LOCUS       NM_001170985            7076 bp    mRNA    linear   ROD 21-AUG-2024
DEFINITION  Mus musculus kirre like nephrin family adhesion molecule 1
            (Kirrel1), transcript variant 1, mRNA.
ACCESSION   NM_001170985
VERSION     NM_001170985.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 7076)
  AUTHORS   Baltar,J., Miranda,R.M., Cabral,M., Rebelo,S., Grahammer,F.,
            Huber,T.B., Reguenga,C. and Monteiro,F.A.
  TITLE     Neph1 is required for neurite branching and is negatively regulated
            by the PRRXL1 homeodomain factor in the developing spinal cord
            dorsal horn
  JOURNAL   Neural Dev 19 (1), 13 (2024)
   PUBMED   39049046
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 7076)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 7076)
  AUTHORS   Solanki,A.K., Arif,E., Srivastava,P., Furcht,C.M., Rahman,B.,
            Wen,P., Singh,A., Holzman,L.B., Fitzgibbon,W.R.,
            Budisavljevic,M.N., Lobo,G.P., Kwon,S.H., Han,Z., Lazzara,M.J.,
            Lipschutz,J.H. and Nihalani,D.
  TITLE     Phosphorylation of slit diaphragm proteins NEPHRIN and NEPH1 upon
            binding of HGF promotes podocyte repair
  JOURNAL   J Biol Chem 297 (3), 101079 (2021)
   PUBMED   34391780
  REMARK    GeneRIF: Phosphorylation of slit diaphragm proteins NEPHRIN and
            NEPH1 upon binding of HGF promotes podocyte repair.
REFERENCE   4  (bases 1 to 7076)
  AUTHORS   Zhang,M.J., Hong,Y.Y. and Li,N.
  TITLE     Overexpression of Kin of IRRE-Like Protein 1 (KIRREL) in Gastric
            Cancer and Its Clinical Prognostic Significance
  JOURNAL   Med Sci Monit 24, 2711-2719 (2018)
   PUBMED   29717104
  REMARK    GeneRIF: KIRREL was overexpressed in gastric cancer.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 7076)
  AUTHORS   Bibollet-Bahena,O., Okafuji,T., Hokamp,K., Tear,G. and
            Mitchell,K.J.
  TITLE     A dual-strategy expression screen for candidate connectivity labels
            in the developing thalamus
  JOURNAL   PLoS One 12 (5), e0177977 (2017)
   PUBMED   28558017
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 7076)
  AUTHORS   Beltcheva,O., Kontusaari,S., Fetissov,S., Putaala,H.,
            Kilpelainen,P., Hokfelt,T. and Tryggvason,K.
  TITLE     Alternatively used promoters and distinct elements direct
            tissue-specific expression of nephrin
  JOURNAL   J Am Soc Nephrol 14 (2), 352-358 (2003)
   PUBMED   12538735
  REMARK    GeneRIF: Analysis of five promoter-reporter gene constructs showed
            that regulatory elements driving expression encoded by exon 1A in
            kidney and brain are localized in region between -4 kb and 2.1 kb.
REFERENCE   7  (bases 1 to 7076)
  AUTHORS   Sellin,L., Huber,T.B., Gerke,P., Quack,I., Pavenstadt,H. and
            Walz,G.
  TITLE     NEPH1 defines a novel family of podocin interacting proteins
  JOURNAL   FASEB J 17 (1), 115-117 (2003)
   PUBMED   12424224
REFERENCE   8  (bases 1 to 7076)
  AUTHORS   Schwarz,K., Simons,M., Reiser,J., Saleem,M.A., Faul,C., Kriz,W.,
            Shaw,A.S., Holzman,L.B. and Mundel,P.
  TITLE     Podocin, a raft-associated component of the glomerular slit
            diaphragm, interacts with CD2AP and nephrin
  JOURNAL   J Clin Invest 108 (11), 1621-1629 (2001)
   PUBMED   11733557
REFERENCE   9  (bases 1 to 7076)
  AUTHORS   Huber,T.B., Kottgen,M., Schilling,B., Walz,G. and Benzing,T.
  TITLE     Interaction with podocin facilitates nephrin signaling
  JOURNAL   J Biol Chem 276 (45), 41543-41546 (2001)
   PUBMED   11562357
REFERENCE   10 (bases 1 to 7076)
  AUTHORS   Donoviel,D.B., Freed,D.D., Vogel,H., Potter,D.G., Hawkins,E.,
            Barrish,J.P., Mathur,B.N., Turner,C.A., Geske,R., Montgomery,C.A.,
            Starbuck,M., Brandt,M., Gupta,A., Ramirez-Solis,R., Zambrowicz,B.P.
            and Powell,D.R.
  TITLE     Proteinuria and perinatal lethality in mice lacking NEPH1, a novel
            protein with homology to NEPHRIN
  JOURNAL   Mol Cell Biol 21 (14), 4829-4836 (2001)
   PUBMED   11416156
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC102115.11.
            
            On Dec 11, 2019 this sequence version replaced NM_001170985.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7652917.667646.1,
                                           SRR7345562.3736892.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-142               AC102115.11        55524-55665
            143-288             AC102115.11        88939-89084
            289-453             AC102115.11        132155-132319
            454-603             AC102115.11        134275-134424
            604-761             AC102115.11        137799-137956
            762-912             AC102115.11        139453-139603
            913-1018            AC102115.11        140160-140265
            1019-1167           AC102115.11        140431-140579
            1168-1295           AC102115.11        140783-140910
            1296-1422           AC102115.11        141576-141702
            1423-1523           AC102115.11        141795-141895
            1524-1722           AC102115.11        143481-143679
            1723-1830           AC102115.11        144872-144979
            1831-1970           AC102115.11        145117-145256
            1971-2048           AC102115.11        146117-146194
            2049-7076           AC102115.11        146441-151468
FEATURES             Location/Qualifiers
     source          1..7076
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 38.18 cM"
     gene            1..7076
                     /gene="Kirrel1"
                     /gene_synonym="6720469N11Rik; Kirrel; Neph1"
                     /note="kirre like nephrin family adhesion molecule 1"
                     /db_xref="GeneID:170643"
                     /db_xref="MGI:MGI:1891396"
     exon            1..142
                     /gene="Kirrel1"
                     /gene_synonym="6720469N11Rik; Kirrel; Neph1"
                     /inference="alignment:Splign:2.1.0"
     exon            143..288
                     /gene="Kirrel1"
                     /gene_synonym="6720469N11Rik; Kirrel; Neph1"
                     /inference="alignment:Splign:2.1.0"
     CDS             156..2525
                     /gene="Kirrel1"
                     /gene_synonym="6720469N11Rik; Kirrel; Neph1"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; nephrin 1; kin of IRRE-like protein 1;
                     nephrin-like protein 1; kin of irregular chiasm-like
                     protein 1; kin of IRRE like 1"
                     /codon_start=1
                     /product="kin of IRRE-like protein 1 isoform 1 precursor"
                     /protein_id="NP_001164456.1"
                     /db_xref="CCDS:CCDS17450.1"
                     /db_xref="GeneID:170643"
                     /db_xref="MGI:MGI:1891396"
                     /translation="MTLESPSTRLMTCQSSLLPEKPRFLSQKMWAPHLVVAYLIFVTL
                     ALALPGTQTRFSQEPADQTVVAGQRAVLPCVLLNYSGIVQWTKDGLALGMGQGLKAWP
                     RYRVVGSADAGQYNLEITDAELSDDASYECQATEAALRSRRAKLTVLIPPEETRIDGG
                     PVILLQAGTPYNLTCRAFNAKPAATIIWFRDGTQQEGAVTSTELLKDGKRETTISQLL
                     IEPTDLDIGRVFTCRSMNEAIPNGKETSIELDVHHPPTVTLSIEPQTVLEGERVIFTC
                     QATANPEILGYRWAKGGFLIEDAHESRYETNVDYSFFTEPVSCEVYNKVGSTNVSTLV
                     NVHFAPRIVVYPKPTTTDIGSDVTLTCVWVGNPPLTLTWTKKDSNMVLSNSNQLLLKS
                     VTQADAGTYTCRAIVPRIGVAEREVPLYVNGPPIISSEAVQFAVRGDGGKVECFIGST
                     PPPDRIAWAWKENFLEVGTLERYTVERTNSGSGVLSTLTINNVMEADFQTHYNCTAWN
                     SFGPGTAIIQLEEREVLPVGIIAGATIGAGILVVFSFAALVFFLYRRRKGSRKDVTLR
                     KLDIKVETVNREPLTMHSDREDDTASISTATRVMKAIYSSFKDDVDLKQDLRCDTIDT
                     REEYEMKDPTNGYYNVRAHEDRPSSRAVLYADYRAPGPTRFDGRPSSRLSHSSGYAQL
                     NTYSRAPASDYGTEPTPSGPSAPGGTDTTSQLSYENYEKFNSHPFPGAAGYPTYRLGY
                     PQAPPSGLERTPYEAYDPIGKYATATRFSYTSQHSDYGQRFQQRMQTHV"
     exon            289..453
                     /gene="Kirrel1"
                     /gene_synonym="6720469N11Rik; Kirrel; Neph1"
                     /inference="alignment:Splign:2.1.0"
     exon            454..603
                     /gene="Kirrel1"
                     /gene_synonym="6720469N11Rik; Kirrel; Neph1"
                     /inference="alignment:Splign:2.1.0"
     exon            604..761
                     /gene="Kirrel1"
                     /gene_synonym="6720469N11Rik; Kirrel; Neph1"
                     /inference="alignment:Splign:2.1.0"
     exon            762..912
                     /gene="Kirrel1"
                     /gene_synonym="6720469N11Rik; Kirrel; Neph1"
                     /inference="alignment:Splign:2.1.0"
     exon            913..1018
                     /gene="Kirrel1"
                     /gene_synonym="6720469N11Rik; Kirrel; Neph1"
                     /inference="alignment:Splign:2.1.0"
     exon            1019..1167
                     /gene="Kirrel1"
                     /gene_synonym="6720469N11Rik; Kirrel; Neph1"
                     /inference="alignment:Splign:2.1.0"
     exon            1168..1295
                     /gene="Kirrel1"
                     /gene_synonym="6720469N11Rik; Kirrel; Neph1"
                     /inference="alignment:Splign:2.1.0"
     exon            1296..1422
                     /gene="Kirrel1"
                     /gene_synonym="6720469N11Rik; Kirrel; Neph1"
                     /inference="alignment:Splign:2.1.0"
     exon            1423..1523
                     /gene="Kirrel1"
                     /gene_synonym="6720469N11Rik; Kirrel; Neph1"
                     /inference="alignment:Splign:2.1.0"
     exon            1524..1722
                     /gene="Kirrel1"
                     /gene_synonym="6720469N11Rik; Kirrel; Neph1"
                     /inference="alignment:Splign:2.1.0"
     exon            1723..1830
                     /gene="Kirrel1"
                     /gene_synonym="6720469N11Rik; Kirrel; Neph1"
                     /inference="alignment:Splign:2.1.0"
     exon            1831..1970
                     /gene="Kirrel1"
                     /gene_synonym="6720469N11Rik; Kirrel; Neph1"
                     /inference="alignment:Splign:2.1.0"
     exon            1971..2048
                     /gene="Kirrel1"
                     /gene_synonym="6720469N11Rik; Kirrel; Neph1"
                     /inference="alignment:Splign:2.1.0"
     exon            2049..7076
                     /gene="Kirrel1"
                     /gene_synonym="6720469N11Rik; Kirrel; Neph1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3373..3378
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Kirrel1"
                     /gene_synonym="6720469N11Rik; Kirrel; Neph1"
                     /note="hexamer: AATAAA"
     polyA_site      3397
                     /gene="Kirrel1"
                     /gene_synonym="6720469N11Rik; Kirrel; Neph1"
                     /note="major polyA site"
     regulatory      7057..7062
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Kirrel1"
                     /gene_synonym="6720469N11Rik; Kirrel; Neph1"
                     /note="hexamer: TATAAA"
     polyA_site      7076
                     /gene="Kirrel1"
                     /gene_synonym="6720469N11Rik; Kirrel; Neph1"
ORIGIN      
        1 gtgcgccttg tgtgcaaggg cgggagggag gagagagagc cagcggcggc cccgctcgcg
       61 ccgactgggg cccagcggcg ggcggacagc atgctgagcc tcctcatctg gatcctcact
      121 ctctacaaca ctttctcaca agcagggctt taggaatgac tctggagagc cctagcacac
      181 gtctaatgac ctgccaatca agcctgctcc ctgagaagcc caggtttctg agtcagaaga
      241 tgtgggctcc acacttagtc gttgcttatc ttatctttgt gactttggct ttggctttgc
      301 ccgggactca gactcgcttc agccaggagc cagctgatca gactgtggtg gccggacagc
      361 gggcggtgct cccgtgtgtg ctccttaact actctgggat tgtacagtgg accaaggacg
      421 ggctggccct gggtatgggc cagggcctca aagcctggcc acggtaccgg gtcgtgggct
      481 ctgcggatgc tgggcaatac aacttggaga tcacagatgc cgagctgtct gatgacgctt
      541 cctatgagtg ccaggccacg gaggctgccc tgcgctctcg gcgggccaaa ctcaccgtgc
      601 tcattcctcc agaggaaaca aggattgatg ggggcccggt gattctgctg caagcaggca
      661 ccccctacaa cctcacgtgc agagcattta atgccaaacc tgctgccacc atcatttggt
      721 tccgagatgg gacacagcag gagggggctg tgactagcac ggagctgctg aaggatggga
      781 aaagggagac cacaatcagc caactgctca ttgagcccac agacctagac attggccgcg
      841 tattcacctg tcgcagtatg aatgaggcca tccccaatgg caaggagaca tccattgagc
      901 ttgatgtgca ccaccctccc acagtgactc tgtccatcga gccccagaca gtgctggaag
      961 gcgagcgtgt catttttaca tgccaggcca cagccaaccc agagatcttg ggctacaggt
     1021 gggccaaagg gggcttcttg attgaagacg cccatgagag tcgctatgag acaaacgttg
     1081 actattcctt cttcacggag cctgtgtctt gtgaggttta taacaaagtc gggagcacca
     1141 atgtcagcac tttagtgaat gttcacttcg ccccccggat tgtagtttac ccaaagccca
     1201 ccaccacaga cattggatct gatgtgaccc tcacctgtgt ctgggttggg aatcctcccc
     1261 tcaccctcac ctggaccaag aaggactcaa acatggtcct gagtaacagc aatcaactgt
     1321 tgctgaagtc agtgacccag gcagatgctg gcacctatac ctgccgggcc atcgtgcctc
     1381 ggatcggagt ggctgagcga gaggtaccgc tttatgtaaa cggacctcct atcatctcca
     1441 gcgaggcggt acagtttgct gtgagaggtg atggcggtaa ggtggagtgc tttatcggga
     1501 gtaccccacc tccggatcga attgcatggg catggaagga gaacttcctc gaggtgggga
     1561 ccctggaacg ctacaccgtg gagaggacga actcaggcag cggtgtgctg tccacgctca
     1621 ccattaataa tgtcatggag gcggacttcc agacccacta caactgcact gcctggaaca
     1681 gctttggacc aggcacagcc atcatccagc tggaagagcg agaggtgtta cctgtgggca
     1741 tcattgccgg ggccaccatc ggtgccggca tcctggtcgt cttctctttt gctgccttag
     1801 tgttcttcct ctaccgacgt cgcaaaggca gtcgaaagga tgtgacgttg aggaagctgg
     1861 acatcaaggt ggagacggtg aatcgggagc cacttacgat gcactctgac cgggaggatg
     1921 atactgccag catttccacg gcaacgcggg tcatgaaggc catctactcg tcctttaagg
     1981 atgatgtgga tctgaagcag gacctgcgct gtgacaccat tgacacccgg gaagagtatg
     2041 agatgaagga tcccaccaat ggttattaca atgtgcgcgc ccacgaagat cgcccgtcct
     2101 ccagggcggt gctgtatgct gactaccgtg cccctggccc tactcgtttt gatgggcgcc
     2161 catcatcccg cctgtcccac tccagtggtt atgcccagct caatacgtac agccgggccc
     2221 ctgcctctga ctatggcaca gagcctacac cctctggccc ttctgctccg ggtggcaccg
     2281 atacgaccag ccagctgtcc tacgagaact atgagaagtt caactcccac ccctttcccg
     2341 gggcagctgg gtatcctaca taccgtctag gctaccccca ggccccaccc tctggcctgg
     2401 agaggacccc ctacgaagcg tatgacccta ttggcaagta tgccaccgcc actcggttct
     2461 cctacacctc tcagcactca gactatggcc agcgattcca gcagcgcatg cagactcatg
     2521 tgtagaggct ggatctggct ggggtatctc tgcggggcag aggagatggc ttcccagctg
     2581 ttccctgaca ttcagggaca ttgctcattg ctcctttcat ggacccagcc tttctcctcc
     2641 tggccatcac aaatgaggag caggtctccc agtaacatcc catcccaagg atggtgctct
     2701 gcgcaggccc cagtctcccg ggcctgccct ttcctctcct tcaggagaat gtctcttctg
     2761 acctttgctc tgcctgaccc aagcatgggg aaaggagagg ggaggttggg gaaggggagg
     2821 agaagggaga ggagaagaat acaatttatc atttcctatc tggcctgctc ctctggtctc
     2881 ccataagagg gcatggagct aagctgaggc gggcaggctg ctggaacgtg ggacagccac
     2941 tagtcccgat cttgatttct ttataccttg tgttcatctt tcccatctca gggggttaca
     3001 gacggaacaa caagttcaga tccagccctt ggtcagttgg ggtcaaatgc cagtccccct
     3061 ggctgctgtg gtatccatct gcctgagtgg agagggcttc ataaatcccc aggaacacgg
     3121 tttcctttct tctcagcttt gtgctggacc agccagatgt gtcctggatg tgagcaagga
     3181 ggggtcaggg ccaggctctg gttgataggc caaggaccat ggtgtagtgc atggcagttc
     3241 ccagatccac cactagtggg agccacacaa gcttctctcc ggtatctgtc ccacttcttg
     3301 gtgttaactc ttgagccttg gagagttggg gggaacagag gctaactttt cctggggcta
     3361 tttttcaaaa gcaataaaac ctcatttgga aagaaaagct gtaggggttt cccccactat
     3421 acacaagtcc cgtggaaaag agagggtcac ctgccctctg ccagactcct aagtccttgt
     3481 attactatat ccaagtctct aagcactttg aatctagcat atacatccaa atggtgagac
     3541 ctgcctgctg gtggattctg ataagagtta agcagtatcc cgagtctcag actcagctat
     3601 cctaccctgt ctatcacagc tagaaactac cttgcagatg gcgtggtaga tactttatcc
     3661 agacaaattt tggttttgtc tcctcctcac tgccccccac cccacccctg accaatcaga
     3721 ttccttcttc cattttcagt gccttgagtg tcaggtttgt gatgatgtcc ctgtgtgggg
     3781 agcagggacc ttgtgagctt gagcttgtcc catgttagca tccaaggaga gacaagtgag
     3841 aggacatgag gggatggggg cctggaaatg gtggcgaagg aaacgtctta ctgacctaga
     3901 tggagatctt agtgtagaac aacacaaacg gcactgaatt ccatgggcca tgctatcttt
     3961 tcccacacag catgcacaca tgagcacaca cacattccgt gccacatctc atctaccacc
     4021 ttctgaccaa agagaatctg taactcgtag ctcagcctca tcttcccaag aaaacaactg
     4081 cccaacagga gcctactgtc catgtccccg ctgagacctg cgcgatggga gggagtagtc
     4141 ccagaatgct ccttgctttt tctcattggt caccattcgt tagtcatgtt tactttaatg
     4201 agctacatgt tcatcaggca cggtccatca ctaaccttct agatgggcct gtggggtgat
     4261 atctgaggct atctccttct cgataaggac caggtgatat ctgggaatca gggagtcccg
     4321 tttccagcct ggcaggcagc tgctgcttcc tcctctcctc ctcctcctcc agtgaatgcg
     4381 tgcacagagt gggcccttcc tgcagcagtg accgacttgt agctgcatcc cagttcagaa
     4441 gactcacgct cgcagaaccc tttcatgaga gctcagtggg gcggtgggtt tgcagtgtag
     4501 gtccttgtga atatggattc atacaggctt tcatgttctc tgacctctga agccgtgggt
     4561 gagccaaaca cttctgaagt ctaaatagag tggcatttta tactccctaa agtcatcatc
     4621 ttgtgtgggg tttggcttga ttctcttgtt tctctctgat ttaagtagta ggtccctcct
     4681 atggaaataa gagcagcact aaggagaact ctgagagtca agcgcacagc catgcgaggg
     4741 acaggaaaca gcaactgaga cagactcctg ccactcacac tccgcaatca gaatcagagt
     4801 tgggccctgc tgaatgacca gtgttgcttg tcgggggagt tgaaagtccc ttaatcacga
     4861 ggctcttccg tctgaagcta gcatcttcca gcatgttggt actttgagtc taagcaccct
     4921 gggtgctgtt gctttagttg aaagaataag aaaccaagag tcgagagatc caggatccca
     4981 ttctgcggct gctgtttgct gagtaaccct ggtctgacct ccttattttc cgtgcttcca
     5041 tcttctggtc tttccctaaa cctattctct gttggctgtg ttcatctggg gcaggagatt
     5101 gcccattcct cgggaacagt gagcagtctc ggtgaggctt ggggcaggga ggcacagcct
     5161 gctagaagga gctttaacca ccaacttctt gatcttgtct gtcaccctac ccctgagtga
     5221 aatgaagtta ttggtgttgc tctcatctta gattcagtag gctgctgtga tcacggtagg
     5281 gctcggtcat ggatgcggtc tgcggcagca catacagact gggagaggca gagaaactgt
     5341 cttctacttc agtcttcagg aacagtcatc tggcctaaag actgctctcc ctgttccccc
     5401 aacaaggtga agcctacatc ccccccgccc gtgcccccct ccctgcagtc ttgaatcaga
     5461 aagcaggaga gagagcagct gaccccgccc tgtagactga aaggggtgtt cctagcagga
     5521 agaaggggtt agtggttttt atataaatgc tgcatatgtt aaaggttctt gtggctctgg
     5581 ataggccttg ccctttgtag agaacccagc ctgcttgctg aatcctggtc cccaccccat
     5641 ccccaccact gccaaagtct aactacagac tatgcatgaa gcaggaaaga gagaggaaag
     5701 ctcgcaggag caggggcaat gctcagcttt cacaaatgtc tgggtcagaa cgaaaaacat
     5761 gagctcaact aatgtgattc tgggtgagac aagacacagt gacccgtgtc ttcccccttg
     5821 tgctctgtca ggagccatag ctcctgggat ccttaagata gaagtgggtg acccgtgtac
     5881 acttggcccc ctgcatagca atgttaggca attgggattt atagaaactc acgttaaagc
     5941 caaagaccgt gtttgggcat gtaacgtcta ctggcttagt cactgcctca tcctgctgtg
     6001 tgagcagctc tgttcctctg ggtgaattgc atgaactccc aaggccactg caggctcaaa
     6061 acacctgctt tccctactat tccatttctg tggaacccga ggccaggcgc tacacccatt
     6121 gagccaagcg ctgacggtaa tacaatcctg gggacacaga cctcaagact ccactggggg
     6181 tgcattgact gttatggaag gactctaaag ttgtcaccta aacaccacat tcccttctcg
     6241 ctgcgatttt tctttctcct ctcctaaaga cagtacattc tgaccagtgc tggctgacct
     6301 tcctcagctg ctgacaccac ccgtgggcca gtaaagagga ctgaggtctg tggcttgttg
     6361 tatggatttg agaggagggt gcaacattca gttttccagc atcactgtga gggaaccttt
     6421 cccaagggaa tgtaattttt tgcacagaag acagaggcca cactaggaag tcctggtgca
     6481 aacctgctct taacaaaagt aatgattctg tgtgcacaga actcccctta ccagccctgt
     6541 ttgtaaaacc atcttaggct tttaatgttc acaaccactg gcctttgcga actggtggcc
     6601 agactgttcc attggtttca ggagctgtcc atcgcccctg ggaataccag gatggaaggg
     6661 ggcggggaaa gaggggagca ttcagtttgc tgatacaatc aatacatagg cttcttagca
     6721 aaagtgaccc acaaggcctc cacttttaac aaggtgccca ggtcagactg ccaaccccag
     6781 tcattcctcg gattgttatc tccatctgat gcctgttgaa tcttctctac ccaaatcctc
     6841 ctcataaatg gatccatgat gacagctaag agaaaaaaaa taagtatttt tgttaggaca
     6901 aaccatcata gatttttagc aatgtgtatc tgtgtgtcct ttatgccttt cctattctga
     6961 cattttttct tttttttttt taaaaaaata ttgtgtacta tatttttagt ctcaaacaca
     7021 ctatatatta tatatttaat tttatatata tataaatata aatgttttaa aaagta
//
