LOCUS       NM_001372314            3608 bp    mRNA    linear   ROD 15-OCT-2024
DEFINITION  Mus musculus kinesin family member C3 (Kifc3), transcript variant
            6, mRNA.
ACCESSION   NM_001372314 XM_030243307
VERSION     NM_001372314.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3608)
  AUTHORS   Ma,Y., Zhang,Y., Jiang,X., Guan,J., Wang,H., Zhang,J., Tong,Y.,
            Qiu,X. and Zhou,R.
  TITLE     KIFC3 promotes the proliferation, migration and invasion of
            non-small cell lung cancer through the PI3K/AKT signaling pathway
  JOURNAL   Sci Rep 14 (1), 20471 (2024)
   PUBMED   39227687
  REMARK    GeneRIF: KIFC3 promotes the proliferation, migration and invasion
            of non-small cell lung cancer through the PI3K/AKT signaling
            pathway.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3608)
  AUTHORS   Ju,J.Q., Zhang,H.L., Wang,Y., Hu,L.L. and Sun,S.C.
  TITLE     Kinesin KIFC3 is essential for microtubule stability and
            cytokinesis in oocyte meiosis
  JOURNAL   Cell Commun Signal 22 (1), 199 (2024)
   PUBMED   38553728
  REMARK    GeneRIF: Kinesin KIFC3 is essential for microtubule stability and
            cytokinesis in oocyte meiosis.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3608)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (bases 1 to 3608)
  AUTHORS   Goo,B.S., Mun,D.J., Kim,S., Nhung,T.T.M., Lee,S.B., Woo,Y.,
            Kim,S.J., Suh,B.K., Park,S.J., Lee,H.E., Park,K., Jang,H.,
            Rah,J.C., Yoon,K.J., Baek,S.T., Park,S.Y. and Park,S.K.
  TITLE     Schizophrenia-associated Mitotic Arrest Deficient-1 (MAD1)
            regulates the polarity of migrating neurons in the developing
            neocortex
  JOURNAL   Mol Psychiatry 28 (2), 856-870 (2023)
   PUBMED   36357673
REFERENCE   5  (bases 1 to 3608)
  AUTHORS   Bejarano,E., Murray,J.W., Wang,X., Pampliega,O., Yin,D., Patel,B.,
            Yuste,A., Wolkoff,A.W. and Cuervo,A.M.
  TITLE     Defective recruitment of motor proteins to autophagic compartments
            contributes to autophagic failure in aging
  JOURNAL   Aging Cell 17 (4), e12777 (2018)
   PUBMED   29845728
  REMARK    GeneRIF: The study connects defects in intracellular trafficking
            with insufficient autophagy in old organisms and identifies Kifc3
            as a novel target for future interventions aiming at correcting
            autophagic activity with anti-aging purposes.
REFERENCE   6  (bases 1 to 3608)
  AUTHORS   Yang,Z., Xia,Ch., Roberts,E.A., Bush,K., Nigam,S.K. and
            Goldstein,L.S.
  TITLE     Molecular cloning and functional analysis of mouse C-terminal
            kinesin motor KifC3
  JOURNAL   Mol Cell Biol 21 (3), 765-770 (2001)
   PUBMED   11154264
REFERENCE   7  (bases 1 to 3608)
  AUTHORS   Araki,K., Imaizumi,T., Sekimoto,T., Yoshinobu,K., Yoshimuta,J.,
            Akizuki,M., Miura,K., Araki,M. and Yamamura,K.
  TITLE     Exchangeable gene trap using the Cre/mutated lox system
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 45 (5), 737-750 (1999)
   PUBMED   10512203
REFERENCE   8  (bases 1 to 3608)
  AUTHORS   Sakaguchi,A.Y., Padalecki,S.S., Mattern,V., Rodriguez,A.,
            Leach,R.J., McGill,J.R., Chavez,M. and Giambernardi,T.A.
  TITLE     Chromosomal sublocalization of the transcribed human telomere
            repeat binding factor 2 gene and comparative mapping in the mouse
  JOURNAL   Somat Cell Mol Genet 24 (3), 157-163 (1998)
   PUBMED   10226653
REFERENCE   9  (bases 1 to 3608)
  AUTHORS   Yang,Z., Hanlon,D.W., Marszalek,J.R. and Goldstein,L.S.
  TITLE     Identification, partial characterization, and genetic mapping of
            kinesin-like protein genes in mouse
  JOURNAL   Genomics 45 (1), 123-131 (1997)
   PUBMED   9339368
REFERENCE   10 (bases 1 to 3608)
  AUTHORS   Nakagawa,T., Tanaka,Y., Matsuoka,E., Kondo,S., Okada,Y., Noda,Y.,
            Kanai,Y. and Hirokawa,N.
  TITLE     Identification and classification of 16 new kinesin superfamily
            (KIF) proteins in mouse genome
  JOURNAL   Proc Natl Acad Sci U S A 94 (18), 9654-9659 (1997)
   PUBMED   9275178
  REMARK    Erratum:[Proc Natl Acad Sci U S A 1999 Mar 30;96(7):4214]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC103935.10.
            
            On Aug 29, 2019 this sequence version replaced XM_030243307.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7974084.12866.1,
                                           SRR17784643.1555201.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-126               AC103935.10        172834-172959       c
            127-331             AC103935.10        168317-168521       c
            332-474             AC103935.10        165119-165261       c
            475-613             AC103935.10        159598-159736       c
            614-795             AC103935.10        156928-157109       c
            796-861             AC103935.10        141096-141161       c
            862-1005            AC103935.10        140532-140675       c
            1006-1245           AC103935.10        140186-140425       c
            1246-1419           AC103935.10        139584-139757       c
            1420-1567           AC103935.10        138977-139124       c
            1568-1698           AC103935.10        138757-138887       c
            1699-1810           AC103935.10        137826-137937       c
            1811-1992           AC103935.10        136865-137046       c
            1993-2097           AC103935.10        136122-136226       c
            2098-2228           AC103935.10        134297-134427       c
            2229-2352           AC103935.10        133813-133936       c
            2353-2482           AC103935.10        133065-133194       c
            2483-2712           AC103935.10        132749-132978       c
            2713-2847           AC103935.10        132414-132548       c
            2848-2956           AC103935.10        131811-131919       c
            2957-2983           AC103935.10        131049-131075       c
            2984-3608           AC103935.10        130230-130854       c
FEATURES             Location/Qualifiers
     source          1..3608
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 47.12 cM"
     gene            1..3608
                     /gene="Kifc3"
                     /note="kinesin family member C3"
                     /db_xref="GeneID:16582"
                     /db_xref="MGI:MGI:109202"
     exon            1..126
                     /gene="Kifc3"
                     /inference="alignment:Splign:2.1.0"
     exon            127..331
                     /gene="Kifc3"
                     /inference="alignment:Splign:2.1.0"
     CDS             166..2961
                     /gene="Kifc3"
                     /note="isoform f is encoded by transcript variant 6;
                     kinesin-like protein KIFC3"
                     /codon_start=1
                     /product="kinesin-like protein KIFC3 isoform f"
                     /protein_id="NP_001359243.1"
                     /db_xref="GeneID:16582"
                     /db_xref="MGI:MGI:109202"
                     /translation="MVPSRRTWNLGATPSLRGLWRVGRVQEPKPGMARPAPASPAARP
                     FPHTGQGRLRTGRGKDILPSGEEDSTSRTAARPSLAQCRALSVDWPGPRSPHRLYLTV
                     QQALRDKGCESKSQGTKEDELPKRQAPAPRRDREAPEAGGTMNVENTGGRLFGIGRCS
                     SLSGAPGPDPVVHRTVEAMSQLQEELVVLRERLALHDSDRQATTTQLQNQVENLKEKL
                     ISQAQEVSRLRSELGGTDAEKHRDRLMVENEQLRQELRRCEVELQELRAQPVVPCEGC
                     EHSQESSQLRDKLSQLQLEVAENKGMLSELNLEVQQKTDRLAEVELRLKDCLAEKAQE
                     EERLSRRLRDSHETIASLRAQSPPVKYVIKTVEVESSKTKQALSESQTRNQHLQEQVA
                     MQRQVLKEMEQQLQNSHQLTVQLRAQIAMYEAELERAHGQMLEEMQSLEEDKNRAIEE
                     AFARAQVEMKAVHENLAGVRTNLLTLQPALRTLTNDYNGLKRQVRGFPLLLQEALRSV
                     KAEIGQAIEEVNSNNQELLRKYRRELQLRKKCHNELVRLKGNIRVIARVRPVTKEDGE
                     GPEATNAVTFDPDDDSIIHLLHKGKPVSFELDKVFSPWASQQDVFQEVQALITSCIDG
                     FNVCIFAYGQTGAGKTYTMEGTPENPGINQRALQLLFSEVQEKASDWQYNITVSAAEI
                     YNEVLRDLLGKEPQEKLEIRLCPDGSGQLYVPGLTEFQVQSVDDINKVFEFGYNNRTT
                     EFTNLNEHSSRSHALLIVTVRGVDCSTGLRTTGKLNLVDLAGSERVGKSGAEGNRLRE
                     AQHINRSLSALGDVIAALRSRQGHVPFRNSKLTYLLQDSLSGDSKTLMVVQVSPVEKN
                     TSETLYSLRFAERVRSVELGPGSRRTELGSWSSQEHLEWEPACQTPQPTARAHSAPGS
                     GTSSRPGSIRRKLQPSA"
     exon            332..474
                     /gene="Kifc3"
                     /inference="alignment:Splign:2.1.0"
     exon            475..613
                     /gene="Kifc3"
                     /inference="alignment:Splign:2.1.0"
     exon            614..795
                     /gene="Kifc3"
                     /inference="alignment:Splign:2.1.0"
     exon            796..861
                     /gene="Kifc3"
                     /inference="alignment:Splign:2.1.0"
     exon            862..1005
                     /gene="Kifc3"
                     /inference="alignment:Splign:2.1.0"
     exon            1006..1245
                     /gene="Kifc3"
                     /inference="alignment:Splign:2.1.0"
     exon            1246..1419
                     /gene="Kifc3"
                     /inference="alignment:Splign:2.1.0"
     exon            1420..1567
                     /gene="Kifc3"
                     /inference="alignment:Splign:2.1.0"
     exon            1568..1698
                     /gene="Kifc3"
                     /inference="alignment:Splign:2.1.0"
     exon            1699..1810
                     /gene="Kifc3"
                     /inference="alignment:Splign:2.1.0"
     exon            1811..1992
                     /gene="Kifc3"
                     /inference="alignment:Splign:2.1.0"
     exon            1993..2097
                     /gene="Kifc3"
                     /inference="alignment:Splign:2.1.0"
     exon            2098..2228
                     /gene="Kifc3"
                     /inference="alignment:Splign:2.1.0"
     exon            2229..2352
                     /gene="Kifc3"
                     /inference="alignment:Splign:2.1.0"
     exon            2353..2482
                     /gene="Kifc3"
                     /inference="alignment:Splign:2.1.0"
     exon            2483..2712
                     /gene="Kifc3"
                     /inference="alignment:Splign:2.1.0"
     exon            2713..2847
                     /gene="Kifc3"
                     /inference="alignment:Splign:2.1.0"
     exon            2848..2956
                     /gene="Kifc3"
                     /inference="alignment:Splign:2.1.0"
     exon            2957..2983
                     /gene="Kifc3"
                     /inference="alignment:Splign:2.1.0"
     exon            2984..3608
                     /gene="Kifc3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3583..3588
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Kifc3"
                     /note="hexamer: ATTAAA"
     regulatory      3588..3593
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Kifc3"
                     /note="hexamer: AATGAA"
     polyA_site      3603
                     /gene="Kifc3"
                     /note="major polyA site"
     polyA_site      3608
                     /gene="Kifc3"
                     /note="major polyA site"
ORIGIN      
        1 gggccaagga ggcagcggcg gcggcgtgga gctgcctcgc gcgggcgggc gggccggagc
       61 cggccggagc gggccgagcc cggggcgctg cggtggcggc gctgggatcc tgtctccgct
      121 aggccgcttg cccggcaccc agaagaggtt actgagcccc gggccatggt cccctctcgc
      181 aggacgtgga acttgggagc cacgccttca ctgcgaggcc tgtggagagt gggccgggtc
      241 caggagccca agcccgggat ggctcgcccc gccccagcca gcccagccgc ccgccctttc
      301 ccacacaccg gccaggggag gttgagaact gggcgtggaa aagatattct acccagtggc
      361 gaggaagact ccacttctcg gactgcagct cgcccgtctc ttgcacagtg tcgagccctc
      421 agcgtggact ggcctggccc taggagtccc catagactct acctgacagt gcagcaggcc
      481 ctgcgggaca aggggtgcga gagcaagagt caggggacga aagaagacga gctcccgaag
      541 aggcaggcgc cggcccccag gcgggaccgg gaggccccag aagctggtgg taccatgaat
      601 gtagaaaata caggtgggcg gctctttggc atcgggaggt gctcaagcct gtccggggca
      661 ccaggcccag accccgtggt acataggacc gtggaggcca tgtcccagct tcaggaggag
      721 ctggtagtcc ttcgggagag gctggccctc cacgacagtg accggcaagc cacaaccacc
      781 cagctgcaga accaggtgga gaatctaaag gaaaagctca ttagccaggc ccaggaagtg
      841 agccgactgc gatcagaact gggaggcacg gacgcggaga agcacaggga cagactgatg
      901 gtggagaatg agcagctgag gcaggagctg aggcgctgtg aggtcgaact gcaggagctt
      961 cgggcccagc cggtggtgcc ctgcgagggc tgtgagcaca gccaggagag cagccagctc
     1021 cgtgacaagc tgtcccagct gcagttggaa gtggctgaga acaaaggcat gctgtcggaa
     1081 ctgaacctgg aggtgcagca gaaaacggac cggctggcag aggtagagct gcgcctcaag
     1141 gactgtctgg ctgagaaagc ccaggaggag gaacggctca gccggcgcct gcgtgacagc
     1201 catgagacta tcgccagtct gagggcccag tccccacctg ttaagtatgt catcaagaca
     1261 gtggaggtag agtcttccaa gaccaagcag gccctcagcg agtcccagac ccggaaccag
     1321 cacctgcagg agcaagtggc catgcagcgg caggtgctga aggagatgga gcagcagcta
     1381 cagaactccc accagctgac agtccagttg cgggctcaga ttgccatgta tgaggcagag
     1441 ctggagcggg cacacgggca gatgctggag gagatgcagt ccttggagga ggataagaac
     1501 cgggccattg aggaggcctt tgcacgggcc caggtggaga tgaaggcagt acacgagaac
     1561 ctggcaggtg tcaggaccaa cctgctgacg ctgcagcctg cgctgaggac cctcaccaac
     1621 gactacaatg ggctcaagcg gcaggtgcgg ggcttcccct tgctgctgca ggaggctctc
     1681 aggagtgtca aagctgagat cggccaggcc atcgaggagg ttaatagcaa caaccaggag
     1741 ctgttgcgca agtaccgccg ggaactacag ctgcgcaaga aatgccataa cgagctggtc
     1801 cggctgaagg gaaacatccg ggtgattgcc cgagtccggc cagtcaccaa ggaggatgga
     1861 gaaggacccg aggcaaccaa tgctgtgacc tttgaccctg atgatgactc catcatccac
     1921 ctgctgcaca agggcaagcc cgtgtccttc gagctggaca aggtcttctc cccgtgggct
     1981 tcccagcagg acgtgttcca ggaggtgcag gccctcatta cctcctgcat cgatggcttc
     2041 aatgtctgta tctttgctta cggccagaca ggtgccggca agacatatac aatggagggg
     2101 actcccgaga acccgggcat caaccagcgg gccctgcagc tgctcttctc ggaggtgcag
     2161 gagaaggcgt ctgactggca gtacaacatc accgtcagcg cagctgagat ttacaatgaa
     2221 gtcctcaggg acctgctggg gaaagagcct caggagaagc tggagatccg actgtgcccg
     2281 gatggcagtg ggcaactgta tgtgccaggg ctgactgagt tccaggtgca gagcgtggat
     2341 gacatcaaca aggtgtttga gtttggctac aacaaccgca ccaccgagtt caccaacctg
     2401 aacgaacaca gctcccgctc ccacgctctg ctcatcgtga cagtgagagg tgtggattgc
     2461 agcacaggcc tccgcaccac ggggaagctg aacctggtgg acctggctgg ttcagagcgt
     2521 gtgggcaagt cgggggctga gggcaaccgc ctgcgagagg cacagcacat caacaggtca
     2581 ctatccgccc tgggggacgt cattgctgcc ctgcgttctc gacaaggcca tgtgcccttc
     2641 cgcaattcca aactcaccta cctgctgcag gactcactca gtggtgacag caagaccctt
     2701 atggtggtac aggtgtcccc agtggagaag aacaccagcg agactctgta ctccctcaga
     2761 tttgctgaga gggttcgctc tgtggagttg ggccctgggt cccgccgcac agagctgggt
     2821 tcctggtcaa gccaggagca cctggagtgg gagccggctt gccagacacc acagcctaca
     2881 gcacgagccc actctgcccc tggctctggg accagtagcc gcccaggttc catccgaagg
     2941 aaactgcagc cgtcagcctg acagctgggg ctgcagtctc cagggaagtt gaggccagtg
     3001 cctgtgtgaa gatgtgccac gctgccaggc cctgtggcct ggcgacctgc tgtaacaccc
     3061 acctaccatg aatgcaggag atggaggctc tcccgccctg cctctcctca gagatgagaa
     3121 acatgttcag aaggaagcga gtctctgtgt ggctctgggc acccaagcat ggggcttctg
     3181 gaagggcagg gatggcactc tgcctggtgg taggcttggg agtctagccg ttgctgggag
     3241 ggtgggctct ctccccacct ggcccttggg ctggactgtt ctctactagt tgagaagact
     3301 tgaggaacca gctggggggt tagggagagc aagagcatct ctatctaccc tcctgaggag
     3361 gggagccctc acagggcatg tatataatgt tctaggtgta tatagaagtc ctcaccctgt
     3421 cagaggtctg ggctatattt atggctggca gaggccagtg tggaagggct gggttctgtt
     3481 catctgcctg acaccaggca ctctccctgc ccactgattc tcaacatgtt cctctcccca
     3541 aatcctattt aagaactttt ggaagcttag ccatttttac ttattaaaat gaatgtcttt
     3601 ttacacaa
//
