LOCUS       NM_001195298            2330 bp    mRNA    linear   ROD 02-JUL-2024
DEFINITION  Mus musculus kinesin family member C1 (Kifc1), transcript variant
            1, mRNA.
ACCESSION   NM_001195298 XM_001479207
VERSION     NM_001195298.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2330)
  AUTHORS   Becker,I.C., Wilkie,A.R., Nikols,E., Carminita,E., Roweth,H.G.,
            Tilburg,J., Sciaudone,A.R., Noetzli,L.J., Fatima,F., Couldwell,G.,
            Ray,A., Mogilner,A., Machlus,K.R. and Italiano,J.E. Jr.
  TITLE     Cell cycle-dependent centrosome clustering precedes proplatelet
            formation
  JOURNAL   Sci Adv 10 (25), eadl6153 (2024)
   PUBMED   38896608
REFERENCE   2  (bases 1 to 2330)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 2330)
  AUTHORS   Wei,Y.L., Fan,X.J., Diao,Y.Y., She,Z.Y. and Wang,X.R.
  TITLE     Kinesin-14 KIFC1 modulates spindle assembly and chromosome
            segregation in mouse spermatocytes
  JOURNAL   Exp Cell Res 414 (1), 113095 (2022)
   PUBMED   35259401
  REMARK    GeneRIF: Kinesin-14 KIFC1 modulates spindle assembly and chromosome
            segregation in mouse spermatocytes.
REFERENCE   4  (bases 1 to 2330)
  AUTHORS   Shan,M.M., Zou,Y.J., Pan,Z.N., Zhang,H.L., Xu,Y., Ju,J.Q. and
            Sun,S.C.
  TITLE     Kinesin motor KIFC1 is required for tubulin acetylation and
            actin-dependent spindle migration in mouse oocyte meiosis
  JOURNAL   Development 149 (5) (2022)
   PUBMED   35142352
  REMARK    GeneRIF: Kinesin motor KIFC1 is required for tubulin acetylation
            and actin-dependent spindle migration in mouse oocyte meiosis.
REFERENCE   5  (bases 1 to 2330)
  AUTHORS   Venuto,S., Monteonofrio,L., Cozzolino,F., Monti,M., Appolloni,I.,
            Mazza,T., Canetti,D., Giambra,V., Panelli,P., Fusco,C., Squeo,G.M.,
            Croce,A.I., Pucci,P., Malatesta,P., Soddu,S., Merla,G. and
            Micale,L.
  TITLE     TRIM8 interacts with KIF11 and KIFC1 and controls bipolar spindle
            formation and chromosomal stability
  JOURNAL   Cancer Lett 473, 98-106 (2020)
   PUBMED   31904480
  REMARK    GeneRIF: TRIM8 interacts with KIF11 and KIFC1 and controls bipolar
            spindle formation and chromosomal stability.
REFERENCE   6  (bases 1 to 2330)
  AUTHORS   Yang,Z., Hanlon,D.W., Marszalek,J.R. and Goldstein,L.S.
  TITLE     Identification, partial characterization, and genetic mapping of
            kinesin-like protein genes in mouse
  JOURNAL   Genomics 45 (1), 123-131 (1997)
   PUBMED   9339368
REFERENCE   7  (bases 1 to 2330)
  AUTHORS   Saito,N., Okada,Y., Noda,Y., Kinoshita,Y., Kondo,S. and Hirokawa,N.
  TITLE     KIFC2 is a novel neuron-specific C-terminal type kinesin
            superfamily motor for dendritic transport of multivesicular
            body-like organelles
  JOURNAL   Neuron 18 (3), 425-438 (1997)
   PUBMED   9115736
REFERENCE   8  (bases 1 to 2330)
  AUTHORS   Himmelbauer,H., Artzt,K., Barlow,D., Fischer-Lindahl,K., Lyon,M.,
            Klein,J. and Silver,L.M.
  TITLE     Encyclopedia of the mouse genome III. October 1993. Mouse
            chromosome 17
  JOURNAL   Mamm Genome 4 Spec No, S230-S252 (1993)
   PUBMED   8268678
REFERENCE   9  (bases 1 to 2330)
  AUTHORS   Yeom,Y.I., Abe,K., Bennett,D. and Artzt,K.
  TITLE     Testis-/embryo-expressed genes are clustered in the mouse H-2K
            region
  JOURNAL   Proc Natl Acad Sci U S A 89 (2), 773-777 (1992)
   PUBMED   1731353
REFERENCE   10 (bases 1 to 2330)
  AUTHORS   Ha,H., Howard,C.A., Yeom,Y.I., Abe,K., Uehara,H., Artzt,K. and
            Bennett,D.
  TITLE     Several testis-expressed genes in the mouse t-complex have
            expression differences between wild-type and t-mutant mice
  JOURNAL   Dev Genet 12 (4), 318-332 (1991)
   PUBMED   1718647
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK133900.1, CX209658.1, CX205646.1, AI322653.1 and AI326799.1.
            
            On Sep 2, 2010 this sequence version replaced XM_001479207.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC057162.1, AK133900.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-523               AK133900.1         2-524
            524-553             CX209658.1         485-514
            554-774             AK133900.1         556-776
            775-811             CX205646.1         225-261
            812-1557            AK133900.1         816-1561
            1558-1565           AI322653.1         104-111
            1566-1855           AK133900.1         1571-1860
            1856-1863           AI322653.1         402-409
            1864-2320           AK133900.1         1870-2326
            2321-2330           AI326799.1         1-10                c
FEATURES             Location/Qualifiers
     source          1..2330
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 17.98 cM"
     gene            1..2330
                     /gene="Kifc1"
                     /gene_synonym="100042970; Gm4137; HSET; Kifc5a; KNSL2;
                     Knsl2a; Tctex-7; Tctex-7A; Tctex7; Tctex7a"
                     /note="kinesin family member C1"
                     /db_xref="GeneID:100502766"
                     /db_xref="MGI:MGI:109596"
     exon            1..156
                     /gene="Kifc1"
                     /gene_synonym="100042970; Gm4137; HSET; Kifc5a; KNSL2;
                     Knsl2a; Tctex-7; Tctex-7A; Tctex7; Tctex7a"
                     /inference="alignment:Splign:2.1.0"
     CDS             139..2163
                     /gene="Kifc1"
                     /gene_synonym="100042970; Gm4137; HSET; Kifc5a; KNSL2;
                     Knsl2a; Tctex-7; Tctex-7A; Tctex7; Tctex7a"
                     /note="isoform 1 is encoded by transcript variant 1;
                     kinesin motor protein KIFC4; kinesin-related protein
                     KIFC5A; kinesin family c-terminal 5A; kinesin-like 2a;
                     kinesin-like protein KIFC1"
                     /codon_start=1
                     /product="kinesin-like protein KIFC1 isoform 1"
                     /protein_id="NP_001182227.1"
                     /db_xref="CCDS:CCDS57065.1"
                     /db_xref="GeneID:100502766"
                     /db_xref="MGI:MGI:109596"
                     /translation="MDVQAQRPPLLEVKRNVELKAALVKSSSRVPLSASRLKRGPDQM
                     EDALEPAKKRTRVMGAVTKVDTSRPRGPLLSTVSQTQGHTAAQKGPKKTGPRGCSAIG
                     TVLRSQKPVPAAPAQKPGTSTAPVVVGKRAGKRPAWDLKGQLCDLNEELKRYREKTQT
                     LELENRGLREQLREVQEQATTLGTERNTLEGELASVRSRAEQDQQRLETLSARVLELE
                     ECLGTRERLLQELQGERLQLQEERSTLSTQLEEQERRFQATEAALSSSQEEVVCLRQK
                     TEAQVTLLAEQGDRLYGLEMERRRLHNQLQELKGNIRVFCRVRPVLEGESTPSPGFLV
                     FPPGPAGPSDPPTGLSLSRSDDRRSTLTGAPAPTVRHDFSFDRVFPPGSKQEEVFEEI
                     AMLVQSALDGYPVCIFAYGQTGSGKTFTMEGGPRGDPQLEGLIPRAMRHLFSVAQEMS
                     GQGWTYSFVASYVEIYNETVRDLLATGPRKGQGGECEIRRASPGSEELTVTNARYVPV
                     SCEKEVEALLHLAHQNRAVAHTAQNKRSSRSHSVFQLQISGEHAARGLQCGAPLNLVD
                     LAGSERLDPGLHLGPGERDRLRETQAINSSLSTLGLVIMALSNKESHVPYRNSKLTYL
                     LQNSLGGSAKMLMFVNISPLEENVSESLNSLRFASKVNQCVIGTAQANKK"
     exon            157..294
                     /gene="Kifc1"
                     /gene_synonym="100042970; Gm4137; HSET; Kifc5a; KNSL2;
                     Knsl2a; Tctex-7; Tctex-7A; Tctex7; Tctex7a"
                     /inference="alignment:Splign:2.1.0"
     exon            295..394
                     /gene="Kifc1"
                     /gene_synonym="100042970; Gm4137; HSET; Kifc5a; KNSL2;
                     Knsl2a; Tctex-7; Tctex-7A; Tctex7; Tctex7a"
                     /inference="alignment:Splign:2.1.0"
     exon            395..448
                     /gene="Kifc1"
                     /gene_synonym="100042970; Gm4137; HSET; Kifc5a; KNSL2;
                     Knsl2a; Tctex-7; Tctex-7A; Tctex7; Tctex7a"
                     /inference="alignment:Splign:2.1.0"
     exon            449..499
                     /gene="Kifc1"
                     /gene_synonym="100042970; Gm4137; HSET; Kifc5a; KNSL2;
                     Knsl2a; Tctex-7; Tctex-7A; Tctex7; Tctex7a"
                     /inference="alignment:Splign:2.1.0"
     exon            500..897
                     /gene="Kifc1"
                     /gene_synonym="100042970; Gm4137; HSET; Kifc5a; KNSL2;
                     Knsl2a; Tctex-7; Tctex-7A; Tctex7; Tctex7a"
                     /inference="alignment:Splign:2.1.0"
     exon            898..1677
                     /gene="Kifc1"
                     /gene_synonym="100042970; Gm4137; HSET; Kifc5a; KNSL2;
                     Knsl2a; Tctex-7; Tctex-7A; Tctex7; Tctex7a"
                     /inference="alignment:Splign:2.1.0"
     exon            1678..1968
                     /gene="Kifc1"
                     /gene_synonym="100042970; Gm4137; HSET; Kifc5a; KNSL2;
                     Knsl2a; Tctex-7; Tctex-7A; Tctex7; Tctex7a"
                     /inference="alignment:Splign:2.1.0"
     exon            1969..2042
                     /gene="Kifc1"
                     /gene_synonym="100042970; Gm4137; HSET; Kifc5a; KNSL2;
                     Knsl2a; Tctex-7; Tctex-7A; Tctex7; Tctex7a"
                     /inference="alignment:Splign:2.1.0"
     exon            2043..2118
                     /gene="Kifc1"
                     /gene_synonym="100042970; Gm4137; HSET; Kifc5a; KNSL2;
                     Knsl2a; Tctex-7; Tctex-7A; Tctex7; Tctex7a"
                     /inference="alignment:Splign:2.1.0"
     exon            2119..2322
                     /gene="Kifc1"
                     /gene_synonym="100042970; Gm4137; HSET; Kifc5a; KNSL2;
                     Knsl2a; Tctex-7; Tctex-7A; Tctex7; Tctex7a"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2306..2311
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Kifc1"
                     /gene_synonym="100042970; Gm4137; HSET; Kifc5a; KNSL2;
                     Knsl2a; Tctex-7; Tctex-7A; Tctex7; Tctex7a"
                     /note="hexamer: AATAAT"
     polyA_site      2322
                     /gene="Kifc1"
                     /gene_synonym="100042970; Gm4137; HSET; Kifc5a; KNSL2;
                     Knsl2a; Tctex-7; Tctex-7A; Tctex7; Tctex7a"
                     /note="major polyA site"
ORIGIN      
        1 attcaaaagt ggcgggtgtg gctgattggc ctggctcctg gacagcctgg cttcggcgtt
       61 ttgcggcgcg agcccttgag aggacgcggg tctcatcgtc ctgcctgctg cctttgcacc
      121 ctttctgtgc ggaccaccat ggacgtgcag gcgcagaggc cacctttgtt ggaagtgaag
      181 aggaacgtag aactgaaggc agccctggtg aagtcctcct cccgagtgcc cctgtcagca
      241 agcaggctca agaggggtcc tgaccagatg gaggatgcct tggagcctgc aaagaaacgg
      301 acacgagtca tgggtgcagt gaccaaagtt gacacatccc gtcccagagg accactcctc
      361 agcacagtgt cacagaccca gggccacact gcagctcaga aaggccctaa gaagacagga
      421 cctcgtgggt gctctgctat tggtacagtg ctgaggagcc agaagccagt tcccgctgct
      481 cctgcccaga agcctggcac atccactgct cctgtggtgg tagggaagag agctggcaaa
      541 cgccctgcct gggacctgaa gggccagttg tgtgacctca atgaagagtt gaaacgctat
      601 cgggagaaga ctcaaacgct ggaactggag aaccggggtc ttcgggagca actcagagag
      661 gtccaggagc aggccacgac cctggggaca gagcggaaca ccctggaagg ggagctggcc
      721 agtgtacgca gccgagctga gcaggaccag cagaggctgg agacgctgag tgcccgtgtc
      781 ttggagctgg aggaatgtct gggtaccagg gaaaggctgc ttcaggagct tcagggagag
      841 cggctgcaat tgcaggagga gcggagcaca ctgagcaccc agctggagga gcaggagagg
      901 aggtttcagg ccacagaagc agctctgtca agcagccaag aagaggtggt gtgtcttcgg
      961 cagaagactg aagcccaggt gaccttactg gctgagcaag gagaccggct ctatgggtta
     1021 gagatggagc ggcgacgact ccacaaccag ctgcaggaac tgaagggcaa tatccgggtg
     1081 ttctgccgcg tgcgccctgt cctcgaaggg gaatccactc catctcctgg cttcctcgtg
     1141 tttcctcctg gccctgctgg accctctgat cccccgacgg gccttagcct ctcacgatct
     1201 gatgatcggc gctccaccct gactggggcc ccggccccca ctgtccgcca tgatttctcc
     1261 tttgatcggg tgttcccgcc gggaagcaag caggaggaag tgtttgagga gatcgccatg
     1321 cttgtccagt cagcactgga tggctaccct gtgtgcattt ttgcctatgg acagacaggc
     1381 agtggcaaga ccttcactat ggaaggaggg cctaggggag acccccaatt ggaagggctg
     1441 atccctcggg ccatgcggca tctgttctct gtggcccagg agatgagcgg ccagggctgg
     1501 acatacagtt ttgtggcgag ttacgtagag atctacaatg agaccgttcg agacctgcta
     1561 gctactgggc cccgcaaggg acaagggggc gagtgtgaga tccgtcgggc aagcccagga
     1621 agtgaggagc ttactgtcac caatgcccgc tatgtccctg tttcctgtga gaaagaggtg
     1681 gaggccctgc tccatttggc tcatcagaac cgggctgtgg cccacactgc ccaaaataag
     1741 agatcatcac gcagtcatag tgtgttccag ctgcagattt ctggagagca tgcagctcgg
     1801 ggcctgcagt gtggcgctcc gctcaacctt gtggacctag ctgggagtga gcggctagac
     1861 cctggcttac acctaggccc tggggagcgt gatcgtcttc gggagacaca ggccattaac
     1921 agcagtctgt ctacactggg actggtcata atggccctga gcaataagga gtcccacgtg
     1981 ccttaccgaa acagcaagct cacctacttg ctgcagaact ctctgggtgg cagtgccaag
     2041 atgcttatgt ttgtgaatat ttctcctctg gaagagaatg tctccgagtc tctgaattca
     2101 ctacgctttg cttccaaggt gaaccagtgt gtcattggta ctgctcaggc taataagaag
     2161 tgaagtcgga tccagagcct gattcccttg caagccagtg cgcatgcgtc tctgttttag
     2221 tgtgtattcg gtgggggtgg gtgggagttg agacatgatt ttattgggtg aacaatattt
     2281 attatgtaat caactataaa taaagaataa tctgttggtt aaaaaaaaaa
//
