LOCUS       NM_178260                656 bp    mRNA    linear   ROD 11-MAR-2025
DEFINITION  Mus musculus KiSS-1 metastasis-suppressor (Kiss1), transcript
            variant 1, mRNA.
ACCESSION   NM_178260
VERSION     NM_178260.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 656)
  AUTHORS   Qiu,J., Talbi,R., Bosch,M.A., Medve,E., Zweifel,L.S.,
            Ronnekleiv,O.K., Navarro,V.M. and Kelly,M.J.
  TITLE     Glutamatergic Input From Arcuate Nucleus Kiss1 Neurons to Preoptic
            Kiss1 Neurons Is Required for LH Surge in Female Mice
  JOURNAL   Endocrinology 166 (2) (2025)
   PUBMED   39865886
REFERENCE   2  (bases 1 to 656)
  AUTHORS   Avendano,M.S., Perdices-Lopez,C., Guerrero-Ruiz,Y., Ruiz-Pino,F.,
            Rodriguez-Sanchez,A.B., Sanchez-Tapia,M.J., Sobrino,V., Pineda,R.,
            Barroso,A., Correa-Saez,A., Lara-Chica,M., Fernandez-Garcia,J.C.,
            Garcia-Redondo,A.B., Hernanz,R., Ruiz-Cruz,M., Garcia-Galiano,D.,
            Pitteloud,N., Calzado,M.A., Briones,A.M., Vazquez,M.J. and
            Tena-Sempere,M.
  TITLE     The evolutionary conserved miR-137/325 tandem mediates
            obesity-induced hypogonadism and metabolic comorbidities by
            repressing hypothalamic kisspeptin
  JOURNAL   Metabolism 157, 155932 (2024)
   PUBMED   38729600
REFERENCE   3  (bases 1 to 656)
  AUTHORS   Liang,C., Li,X., Song,G., Schmidt,S.F., Sun,L., Chen,J., Pan,X.,
            Zhao,H. and Yan,Y.
  TITLE     Adipose Kiss1 controls aerobic exercise-related adaptive responses
            in adipose tissue energy homeostasis
  JOURNAL   FASEB J 38 (13), e23743 (2024)
   PUBMED   38877852
  REMARK    GeneRIF: Adipose Kiss1 controls aerobic exercise-related adaptive
            responses in adipose tissue energy homeostasis.
REFERENCE   4  (bases 1 to 656)
  AUTHORS   Panting,E.N., Weight,J.H., Sartori,J.A., Coall,D.A. and Smith,J.T.
  TITLE     The role of placental kisspeptin in trophoblast invasion and
            migration: an assessment in Kiss1r knockout mice, BeWo cell lines
            and human term placenta
  JOURNAL   Reprod Fertil Dev 36 (2024)
   PUBMED   38976640
  REMARK    GeneRIF: The role of placental kisspeptin in trophoblast invasion
            and migration: an assessment in Kiss1r knockout mice, BeWo cell
            lines and human term placenta.
REFERENCE   5  (bases 1 to 656)
  AUTHORS   Zhang,X., Wang,Y. and Lv,J.
  TITLE     STAT4 targets KISS1 to inhibit the oxidative damage, inflammation
            and neuronal apoptosis in experimental PD models by inactivating
            the MAPK pathway
  JOURNAL   Neurochem Int 175, 105683 (2024)
   PUBMED   38341034
  REMARK    GeneRIF: STAT4 targets KISS1 to inhibit the oxidative damage,
            inflammation and neuronal apoptosis in experimental PD models by
            inactivating the MAPK pathway.
REFERENCE   6  (bases 1 to 656)
  AUTHORS   Navarro,V.M., Castellano,J.M., Fernandez-Fernandez,R., Tovar,S.,
            Roa,J., Mayen,A., Nogueiras,R., Vazquez,M.J., Barreiro,M.L.,
            Magni,P., Aguilar,E., Dieguez,C., Pinilla,L. and Tena-Sempere,M.
  TITLE     Characterization of the potent luteinizing hormone-releasing
            activity of KiSS-1 peptide, the natural ligand of GPR54
  JOURNAL   Endocrinology 146 (1), 156-163 (2005)
   PUBMED   15375028
  REMARK    GeneRIF: Potent stimulatory effect of KiSS-1 on LH release, acting
            at central levels (likely hypothalamus) and eventually at
            pituitary. Novel role of KiSS-1/GPR54 system as relevant downstream
            element in neuroendocrine network governing LH secretion.
REFERENCE   7  (bases 1 to 656)
  AUTHORS   Navarro,V.M., Fernandez-Fernandez,R., Castellano,J.M., Roa,J.,
            Mayen,A., Barreiro,M.L., Gaytan,F., Aguilar,E., Pinilla,L.,
            Dieguez,C. and Tena-Sempere,M.
  TITLE     Advanced vaginal opening and precocious activation of the
            reproductive axis by KiSS-1 peptide, the endogenous ligand of GPR54
  JOURNAL   J Physiol 561 (Pt 2), 379-386 (2004)
   PUBMED   15486019
  REMARK    GeneRIF: The KiSS-1 system plays a role as a downstream element in
            the hypothalamic network triggering the onset of puberty.
REFERENCE   8  (bases 1 to 656)
  AUTHORS   Gottsch,M.L., Cunningham,M.J., Smith,J.T., Popa,S.M., Acohido,B.V.,
            Crowley,W.F., Seminara,S., Clifton,D.K. and Steiner,R.A.
  TITLE     A role for kisspeptins in the regulation of gonadotropin secretion
            in the mouse
  JOURNAL   Endocrinology 145 (9), 4073-4077 (2004)
   PUBMED   15217982
  REMARK    GeneRIF: KiSS-1 mRNA is expressed in areas of the hypothalamus
            implicated in the neuroendocrine regulation of gonadotropin
            secretion
REFERENCE   9  (bases 1 to 656)
  AUTHORS   Terao,Y., Kumano,S., Takatsu,Y., Hattori,M., Nishimura,A.,
            Ohtaki,T. and Shintani,Y.
  TITLE     Expression of KiSS-1, a metastasis suppressor gene, in trophoblast
            giant cells of the rat placenta
  JOURNAL   Biochim Biophys Acta 1678 (2-3), 102-110 (2004)
   PUBMED   15157736
  REMARK    GeneRIF: metastin/OT7T175 signaling may participate in implantation
            of the mammalian embryo, placenta formation, and maintenance of
            pregnancy
REFERENCE   10 (bases 1 to 656)
  AUTHORS   Stafford,L.J., Xia,C., Ma,W., Cai,Y. and Liu,M.
  TITLE     Identification and characterization of mouse metastasis-suppressor
            KiSS1 and its G-protein-coupled receptor
  JOURNAL   Cancer Res 62 (19), 5399-5404 (2002)
   PUBMED   12359743
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC068906.14.
            
            On Oct 13, 2022 this sequence version replaced NM_178260.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB666166.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN00849384
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-83                AC068906.14        62298-62380
            84-289              AC068906.14        65467-65672
            290-656             AC068906.14        67688-68054
FEATURES             Location/Qualifiers
     source          1..656
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 57.91 cM"
     gene            1..656
                     /gene="Kiss1"
                     /gene_synonym="kisspeptin; metastatin"
                     /note="KiSS-1 metastasis-suppressor"
                     /db_xref="GeneID:280287"
                     /db_xref="MGI:MGI:2663985"
     exon            1..83
                     /gene="Kiss1"
                     /gene_synonym="kisspeptin; metastatin"
                     /inference="alignment:Splign:2.1.0"
     exon            84..289
                     /gene="Kiss1"
                     /gene_synonym="kisspeptin; metastatin"
                     /inference="alignment:Splign:2.1.0"
     CDS             199..579
                     /gene="Kiss1"
                     /gene_synonym="kisspeptin; metastatin"
                     /note="metastasis-suppressor KiSS-1; metastin;
                     0610012C01Rik; kisspeptin-1; Kiss1 metastasis-suppressor"
                     /codon_start=1
                     /product="metastasis-suppressor KiSS-1 precursor"
                     /protein_id="NP_839991.2"
                     /db_xref="CCDS:CCDS48362.1"
                     /db_xref="GeneID:280287"
                     /db_xref="MGI:MGI:2663985"
                     /translation="MISMASWQLLLLLCVATYGEPLAKVKPGSTGQQSGPQELVNAWE
                     KESRYAESKPGSAGLRARRSSPCPPVEGPAGRQRPLCASRSRLIPAPRGAVLVQREKD
                     LSTYNWNSFGLRYGRRQAARAARG"
     exon            290..656
                     /gene="Kiss1"
                     /gene_synonym="kisspeptin; metastatin"
                     /inference="alignment:Splign:2.1.0"
     regulatory      636..641
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Kiss1"
                     /gene_synonym="kisspeptin; metastatin"
                     /note="hexamer: AATAAA"
     polyA_site      656
                     /gene="Kiss1"
                     /gene_synonym="kisspeptin; metastatin"
                     /note="major polyA site"
ORIGIN      
        1 agagtaagcc caggagccag tggctccccg ctgtgtgttc caactaccca gccctccagc
       61 cctcaagcca ggacccagtc aaggctctct ctctttgacc taggctctgg tgaagtacga
      121 actctgacct ggtcttcatt gcctctctct gtcctcagtc cctggaagga gactgtagac
      181 ctgccccttc ctcccagaat gatctcaatg gcttcttggc agctgctgct tctcctctgt
      241 gtcgccacct atggggagcc gctggcaaaa gtgaagcctg gatccacagg ccagcagtcc
      301 ggaccccagg aactcgttaa tgcctgggaa aaggaatcgc ggtatgcaga gagcaagcct
      361 gggtctgcag ggctgcgcgc tcgtaggtcg tcgccatgcc cgccggttga gggccccgcg
      421 gggcgccagc ggcccctgtg tgcctcccgc agtcgcctga tccctgcgcc ccgcggagcg
      481 gtgctggtgc agcgggagaa ggacctgtcc acctacaact ggaactcctt cggcctgcgc
      541 tacggcagga ggcaggcggc gcgggcagca cggggctgag tgctgggctg caggtggatt
      601 gtagaggcca aggcagggag cttctagact tgtgcaataa aagcaatgct gccgtc
//
