LOCUS       NP_001182227             674 aa            linear   ROD 28-APR-2025
DEFINITION  kinesin-like protein KIFC1 isoform 1 [Mus musculus].
ACCESSION   NP_001182227 XP_001479257
VERSION     NP_001182227.1
DBSOURCE    REFSEQ: accession NM_001195298.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 674)
  AUTHORS   Becker,I.C., Wilkie,A.R., Nikols,E., Carminita,E., Roweth,H.G.,
            Tilburg,J., Sciaudone,A.R., Noetzli,L.J., Fatima,F., Couldwell,G.,
            Ray,A., Mogilner,A., Machlus,K.R. and Italiano,J.E. Jr.
  TITLE     Cell cycle-dependent centrosome clustering precedes proplatelet
            formation
  JOURNAL   Sci Adv 10 (25), eadl6153 (2024)
   PUBMED   38896608
REFERENCE   2  (residues 1 to 674)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (residues 1 to 674)
  AUTHORS   Wei,Y.L., Fan,X.J., Diao,Y.Y., She,Z.Y. and Wang,X.R.
  TITLE     Kinesin-14 KIFC1 modulates spindle assembly and chromosome
            segregation in mouse spermatocytes
  JOURNAL   Exp Cell Res 414 (1), 113095 (2022)
   PUBMED   35259401
  REMARK    GeneRIF: Kinesin-14 KIFC1 modulates spindle assembly and chromosome
            segregation in mouse spermatocytes.
REFERENCE   4  (residues 1 to 674)
  AUTHORS   Shan,M.M., Zou,Y.J., Pan,Z.N., Zhang,H.L., Xu,Y., Ju,J.Q. and
            Sun,S.C.
  TITLE     Kinesin motor KIFC1 is required for tubulin acetylation and
            actin-dependent spindle migration in mouse oocyte meiosis
  JOURNAL   Development 149 (5) (2022)
   PUBMED   35142352
  REMARK    GeneRIF: Kinesin motor KIFC1 is required for tubulin acetylation
            and actin-dependent spindle migration in mouse oocyte meiosis.
REFERENCE   5  (residues 1 to 674)
  AUTHORS   Venuto,S., Monteonofrio,L., Cozzolino,F., Monti,M., Appolloni,I.,
            Mazza,T., Canetti,D., Giambra,V., Panelli,P., Fusco,C., Squeo,G.M.,
            Croce,A.I., Pucci,P., Malatesta,P., Soddu,S., Merla,G. and
            Micale,L.
  TITLE     TRIM8 interacts with KIF11 and KIFC1 and controls bipolar spindle
            formation and chromosomal stability
  JOURNAL   Cancer Lett 473, 98-106 (2020)
   PUBMED   31904480
  REMARK    GeneRIF: TRIM8 interacts with KIF11 and KIFC1 and controls bipolar
            spindle formation and chromosomal stability.
REFERENCE   6  (residues 1 to 674)
  AUTHORS   Yang,Z., Hanlon,D.W., Marszalek,J.R. and Goldstein,L.S.
  TITLE     Identification, partial characterization, and genetic mapping of
            kinesin-like protein genes in mouse
  JOURNAL   Genomics 45 (1), 123-131 (1997)
   PUBMED   9339368
REFERENCE   7  (residues 1 to 674)
  AUTHORS   Saito,N., Okada,Y., Noda,Y., Kinoshita,Y., Kondo,S. and Hirokawa,N.
  TITLE     KIFC2 is a novel neuron-specific C-terminal type kinesin
            superfamily motor for dendritic transport of multivesicular
            body-like organelles
  JOURNAL   Neuron 18 (3), 425-438 (1997)
   PUBMED   9115736
REFERENCE   8  (residues 1 to 674)
  AUTHORS   Himmelbauer,H., Artzt,K., Barlow,D., Fischer-Lindahl,K., Lyon,M.,
            Klein,J. and Silver,L.M.
  TITLE     Encyclopedia of the mouse genome III. October 1993. Mouse
            chromosome 17
  JOURNAL   Mamm Genome 4 Spec No, S230-S252 (1993)
   PUBMED   8268678
REFERENCE   9  (residues 1 to 674)
  AUTHORS   Yeom,Y.I., Abe,K., Bennett,D. and Artzt,K.
  TITLE     Testis-/embryo-expressed genes are clustered in the mouse H-2K
            region
  JOURNAL   Proc Natl Acad Sci U S A 89 (2), 773-777 (1992)
   PUBMED   1731353
REFERENCE   10 (residues 1 to 674)
  AUTHORS   Ha,H., Howard,C.A., Yeom,Y.I., Abe,K., Uehara,H., Artzt,K. and
            Bennett,D.
  TITLE     Several testis-expressed genes in the mouse t-complex have
            expression differences between wild-type and t-mutant mice
  JOURNAL   Dev Genet 12 (4), 318-332 (1991)
   PUBMED   1718647
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK133900.1, CX209658.1, CX205646.1, AI322653.1 and AI326799.1.
            
            On Sep 2, 2010 this sequence version replaced XP_001479257.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC057162.1, AK133900.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..674
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 17.98 cM"
     Protein         1..674
                     /product="kinesin-like protein KIFC1 isoform 1"
                     /note="kinesin motor protein KIFC4; kinesin-related
                     protein KIFC5A; kinesin family c-terminal 5A; kinesin-like
                     2a; kinesin-like protein KIFC1"
                     /calculated_mol_wt=74022
     Site            28
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9BW19; propagated from
                     UniProtKB/Swiss-Prot (Q9QWT9.2)"
     Site            33
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9BW19; propagated from
                     UniProtKB/Swiss-Prot (Q9QWT9.2)"
     Site            35
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9BW19; propagated from
                     UniProtKB/Swiss-Prot (Q9QWT9.2)"
     Region          66..96
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9QWT9.2)"
     Region          <146..308
                     /region_name="SMC_prok_B"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; TIGR02168"
                     /db_xref="CDD:274008"
     Region          309..666
                     /region_name="KISc_C_terminal"
                     /note="Kinesin motor domain, KIFC2/KIFC3/ncd-like
                     carboxy-terminal kinesins; cd01366"
                     /db_xref="CDD:276817"
     Site            order(319,411,414,416..419,566)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:276817"
     Region          327..366
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9QWT9.2)"
     Site            360
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:Q9BW19; propagated from
                     UniProtKB/Swiss-Prot (Q9QWT9.2)"
     Site            order(617,620,623)
                     /site_type="other"
                     /note="microtubule interaction site [polypeptide binding]"
                     /db_xref="CDD:276817"
     CDS             1..674
                     /gene="Kifc1"
                     /gene_synonym="100042970; Gm4137; HSET; Kifc5a; KNSL2;
                     Knsl2a; Tctex-7; Tctex-7A; Tctex7; Tctex7a"
                     /coded_by="NM_001195298.1:139..2163"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS57065.1"
                     /db_xref="GeneID:100502766"
                     /db_xref="MGI:MGI:109596"
ORIGIN      
        1 mdvqaqrppl levkrnvelk aalvksssrv plsasrlkrg pdqmedalep akkrtrvmga
       61 vtkvdtsrpr gpllstvsqt qghtaaqkgp kktgprgcsa igtvlrsqkp vpaapaqkpg
      121 tstapvvvgk ragkrpawdl kgqlcdlnee lkryrektqt lelenrglre qlrevqeqat
      181 tlgterntle gelasvrsra eqdqqrletl sarvleleec lgtrerllqe lqgerlqlqe
      241 erstlstqle eqerrfqate aalsssqeev vclrqkteaq vtllaeqgdr lyglemerrr
      301 lhnqlqelkg nirvfcrvrp vlegestpsp gflvfppgpa gpsdpptgls lsrsddrrst
      361 ltgapaptvr hdfsfdrvfp pgskqeevfe eiamlvqsal dgypvcifay gqtgsgktft
      421 meggprgdpq leglipramr hlfsvaqems gqgwtysfva syveiynetv rdllatgprk
      481 gqggeceirr aspgseeltv tnaryvpvsc ekeveallhl ahqnravaht aqnkrssrsh
      541 svfqlqisge haarglqcga plnlvdlags erldpglhlg pgerdrlret qainsslstl
      601 glvimalsnk eshvpyrnsk ltyllqnslg gsakmlmfvn ispleenvse slnslrfask
      661 vnqcvigtaq ankk
//
