LOCUS       NM_177749               1555 bp    mRNA    linear   ROD 04-APR-2024
DEFINITION  Mus musculus killer cell immunoglobulin-like receptor, three
            domains, long cytoplasmic tail, 1 (Kir3dl1), transcript variant 1,
            mRNA.
ACCESSION   NM_177749
VERSION     NM_177749.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1555)
  AUTHORS   Timmermans,S. and Libert,C.
  TITLE     Overview of inactivating mutations in the protein-coding genome of
            the mouse reference strain C57BL/6J
  JOURNAL   JCI Insight 3 (13), 121758 (2018)
   PUBMED   29997285
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1555)
  AUTHORS   Qin,H., Wang,Z., Du,W., Lee,W.H., Wu,X., Riggs,A.D. and Liu,C.P.
  TITLE     Killer cell Ig-like receptor (KIR) 3DL1 down-regulation enhances
            inhibition of type 1 diabetes by autoantigen-specific regulatory T
            cells
  JOURNAL   Proc Natl Acad Sci U S A 108 (5), 2016-2021 (2011)
   PUBMED   21245333
  REMARK    GeneRIF: studies indicate that KIR3DL1 expression may negatively
            regulate Treg function and suggest a previously undescribed target
            for improving immune tolerance for potential treatment of
            autoimmune diseases like IDDM
REFERENCE   3  (bases 1 to 1555)
  AUTHORS   Wilson,E.B., Parachoniak,C.A., Carpenito,C., Mager,D.L. and
            Takei,F.
  TITLE     Expression of murine killer immunoglobulin-like receptor KIRL1 on
            CD1d-independent NK1.1(+) T cells
  JOURNAL   Immunogenetics 59 (8), 641-651 (2007)
   PUBMED   17516061
  REMARK    GeneRIF: cloned Kir cDNAs from multiple strains of mice. Sequencing
            of the cDNA clones showed that the Kir3dl1 gene is found in C3H/HeJ
            and CBA/J but not in B6 mice.
REFERENCE   4  (bases 1 to 1555)
  AUTHORS   Bryceson,Y.T., Foster,J.A., Kuppusamy,S.P., Herkenham,M. and
            Long,E.O.
  TITLE     Expression of a killer cell receptor-like gene in plastic regions
            of the central nervous system
  JOURNAL   J Neuroimmunol 161 (1-2), 177-182 (2005)
   PUBMED   15748957
  REMARK    GeneRIF: Selective expression of killer cell immunoglobulin-like
            receptor (KIR) genes in subregions of the mouse brain where
            synaptic plasticity and neurogenesis occur, including olfactory
            bulbs, rostral migratory stream and dentate gyrus of hippocampus.
REFERENCE   5  (bases 1 to 1555)
  AUTHORS   Hoelsbrekken,S.E., Nylenna,O., Saether,P.C., Slettedal,I.O.,
            Ryan,J.C., Fossum,S. and Dissen,E.
  TITLE     Cutting edge: molecular cloning of a killer cell Ig-like receptor
            in the mouse and rat
  JOURNAL   J Immunol 170 (5), 2259-2263 (2003)
   PUBMED   12594244
REFERENCE   6  (bases 1 to 1555)
  AUTHORS   Welch,A.Y., Kasahara,M. and Spain,L.M.
  TITLE     Identification of the mouse killer immunoglobulin-like
            receptor-like (Kirl) gene family mapping to chromosome X
  JOURNAL   Immunogenetics 54 (11), 782-790 (2003)
   PUBMED   12618911
  REMARK    GeneRIF: first close rodent homologue of the NK receptor KIR
            family; shares 40% amino acid identity with primate KIR family
            members
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AY152727.1 and AY530782.1.
            
            On Jul 17, 2015 this sequence version replaced NM_177749.3.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer protein (isoform 1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY530782.1, AY130461.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-27                AY152727.1         1-27
            28-1555             AY530782.1         1-1528
FEATURES             Location/Qualifiers
     source          1..1555
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 58.77 cM"
     gene            1..1555
                     /gene="Kir3dl1"
                     /gene_synonym="Kirl1; Kirl2; Krl1"
                     /note="killer cell immunoglobulin-like receptor, three
                     domains, long cytoplasmic tail, 1"
                     /db_xref="GeneID:245616"
                     /db_xref="MGI:MGI:2652397"
     exon            1..66
                     /gene="Kir3dl1"
                     /gene_synonym="Kirl1; Kirl2; Krl1"
                     /inference="alignment:Splign:2.1.0"
     CDS             33..1262
                     /gene="Kir3dl1"
                     /gene_synonym="Kirl1; Kirl2; Krl1"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; killer cell immunoglobulin-like receptor
                     Kir3dl1; killer cell immunoglobulin-like receptor 3DL1;
                     killer immunoglobulin receptor-like protein 1; KIR-like
                     receptor 1"
                     /codon_start=1
                     /product="killer cell immunoglobulin-like receptor 3DL1
                     isoform 1 precursor"
                     /protein_id="NP_808417.2"
                     /db_xref="CCDS:CCDS41134.1"
                     /db_xref="GeneID:245616"
                     /db_xref="MGI:MGI:2652397"
                     /translation="MLLWFLSLVCSGFFLVQRMSAHLGSHDKPFLSAWPSYVVPLGQN
                     VTLTCDSHRGSNIFKLYKEEGSPNHQLHETTFQKSQVFGPVTTEHAGTYRCFHPQYAN
                     VLSAHSEPLKIIISGIYMKPFLLILQSPLVDTGGNVTLECHSENMFDTYILISHRMGI
                     IKNSVQVSAEHHESGSHVSYSIGPMTPDLVGTYTCYGANSYYPYEWSDSSDPIDIKIT
                     GIYKKPSLSALMGPVLMMSGETMTLSCISDHQFDTFHMSREGVPRGQGMPAVQSHSGK
                     FEAKFLLSPMIQKGNYRCYGSFRNASHVWSSPSDPLYLPAKGNCPAYTEADTKTNNYK
                     NLHILTGLLVTMVLVVIIIFYSCYFSKQNKSQKQAAASMEQEYEVKNTINTQDFERQE
                     GQGLHTQNLSRESSTKT"
     exon            67..102
                     /gene="Kir3dl1"
                     /gene_synonym="Kirl1; Kirl2; Krl1"
                     /inference="alignment:Splign:2.1.0"
     exon            103..381
                     /gene="Kir3dl1"
                     /gene_synonym="Kirl1; Kirl2; Krl1"
                     /inference="alignment:Splign:2.1.0"
     exon            382..687
                     /gene="Kir3dl1"
                     /gene_synonym="Kirl1; Kirl2; Krl1"
                     /inference="alignment:Splign:2.1.0"
     exon            688..984
                     /gene="Kir3dl1"
                     /gene_synonym="Kirl1; Kirl2; Krl1"
                     /inference="alignment:Splign:2.1.0"
     exon            985..1023
                     /gene="Kir3dl1"
                     /gene_synonym="Kirl1; Kirl2; Krl1"
                     /inference="alignment:Splign:2.1.0"
     exon            1024..1140
                     /gene="Kir3dl1"
                     /gene_synonym="Kirl1; Kirl2; Krl1"
                     /inference="alignment:Splign:2.1.0"
     exon            1141..1190
                     /gene="Kir3dl1"
                     /gene_synonym="Kirl1; Kirl2; Krl1"
                     /inference="alignment:Splign:2.1.0"
     exon            1191..1555
                     /gene="Kir3dl1"
                     /gene_synonym="Kirl1; Kirl2; Krl1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agactttgtt ctggctctgc tccttgccag ccatgctgct ctggttcctc agcctcgtgt
       61 gttctggttt cttcctagtc cagaggatgt cagcacactt gggaagccat gataaaccat
      121 tcctatctgc ctggccaagt tatgttgttc ctctgggaca gaatgtgact cttacatgtg
      181 actctcatag aggatctaac atattcaagc tgtacaaaga agaagggtct ccaaaccatc
      241 agttacatga gactacattt cagaagagcc aggtctttgg tcctgtgaca acagaacatg
      301 caggaaccta cagatgcttc catcctcaat atgctaatgt attgtcagca catagtgagc
      361 ctctgaaaat cataatttca ggaatctaca tgaagccttt cctcttgatt ctacaaagtc
      421 ccctggtgga tacaggaggg aatgtgaccc tggaatgtca ctcagagaat atgttcgata
      481 catacatttt gatttcacac agaatgggaa taatcaagaa ctctgtccaa gtttctgcag
      541 aacatcatga aagtgggtca catgtcagct actcaatagg tcccatgaca cctgaccttg
      601 ttgggactta cacatgctat ggtgctaaca gttactaccc ctatgaatgg tcagactcca
      661 gtgaccccat tgacatcaag atcacaggta tatacaagaa accttctctg tcagccctga
      721 tgggccctgt gctgatgatg tcaggagaga ccatgaccct gtcttgcatc tctgaccatc
      781 agtttgacac gttccatatg tccagggaag gggtgcctcg gggacagggg atgcctgcag
      841 tgcagagcca cagtggtaaa ttcgaggcaa aattccttct tagtccaatg atccaaaaag
      901 ggaactatag atgctatggc tctttcagga acgcttccca tgtgtggtcc tccccaagtg
      961 accccttgta ccttcctgcc aaaggaaact gtcctgcata cacagaagca gataccaaaa
     1021 caaataacta caagaacctg cacattctaa ctgggctctt agtaaccatg gtccttgtcg
     1081 tcatcatcat cttttactct tgttacttct ccaaacagaa taagtctcag aaacaagcag
     1141 cagccagcat ggaacaagag tatgaagtta aaaacacaat aaacacacag gactttgaaa
     1201 gacaagaagg acaggggtta catacacaga acttgagcag agaatcttca accaaaactt
     1261 gatgcctccc atttcccgaa tttctgagtt ttctgcagat accattgtgt acatggaaat
     1321 tatgaaatga taaactgaga tcaaagaatg tctgcaccct ctgagttctc aaagaaagat
     1381 ctaaggaagt cttttgtgga aaacagagcc ttttcatcaa caaaggctgt ttgatgcagt
     1441 gaaataacag ctggaatatg aaggcataag ttttaaattt ggggttatcc ttaattgttc
     1501 caatactgtt cttaatgtag tttactaata cataaaaaga ctatggtcct cactg
//
