LOCUS       NM_001122733            5205 bp    mRNA    linear   ROD 28-JAN-2025
DEFINITION  Mus musculus KIT proto-oncogene receptor tyrosine kinase (Kit),
            transcript variant 1, mRNA.
ACCESSION   NM_001122733
VERSION     NM_001122733.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5205)
  AUTHORS   Araki,D., Chen,V., Redekar,N., Salisbury-Ruf,C., Luo,Y., Liu,P.,
            Li,Y., Smith,R.H., Dagur,P., Combs,C. and Larochelle,A.
  TITLE     Post-transplant G-CSF impedes engraftment of gene-edited human
            hematopoietic stem cells by exacerbating p53-mediated DNA damage
            response
  JOURNAL   Cell Stem Cell 32 (1), 53-70 (2025)
   PUBMED   39536761
REFERENCE   2  (bases 1 to 5205)
  AUTHORS   Canu,G., Correra,R., Diez-Pinel,G., Castellan,R.F.P., Denti,L.,
            Fantin,A. and Ruhrberg,C.
  TITLE     A Pax3 lineage gives rise to transient haematopoietic progenitors
  JOURNAL   Development 151 (23) (2024)
   PUBMED   39629666
REFERENCE   3  (bases 1 to 5205)
  AUTHORS   Sa da Bandeira,D., Nevitt,C.D., Segato Dezem,F., Marcao,M., Liu,Y.,
            Kelley,Z., DuBose,H., Chabot,A., Hall,T., Caprio,C., Okhomina,V.,
            Kang,G., Plummer,J., McKinney-Freeman,S., Clements,W.K. and
            Ganuza,M.
  TITLE     NR4A1 and NR4A2 orphan nuclear receptors regulate
            endothelial-to-hematopoietic transition in mouse hematopoietic stem
            cell specification
  JOURNAL   Development 151 (22) (2024)
   PUBMED   39589268
REFERENCE   4  (bases 1 to 5205)
  AUTHORS   Smith,E.R., Ye,D., Luo,S., Xu,I.R.L. and Xu,X.X.
  TITLE     AMH regulates a mosaic population of AMHR2-positive cells in the
            ovarian surface epithelium
  JOURNAL   J Biol Chem 300 (11), 107897 (2024)
   PUBMED   39424141
REFERENCE   5  (bases 1 to 5205)
  AUTHORS   Islam,M., Yang,Y., Simmons,A.J., Shah,V.M., Musale,K.P., Xu,Y.,
            Tasneem,N., Chen,Z., Trinh,L.T., Molina,P., Ramirez-Solano,M.A.,
            Sadien,I.D., Dou,J., Rolong,A., Chen,K., Magnuson,M.A.,
            Rathmell,J.C., Macara,I.G., Winton,D.J., Liu,Q., Zafar,H.,
            Kalhor,R., Church,G.M., Shrubsole,M.J., Coffey,R.J. and Lau,K.S.
  TITLE     Temporal recording of mammalian development and precancer
  JOURNAL   Nature 634 (8036), 1187-1195 (2024)
   PUBMED   39478207
REFERENCE   6  (bases 1 to 5205)
  AUTHORS   Fleischman,R.A. and Mintz,B.
  TITLE     Prevention of genetic anemias in mice by microinjection of normal
            hematopoietic stem cells into the fetal placenta
  JOURNAL   Proc Natl Acad Sci U S A 76 (11), 5736-5740 (1979)
   PUBMED   42904
REFERENCE   7  (bases 1 to 5205)
  AUTHORS   Poole,T.W. and Silvers,W.K.
  TITLE     Capacity of adult steel (SI/SId) and dominant spotting (W/Wv) mouse
            skin to support melanogenesis
  JOURNAL   Dev Biol 72 (2), 398-400 (1979)
   PUBMED   389712
REFERENCE   8  (bases 1 to 5205)
  AUTHORS   Kitamura,Y. and Go,S.
  TITLE     Decreased production of mast cells in S1/S1d anemic mice
  JOURNAL   Blood 53 (3), 492-497 (1979)
   PUBMED   367470
REFERENCE   9  (bases 1 to 5205)
  AUTHORS   Lamoreux,M.L. and Russell,E.S.
  TITLE     Developmental interaction in the pigmentary system of mice. I.
            Interactions between effects of genes on color of pigment and on
            distribution of pigmentation in the coat of the house mouse (Mus
            musculus)
  JOURNAL   J Hered 70 (1), 31-36 (1979)
   PUBMED   469221
REFERENCE   10 (bases 1 to 5205)
  AUTHORS   Sharkis,S.J., Wiktor-Jedrzejczak,W., Ahmed,A., Santos,G.W.,
            McKee,A. and Sell,K.W.
  TITLE     Antitheta-sensitive regulatory cell (TSRC) and hematopoiesis:
            regulation of differentiation of transplanted stem cells in W/Wv
            anemic and normal mice
  JOURNAL   Blood 52 (4), 802-817 (1978)
   PUBMED   28803
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BY123520.1, AK047010.1 and
            BC052457.1.
            
            Summary: The c-Kit proto-oncogene is the cellular homolog of the
            transforming gene of a feline retrovirus (v-Kit). The c-kit protein
            includes characteristics of a protein kinase transmembrane
            receptor. Alternatively spliced transcript variants encoding
            different isoforms have been found for this gene. [provided by
            RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC026713.1, SRR1660813.131364.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-9                 BY123520.1         1-9
            10-440              AK047010.1         4-434
            441-635             AK047010.1         436-630
            636-1826            AK047010.1         632-1822
            1827-3213           AK047010.1         1824-3210
            3214-5205           BC052457.1         3173-5164
FEATURES             Location/Qualifiers
     source          1..5205
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 39.55 cM"
     gene            1..5205
                     /gene="Kit"
                     /gene_synonym="Bs; c-KIT; CD117; Fdc; Gsfsco1; Gsfsco5;
                     Gsfsow3; SCO1; SCO5; SOW3; Ssm; Tr-kit; W"
                     /note="KIT proto-oncogene receptor tyrosine kinase"
                     /db_xref="GeneID:16590"
                     /db_xref="MGI:MGI:96677"
     exon            1..132
                     /gene="Kit"
                     /gene_synonym="Bs; c-KIT; CD117; Fdc; Gsfsco1; Gsfsco5;
                     Gsfsow3; SCO1; SCO5; SOW3; Ssm; Tr-kit; W"
                     /inference="alignment:Splign:2.1.0"
     exon            133..405
                     /gene="Kit"
                     /gene_synonym="Bs; c-KIT; CD117; Fdc; Gsfsco1; Gsfsco5;
                     Gsfsow3; SCO1; SCO5; SOW3; Ssm; Tr-kit; W"
                     /inference="alignment:Splign:2.1.0"
     exon            406..687
                     /gene="Kit"
                     /gene_synonym="Bs; c-KIT; CD117; Fdc; Gsfsco1; Gsfsco5;
                     Gsfsow3; SCO1; SCO5; SOW3; Ssm; Tr-kit; W"
                     /inference="alignment:Splign:2.1.0"
     exon            688..824
                     /gene="Kit"
                     /gene_synonym="Bs; c-KIT; CD117; Fdc; Gsfsco1; Gsfsco5;
                     Gsfsow3; SCO1; SCO5; SOW3; Ssm; Tr-kit; W"
                     /inference="alignment:Splign:2.1.0"
     exon            825..999
                     /gene="Kit"
                     /gene_synonym="Bs; c-KIT; CD117; Fdc; Gsfsco1; Gsfsco5;
                     Gsfsow3; SCO1; SCO5; SOW3; Ssm; Tr-kit; W"
                     /inference="alignment:Splign:2.1.0"
     exon            1000..1189
                     /gene="Kit"
                     /gene_synonym="Bs; c-KIT; CD117; Fdc; Gsfsco1; Gsfsco5;
                     Gsfsow3; SCO1; SCO5; SOW3; Ssm; Tr-kit; W"
                     /inference="alignment:Splign:2.1.0"
     exon            1190..1305
                     /gene="Kit"
                     /gene_synonym="Bs; c-KIT; CD117; Fdc; Gsfsco1; Gsfsco5;
                     Gsfsow3; SCO1; SCO5; SOW3; Ssm; Tr-kit; W"
                     /inference="alignment:Splign:2.1.0"
     exon            1306..1420
                     /gene="Kit"
                     /gene_synonym="Bs; c-KIT; CD117; Fdc; Gsfsco1; Gsfsco5;
                     Gsfsow3; SCO1; SCO5; SOW3; Ssm; Tr-kit; W"
                     /inference="alignment:Splign:2.1.0"
     exon            1421..1614
                     /gene="Kit"
                     /gene_synonym="Bs; c-KIT; CD117; Fdc; Gsfsco1; Gsfsco5;
                     Gsfsow3; SCO1; SCO5; SOW3; Ssm; Tr-kit; W"
                     /inference="alignment:Splign:2.1.0"
     exon            1615..1721
                     /gene="Kit"
                     /gene_synonym="Bs; c-KIT; CD117; Fdc; Gsfsco1; Gsfsco5;
                     Gsfsow3; SCO1; SCO5; SOW3; Ssm; Tr-kit; W"
                     /inference="alignment:Splign:2.1.0"
     exon            1722..1848
                     /gene="Kit"
                     /gene_synonym="Bs; c-KIT; CD117; Fdc; Gsfsco1; Gsfsco5;
                     Gsfsow3; SCO1; SCO5; SOW3; Ssm; Tr-kit; W"
                     /inference="alignment:Splign:2.1.0"
     exon            1849..1953
                     /gene="Kit"
                     /gene_synonym="Bs; c-KIT; CD117; Fdc; Gsfsco1; Gsfsco5;
                     Gsfsow3; SCO1; SCO5; SOW3; Ssm; Tr-kit; W"
                     /inference="alignment:Splign:2.1.0"
     exon            1954..2064
                     /gene="Kit"
                     /gene_synonym="Bs; c-KIT; CD117; Fdc; Gsfsco1; Gsfsco5;
                     Gsfsow3; SCO1; SCO5; SOW3; Ssm; Tr-kit; W"
                     /inference="alignment:Splign:2.1.0"
     exon            2065..2215
                     /gene="Kit"
                     /gene_synonym="Bs; c-KIT; CD117; Fdc; Gsfsco1; Gsfsco5;
                     Gsfsow3; SCO1; SCO5; SOW3; Ssm; Tr-kit; W"
                     /inference="alignment:Splign:2.1.0"
     exon            2216..2304
                     /gene="Kit"
                     /gene_synonym="Bs; c-KIT; CD117; Fdc; Gsfsco1; Gsfsco5;
                     Gsfsow3; SCO1; SCO5; SOW3; Ssm; Tr-kit; W"
                     /inference="alignment:Splign:2.1.0"
     exon            2305..2432
                     /gene="Kit"
                     /gene_synonym="Bs; c-KIT; CD117; Fdc; Gsfsco1; Gsfsco5;
                     Gsfsow3; SCO1; SCO5; SOW3; Ssm; Tr-kit; W"
                     /inference="alignment:Splign:2.1.0"
     exon            2433..2555
                     /gene="Kit"
                     /gene_synonym="Bs; c-KIT; CD117; Fdc; Gsfsco1; Gsfsco5;
                     Gsfsow3; SCO1; SCO5; SOW3; Ssm; Tr-kit; W"
                     /inference="alignment:Splign:2.1.0"
     exon            2556..2667
                     /gene="Kit"
                     /gene_synonym="Bs; c-KIT; CD117; Fdc; Gsfsco1; Gsfsco5;
                     Gsfsow3; SCO1; SCO5; SOW3; Ssm; Tr-kit; W"
                     /inference="alignment:Splign:2.1.0"
     exon            2668..2767
                     /gene="Kit"
                     /gene_synonym="Bs; c-KIT; CD117; Fdc; Gsfsco1; Gsfsco5;
                     Gsfsow3; SCO1; SCO5; SOW3; Ssm; Tr-kit; W"
                     /inference="alignment:Splign:2.1.0"
     exon            2768..2873
                     /gene="Kit"
                     /gene_synonym="Bs; c-KIT; CD117; Fdc; Gsfsco1; Gsfsco5;
                     Gsfsow3; SCO1; SCO5; SOW3; Ssm; Tr-kit; W"
                     /inference="alignment:Splign:2.1.0"
     exon            2874..5182
                     /gene="Kit"
                     /gene_synonym="Bs; c-KIT; CD117; Fdc; Gsfsco1; Gsfsco5;
                     Gsfsow3; SCO1; SCO5; SOW3; Ssm; Tr-kit; W"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5156..5161
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Kit"
                     /gene_synonym="Bs; c-KIT; CD117; Fdc; Gsfsco1; Gsfsco5;
                     Gsfsow3; SCO1; SCO5; SOW3; Ssm; Tr-kit; W"
                     /note="hexamer: AATAAA"
     polyA_site      5182
                     /gene="Kit"
                     /gene_synonym="Bs; c-KIT; CD117; Fdc; Gsfsco1; Gsfsco5;
                     Gsfsow3; SCO1; SCO5; SOW3; Ssm; Tr-kit; W"
                     /note="major polyA site"
ORIGIN      
        1 gctcggtgca cttgggcgag agctgtagca gagagaggag ctcagagtct agcgcagcca
       61 ccgcgatgag aggcgctcgc ggcgcctggg atctgctctg cgtcctgttg gtcctgctcc
      121 gtggccagac agccacgtct cagccatctg caagtccagg ggagccgtct ccgccatcca
      181 tccatccagc acaatcagag ttaatagttg aagctggcga caccctcagc ctgacgtgca
      241 ttgatcccga ctttgtcaga tggactttca agacctattt caatgaaatg gttgagaata
      301 aaaaaaatga atggatccag gaaaaagccg aggccactcg cacgggcaca tacacgtgca
      361 gcaacagcaa tggcctcacg agttctattt acgtgtttgt tagagatcct gccaaacttt
      421 tcctggttgg ccttcccttg tttggcaaag aagacagcga cgcgctggtc cgctgccctc
      481 tgacagaccc acaggtgtcc aattattccc tcatcgagtg tgatgggaaa tctctcccca
      541 cggacctgac gtttgtccca aaccccaagg ctggcatcac catcaaaaac gtgaagcgcg
      601 cctaccaccg gctctgtgtc cgctgtgctg ctcagcgtga cggtacatgg ctgcattctg
      661 acaaattcac cctcaaagtg cgggcagcca tcaaggctat ccctgttgtg tctgtgcctg
      721 aaacaagtca cctccttaag aaaggggaca catttacggt ggtgtgcacc ataaaagatg
      781 tgtctacatc cgtgaactcc atgtggctaa agatgaaccc tcagcctcag cacatagccc
      841 aggtaaagca caatagctgg caccggggtg acttcaatta tgaacgccag gagacgctga
      901 ctatcagctc ggcaagagtt gacgattctg gagtgttcat gtgttatgcc aataatactt
      961 ttggatcagc aaatgtcaca acaaccttga aagtagtaga aaaaggattc atcaacatct
     1021 cccctgtgaa gaacactaca gtatttgtaa ccgatggaga aaacgtagat ttggttgttg
     1081 aatacgaggc ctaccccaaa cccgagcacc agcagtggat atatatgaac aggacctcgg
     1141 ctaacaaagg gaaggattat gtcaaatctg ataacaaaag caacatcaga tatgtgaacc
     1201 aacttcgcct gaccagatta aaaggcacag aaggaggcac ttataccttt ctggtgtcca
     1261 actctgatgc cagtgcttcc gtgacattca acgtttacgt gaacacaaaa ccagaaatcc
     1321 tgacgtacga caggctcata aatggcatgc tccagtgtgt ggcagaggga ttcccggagc
     1381 ccacaataga ttggtatttt tgtacaggag cagagcaaag gtgtaccact cctgtctcac
     1441 cagtggacgt acaggtccag aatgtatctg tgtcaccatt tggaaaactg gtggttcaga
     1501 gttccataga ctccagcgtc ttccggcaca acggcacggt ggagtgtaag gcctccaacg
     1561 atgtgggcaa gagttccgcc ttctttaact ttgcatttaa aggtaacaac aaagagcaaa
     1621 tccaggccca cactctgttc acgccgctgc tcattggctt tgtggttgca gctggcgcga
     1681 tggggatcat tgtgatggtg ctcacctaca aatatttgca gaaacccatg tatgaagtac
     1741 aatggaaggt tgtcgaggag ataaatggaa acaattatgt ttacatagac ccgacgcaac
     1801 ttccttatga tcacaaatgg gagtttccca gaaacaggct gagttttgga aagacattgg
     1861 gagctggtgc cttcgggaag gtcgttgagg ccactgcata tggcttgatt aagtcggatg
     1921 ctgccatgac agttgccgtg aagatgctca aaccaagtgc ccatttaaca gaaagagagg
     1981 ccctaatgtc ggaactgaag gtcctgagct acctgggcaa tcacatgaat attgtgaacc
     2041 tgcttggcgc atgcacggtg ggagggccca ccctggtcat tacagaatat tgttgctatg
     2101 gtgatctttt gaattttttg agaaggaagc gtgactcgtt tattttctca aagcaagaag
     2161 agcaggcaga agcggcactt tataagaacc ttctgcactc aacggagcct tcctgtgaca
     2221 gttcaaatga atatatggac atgaagcctg gcgtttccta cgtggtgcca accaagacag
     2281 acaagaggag atccgcaaga atagactcgt acatagaaag agacgtgact cctgccatca
     2341 tggaagatga cgagctggct ctggacctgg atgatttgct gagcttctcc taccaggtgg
     2401 ccaagggcat ggcgttcctc gcctccaaga attgtattca cagagatttg gcagccagga
     2461 atatcctcct cactcacggg cggatcacaa agatttgcga tttcgggcta gccagagaca
     2521 tcaggaatga ttcgaattac gtggtcaaag gaaatgcacg actgcccgtg aagtggatgg
     2581 caccagagag cattttcagc tgcgtgtaca catttgaaag tgatgtctgg tcctatggga
     2641 ttttcctctg ggagctcttc tccttaggaa gcagccccta cccagggatg ccggtcgact
     2701 ccaagttcta caagatgatc aaggaaggct tccggatggt cagcccggag cacgcgcctg
     2761 ccgaaatgta tgacgtcatg aagacttgct gggacgctga ccccttgaaa aggccaacat
     2821 tcaagcaggt tgtccaactt attgagaagc agatctcgga cagcaccaag cacatttact
     2881 ccaacttggc aaactgcaac cccaacccag agaaccccgt ggtggtggac cattccgtga
     2941 gggtcaactc ggtgggcagc agcgcctctt ctacgcagcc cctgctcgtg cacgaagatg
     3001 cctgagcaga aacccaagtc caacaggctt tgctgctgtc tccgaccccg tccttctggc
     3061 ttctgtgatg gttacttggt ttccctttga cttgcatcct attccagggt agcgagttcc
     3121 ccaccccacc tccaacccca ctgtgattcc gcctttacga gcacacactt tagtggccga
     3181 tggccttttc ttttctgcca tcagccaccg tcccgctgcg aaggtccgaa ctgtatgtat
     3241 atattttccc aatagcaaag tagctcctac tgtaaacaga aggactcctc ctgctttaga
     3301 ggagaaggga agggcggggt gaaactggat gcccagagtt cttcccccag tgctcccctg
     3361 agtgtatttg aaaagtatgg ccagtagttc acttgaagaa tagatgtagt cccatttggc
     3421 cctgagagcc atccttaatg atgggagata tatgtagcaa gactagaaaa ggaaagccaa
     3481 gccctttgtg tagaaagcag accattctta gaacagaggg caacggggca tcggaagtct
     3541 ggtcacgcta agaagaccga ggctgagaag gaacaagcca ggggaagcgt gaacaatgat
     3601 gctctgctct gggctgccgc tcgggcttct gtacaactga cctggtttct cagtactttg
     3661 ctgtctggga gtagcattgg aatcaaggcc tcctccctag tcagcctttg tatatactca
     3721 tctatacgtt gtatgcgttc atactttgga ggagggattt cccacaagct ttcgtttctg
     3781 tgtacagccc tggcattaga cctactgtgt gtaagaatag attaagagcc atacatattt
     3841 gaaggaaaca gttaaatgtt ttttggttgt ggttgttgtt gttgttgttt taaagaaaaa
     3901 aatgtatatg ctaagcacaa tctttataag acctcttagc caacatactt gctctgtcta
     3961 cacttcggaa caagccttcc atgtcagagt ggctttgcag gcaggagaac tgaggctgtt
     4021 tgaaaaggtt accacaggat ggagaaaaca gtgcagtcct ggtttggatt ctcacatagc
     4081 agggagcaca agttaaactc agccttttat aggcacgtcc cggacatcgg gccagtatct
     4141 attcaagtgt gtatgtgtgt gcatgcgtgt gtctatgcgt gtgggtgagt tgtgttggga
     4201 aacttgccct gcatccctga gggtcctcct tcaggaccca agacgtaaca gcttctgtca
     4261 ccgctcctgt ctctccagtt tccctgcatg tcgctcactg tctagaattt actcaaagcc
     4321 gccacagagg cttagcggag tgaagtgccg aaggacctct ttatttggag tcctcctgta
     4381 tttaacaaca ctcttatcgt agacccattc attagacctt atgtaatgct gccaatccag
     4441 ggaaacagat ttaaagtgta ccccgtagac agggcccaga ggttcccttg tccttgccct
     4501 cccccacacc acccatgatc actgtccaac ataaagggtt cagtgtgtac gtggtcatgt
     4561 gttgtcctta caggattcag gtatgttgcc ttcacggttt tccccacccc ctcctgccct
     4621 ttatccttta ggccgtgtgg ccatgaacct ggaagaagtg atcgtttgca cttgagtgct
     4681 acactcttgc acctttccaa agtaagctgg tttggaggtc ctgttgtcat gtacgagact
     4741 gtcaccagtt accgcgctct gtttgaaaca tgtctttgta ttcctaatga cttcagttag
     4801 agtaaggaga atagctgtta atatggatgt caggtactta aggggccaca ccattgagaa
     4861 ttttgtcttg gatattcttg aaagtttata tttttataat tttttttaca tcagatgtca
     4921 gatgtttctt tcagttgctt gatgtttgga attattatgt ggcttttttt gtaaatattg
     4981 aaatgtagca ataatgtctt ttgaatattc ctgagcccat gagtccctga aaatattttt
     5041 tatatataca gtaactttat gtgtaaataa tacgctgtgc aagtttaaac atgtcacgtt
     5101 acatgtgggt tttttctgat atgttgtcca actgttgaca gttctgaaga attctaataa
     5161 aaatgtaaat atataaatca aaaaaaaaaa aaaaaaaaaa aaaaa
//
