LOCUS       NM_053244               3163 bp    mRNA    linear   ROD 17-DEC-2024
DEFINITION  Mus musculus KISS1 receptor (Kiss1r), transcript variant 1, mRNA.
ACCESSION   NM_053244
VERSION     NM_053244.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3163)
  AUTHORS   Ambhore,N.S., Balraj,P., Kumar,A., Reza,M.I., Ramakrishnan,Y.S.,
            Tesch,J., Lohana,S. and Sathish,V.
  TITLE     Kiss1 receptor knockout exacerbates airway hyperresponsiveness and
            remodeling in a mouse model of allergic asthma
  JOURNAL   Respir Res 25 (1), 387 (2024)
   PUBMED   39468619
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3163)
  AUTHORS   Panting,E.N., Weight,J.H., Sartori,J.A., Coall,D.A. and Smith,J.T.
  TITLE     The role of placental kisspeptin in trophoblast invasion and
            migration: an assessment in Kiss1r knockout mice, BeWo cell lines
            and human term placenta
  JOURNAL   Reprod Fertil Dev 36 (2024)
   PUBMED   38976640
  REMARK    GeneRIF: The role of placental kisspeptin in trophoblast invasion
            and migration: an assessment in Kiss1r knockout mice, BeWo cell
            lines and human term placenta.
REFERENCE   3  (bases 1 to 3163)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (bases 1 to 3163)
  AUTHORS   Kavanagh,G.S., Tadi,J., Balkenhol,S.M., Kauffman,A.S., Maloney,S.K.
            and Smith,J.T.
  TITLE     Kisspeptin impacts on circadian and ultradian rhythms of core body
            temperature: Evidence in kisspeptin receptor knockout and
            kisspeptin knockdown mice
  JOURNAL   Mol Cell Endocrinol 542, 111530 (2022)
   PUBMED   34896241
REFERENCE   5  (bases 1 to 3163)
  AUTHORS   Schaefer,J., Vilos,A.G., Vilos,G.A., Bhattacharya,M. and
            Babwah,A.V.
  TITLE     Uterine kisspeptin receptor critically regulates epithelial
            estrogen receptor alpha transcriptional activity at the time of
            embryo implantation in a mouse model
  JOURNAL   Mol Hum Reprod 27 (10) (2021)
   PUBMED   34524460
  REMARK    GeneRIF: Uterine kisspeptin receptor critically regulates
            epithelial estrogen receptor alpha transcriptional activity at the
            time of embryo implantation in a mouse model.
REFERENCE   6  (bases 1 to 3163)
  AUTHORS   Colledge,W.H.
  TITLE     GPR54 and puberty
  JOURNAL   Trends Endocrinol Metab 15 (9), 448-453 (2004)
   PUBMED   15519892
  REMARK    Review article
REFERENCE   7  (bases 1 to 3163)
  AUTHORS   Funes,S., Hedrick,J.A., Vassileva,G., Markowitz,L., Abbondanzo,S.,
            Golovko,A., Yang,S., Monsma,F.J. and Gustafson,E.L.
  TITLE     The KiSS-1 receptor GPR54 is essential for the development of the
            murine reproductive system
  JOURNAL   Biochem Biophys Res Commun 312 (4), 1357-1363 (2003)
   PUBMED   14652023
  REMARK    GeneRIF: The analysis of the GPR54 mutant mice revealed
            developmental abnormalities of both male and female genitalia and
            histopathological changes in tissues which normally contain
            sexually dimorphic features.
REFERENCE   8  (bases 1 to 3163)
  AUTHORS   Seminara,S.B., Messager,S., Chatzidaki,E.E., Thresher,R.R.,
            Acierno,J.S. Jr., Shagoury,J.K., Bo-Abbas,Y., Kuohung,W.,
            Schwinof,K.M., Hendrick,A.G., Zahn,D., Dixon,J., Kaiser,U.B.,
            Slaugenhaupt,S.A., Gusella,J.F., O'Rahilly,S., Carlton,M.B.,
            Crowley,W.F. Jr., Aparicio,S.A. and Colledge,W.H.
  TITLE     The GPR54 gene as a regulator of puberty
  JOURNAL   N Engl J Med 349 (17), 1614-1627 (2003)
   PUBMED   14573733
  REMARK    GeneRIF: Mutations in GPR54 cause autosomal recessive idiopathic
            hypogonadotropic hypogonadism in humans and mice, suggesting that
            this receptor is essential for normal gonadotropin-releasing
            hormone physiology and for puberty.
REFERENCE   9  (bases 1 to 3163)
  AUTHORS   Stafford,L.J., Xia,C., Ma,W., Cai,Y. and Liu,M.
  TITLE     Identification and characterization of mouse metastasis-suppressor
            KiSS1 and its G-protein-coupled receptor
  JOURNAL   Cancer Res 62 (19), 5399-5404 (2002)
   PUBMED   12359743
REFERENCE   10 (bases 1 to 3163)
  AUTHORS   Clements,M.K., McDonald,T.P., Wang,R., Xie,G., O'Dowd,B.F.,
            George,S.R., Austin,C.P. and Liu,Q.
  TITLE     FMRFamide-related neuropeptides are agonists of the orphan
            G-protein-coupled receptor GPR54
  JOURNAL   Biochem Biophys Res Commun 284 (5), 1189-1193 (2001)
   PUBMED   11414709
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK139303.1, AK039628.1 and AC151846.3.
            
            On Jul 15, 2009 this sequence version replaced NM_053244.4.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK039628.1, BC016531.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-52                AK139303.1         2-53
            53-2704             AK039628.1         54-2705
            2705-3163           AC151846.3         77726-78184         c
FEATURES             Location/Qualifiers
     source          1..3163
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 39.72 cM"
     gene            1..3163
                     /gene="Kiss1r"
                     /gene_synonym="Gpr54; KiSS-1; kiSS-1R"
                     /note="KISS1 receptor"
                     /db_xref="GeneID:114229"
                     /db_xref="MGI:MGI:2148793"
     exon            1..1947
                     /gene="Kiss1r"
                     /gene_synonym="Gpr54; KiSS-1; kiSS-1R"
                     /inference="alignment:Splign:2.1.0"
     CDS             1704..2894
                     /gene="Kiss1r"
                     /gene_synonym="Gpr54; KiSS-1; kiSS-1R"
                     /note="isoform 1 is encoded by transcript variant 1;
                     kiSS-1 receptor; orphan G protein-coupled receptor 54;
                     metastin receptor; kisspeptins receptor; G-protein coupled
                     receptor 54; G-protein coupled receptor OT7T175"
                     /codon_start=1
                     /product="kiSS-1 receptor isoform 1"
                     /protein_id="NP_444474.1"
                     /db_xref="CCDS:CCDS23998.1"
                     /db_xref="GeneID:114229"
                     /db_xref="MGI:MGI:2148793"
                     /translation="MATEATLAPNVTWWAPSNASGCPGCGVNASDDPGSAPRPLDAWL
                     VPLFFATLMLLGLVGNSLVIYVICRHKHMQTVTNFYIANLAATDVTFLLCCVPFTALL
                     YPLPAWVLGDFMCKFVNYIQQVSVQATCATLTAMSVDRWYVTVFPLRALHRRTPRLAL
                     AVSLSIWVGSAAVSAPVLALHRLSPGPRTYCSEAFPSRALERAFALYNLLALYLLPLL
                     ATCACYGAMLRHLGRAAVRPAPTDGALQGQLLAQRAGAVRTKVSRLVAAVVLLFAACW
                     GPIQLFLVLQALGPSGAWHPRSYAAYAVKIWAHCMSYSNSALNPLLYAFLGSHFRQAF
                     CRVCPCCRQRQRRPHTSAHSDRAATHTVPHSRAAHPVRIRSPEPGNPVVRSPCAQSER
                     TASL"
     exon            1948..2072
                     /gene="Kiss1r"
                     /gene_synonym="Gpr54; KiSS-1; kiSS-1R"
                     /inference="alignment:Splign:2.1.0"
     exon            2073..2208
                     /gene="Kiss1r"
                     /gene_synonym="Gpr54; KiSS-1; kiSS-1R"
                     /inference="alignment:Splign:2.1.0"
     exon            2209..2441
                     /gene="Kiss1r"
                     /gene_synonym="Gpr54; KiSS-1; kiSS-1R"
                     /inference="alignment:Splign:2.1.0"
     exon            2442..3163
                     /gene="Kiss1r"
                     /gene_synonym="Gpr54; KiSS-1; kiSS-1R"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3145..3150
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Kiss1r"
                     /gene_synonym="Gpr54; KiSS-1; kiSS-1R"
                     /note="hexamer: AATGAA"
     polyA_site      3163
                     /gene="Kiss1r"
                     /gene_synonym="Gpr54; KiSS-1; kiSS-1R"
                     /note="major polyA site"
ORIGIN      
        1 agtctaggaa cagccgcggt tgctgggcta gaagctctgc ctcggtttcc ctctccgtag
       61 acatggggcg gtgtcaccca ccaggacgtg ctggctgagg acaaagtctg agccacccgg
      121 gaggagacgg tggggcacac cagccccggg gcgactgcgg agatgcgaaa ggctccttgg
      181 ggcgcagatg cgggaggggt atgcgagccc cgcgaacagt cccagggtga cagaacagtg
      241 caggggactg aggccgaaaa ggaggacccg cccgcagacc caacacctcc agaccactgt
      301 ctgtgagagc tagtctggtg aaaacaagcg aaggggaaac tggccgtggt gcacagctga
      361 gctagaggct gaggcagcaa gatcagtgga gttccagccc agcctcagcc acaaaaccta
      421 attggggtgg agtggcaggt gtggtgcact cctggcctag cataggttag acggaagcag
      481 taggatcagg ctttcaagtc atcattaacc aacagcaagt tcaaggccag cctgggctcc
      541 aggaaagcca cgtgctttta gaaaaactat tacacttggt tgattaatca actaattaat
      601 taaaacaaaa gacccaaaag aaagcatcca ctctgagggt ttgtatagac aggtgaagcg
      661 atggccgagc tcatgagtct ggtgcagagg ggactcaggg gaaggggacc tggggacttg
      721 gactcctgac atcacaccag agttgttctg tggctgaaag agagggaagg ggttcattgc
      781 agagccctca gtctgcatct tgctccccac agccccagga cacagtcgct gacaccctca
      841 gagtccccag gctgtaaact tcctggtccc tcagccagga ctgcttctta gttactcagc
      901 cctctcccca gcttccagcc cgccctctag gatgagcctg tggatgacat aaatacactc
      961 cctctgagtc tcacctagaa aatggcagcc tctttttctc tgctgcatag tattctggtg
     1021 gcttgacaag gctaacctct ttgggagcaa gggagcctct gagatacatt tagcagggat
     1081 gcgagggtgt ggctgaggtc agttccttgt agttcctgct gatagtttcc aaagagccta
     1141 ctctccggac aggaactcac tgctggatag aaccttgtaa ctatcagtca gagtcagcca
     1201 aatgtatctg aaggtgctgt cctgtcctga cgtgcatcat ggctcccagt gtcctggaga
     1261 ggcaaactct gccagggctt cttcagaagg cgggcctggg ccaatctgcc tgcagcccat
     1321 ggttgaagct aacccccata gaaggccaag accctccctt gcttggtgcc cagagccctc
     1381 cctcctttag cccatcccct ccttctgtca tccgggcata gctctggaaa gagggagcgc
     1441 aaggctctga agcggctact acgcagggag acgcgaaggc ggggacaagg gagggggcgg
     1501 ggggtataaa agtggccgct gcgaagctag cagaggagcc tctttccagc ccctgccgcc
     1561 agcaacagag gccaggacgc aggtatccct ggagagcggc cctggccccg aggaggagtg
     1621 gggtcctccc tctggtcccc acagtcccag gacacaatcc ttgaaggttg cctggaggaa
     1681 gagagcgaca gaggtgggga agcatggcca ccgaggcgac attggctccc aatgtgacct
     1741 ggtgggctcc gtccaacgct tcaggatgcc caggctgcgg tgtcaacgcc tcggatgacc
     1801 caggctctgc gccaaggccc ctggatgcct ggctggttcc cctgtttttc gctacactca
     1861 tgttgcttgg gctggtcgga aactcattgg tcatctacgt tatctgccgc cacaagcaca
     1921 tgcagacagt taccaacttc tacatcgcta acctggctgc cacagacgtc actttcctac
     1981 tgtgctgcgt gcccttcacc gcactcctct acccgctgcc cgcctgggtg ctgggagact
     2041 tcatgtgcaa attcgtcaac tacatccagc aggtctcggt gcaagccaca tgtgccactc
     2101 tgacggccat gagtgtggac cgctggtatg tgactgtgtt cccgctgcgt gcacttcacc
     2161 gccgcactcc gcgcctggcc ctggctgtca gcctcagcat ctgggtgggg tcagcagctg
     2221 tgtccgcccc ggtgctggcc ctgcaccgcc tgtcgccagg gcctcgcacc tactgcagcg
     2281 aggcgtttcc cagccgcgcc ctggagcgcg ccttcgcgct ctacaacctg ctggctctat
     2341 atctgctgcc gctgctcgcc acctgcgcct gctacggcgc catgctgcgc cacctgggcc
     2401 gtgcggctgt acgccccgca cccactgacg gcgccctgca gggacagctg ctagcacagc
     2461 gcgccggagc agtgcgcacc aaggtctccc ggctggtggc cgctgtcgtc ctgctcttcg
     2521 ccgcctgctg gggcccgatc cagctgttcc tggtgcttca agccctgggc ccctcggggg
     2581 cctggcaccc tcgaagctat gccgcctacg cggtcaagat ctgggctcac tgcatgtcct
     2641 acagcaactc ggcgctcaat ccgctgctct atgccttcct gggttcacac ttcagacagg
     2701 ccttctgccg cgtgtgcccc tgctgccggc aacgccagcg ccggccccac acgtcagcgc
     2761 actcggaccg agctgcaact cacactgtgc cgcacagccg tgctgcgcac cctgtgcgga
     2821 tcaggagccc ggagcctggg aaccctgtgg tgcgctcgcc ctgcgctcag agtgaacgca
     2881 ctgcctcact ctgagccggt cctgcctgtg gggtaaagca tcccaggctg cttgcgctgg
     2941 tgggtggtta atggtttagt taatctttgt aaatggcctt ttcttccatt tggcacccgt
     3001 atgccctggt ttttgctgtg gatgttgtga taattctctg taatctttga agattaatgt
     3061 cctcactttc tgcatctttt tttatttatt ttttcttctc aggtgctgag aaccgaacca
     3121 ggagtttgtg tttatggggc aagcaatgaa ctactaaact aaa
//
