVFGYTAWTLLDGFEWQDAYTTRRGLFYVDFNSEQKERKPKSSAHYYKQIIQDNGFPL
                     KESTPDMKGRFPCDFSWGVTESVLKPEFTVSSPQFTDPHLYVWNVTGNRLLYRVEGVR
                     LKTRPSQCTDYVSIKKRVEMLAKMKVTHYQFALDWTSILPTGNLSKVNRQVLRYYRCV
                     VSEGLKLGVFPMVTLYHPTHSHLGLPLPLLSSGGWLNMNTAKAFQDYAELCFRELGDL
                     VKLWITINEPNRLSDMYNRTSNDTYRAAHNLMIAHAQVWHLYDRQYRPVQHGAVSLSL
                     HCDWAEPANPFVDSHWKAAERFLQFEIAWFADPLFKTGDYPSVMKEYIASKNQRGLSS
                     SVLPRFTAKESRLVKGTVDFYALNHFTTRFVIHKQLNTNRSVADRDVQFLQDITRLSS
                     PSRLAVTPWGVRKLLAWIRRNYRDRDIYITANGIDDLALEDDQIRKYYLEKYVQEALK
                     AYLIDKVKIKGYYAFKLTEEKSKPRFGFFTSDFRAKSSVQFYSKLISSSGLPAENRSP
                     ACGQPAEDTDCTICSFLVEKKPLIFFGCCFISTLAVLLSITVFHHQKRRKFQKARNLQ
                     NIPLKKGHSRVFS"
     exon            827..1331
                     /gene="Klb"
                     /gene_synonym="betaKlotho"
                     /inference="alignment:Splign:2.1.0"
     exon            1332..1600
                     /gene="Klb"
                     /gene_synonym="betaKlotho"
                     /inference="alignment:Splign:2.1.0"
     exon            1601..2744
                     /gene="Klb"
                     /gene_synonym="betaKlotho"
                     /inference="alignment:Splign:2.1.0"
     exon            2745..3439
                     /gene="Klb"
                     /gene_synonym="betaKlotho"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aatgaagaca ggctgtgcag cagggtctcc ggggaatgaa tggattttct tcagctctga
       61 tgaaagaaac acacgctcta ggaaaacaat gtccaacagg gcactgcaaa gatctgccgt
      121 gctgtctgcg tttgttctgc tgcgagctgt taccggcttc tccggagacg ggaaagcaat
      181 atgggataaa aaacagtacg tgagtccggt aaacccaagt cagctgttcc tctatgacac
      241 tttccctaaa aacttttcct ggggcgttgg gaccggagca tttcaagtgg aagggagttg
      301 gaagacagat ggaagaggac cctcgatctg ggatcggtac gtctactcac acctgagagg
      361 tgtcaacggc acagacagat ccactgacag ttacatcttt ctggaaaaag acttgttggc
      421 tctggatttt ttaggagttt ctttttatca gttctcaatc tcctggccac ggttgtttcc
      481 caatggaaca gtagcagcag tgaatgcgca aggtctccgg tactaccgtg cacttctgga
      541 ctcgctggta cttaggaata tcgagcccat tgttaccttg taccattggg atttgcctct
      601 gacgctccag gaagaatatg ggggctggaa aaatgcaact atgatagatc tcttcaacga
      661 ctatgccaca tactgcttcc agacctttgg agaccgtgtc aaatattgga ttacaattca
      721 caacccttac cttgttgctt ggcatgggtt tggcacaggt atgcatgcac caggagagaa
      781 gggaaattta acagctgtct acactgtggg acacaacctg atcaaggcac attcgaaagt
      841 gtggcataac tacgacaaaa acttccgccc tcatcagaag ggttggctct ccatcacctt
      901 ggggtcccat tggatagagc caaacagaac agacaacatg gaggacgtga tcaactgcca
      961 gcactccatg tcctctgtgc ttggatggtt cgccaacccc atccacgggg acggcgacta
     1021 ccctgagttc atgaagacgg gcgccatgat ccccgagttc tctgaggcag agaaggagga
     1081 ggtgaggggc acggctgatt tctttgcctt ttccttcggg cccaacaact tcaggccctc
     1141 aaacaccgtg gtgaaaatgg gacaaaatgt atcactcaac ttaaggcagg tgctgaactg
     1201 gattaaactg gaatacgatg accctcaaat cttgatttcg gagaacggct ggttcacaga
     1261 tagctatata aagacagagg acaccacggc catctacatg atgaagaatt tcctaaacca
     1321 ggttcttcaa gcaataaaat ttgatgaaat ccgcgtgttt ggttatacgg cctggactct
     1381 cctggatggc tttgagtggc aggatgccta tacgacccga cgagggctgt tttatgtgga
     1441 ctttaacagt gagcagaaag agaggaaacc caagtcctcg gctcattact acaagcagat
     1501 catacaagac aacggcttcc ctttgaaaga gtccacgcca gacatgaagg gtcggttccc
     1561 ctgtgatttc tcttggggag tcactgagtc tgttcttaag cccgagttta cggtctcctc
     1621 cccgcagttt accgatcctc acctgtatgt gtggaatgtc actggcaaca gattgctcta
     1681 ccgagtggaa ggggtaaggc tgaaaacaag accatcccag tgcacagatt atgtgagcat
     1741 caaaaaacga gttgaaatgt tggcaaaaat gaaagtcacc cactaccagt ttgctctgga
     1801 ctggacctct atccttccca ctggcaatct gtccaaagtt aacagacaag tgttaaggta
     1861 ctataggtgt gtggtgagcg aaggactgaa gctgggcgtc ttccccatgg tgacgttgta
     1921 ccacccaacc cactcccatc tcggcctccc cctgccactt ctgagcagtg gggggtggct
     1981 aaacatgaac acagccaagg ccttccagga ctacgctgag ctgtgcttcc gggagttggg
     2041 ggacttggtg aagctctgga tcaccatcaa tgagcctaac aggctgagtg acatgtacaa
     2101 ccgcacgagt aatgacacct accgtgcagc ccacaacctg atgatcgccc atgcccaggt
     2161 ctggcacctc tatgataggc agtataggcc ggtccagcat ggggctgtgt cgctgtcctt
     2221 acattgcgac tgggcagaac ctgccaaccc ctttgtggat tcacactgga aggcagccga
     2281 gcgcttcctc cagtttgaga tcgcctggtt tgcagatccg ctcttcaaga ctggcgacta
     2341 tccatcggtt atgaaggaat acatcgcctc caagaaccag cgagggctgt ctagctcagt
     2401 cctgccgcgc ttcaccgcga aggagagcag gctggtgaag ggtaccgtcg acttctacgc
     2461 actgaaccac ttcactacga ggttcgtgat acacaagcag ctgaacacca accgctcagt
     2521 tgcagacagg gacgtccagt tcctgcagga catcacccgc ctaagctcgc ccagccgcct
     2581 ggctgtaaca ccctggggag tgcgcaagct ccttgcgtgg atccggagga actacagaga
     2641 cagggatatc tacatcacag ccaatggcat cgatgacctg gctctagagg atgatcagat
     2701 ccgaaagtac tacttggaga agtatgtcca ggaggctctg aaagcatatc tcattgacaa
     2761 ggtcaaaatc aaaggctact atgcattcaa actgactgaa gagaaatcta agcctagatt
     2821 tggatttttc acctctgact tcagagctaa gtcctctgtc cagttttaca gcaagctgat
     2881 cagcagcagt ggcctccccg ctgagaacag aagtcctgcg tgtggtcagc ctgcggaaga
     2941 cacagactgc accatttgct catttctcgt ggagaagaaa ccactcatct tcttcggttg
     3001 ctgcttcatc tccactctgg ctgtactgct atccatcacc gtttttcatc atcaaaagag
     3061 aagaaaattc cagaaagcaa ggaacttaca aaatatacca ttgaagaaag gccacagcag
     3121 agttttcagc taaactgcca tttctgtcat agtttcaaga ttcactccgg ctccatgtac
     3181 tggtaactta cgatgtgaga gacagctgta accaaggtga agacaatcga tgcctctgaa
     3241 gtgtggttca aataattcct tcaggtcccg acaatcagtg agtccgttct ccgagctgaa
     3301 gacaccctga cagtaactct gggcgtgacc ctaaacatcg cttcaggaag tgtgaatcac
     3361 gacttcacat cctttttctc tagcattctt ctgtaaataa caatcactat tcatggtcaa
     3421 gaaattaatt ttaaaaagt
//
