LOCUS       NM_001190911            3737 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus kirre like nephrin family adhesion molecule 3
            (Kirrel3), transcript variant A, mRNA.
ACCESSION   NM_001190911
VERSION     NM_001190911.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3737)
  AUTHORS   Traenkner,D., Shennib,O., Johnson,A., Weinbrom,A., Taylor,M.R. and
            Williams,M.E.
  TITLE     Modular Splicing Is Linked to Evolution in the Synapse-Specificity
            Molecule Kirrel3
  JOURNAL   eNeuro 10 (12) (2023)
   PUBMED   37977826
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3737)
  AUTHORS   Wang,J., Vaddadi,N., Pak,J.S., Park,Y., Quilez,S., Roman,C.A.,
            Dumontier,E., Thornton,J.W., Cloutier,J.F. and Ozkan,E.
  TITLE     Molecular and structural basis of olfactory sensory neuron axon
            coalescence by Kirrel receptors
  JOURNAL   Cell Rep 37 (5), 109940 (2021)
   PUBMED   34731636
  REMARK    GeneRIF: Molecular and structural basis of olfactory sensory neuron
            axon coalescence by Kirrel receptors.
REFERENCE   3  (bases 1 to 3737)
  AUTHORS   Hisaoka,T., Komori,T., Fujimoto,K., Kitamura,T. and Morikawa,Y.
  TITLE     Comprehensive expression pattern of kin of irregular chiasm-like 3
            in the adult mouse brain
  JOURNAL   Biochem Biophys Res Commun 563, 66-72 (2021)
   PUBMED   34062388
  REMARK    GeneRIF: Comprehensive expression pattern of kin of irregular
            chiasm-like 3 in the adult mouse brain.
REFERENCE   4  (bases 1 to 3737)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3737)
  AUTHORS   Taylor,M.R., Martin,E.A., Sinnen,B., Trilokekar,R., Ranza,E.,
            Antonarakis,S.E. and Williams,M.E.
  TITLE     Kirrel3-Mediated Synapse Formation Is Attenuated by
            Disease-Associated Missense Variants
  JOURNAL   J Neurosci 40 (28), 5376-5388 (2020)
   PUBMED   32503885
  REMARK    GeneRIF: Kirrel3-Mediated Synapse Formation Is Attenuated by
            Disease-Associated Missense Variants.
REFERENCE   6  (bases 1 to 3737)
  AUTHORS   Komori,T., Gyobu,H., Ueno,H., Kitamura,T., Senba,E. and Morikawa,Y.
  TITLE     Expression of kin of irregular chiasm-like 3/mKirre in
            proprioceptive neurons of the dorsal root ganglia and its
            interaction with nephrin in muscle spindles
  JOURNAL   J Comp Neurol 511 (1), 92-108 (2008)
   PUBMED   18752272
  REMARK    GeneRIF: Results suggest that Kirrel3 plays a role in the axonal
            pathfinding, cell recognition, and synapse formation of DRG neurons
            on target cells, including the targeting of proprioceptive neurons
            on muscle spindles through the interaction with nephrin.
REFERENCE   7  (bases 1 to 3737)
  AUTHORS   Morikawa,Y., Komori,T., Hisaoka,T., Ueno,H., Kitamura,T. and
            Senba,E.
  TITLE     Expression of mKirre in the developing sensory pathways: its close
            apposition to nephrin-expressing cells
  JOURNAL   Neuroscience 150 (4), 880-886 (2007)
   PUBMED   18022324
  REMARK    GeneRIF: These results suggest that mKirre may be involved in the
            establishment of the pathway from sensory organs to the brain.
REFERENCE   8  (bases 1 to 3737)
  AUTHORS   Gerke,P., Benzing,T., Hohne,M., Kispert,A., Frotscher,M., Walz,G.
            and Kretz,O.
  TITLE     Neuronal expression and interaction with the synaptic protein CASK
            suggest a role for Neph1 and Neph2 in synaptogenesis
  JOURNAL   J Comp Neurol 498 (4), 466-475 (2006)
   PUBMED   16874800
  REMARK    GeneRIF: In the adult brain, Neph2 is seen in the olfactory nerve
            layer and the glomerular layer of the olfactory bulb, in the
            hippocampus, and in cerebellar Purkinje cells. At the
            ultrastructural level, Neph2 is seen in dendritic shafts of
            pyramidal neurons.
REFERENCE   9  (bases 1 to 3737)
  AUTHORS   Tamura,S., Morikawa,Y., Hisaoka,T., Ueno,H., Kitamura,T. and
            Senba,E.
  TITLE     Expression of mKirre, a mammalian homolog of Drosophila kirre, in
            the developing and adult mouse brain
  JOURNAL   Neuroscience 133 (3), 615-624 (2005)
   PUBMED   15908127
  REMARK    GeneRIF: The spatiotemporal expression pattern of mKirre mRNA
            suggests important roles of mKirre in later developmental
            processes, especially the synapse formation.
REFERENCE   10 (bases 1 to 3737)
  AUTHORS   Ueno,H., Sakita-Ishikawa,M., Morikawa,Y., Nakano,T., Kitamura,T.
            and Saito,M.
  TITLE     A stromal cell-derived membrane protein that supports hematopoietic
            stem cells
  JOURNAL   Nat Immunol 4 (5), 457-463 (2003)
   PUBMED   12665856
  REMARK    GeneRIF: involved in the hematopoietic supportive capacity of OP9
            mouse stromal cells
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC156639.2, AK045373.1 and AC155250.1.
            
            [WARNING] On Oct 8, 2024 this sequence was replaced by
            NM_001190911.2.
            
            Transcript Variant: This variant (A) encodes the longest isoform
            (A).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK045373.1, SRR7652917.457162.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164132
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-97                AC156639.2         19515-19611         c
            98-3701             AK045373.1         3-3606
            3702-3702           AC155250.1         164176-164176
            3703-3733           AK045373.1         3607-3637
            3734-3737           AC155250.1         164208-164211
FEATURES             Location/Qualifiers
     source          1..3737
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 18.97 cM"
     gene            1..3737
                     /gene="Kirrel3"
                     /gene_synonym="1500010O20Rik; 2900036G11Rik; mKIAA1867;
                     NEPH2; SST4"
                     /note="kirre like nephrin family adhesion molecule 3"
                     /db_xref="GeneID:67703"
                     /db_xref="MGI:MGI:1914953"
     exon            1..428
                     /gene="Kirrel3"
                     /gene_synonym="1500010O20Rik; 2900036G11Rik; mKIAA1867;
                     NEPH2; SST4"
                     /inference="alignment:Splign:2.1.0"
     exon            429..506
                     /gene="Kirrel3"
                     /gene_synonym="1500010O20Rik; 2900036G11Rik; mKIAA1867;
                     NEPH2; SST4"
                     /inference="alignment:Splign:2.1.0"
     exon            507..656
                     /gene="Kirrel3"
                     /gene_synonym="1500010O20Rik; 2900036G11Rik; mKIAA1867;
                     NEPH2; SST4"
                     /inference="alignment:Splign:2.1.0"
     exon            657..806
                     /gene="Kirrel3"
                     /gene_synonym="1500010O20Rik; 2900036G11Rik; mKIAA1867;
                     NEPH2; SST4"
                     /inference="alignment:Splign:2.1.0"
     exon            807..964
                     /gene="Kirrel3"
                     /gene_synonym="1500010O20Rik; 2900036G11Rik; mKIAA1867;
                     NEPH2; SST4"
                     /inference="alignment:Splign:2.1.0"
     exon            965..1115
                     /gene="Kirrel3"
                     /gene_synonym="1500010O20Rik; 2900036G11Rik; mKIAA1867;
                     NEPH2; SST4"
                     /inference="alignment:Splign:2.1.0"
     exon            1116..1221
                     /gene="Kirrel3"
                     /gene_synonym="1500010O20Rik; 2900036G11Rik; mKIAA1867;
                     NEPH2; SST4"
                     /inference="alignment:Splign:2.1.0"
     exon            1222..1370
                     /gene="Kirrel3"
                     /gene_synonym="1500010O20Rik; 2900036G11Rik; mKIAA1867;
                     NEPH2; SST4"
                     /inference="alignment:Splign:2.1.0"
     exon            1371..1498
                     /gene="Kirrel3"
                     /gene_synonym="1500010O20Rik; 2900036G11Rik; mKIAA1867;
                     NEPH2; SST4"
                     /inference="alignment:Splign:2.1.0"
     exon            1499..1625
                     /gene="Kirrel3"
                     /gene_synonym="1500010O20Rik; 2900036G11Rik; mKIAA1867;
                     NEPH2; SST4"
                     /inference="alignment:Splign:2.1.0"
     exon            1626..1726
                     /gene="Kirrel3"
                     /gene_synonym="1500010O20Rik; 2900036G11Rik; mKIAA1867;
                     NEPH2; SST4"
                     /inference="alignment:Splign:2.1.0"
     exon            1727..1925
                     /gene="Kirrel3"
                     /gene_synonym="1500010O20Rik; 2900036G11Rik; mKIAA1867;
                     NEPH2; SST4"
                     /inference="alignment:Splign:2.1.0"
     exon            1926..1961
                     /gene="Kirrel3"
                     /gene_synonym="1500010O20Rik; 2900036G11Rik; mKIAA1867;
                     NEPH2; SST4"
                     /inference="alignment:Splign:2.1.0"
     exon            1962..2069
                     /gene="Kirrel3"
                     /gene_synonym="1500010O20Rik; 2900036G11Rik; mKIAA1867;
                     NEPH2; SST4"
                     /inference="alignment:Splign:2.1.0"
     exon            2070..2179
                     /gene="Kirrel3"
                     /gene_synonym="1500010O20Rik; 2900036G11Rik; mKIAA1867;
                     NEPH2; SST4"
                     /inference="alignment:Splign:2.1.0"
     exon            2180..2266
                     /gene="Kirrel3"
                     /gene_synonym="1500010O20Rik; 2900036G11Rik; mKIAA1867;
                     NEPH2; SST4"
                     /inference="alignment:Splign:2.1.0"
     exon            2267..3737
                     /gene="Kirrel3"
                     /gene_synonym="1500010O20Rik; 2900036G11Rik; mKIAA1867;
                     NEPH2; SST4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3710..3715
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Kirrel3"
                     /gene_synonym="1500010O20Rik; 2900036G11Rik; mKIAA1867;
                     NEPH2; SST4"
                     /note="hexamer: AATAAA"
     polyA_site      3736
                     /gene="Kirrel3"
                     /gene_synonym="1500010O20Rik; 2900036G11Rik; mKIAA1867;
                     NEPH2; SST4"
                     /note="major polyA site"
ORIGIN      
        1 tcgtcactcg cttgctcgct cgcccgctcg ctagctcgtt cgctcgctgt gggaggagcc
       61 cgccagagga agccgtgtgc ctgggatgcc aagaaccaga gaatggatct gctccgagtg
      121 ggcacattgc taaggatccc ggcttcccga ggcgactgaa aacaagcatt tggtttcggc
      181 tgcctgcaga tacccggaga cacaacgaga cctaagcgga ccagaggagg gacagaccga
      241 ctgacagata gatggtcggc gcgaaccctg gaggaccggc ggcggaggct gagcaccgcg
      301 agcccagccg ccgcgcttga agagaaacta actgcacacc caagttgccc gccggctgcc
      361 cgcgcgctga ggaatgagac ctttccagct ggatttgctc ttcctctgct tcttcctctt
      421 cagtcaagag cttggcctcc agaagagagg atgctgtctg gtactgggct acatggccaa
      481 ggacaagttt cggagaatga atgaaggtca agtctactcc ttcagccagc aaccccagga
      541 ccaagtggtg gtgtcaggac agccagtgac tctgctgtgt gccatccctg aatatgatgg
      601 cttcgtcctg tggatcaaag atggcttggc tctgggtgta ggcagagacc tctcaagtta
      661 cccccagtac ctggtggtgg ggaaccacct ctcaggagag catcacctga agatcctgag
      721 ggctgagctt caggatgatg ccgtgtatga gtgccaggcc atccaggctg ccatccggtc
      781 ccgccctgca cgcctcaccg tcctggtgcc accagatgac cccatcatcc taggggggcc
      841 tgtgatcagc cttcgggcag gggaccccct caacctcacc tgccacgcag acaatgccaa
      901 gcctgcggct tccatcatct ggctacgtaa aggagaggtc atcaatggag ccacctactc
      961 caagaccctg cttcgagacg gcaaacgaga aagcattgtc agcaccctct tcatctcccc
     1021 aggagacgtg gaaaatggac agagtattgt gtgccgagcc accaacaaag ccatccccgg
     1081 aggaaaagag acctctgtca ccatagacat ccagcatcca ccgcttgtca acttgtccgt
     1141 ggaaccacag ccggtattgg aggacaacat cgtcacgttc cactgctctg caaaggccaa
     1201 cccagctgtc acccagtaca ggtgggccaa acggggtcac atcatcaagg aggcatctgg
     1261 ggagctgtat aggaccacgg tggactacac atacttctca gagcctgtat cctgtgaagt
     1321 aaccaatgcc ctgggcagca ccaacctcag ccgcacagtg gatgtatact tcggtcctcg
     1381 aatgacctca gagcctcagt cactgctggt agatctgggc tccgatgctg tcttcagctg
     1441 tgcgtggatc ggcaacccgt ctctgaccat cgtgtggatg aaacgaggtt ctggtgtggt
     1501 cctgagcaat gaaaagaccc taaccctcaa atctgtccgc caagaggatg ctgggaagta
     1561 cgtgtgccgg gctgtggtgc cccgggtagg agctggggag agagaggtga ccttgactgt
     1621 caatggaccc cccatcatct ccagcacaca gacccagcac gccctccacg gagagaaggg
     1681 ccagatcaaa tgcttcatcc ggagcacacc accgcctgac cgaattgcct ggtcctggaa
     1741 ggagaatgtg ctggagtcag ggacatcagg gcgctacaca gtggagacgg tgaacacgga
     1801 ggagggagtc atctccacat tgaccattag caacattgtg cgtgctgact tccagaccat
     1861 atacaactgt acagcctgga acagctttgg ctctgacaca gagatcatcc gactcaagga
     1921 acaaggttcg gaaatgaagt cgggagccgg gctggaagca gagtctgtac caatggccgt
     1981 catcatcggg gtggccgtag gagctggcgt ggccttcctc gtcctaatgg caaccattgt
     2041 ggccttctgc tgtgcccgtt cccagagaaa tctcaaaggt gttgtatcag ccaaaaatga
     2101 tattcgagtg gaaattgtgc acaaggagcc atcttctggc cgggaggctg aggaccacac
     2161 caccataaag cagctgatga tggaccgggg tgaattccaa caagactcgg tgctgaaaca
     2221 gctggaggtc ctcaaagaag aggagaagga gtttcagaac ctgaaggacc ccaccaacgg
     2281 ctactacagc gtcaacacct tcaaagaaca ccattcaact ccaaccatct ccctgtccag
     2341 ctgccagcca gacctgcgtc cgacaggcaa acagcgtgtg cccacaggca tgtccttcac
     2401 caacatctac agcaccttga gcggccaggg ccgcctctac gactatggac agaggtttgt
     2461 gctgggcatg ggcagctctt ccattgagct ttgtgagcgg gagtttcaga ggggctccct
     2521 cagcgacagc agctccttcc tggacacgca gtgtgacagc agcgtcagca gcagcggcaa
     2581 gcaagatggc tacgtgcagt ttgacaaggc cagcaaggct tctgcctcct cttcccacca
     2641 ttcccagtcc tcttcccaga actccgaccc cagccgaccc ctgcagcggc ggatgcagac
     2701 tcacgtctga ggaccacgcc ctgtggtggg ggatgggcca aggaggagga catggtacat
     2761 tctcgttctc caaggattgg ggctactttg cagaggaccc tagaactggc cacctccggg
     2821 gtggtctccg agcacctctg taaacacctt ccttcaaagc tctgatcaag cacaaatctg
     2881 gctcccaggt gggaaatgga gagtatgcag ctgagcggat agtgctcagg gcctctgtct
     2941 cttgctcttc cctaaaggtc cctcaaccac cttgtcctcc catgggcact cgtggcagct
     3001 agaactttgc ttttatgaaa ctgccgtcca ctttcctagc tcctcttgct gcccataagc
     3061 catccctggt gtctgtattc cttgcagcct tgaggaacgg aggacttttt cccagcactg
     3121 agctgctccg gagaccccag cctccccact gtgcatagcc tataccgcag aggctggggc
     3181 ctgagaaatg gccctgacca aaggagcatc tgcctgggag tccgccccca ctttgtttgg
     3241 tgtttgtgtc tgtattcttg cagttctgtt cttggacttg atacctctgc gcttggtggt
     3301 gggactggcc tatcagagtc tagtgtcctc agagctgagg aagggaaaga gggaaaatgt
     3361 gaactcctgg agaacaactg gcccaacaca ccctgtgcca ggctgtgcag ttcagagccc
     3421 tcaccgtcat cctcaccccc tgccccgtgt tctcccttcc ttcccacagc acaatcgagc
     3481 taatccgagg agtgtgagaa ctcctcttgt cagggttttt tgaacagtta ctgaagcgtg
     3541 cttcctggga gatgtgggtt tgagggggtg ctgaaatcta ggctggagga tgagacagac
     3601 tctttcagct gatgaccaca aggaacaatg atccattctc cagtagatag gactctgtgt
     3661 gcaagaggga cagttttctt cacctctttc ccatcactcc ccacttaaga ataaacgtta
     3721 gggccattac ccccaac
//
