LOCUS       NM_172898               3122 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus kirre like nephrin family adhesion molecule 2
            (Kirrel2), mRNA.
ACCESSION   NM_172898
VERSION     NM_172898.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3122)
  AUTHORS   Wang,J., Vaddadi,N., Pak,J.S., Park,Y., Quilez,S., Roman,C.A.,
            Dumontier,E., Thornton,J.W., Cloutier,J.F. and Ozkan,E.
  TITLE     Molecular and structural basis of olfactory sensory neuron axon
            coalescence by Kirrel receptors
  JOURNAL   Cell Rep 37 (5), 109940 (2021)
   PUBMED   34731636
  REMARK    GeneRIF: Molecular and structural basis of olfactory sensory neuron
            axon coalescence by Kirrel receptors.
REFERENCE   2  (bases 1 to 3122)
  AUTHORS   Wang,Y.Z., Fan,H., Ji,Y., Reynolds,K., Gu,R., Gan,Q., Yamagami,T.,
            Zhao,T., Hamad,S., Bizen,N., Takebayashi,H., Chen,Y., Wu,S.,
            Pleasure,D., Lam,K. and Zhou,C.J.
  TITLE     Olig2 regulates terminal differentiation and maturation of
            peripheral olfactory sensory neurons
  JOURNAL   Cell Mol Life Sci 77 (18), 3597-3609 (2020)
   PUBMED   31758234
  REMARK    Erratum:[Cell Mol Life Sci. 2021 Jul;78(14):5665-5666. doi:
            10.1007/s00018-021-03870-2.. PMID: 34156491]
REFERENCE   3  (bases 1 to 3122)
  AUTHORS   Nakashima,A., Ihara,N., Shigeta,M., Kiyonari,H., Ikegaya,Y. and
            Takeuchi,H.
  TITLE     Structured spike series specify gene expression patterns for
            olfactory circuit formation
  JOURNAL   Science 365 (6448) (2019)
   PUBMED   31171707
REFERENCE   4  (bases 1 to 3122)
  AUTHORS   Vaddadi,N., Iversen,K., Raja,R., Phen,A., Brignall,A., Dumontier,E.
            and Cloutier,J.F.
  TITLE     Kirrel2 is differentially required in populations of olfactory
            sensory neurons for the targeting of axons in the olfactory bulb
  JOURNAL   Development 146 (11) (2019)
   PUBMED   31142543
  REMARK    GeneRIF: Kirrel2 is required for axonal coalescence in subsets of
            Olfactory sensory neurons that project axons to the DII (dorsal)
            region; Kirrel2/3-independent mechanisms also control olfactory
            sensory neurons axonal coalescence in certain regions of the
            Olfactory bulb.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3122)
  AUTHORS   Orchard,P., White,J.S., Thomas,P.E., Mychalowych,A., Kiseleva,A.,
            Hensley,J., Allen,B., Parker,S.C.J. and Keegan,C.E.
  TITLE     Genome-wide chromatin accessibility and transcriptome profiling
            show minimal epigenome changes and coordinated transcriptional
            dysregulation of hedgehog signaling in Danforth's short tail mice
  JOURNAL   Hum Mol Genet 28 (5), 736-750 (2019)
   PUBMED   30380057
REFERENCE   6  (bases 1 to 3122)
  AUTHORS   Hornberg,M., Gussing,F., Berghard,A. and Bohm,S.
  TITLE     Retinoic acid selectively inhibits death of basal vomeronasal
            neurons during late stage of neural circuit formation
  JOURNAL   J Neurochem 110 (4), 1263-1275 (2009)
   PUBMED   19519663
REFERENCE   7  (bases 1 to 3122)
  AUTHORS   Hoffman,B.G., Zavaglia,B., Witzsche,J., Ruiz de Algara,T.,
            Beach,M., Hoodless,P.A., Jones,S.J., Marra,M.A. and Helgason,C.D.
  TITLE     Identification of transcripts with enriched expression in the
            developing and adult pancreas
  JOURNAL   Genome Biol 9 (6), R99 (2008)
   PUBMED   18554416
REFERENCE   8  (bases 1 to 3122)
  AUTHORS   Minaki,Y., Mizuhara,E., Morimoto,K., Nakatani,T., Sakamoto,Y.,
            Inoue,Y., Satoh,K., Imai,T., Takai,Y. and Ono,Y.
  TITLE     Migrating postmitotic neural precursor cells in the ventricular
            zone extend apical processes and form adherens junctions near the
            ventricle in the developing spinal cord
  JOURNAL   Neurosci Res 52 (3), 250-262 (2005)
   PUBMED   15927725
REFERENCE   9  (bases 1 to 3122)
  AUTHORS   Sun,C., Kilburn,D., Lukashin,A., Crowell,T., Gardner,H.,
            Brundiers,R., Diefenbach,B. and Carulli,J.P.
  TITLE     Kirrel2, a novel immunoglobulin superfamily gene expressed
            primarily in beta cells of the pancreatic islets
  JOURNAL   Genomics 82 (2), 130-142 (2003)
   PUBMED   12837264
REFERENCE   10 (bases 1 to 3122)
  AUTHORS   Sellin,L., Huber,T.B., Gerke,P., Quack,I., Pavenstadt,H. and
            Walz,G.
  TITLE     NEPH1 defines a novel family of podocin interacting proteins
  JOURNAL   FASEB J 17 (1), 115-117 (2003)
   PUBMED   12424224
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AC149067.3.
            
            On May 2, 2007 this sequence version replaced NM_172898.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK049284.1, BC052773.2 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-718               AC149067.3         265497-266214       c
            719-868             AC149067.3         265119-265268       c
            869-1018            AC149067.3         264164-264313       c
            1019-1179           AC149067.3         263871-264031       c
            1180-1330           AC149067.3         263208-263358       c
            1331-1436           AC149067.3         262937-263042       c
            1437-1585           AC149067.3         262713-262861       c
            1586-1713           AC149067.3         262335-262462       c
            1714-1846           AC149067.3         262111-262243       c
            1847-1947           AC149067.3         261753-261853       c
            1948-2167           AC149067.3         261380-261599       c
            2168-2266           AC149067.3         259501-259599       c
            2267-2367           AC149067.3         259077-259177       c
            2368-2433           AC149067.3         258536-258601       c
            2434-3122           AC149067.3         256465-257153       c
FEATURES             Location/Qualifiers
     source          1..3122
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 18.36 cM"
     gene            1..3122
                     /gene="Kirrel2"
                     /gene_synonym="C330019F22Rik; NEPH3; NLG1"
                     /note="kirre like nephrin family adhesion molecule 2"
                     /db_xref="GeneID:243911"
                     /db_xref="MGI:MGI:2442334"
     exon            1..718
                     /gene="Kirrel2"
                     /gene_synonym="C330019F22Rik; NEPH3; NLG1"
                     /inference="alignment:Splign:2.1.0"
     CDS             667..2769
                     /gene="Kirrel2"
                     /gene_synonym="C330019F22Rik; NEPH3; NLG1"
                     /note="kin of IRRE-like protein 2; kin of irregular
                     chiasm-like 2; kin of irregular chiasm-like protein 2; X
                     kin of IRRE like 2"
                     /codon_start=1
                     /product="kin of IRRE-like protein 2 precursor"
                     /protein_id="NP_766486.1"
                     /db_xref="CCDS:CCDS39883.1"
                     /db_xref="GeneID:243911"
                     /db_xref="MGI:MGI:2442334"
                     /translation="MLASALLVFLCCFKGHAGSSPHFLQQPEDMVVLLGEEARLPCAL
                     GAYRGLVQWTKDGLALGGERDLPGWSRYWISGNSASGQHDLHIKPVELEDEASYECQA
                     SQAGLRSRPAQLHVMVPPEAPQVLGGPSVSLVAGVPGNLTCRSRGDSRPAPELLWFRD
                     GIRLDGSSFHQTTLKDKATGTVENTLFLTPSSHDDGATLICRARSQALPTGRDTAVTL
                     SLQYPPMVTLSAEPQTVQEGEKVTFLCQATAQPPVTGYRWAKGGSPVLGARGPRLEVV
                     ADATFLTEPVSCEVSNAVGSANRSTALEVLYGPILQAKPKSVSVDVGKDASFSCVWRG
                     NPLPRITWTRMGGSQVLSSGPTLRLPSVALEDAGDYVCRAEPRRTGLGGGKAQARLTV
                     NAPPVVTALQPAPAFLRGPARLQCVVFASPAPDSVVWSWDEGFLEAGSLGRFLVEAFP
                     APEVEGGQGPGLISVLHISGTQESDFTTGFNCSARNRLGEGRVQIHLGRRDLLPTVRI
                     VAGAASAATSLLMVITGVVLCCWRHGSLSKQKNLVRIPGSSEGSSSRGPEEETGSSED
                     RGPIVHTDHSDLVLEEKEALETKDPTNGYYRVRGVSVSLSLGEAPGGGLFLPPPSPIG
                     LPGTPTYYDFKPHLDLVPPCRLYRARAGYLTTPHPRAFTSYMKPTSFGPPELSSGTPP
                     FPYATLSPPSHQRLQTHV"
     exon            719..868
                     /gene="Kirrel2"
                     /gene_synonym="C330019F22Rik; NEPH3; NLG1"
                     /inference="alignment:Splign:2.1.0"
     exon            869..1018
                     /gene="Kirrel2"
                     /gene_synonym="C330019F22Rik; NEPH3; NLG1"
                     /inference="alignment:Splign:2.1.0"
     exon            1019..1179
                     /gene="Kirrel2"
                     /gene_synonym="C330019F22Rik; NEPH3; NLG1"
                     /inference="alignment:Splign:2.1.0"
     exon            1180..1330
                     /gene="Kirrel2"
                     /gene_synonym="C330019F22Rik; NEPH3; NLG1"
                     /inference="alignment:Splign:2.1.0"
     exon            1331..1436
                     /gene="Kirrel2"
                     /gene_synonym="C330019F22Rik; NEPH3; NLG1"
                     /inference="alignment:Splign:2.1.0"
     exon            1437..1585
                     /gene="Kirrel2"
                     /gene_synonym="C330019F22Rik; NEPH3; NLG1"
                     /inference="alignment:Splign:2.1.0"
     exon            1586..1713
                     /gene="Kirrel2"
                     /gene_synonym="C330019F22Rik; NEPH3; NLG1"
                     /inference="alignment:Splign:2.1.0"
     exon            1714..1846
                     /gene="Kirrel2"
                     /gene_synonym="C330019F22Rik; NEPH3; NLG1"
                     /inference="alignment:Splign:2.1.0"
     exon            1847..1947
                     /gene="Kirrel2"
                     /gene_synonym="C330019F22Rik; NEPH3; NLG1"
                     /inference="alignment:Splign:2.1.0"
     exon            1948..2167
                     /gene="Kirrel2"
                     /gene_synonym="C330019F22Rik; NEPH3; NLG1"
                     /inference="alignment:Splign:2.1.0"
     exon            2168..2266
                     /gene="Kirrel2"
                     /gene_synonym="C330019F22Rik; NEPH3; NLG1"
                     /inference="alignment:Splign:2.1.0"
     exon            2267..2367
                     /gene="Kirrel2"
                     /gene_synonym="C330019F22Rik; NEPH3; NLG1"
                     /inference="alignment:Splign:2.1.0"
     exon            2368..2433
                     /gene="Kirrel2"
                     /gene_synonym="C330019F22Rik; NEPH3; NLG1"
                     /inference="alignment:Splign:2.1.0"
     exon            2434..3122
                     /gene="Kirrel2"
                     /gene_synonym="C330019F22Rik; NEPH3; NLG1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctctctccga cccgcaggcc cacgggagcc tgagctccgc ctccccaggg cgcggaagct
       61 ggcgaagccc cagggattcc catttatagc ttggtttcca ctcagctcag tccctccagg
      121 actcgggctg agcaagtttc ttccattccc ttctctcctc cctccacccc cttctcctcc
      181 tccttctcct tcttttcttc ctcctcattc ccgcctcccc ttcaacctca gcagggtgca
      241 ggtgtccaac tcgaacaagg gccccaactt ggactcagat gttcccactc tcagaccccc
      301 tgataatgca ggggcgcccg cctgctgcgc ggacagctac cctgagcatc cgtagccgtc
      361 cgcacacaag gcgcgggagt ttctcaatgg gaagaggccg ggactctagg aggcggggcg
      421 aataggattc ctcccgccta gtgggtccct cgcagtccta gggttgcaac ccttgagcgg
      481 tagagaacac cggagactgc ggatgagcca gatttcgggg acataaaatc ttccagcccg
      541 gagagaattg tgtgcagaga ggggctccag tccagcgtgg tgtgagaggc gtgctatcaa
      601 gaaagaagtt ggaggggaac cagtgcaacc ctaactctgc gagatcttgg ggtacacaca
      661 ctcgggatgc tggcctccgc cctcctcgtt ttcctttgct gtttcaaagg acatgcaggc
      721 tcatcgcccc atttcctaca acagccagag gacatggtgg tgctgttggg ggaggaagcc
      781 cggctgccct gcgctctggg cgcgtacagg gggctcgtgc agtggactaa ggatgggctg
      841 gctctagggg gcgaaagaga ccttccaggg tggtcccggt actggatatc ggggaattca
      901 gccagtggcc agcatgacct ccacattaag cctgtggaat tggaagatga ggcatcgtat
      961 gagtgccagg cttcgcaagc aggtctccga tcacgaccag cccaactgca cgtgatggtc
     1021 cccccagaag ctccccaggt actaggcggc ccctctgtgt ctctggttgc tggagttcct
     1081 ggaaatctga cctgtcggag tcgtggggat tcacgacctg cccctgaact actgtggttc
     1141 cgagatggga tccggctgga tgggagcagc ttccaccaga ccacgctgaa ggacaaggcc
     1201 actggaacag tggaaaacac cttattcctg accccttcca gtcatgatga tggtgccacc
     1261 ttgatctgca gagcgcgaag ccaggccctg cccacaggga gggacacagc tgttacactg
     1321 agccttcagt atcccccaat ggtgactctg tctgctgagc cccagactgt gcaggaggga
     1381 gagaaggtga ctttcctgtg tcaagccact gcccagcctc ctgtcactgg ctacaggtgg
     1441 gcgaaggggg gatccccggt gcttggggca cgtgggccaa ggttggaggt cgttgcagat
     1501 gccactttcc tgactgagcc ggtgtcctgc gaggtcagca acgcggtcgg aagcgccaac
     1561 cgcagcaccg cgctggaagt gttgtatgga cccattctgc aggcaaaacc taagtccgtg
     1621 tccgtggacg tggggaaaga tgcctccttc agctgtgtct ggcgcgggaa cccacttcca
     1681 cggataacct ggacccgcat gggtggctct caggtgctga gctccgggcc cacgctgcgg
     1741 cttccgtccg tggcactgga ggatgcgggc gactatgtat gcagggctga gccgaggaga
     1801 acgggtctgg gaggcggcaa agcgcaggcg aggctgactg tgaacgcacc ccctgtagtg
     1861 acagccctgc aacctgcacc agcctttctg aggggtcctg ctcgcctcca gtgtgtggtg
     1921 tttgcctccc ctgccccaga ctcggtggtt tggtcttggg acgagggctt cttggaggca
     1981 ggctcactgg gcaggttcct agtggaagcc ttcccagccc cggaagtgga ggggggacag
     2041 ggccctggcc ttatttctgt gctacacatt tccggaaccc aggagtccga ctttaccacc
     2101 ggcttcaact gcagtgcccg caaccggcta ggagagggac gagtccagat ccacttgggc
     2161 cgtagagact tgctgcctac tgtccggatt gtggctggtg cagcatctgc agccacctct
     2221 ctccttatgg tcatcactgg agtggtcctc tgctgctggc gccatggctc tctctctaag
     2281 caaaagaact tggtccggat cccaggaagc agcgagggtt ccagttcacg tggccctgag
     2341 gaggagacag gcagcagtga ggaccggggt cccattgtgc acaccgacca cagtgatttg
     2401 gttcttgagg aaaaagaggc tctggagaca aaggatccaa ccaacggtta ctacagggtt
     2461 cgaggggtca gtgtgagcct tagccttggg gaagctcctg gaggaggcct cttcttgcca
     2521 ccgccctctc cgatcggtct cccagggact cctacttact atgacttcaa gccacatctg
     2581 gacttagtcc ctccctgcag actgtacaga gcgagggcag gttatcttac caccccccat
     2641 ccccgtgcct tcaccagcta catgaaaccc acatcctttg gacccccaga attgagctct
     2701 ggaactcccc ccttcccgta tgctaccttg tctccaccca gccaccagcg tctccagact
     2761 catgtgtgaa tccatctctc caagtgaagg gtcttggaat cttctgtttg ccatatagtg
     2821 tgttgtccag atttctgggg agtcagaaca agttgatgac caacccctcc aaaactgaac
     2881 attgaaggag ggaaagatca ttacaagcat caggactgtt ggtgtacact cagttcagcc
     2941 aaagtggatt ctccaagtgg gagcaatatg gccgctttcc catgagaaag acattcaaga
     3001 tggtgactaa atgactaaat actttgcaga gggacaaaga tgggaactag ggatatggat
     3061 ggaagtagta gagaagatat atgaccatct gcatcaagag aaaggataac ataagacaaa
     3121 tc
//
