LOCUS       NM_053173               2627 bp    mRNA    linear   ROD 04-AUG-2023
DEFINITION  Mus musculus kinesin family member C5B (Kifc5b), mRNA.
ACCESSION   NM_053173 XM_001005165
VERSION     NM_053173.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2627)
  AUTHORS   Li X, Li L, Li J, Sipple J, Schick J, Mehta PA, Davies SM, Dasgupta
            B, Waclaw RR and Pang Q.
  TITLE     Concomitant inactivation of foxo3a and fancc or fancd2 reveals a
            two-tier protection from oxidative stress-induced hydrocephalus
  JOURNAL   Antioxid Redox Signal 21 (12), 1675-1692 (2014)
   PUBMED   24483844
REFERENCE   2  (bases 1 to 2627)
  AUTHORS   Rousseaux MW, Marcogliese PC, Qu D, Hewitt SJ, Seang S, Kim RH,
            Slack RS, Schlossmacher MG, Lagace DC, Mak TW and Park DS.
  TITLE     Progressive dopaminergic cell loss with unilateral-to-bilateral
            progression in a genetic model of Parkinson disease
  JOURNAL   Proc Natl Acad Sci U S A 109 (39), 15918-15923 (2012)
   PUBMED   23019375
  REMARK    Erratum:[Proc Natl Acad Sci U S A. 2013 Jul 2;110(27):11212]
REFERENCE   3  (bases 1 to 2627)
  AUTHORS   Nath S, Bananis E, Sarkar S, Stockert RJ, Sperry AO, Murray JW and
            Wolkoff AW.
  TITLE     Kif5B and Kifc1 interact and are required for motility and fission
            of early endocytic vesicles in mouse liver
  JOURNAL   Mol Biol Cell 18 (5), 1839-1849 (2007)
   PUBMED   17360972
REFERENCE   4  (bases 1 to 2627)
  AUTHORS   Christodoulou A, Lederer CW, Surrey T, Vernos I and Santama N.
  TITLE     Motor protein KIFC5A interacts with Nubp1 and Nubp2, and is
            implicated in the regulation of centrosome duplication
  JOURNAL   J Cell Sci 119 (Pt 10), 2035-2047 (2006)
   PUBMED   16638812
  REMARK    GeneRIF: KIFC5A and the Nubp proteins in a common regulatory
            pathway involved in the control of centrosome duplication in
            mammalian cells.
REFERENCE   5  (bases 1 to 2627)
  AUTHORS   Abe K, Yuzuriha M, Sugimoto M, Ko MS, Brathwaite M, Waeltz P and
            Nagaraja R.
  TITLE     Gene content of the 750-kb critical region for mouse embryonic
            ectoderm lethal tcl-w5
  JOURNAL   Mamm Genome 15 (4), 265-276 (2004)
   PUBMED   15112104
REFERENCE   6  (bases 1 to 2627)
  AUTHORS   Miki H, Setou M, Kaneshiro K and Hirokawa N.
  TITLE     All kinesin superfamily protein, KIF, genes in mouse and human
  JOURNAL   Proc Natl Acad Sci U S A 98 (13), 7004-7011 (2001)
   PUBMED   11416179
  REMARK    Review article
REFERENCE   7  (bases 1 to 2627)
  AUTHORS   Hwang SY, Oh B, Knowles BB, Solter D and Lee JS.
  TITLE     Expression of genes involved in mammalian meiosis during the
            transition from egg to embryo
  JOURNAL   Mol Reprod Dev 59 (2), 144-158 (2001)
   PUBMED   11389549
REFERENCE   8  (bases 1 to 2627)
  AUTHORS   Navolanic PM and Sperry AO.
  TITLE     Identification of isoforms of a mitotic motor in mammalian
            spermatogenesis
  JOURNAL   Biol Reprod 62 (5), 1360-1369 (2000)
   PUBMED   10775188
REFERENCE   9  (bases 1 to 2627)
  AUTHORS   Yang Z, Hanlon DW, Marszalek JR and Goldstein LS.
  TITLE     Identification, partial characterization, and genetic mapping of
            kinesin-like protein genes in mouse
  JOURNAL   Genomics 45 (1), 123-131 (1997)
   PUBMED   9339368
REFERENCE   10 (bases 1 to 2627)
  AUTHORS   Saito N, Okada Y, Noda Y, Kinoshita Y, Kondo S and Hirokawa N.
  TITLE     KIFC2 is a novel neuron-specific C-terminal type kinesin
            superfamily motor for dendritic transport of multivesicular
            body-like organelles
  JOURNAL   Neuron 18 (3), 425-438 (1997)
   PUBMED   9115736
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB638629.1, BI733451.1, AF221103.1, AC144621.3, AK081484.1 and
            AI604818.1.
            
            On Oct 25, 2006 this sequence version replaced NM_053173.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN00849374,
                              SAMN00849376 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-430               BB638629.1         2-431
            431-625             BI733451.1         235-429
            626-879             AF221103.1         440-693
            880-930             AC144621.3         153803-153853
            931-1329            AC144621.3         154560-154958
            1330-2329           AK081484.1         1-1000
            2330-2627           AI604818.1         7-304               c
FEATURES             Location/Qualifiers
     source          1..2627
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 13.6 cM"
     gene            1..2627
                     /gene="Kifc5b"
                     /gene_synonym="Hset; Kifc5a; KNSL2"
                     /note="kinesin family member C5B"
                     /db_xref="GeneID:16580"
                     /db_xref="MGI:MGI:2137414"
     exon            1..195
                     /gene="Kifc5b"
                     /gene_synonym="Hset; Kifc5a; KNSL2"
                     /inference="alignment:Splign:2.1.0"
     CDS             178..2196
                     /gene="Kifc5b"
                     /gene_synonym="Hset; Kifc5a; KNSL2"
                     /note="kinesin family member C5A; kinesin-related protein
                     KIFC5A; kinesin family c-terminal 5A; kinesin family
                     c-terminal 5B"
                     /codon_start=1
                     /product="kinesin family member C5B"
                     /protein_id="NP_444403.2"
                     /db_xref="CCDS:CCDS37517.1"
                     /db_xref="GeneID:16580"
                     /db_xref="MGI:MGI:2137414"
                     /translation="MDVQAQRKGREGKRNVELKAALVKSSSRLPLSASSLKRGPDQME
                     DALEPAKKRTRVMGAVTKVDTSRPRGPLLSTVSQTQGHNAAQKGPKKTGPGGCSAVGT
                     VLRSQKPAPAAPAKPGTSTAPVVVGKRAGKRPAWDLKGQLCDLNEELKRYREKTETLE
                     LENRGLREQLREVQEQATTLGTERNTLEGELASVRSRAEQDQQRLETLSARVLELEEC
                     LGTRERLLQELQGERLQLQEERSTLSTQLEEQERRFQATEAALSSSQEEVVCLRQKTE
                     AQVTLLAEQGDRLYGLEMERRRLHNQLQELKGNIRVFCRVRPVLEGESTPSPGFLVFP
                     PGPAGPSDRPTGLSLSRSDDRRSTLTGAPAPTVRHDFSFDRVFPPGSKQEEVFEEIAM
                     LVQSALDGYPVCIFAYGQTGSGKTFTMEGGPRGDPQLAGLIPRAMRHLFSVAQEMSGQ
                     GWTYSFVASYVEIYNETVRDLLATGPRKGQGGECEIRRASPGSEELTVTNARYVPVSC
                     EKEVEALLHLAHQNRAVAHTAQNKRSSRSHSVFQLQISGEHAARGLQCGAPLNLVDLA
                     GSERLDPGLPLGPGERDRLRETQAINSSLSTLGLVIMALSNKESHVPYRNSKLTYLLQ
                     NSLGGSAKMLMFVNISPLEENVSESLNSLRFASKVNQCVIGTAQANKK"
     exon            196..330
                     /gene="Kifc5b"
                     /gene_synonym="Hset; Kifc5a; KNSL2"
                     /inference="alignment:Splign:2.1.0"
     exon            331..430
                     /gene="Kifc5b"
                     /gene_synonym="Hset; Kifc5a; KNSL2"
                     /inference="alignment:Splign:2.1.0"
     exon            431..484
                     /gene="Kifc5b"
                     /gene_synonym="Hset; Kifc5a; KNSL2"
                     /inference="alignment:Splign:2.1.0"
     exon            485..532
                     /gene="Kifc5b"
                     /gene_synonym="Hset; Kifc5a; KNSL2"
                     /inference="alignment:Splign:2.1.0"
     exon            533..930
                     /gene="Kifc5b"
                     /gene_synonym="Hset; Kifc5a; KNSL2"
                     /inference="alignment:Splign:2.1.0"
     exon            931..1710
                     /gene="Kifc5b"
                     /gene_synonym="Hset; Kifc5a; KNSL2"
                     /inference="alignment:Splign:2.1.0"
     exon            1711..2001
                     /gene="Kifc5b"
                     /gene_synonym="Hset; Kifc5a; KNSL2"
                     /inference="alignment:Splign:2.1.0"
     exon            2002..2075
                     /gene="Kifc5b"
                     /gene_synonym="Hset; Kifc5a; KNSL2"
                     /inference="alignment:Splign:2.1.0"
     exon            2076..2151
                     /gene="Kifc5b"
                     /gene_synonym="Hset; Kifc5a; KNSL2"
                     /inference="alignment:Splign:2.1.0"
     exon            2152..2627
                     /gene="Kifc5b"
                     /gene_synonym="Hset; Kifc5a; KNSL2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2311..2316
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Kifc5b"
                     /gene_synonym="Hset; Kifc5a; KNSL2"
                     /note="putative"
ORIGIN      
        1 gaagtgcgtt gactgcgcgg aggttgaaat tcaaaagtga ctggtgtggc ggattggctt
       61 ggccgattgg cctggcgaat tggcctggct ccgacgtttt gcggcgcgag cccttgagag
      121 gacgcgggtc tcgtcaccct gcctgctgcc tttgcatccc ttcctgtgcg gaccaccatg
      181 gacgtgcagg cgcagagaaa gggaagggaa gggaagagga acgtagaact gaaggcggcc
      241 ctggtcaagt cctcctcccg actgcccctg tcagcaagca gcctcaagag gggtcctgac
      301 cagatggagg atgccttgga gcctgcaaag aaacggacac gagtcatggg tgcagtgacc
      361 aaagttgaca catcccgtcc cagaggacca ctcctcagca cagtgtcaca gacccagggc
      421 cacaatgcag ctcagaaagg ccctaagaag acaggacctg gtgggtgctc tgctgttggt
      481 acagtgctga ggagccagaa gccagctccc gctgctcctg cgaagcctgg cacatccact
      541 gctcctgtgg tggtagggaa gagagctggc aaacgccctg cctgggacct gaagggccag
      601 ttgtgtgacc tcaatgaaga gttgaaacgc tatcgggaga agactgaaac gctggaactg
      661 gagaaccggg gtcttcggga gcaactcaga gaggtccagg agcaggccac gaccctgggg
      721 acagagcgga acaccctgga aggggagctg gccagtgtac gcagccgagc tgagcaggac
      781 cagcagaggc tggagacgct gagtgcccgt gtcttggagc tggaggaatg tctgggtacc
      841 agggaaaggc tgcttcagga gcttcaggga gagcggctgc aattgcagga ggagcggagc
      901 acactgagca cccaactgga ggagcaggag aggaggtttc aggccacaga agcagctctg
      961 tcaagcagcc aagaagaggt ggtgtgtctt cggcagaaga ctgaagccca ggtgacctta
     1021 ctggctgagc aaggagaccg gctctatggg ttagagatgg agcggcggcg actccacaac
     1081 cagctgcagg aactgaaggg caatatccgg gtgttctgcc gcgtgcgccc tgtcctcgaa
     1141 ggggaatcca ctccatctcc tggcttcctc gtgtttcctc ctggccctgc tggaccctct
     1201 gatcgcccga cgggccttag cctctcacga tctgatgatc ggcgctccac cctgactggg
     1261 gccccggcac ccactgtccg ccatgatttc tcctttgatc gggtgttccc gccgggaagc
     1321 aagcaggagg aagtgtttga ggagatcgcc atgcttgtcc agtcagcact agatggctac
     1381 cctgtgtgca tttttgccta tggacagaca ggcagtggca agaccttcac tatggaagga
     1441 gggcctaggg gagaccccca attggcaggg ctgatccctc gggccatgcg gcatctgttc
     1501 tctgtggccc aggagatgag cggccagggc tggacataca gttttgtggc gagttacgta
     1561 gagatctaca atgagaccgt tcgagacctg ctagctactg ggccccgcaa gggacaaggg
     1621 ggcgagtgcg agatccgtcg ggcaagccca gggagtgagg agcttactgt caccaatgcc
     1681 cgctatgtcc ctgtttcctg tgagaaagag gtggaggccc tgctccattt ggctcaccag
     1741 aaccgggctg tggcccacac tgcccagaat aagagatcat cacgcagtca tagtgtgttc
     1801 cagctgcaga tttctggaga gcatgcagcc cggggcctgc agtgtggcgc tcccctcaac
     1861 cttgtggacc tagctgggag tgagcggcta gaccctggct tacccctagg ccctggggag
     1921 cgtgatcgtc ttcgggagac acaggccatt aacagcagtc tgtctacatt gggactggtc
     1981 ataatggccc tgagcaataa ggagtcccac gtgccttacc gaaacagcaa gctcacctac
     2041 ttgctgcaga actctctggg tggcagtgcc aagatgctta tgtttgtgaa tatttctcct
     2101 ctggaagaga atgtctccga gtctctgaat tcactacgct ttgcttccaa ggtgaaccag
     2161 tgtgtcattg gtactgctca ggctaataag aagtgaagtc ggatccagag cccttgcaag
     2221 ccagtgcgca tgcgtctctg ttttagtgtg tatttattcg gtgggggtgg gtgggagttg
     2281 agacatgata ttactgggta tttattatgt aataaagaat aatcttttgt atgttaatcc
     2341 ttttcttaat cttagatttt aaaaaattgt gtgcagttgt tttgcctgag tgtatatgca
     2401 tgcaccatgt gcatgtctcc tgctccagtg agttcagaac agggcttcag gtccttcaag
     2461 aactgggatt atggaataca tgtgggtcct ctgcaaaatc agtcagtgct cttaaccgcc
     2521 cagccatctt cccagcccgg cccttgttac agctctaaac ggttttatta acttaacggt
     2581 tttagctgcc aaaggaaggt attgtaaata aatactgtaa gcacgta
//
