LOCUS       NM_025280               1379 bp    mRNA    linear   ROD 17-DEC-2022
DEFINITION  Mus musculus Kin17 DNA and RNA binding protein (Kin), mRNA.
ACCESSION   NM_025280
VERSION     NM_025280.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1379)
  AUTHORS   Le MX, Haddad D, Ling AK, Li C, So CC, Chopra A, Hu R, Angulo JF,
            Moffat J and Martin A.
  TITLE     Kin17 facilitates multiple double-strand break repair pathways that
            govern B cell class switching
  JOURNAL   Sci Rep 6, 37215 (2016)
   PUBMED   27853268
  REMARK    GeneRIF: This report demonstrates the importance of Kin17 as a
            critical factor that acts prior to the repair phase of DSB repair
            and is of bona fide importance for CSR.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1379)
  AUTHORS   Wang Q, Chow J, Hong J, Smith AF, Moreno C, Seaby P, Vrana P, Miri
            K, Tak J, Chung ED, Mastromonaco G, Caniggia I and Varmuza S.
  TITLE     Recent acquisition of imprinting at the rodent Sfmbt2 locus
            correlates with insertion of a large block of miRNAs
  JOURNAL   BMC Genomics 12, 204 (2011)
   PUBMED   21510876
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1379)
  AUTHORS   O'Leary J and Osborne LR.
  TITLE     Global analysis of gene expression in the developing brain of
            Gtf2ird1 knockout mice
  JOURNAL   PLoS One 6 (8), e23868 (2011)
   PUBMED   21909369
REFERENCE   4  (bases 1 to 1379)
  AUTHORS   Yokoyama S, Ito Y, Ueno-Kudoh H, Shimizu H, Uchibe K, Albini S,
            Mitsuoka K, Miyaki S, Kiso M, Nagai A, Hikata T, Osada T, Fukuda N,
            Yamashita S, Harada D, Mezzano V, Kasai M, Puri PL, Hayashizaki Y,
            Okado H, Hashimoto M and Asahara H.
  TITLE     A systems approach reveals that the myogenesis genome network is
            regulated by the transcriptional repressor RP58
  JOURNAL   Dev Cell 17 (6), 836-848 (2009)
   PUBMED   20059953
REFERENCE   5  (bases 1 to 1379)
  AUTHORS   Pinon-Lataillade G, Masson C, Bernardino-Sgherri J, Henriot V,
            Mauffrey P, Frobert Y, Araneda S and Angulo JF.
  TITLE     KIN17 encodes an RNA-binding protein and is expressed during mouse
            spermatogenesis
  JOURNAL   J Cell Sci 117 (Pt 16), 3691-3702 (2004)
   PUBMED   15252136
  REMARK    GeneRIF: identification of KIN17 as a component of the human
            spliceosome indicate that this protein may participate in RNA
            processing
REFERENCE   6  (bases 1 to 1379)
  AUTHORS   Aizawa H, Sekine Y, Takemura R, Zhang Z, Nangaku M and Hirokawa N.
  TITLE     Kinesin family in murine central nervous system
  JOURNAL   J Cell Biol 119 (5), 1287-1296 (1992)
   PUBMED   1447303
REFERENCE   7  (bases 1 to 1379)
  AUTHORS   Traber PG, Wu GD and Wang W.
  TITLE     Novel DNA-binding proteins regulate intestine-specific
            transcription of the sucrase-isomaltase gene
  JOURNAL   Mol Cell Biol 12 (8), 3614-3627 (1992)
   PUBMED   1378530
REFERENCE   8  (bases 1 to 1379)
  AUTHORS   Angulo JF, Rouer E, Mazin A, Mattei MG, Tissier A, Horellou P,
            Benarous R and Devoret R.
  TITLE     Identification and expression of the cDNA of KIN17, a zinc-finger
            gene located on mouse chromosome 2, encoding a new DNA-binding
            protein
  JOURNAL   Nucleic Acids Res 19 (19), 5117-5123 (1991)
   PUBMED   1923796
REFERENCE   9  (bases 1 to 1379)
  AUTHORS   Angulo JF, Rouer E, Benarous R and Devoret R.
  TITLE     Identification of a mouse cDNA fragment whose expressed polypeptide
            reacts with anti-recA antibodies
  JOURNAL   Biochimie 73 (2-3), 251-256 (1991)
   PUBMED   1715759
REFERENCE   10 (bases 1 to 1379)
  AUTHORS   Witkin,E.M.
  TITLE     Ultraviolet mutagenesis and inducible DNA repair in Escherichia
            coli
  JOURNAL   Bacteriol Rev 40 (4), 869-907 (1976)
   PUBMED   795416
  REMARK    Review article
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL772367.7.
            
            [WARNING] On Apr 28, 2023 this sequence was replaced by
            NM_025280.3.
            
            On Nov 17, 2006 this sequence version replaced NM_025280.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC028860.1, X58472.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-133               AL772367.7         151252-151384       c
            134-228             AL772367.7         146172-146266       c
            229-272             AL772367.7         141840-141883       c
            273-395             AL772367.7         141633-141755       c
            396-1379            AL772367.7         139295-140278       c
FEATURES             Location/Qualifiers
     source          1..1379
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2"
     gene            1..1379
                     /gene="Kin"
                     /gene_synonym="Kin17"
                     /note="Kin17 DNA and RNA binding protein"
                     /db_xref="GeneID:16588"
                     /db_xref="MGI:MGI:96676"
     exon            1..133
                     /gene="Kin"
                     /gene_synonym="Kin17"
                     /inference="alignment:Splign:2.1.0"
     CDS             20..1195
                     /gene="Kin"
                     /gene_synonym="Kin17"
                     /note="KIN, antigenic determinant of recA protein homolog;
                     binding to curved DNA; antigenic determinant of rec-A
                     protein"
                     /codon_start=1
                     /product="DNA/RNA-binding protein KIN17"
                     /protein_id="NP_079556.1"
                     /db_xref="CCDS:CCDS15676.1"
                     /db_xref="GeneID:16588"
                     /db_xref="MGI:MGI:96676"
                     /translation="MGKSDFLSPKAIANRIKSKGLQKLRWYCQMCQKQCRDENGFKCH
                     CMSESHQRQLLLASENPQQFMDYFSEEFRNDFLELLRRRFGTKRVHNNIVYNEYISHR
                     EHIHMNATQWETLTDFTKWLGREGLCKVDETPKGWYIQYIDRDPETIRRQLELEKKKK
                     QDLDDEEKTAKFIEEQVRRGLEGKEQETPVFTELSRENEEEKVTFNLNKGAGGSAGAT
                     TSKSSSLGPSALKLLGSAASGKRKESSQSSAQPAKKKKSALDEIMELEEEKKRTARTD
                     AWLQPGIVVKIITKKLGEKYHKKKGVVKEVIDRYTAVVKMTDSGDRLKLDQTHLETVI
                     PAPGKRVLVLNGGYRGNEGTLESINEKAFSATIVIETGPLKGRRVEGIQYEDISKLA"
     exon            134..228
                     /gene="Kin"
                     /gene_synonym="Kin17"
                     /inference="alignment:Splign:2.1.0"
     exon            229..272
                     /gene="Kin"
                     /gene_synonym="Kin17"
                     /inference="alignment:Splign:2.1.0"
     exon            273..395
                     /gene="Kin"
                     /gene_synonym="Kin17"
                     /inference="alignment:Splign:2.1.0"
     exon            396..1379
                     /gene="Kin"
                     /gene_synonym="Kin17"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tgtagcgctc agggtcgcca tgggcaagtc ggattttctg agccccaagg ccatcgccaa
       61 tagaattaag tccaaagggc tccagaagct tcgctggtac tgccagatgt gccaaaagca
      121 atgccgcgac gagaatggct ttaagtgtca ctgtatgtct gaatctcatc aaagacaact
      181 gttgctggct tcagaaaacc ctcagcagtt tatggattat ttttcagagg aattccgaaa
      241 tgactttctg gaacttctga ggcgacgctt tggcactaaa agggtccaca acaacattgt
      301 ctacaatgaa tacatcagcc accgagagca catccacatg aacgctaccc agtgggagac
      361 actgaccgac tttaccaagt ggctgggcag agagggcttg tgtaaagtgg atgagacacc
      421 gaaaggctgg tacattcagt acatagacag agacccagaa accatccgtc ggcaactgga
      481 attagaaaaa aagaagaagc aagatctgga cgatgaagaa aaaactgcca agttcattga
      541 ggagcaggtg agaagaggcc tggaagggaa agagcaggag acacctgttt ttacagaact
      601 tagccgagaa aatgaggaag aaaaagttac gttcaatctg aataaaggag cgggtggctc
      661 agcgggagct acaacatcca agtcaagctc tttgggacca agtgcactga agctgctggg
      721 gagcgcagca tccgggaaac ggaaagagtc ttcacagagc tccgcccagc ctgcgaagaa
      781 gaagaagtcg gccctggatg agatcatgga gctcgaagag gaaaagaaaa ggaccgcacg
      841 gacagacgcc tggttacagc cggggatcgt tgtgaaaatt ataacgaaga agcttgggga
      901 gaaatatcac aagaagaaag gggtcgttaa ggaagtgatt gacaggtaca cagctgtggt
      961 aaagatgact gactctggag acaggctgaa actggaccag actcatttag agacagtcat
     1021 tccggccccg gggaaaaggg ttctagtttt aaatggaggc tacagaggaa atgaaggcac
     1081 tctcgaatcc atcaatgaga aggctttttc agccacgata gtcattgaaa ctggaccttt
     1141 gaaaggacgc agagttgaag gtattcaata tgaagacata tctaaacttg cttgagtttg
     1201 aaaatttgat aacaacacat tgaaactgtg aagcatcaaa ttggtgttag ccaaggcact
     1261 gtgtaactct actgtgttag gggatttgtt ttgtattaaa aaaaaaaaaa tcatctattt
     1321 aaatactagt gaatagttgg gtaaatttat aataaaatct atgttttttt taagtgtca
//
