LOCUS       NM_001033298            2167 bp    mRNA    linear   ROD 05-JUN-2024
DEFINITION  Mus musculus kizuna centrosomal protein (Kiz), mRNA.
ACCESSION   NM_001033298 XM_130476 XM_902357 XM_902359 XM_918356 XM_925683
            XM_925684 XM_925685
VERSION     NM_001033298.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2167)
  AUTHORS   Sun,J., Yang,Q., Liu,E., Chen,D. and Sun,Q.
  TITLE     KIZ/GM114 Balances the NF-kB Signaling by Antagonizing the
            Association of TRAF2/6 With Their Upstream Adaptors
  JOURNAL   Front Cell Dev Biol 10, 877039 (2022)
   PUBMED   35433693
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2167)
  AUTHORS   El Shamieh,S., Neuille,M., Terray,A., Orhan,E., Condroyer,C.,
            Demontant,V., Michiels,C., Antonio,A., Boyard,F., Lancelot,M.E.,
            Letexier,M., Saraiva,J.P., Leveillard,T., Mohand-Said,S.,
            Goureau,O., Sahel,J.A., Zeitz,C. and Audo,I.
  TITLE     Whole-exome sequencing identifies KIZ as a ciliary gene associated
            with autosomal-recessive rod-cone dystrophy
  JOURNAL   Am J Hum Genet 94 (4), 625-633 (2014)
   PUBMED   24680887
REFERENCE   3  (bases 1 to 2167)
  AUTHORS   Cook,M.S., Munger,S.C., Nadeau,J.H. and Capel,B.
  TITLE     Regulation of male germ cell cycle arrest and differentiation by
            DND1 is modulated by genetic background
  JOURNAL   Development 138 (1), 23-32 (2011)
   PUBMED   21115610
REFERENCE   4  (bases 1 to 2167)
  AUTHORS   Krentz,A.D., Murphy,M.W., Kim,S., Cook,M.S., Capel,B., Zhu,R.,
            Matin,A., Sarver,A.L., Parker,K.L., Griswold,M.D., Looijenga,L.H.,
            Bardwell,V.J. and Zarkower,D.
  TITLE     The DM domain protein DMRT1 is a dose-sensitive regulator of fetal
            germ cell proliferation and pluripotency
  JOURNAL   Proc Natl Acad Sci U S A 106 (52), 22323-22328 (2009)
   PUBMED   20007774
REFERENCE   5  (bases 1 to 2167)
  AUTHORS   Tang,H., Ross,A. and Capel,B.
  TITLE     Expression and functional analysis of Gm114, a putative mammalian
            ortholog of Drosophila bam
  JOURNAL   Dev Biol 318 (1), 73-81 (2008)
   PUBMED   18423593
  REMARK    GeneRIF: Results describe the expression and functional analysis of
            Gm114, a putative mammalian ortholog of Drosophila bam.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL929215.18 and AK135486.1.
            
            On Apr 26, 2018 this sequence version replaced NM_001033298.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC150845.1, AK135486.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-9                 AL929215.18        33658-33666
            10-2159             AK135486.1         4-2153
            2160-2167           AL929215.18        147868-147875
FEATURES             Location/Qualifiers
     source          1..2167
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 72.63 cM"
     gene            1..2167
                     /gene="Kiz"
                     /gene_synonym="Gm114; Ncrna00153; Plk1s1"
                     /note="kizuna centrosomal protein"
                     /db_xref="GeneID:228730"
                     /db_xref="MGI:MGI:2684960"
     exon            1..164
                     /gene="Kiz"
                     /gene_synonym="Gm114; Ncrna00153; Plk1s1"
                     /inference="alignment:Splign:2.1.0"
     CDS             43..2130
                     /gene="Kiz"
                     /gene_synonym="Gm114; Ncrna00153; Plk1s1"
                     /note="polo-like kinase 1 substrate 1"
                     /codon_start=1
                     /product="centrosomal protein kizuna"
                     /protein_id="NP_001028470.1"
                     /db_xref="CCDS:CCDS16832.1"
                     /db_xref="GeneID:228730"
                     /db_xref="MGI:MGI:2684960"
                     /translation="MPRGRGGGGGGLRQASATSAPLASPSYYERVGQLQQALRDSEKK
                     RLDLEDKLYEYNKSDKCRAKLKCAKLKKYLKEVCESERRAQVRNQGYLKKFECVQTYV
                     EHLTTNTEKLQKLKTEYEAEVKRMRLLSKDSLGMSDEDGAKDAVQAGINSGTAMSRGL
                     YQPATIFMGRQMSAISSIEDFSTELKSNQPTKNFSISDPHSHQQTAQSSCVTDSCVVQ
                     TNGDTQCLNKSDKIHGKTSLQTGEKAPVTSYVLSAEEQTHCLEIGSSTQHSKSNLSEG
                     RKSAELHSSLQERLSPENSITDLKCDSSSRSEGSDREILTQEHIEVREERAGPLVPMM
                     AASEHCTSAKKWAGEKHSAWEASSDDLDHGDSKSQKAVLKHEEEQEEGSSCSSSDLTV
                     SVSEDDLILESLAALSNPGAKMAGKDGMQALRAAHTEPRQDSLFTEYVLQTQSFPDSK
                     REPSPDSPRQPEKVPDCHLLKTRGQCMKEHDNSLKEEATTLLKKVLTEECDHRSAIHS
                     NESSCSMPSILNDNNGIKEAKPALRLNSVLTREQEVSSGCGDESKEESIAAAPGTGHR
                     EADLVPSELFQFSLGAAMKETKAYQLLKKSTLQDNSNQAEERFESQFSGLDIGGSMFT
                     TKTAHKIASEASFSSSEGSPLSRHESKRDPVTTIKSNAFWGESDDSNSEIEAALRPRD
                     HDMPDDFDDFYDT"
     exon            165..227
                     /gene="Kiz"
                     /gene_synonym="Gm114; Ncrna00153; Plk1s1"
                     /inference="alignment:Splign:2.1.0"
     exon            228..390
                     /gene="Kiz"
                     /gene_synonym="Gm114; Ncrna00153; Plk1s1"
                     /inference="alignment:Splign:2.1.0"
     exon            391..471
                     /gene="Kiz"
                     /gene_synonym="Gm114; Ncrna00153; Plk1s1"
                     /inference="alignment:Splign:2.1.0"
     exon            472..1117
                     /gene="Kiz"
                     /gene_synonym="Gm114; Ncrna00153; Plk1s1"
                     /inference="alignment:Splign:2.1.0"
     exon            1118..1421
                     /gene="Kiz"
                     /gene_synonym="Gm114; Ncrna00153; Plk1s1"
                     /inference="alignment:Splign:2.1.0"
     exon            1422..1503
                     /gene="Kiz"
                     /gene_synonym="Gm114; Ncrna00153; Plk1s1"
                     /inference="alignment:Splign:2.1.0"
     exon            1504..1669
                     /gene="Kiz"
                     /gene_synonym="Gm114; Ncrna00153; Plk1s1"
                     /inference="alignment:Splign:2.1.0"
     exon            1670..1732
                     /gene="Kiz"
                     /gene_synonym="Gm114; Ncrna00153; Plk1s1"
                     /inference="alignment:Splign:2.1.0"
     exon            1733..1798
                     /gene="Kiz"
                     /gene_synonym="Gm114; Ncrna00153; Plk1s1"
                     /inference="alignment:Splign:2.1.0"
     exon            1799..1885
                     /gene="Kiz"
                     /gene_synonym="Gm114; Ncrna00153; Plk1s1"
                     /inference="alignment:Splign:2.1.0"
     exon            1886..1982
                     /gene="Kiz"
                     /gene_synonym="Gm114; Ncrna00153; Plk1s1"
                     /inference="alignment:Splign:2.1.0"
     exon            1983..2026
                     /gene="Kiz"
                     /gene_synonym="Gm114; Ncrna00153; Plk1s1"
                     /inference="alignment:Splign:2.1.0"
     exon            2027..2167
                     /gene="Kiz"
                     /gene_synonym="Gm114; Ncrna00153; Plk1s1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2148..2153
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Kiz"
                     /gene_synonym="Gm114; Ncrna00153; Plk1s1"
                     /note="hexamer: AATAAA"
     polyA_site      2167
                     /gene="Kiz"
                     /gene_synonym="Gm114; Ncrna00153; Plk1s1"
                     /note="major polyA site"
ORIGIN      
        1 ggtctccttg ggcaacgctg gcccgccagc tgccctgtgg caatgccgcg agggcgcggt
       61 ggcggtggtg gtggcctgcg ccaggcctcc gccacctctg cgcccttggc gagccccagc
      121 tactacgaaa gggtgggcca gctccagcag gctctgcggg acagtgaaaa gaagagattg
      181 gacctggaag acaagcttta tgaatacaat aaatctgata agtgcagagc taagctgaaa
      241 tgtgcaaaac taaagaaata cctgaaggaa gtatgtgagt ctgagaggag ggctcaggtt
      301 cgaaaccaag gatatttaaa gaagtttgaa tgtgtccaga cgtatgttga acacttgacc
      361 acaaatacag agaagcttca aaaactgaag actgaatatg aggctgaagt gaagaggatg
      421 cgcctcctgt caaaggatag cctgggaatg agtgacgaag acggagcaaa ggatgcagtg
      481 caggcaggaa ttaactcggg gacagctatg tcaagaggat tgtatcaacc agcaacaatc
      541 tttatgggcc gccaaatgtc agccatctca agcattgaag atttcagtac agagctgaaa
      601 tctaaccaac ccacaaagaa cttttcaatc tctgacccac attcacacca acagacagcc
      661 cagagcagct gtgtgacaga cagctgtgta gtgcagacta atggtgacac acagtgctta
      721 aataagtctg acaaaataca tggaaagaca tctcttcaga ctggtgagaa ggcgccagtc
      781 acaagctatg tattgtctgc agaagaacaa actcattgct tggagatagg aagcagcaca
      841 cagcacagca agagtaattt atctgaaggc agaaagtctg ctgaactcca ttcctcgtta
      901 caggaaagat taagtccaga gaacagcatc actgatttaa agtgtgacag ttccagcaga
      961 tcagagggat cagacagaga aatactgaca caagaacata ttgaagtcag ggaagaaaga
     1021 gccggcccgc tggtccccat gatggcagct tcagaacact gtacatctgc aaagaagtgg
     1081 gctggagaga agcattctgc ttgggaagct tcctcagatg atcttgacca cggggactca
     1141 aagtcacaga aggccgtcct gaaacatgag gaagagcagg aggagggaag ctcatgcagc
     1201 agcagcgacc tcacagtttc tgtcagtgaa gatgatctga ttctagagag tctggccgca
     1261 ctgtcgaatc caggagccaa gatggcgggc aaagatggaa tgcaggcctt gcgagcggcc
     1321 cacactgaac caagacaaga ttcgctcttc acggaatatg ttttacagac ccaaagcttt
     1381 cctgattcaa aaagggaacc ctccccagat tcaccaagac aacctgaaaa agtaccagat
     1441 tgtcacttat tgaagacacg agggcaatgt atgaaggaac atgataattc tcttaaagag
     1501 gaggcaacaa cattattgaa aaaagtcctt acagaagaat gtgaccatag gtcagctatt
     1561 cacagtaatg aatcatcttg cagcatgcca tctattctga atgacaataa tggaataaag
     1621 gaagcaaaac ccgctctgcg gctcaacagt gttcttacaa gggaacaaga agtttcaagt
     1681 ggctgtggag atgagagcaa ggaagaaagc atagctgcgg ccccaggcac aggacacaga
     1741 gaggcggatc tagtaccctc agaactgttt cagttcagct tgggagcagc catgaaagaa
     1801 acaaaagcct accagttact gaagaagtct acccttcagg acaattcaaa tcaagctgaa
     1861 gagagatttg aaagtcagtt ttcaggtctg gatattggtg gcagcatgtt cacaacaaag
     1921 acagcccaca aaatcgcctc ggaagctagt ttttcatcta gtgaaggaag tcctttgtca
     1981 aggcacgaaa gcaaaaggga cccagtgacc accataaagt caaatgcctt ctggggggag
     2041 tctgatgaca gtaactctga aatcgaagct gccctacgtc ctagagacca tgacatgccc
     2101 gatgattttg atgattttta tgacacatga gctgttgcat gcttagaaat aaagtcttta
     2161 aaacaaa
//
