LOCUS       NM_001305643            3961 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus kinesin-associated protein 3 (Kifap3), transcript
            variant 1, mRNA.
ACCESSION   NM_001305643 XM_006496680
VERSION     NM_001305643.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3961)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3961)
  AUTHORS   Wang,N., Langfelder,P., Stricos,M., Ramanathan,L., Richman,J.B.,
            Vaca,R., Plascencia,M., Gu,X., Zhang,S., Tamai,T.K., Zhang,L.,
            Gao,F., Ouk,K., Lu,X., Ivanov,L.V., Vogt,T.F., Lu,Q.R.,
            Morton,A.J., Colwell,C.S., Aaronson,J.S., Rosinski,J., Horvath,S.
            and Yang,X.W.
  TITLE     Mapping brain gene coexpression in daytime transcriptomes unveils
            diurnal molecular networks and deciphers perturbation gene
            signatures
  JOURNAL   Neuron 110 (20), 3318-3338 (2022)
   PUBMED   36265442
REFERENCE   3  (bases 1 to 3961)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3961)
  AUTHORS   Farini,D., Cesari,E., Weatheritt,R.J., La Sala,G., Naro,C.,
            Pagliarini,V., Bonvissuto,D., Medici,V., Guerra,M., Di Pietro,C.,
            Rizzo,F.R., Musella,A., Carola,V., Centonze,D., Blencowe,B.J.,
            Marazziti,D. and Sette,C.
  TITLE     A Dynamic Splicing Program Ensures Proper Synaptic Connections in
            the Developing Cerebellum
  JOURNAL   Cell Rep 31 (9), 107703 (2020)
   PUBMED   32492419
REFERENCE   5  (bases 1 to 3961)
  AUTHORS   Haraguchi,K., Hayashi,T., Jimbo,T., Yamamoto,T. and Akiyama,T.
  TITLE     Role of the kinesin-2 family protein, KIF3, during mitosis
  JOURNAL   J Biol Chem 281 (7), 4094-4099 (2006)
   PUBMED   16298999
  REMARK    GeneRIF: Interaction of KIF3A/3B with KAP3 may be important for the
            proper progression of mitosis.
REFERENCE   6  (bases 1 to 3961)
  AUTHORS   Teng,J., Rai,T., Tanaka,Y., Takei,Y., Nakata,T., Hirasawa,M.,
            Kulkarni,A.B. and Hirokawa,N.
  TITLE     The KIF3 motor transports N-cadherin and organizes the developing
            neuroepithelium
  JOURNAL   Nat Cell Biol 7 (5), 474-482 (2005)
   PUBMED   15834408
  REMARK    Erratum:[Nat Cell Biol. 2005 Jun;7(6):637]
REFERENCE   7  (bases 1 to 3961)
  AUTHORS   Baker,S.A., Freeman,K., Luby-Phelps,K., Pazour,G.J. and
            Besharse,J.C.
  TITLE     IFT20 links kinesin II with a mammalian intraflagellar transport
            complex that is conserved in motile flagella and sensory cilia
  JOURNAL   J Biol Chem 278 (36), 34211-34218 (2003)
   PUBMED   12821668
REFERENCE   8  (bases 1 to 3961)
  AUTHORS   Dupuis,L., de Tapia,M., Rene,F., Lutz-Bucher,B., Gordon,J.W.,
            Mercken,L., Pradier,L. and Loeffler,J.P.
  TITLE     Differential screening of mutated SOD1 transgenic mice reveals
            early up-regulation of a fast axonal transport component in spinal
            cord motor neurons
  JOURNAL   Neurobiol Dis 7 (4), 274-285 (2000)
   PUBMED   10964600
REFERENCE   9  (bases 1 to 3961)
  AUTHORS   Takakura,A., Miyoshi,J., Ishizaki,H., Tanaka,M., Togawa,A.,
            Nishizawa,Y., Yoshida,H., Nishikawa,Si. and Takai,Y.
  TITLE     Involvement of a small GTP-binding protein (G protein) regulator,
            small G protein GDP dissociation stimulator, in antiapoptotic cell
            survival signaling
  JOURNAL   Mol Biol Cell 11 (5), 1875-1886 (2000)
   PUBMED   10793158
REFERENCE   10 (bases 1 to 3961)
  AUTHORS   Yamazaki,H., Nakata,T., Okada,Y. and Hirokawa,N.
  TITLE     Cloning and characterization of KAP3: a novel kinesin
            superfamily-associated protein of KIF3A/3B
  JOURNAL   Proc Natl Acad Sci U S A 93 (16), 8443-8448 (1996)
   PUBMED   8710890
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK013954.1, BC040362.1,
            AK133957.1 and BU701040.1.
            
            On Mar 25, 2015 this sequence version replaced XM_006496680.1.
            
            Summary: The protein encoded by this gene is the non-motor subunit
            of kinesin-2 complex, and forms a heterotrimer with two members of
            the kinesin superfamily of proteins that together form a
            microtubule plus-end directed translocator that plays an important
            role in intracellular transport, mitosis, and cell-cell adhesion.
            This protein contains multiple armadillo repeats involved in
            protein binding, and may serve as an adaptor to regulate binding of
            cargo with the motor proteins. Conditional disruption of this gene
            in mouse neural precursor cells caused a tumor-like phenotype and
            defective organization of the neuroepithelium thought to be the
            result of altered N-cadherin subcellular localization. Alternative
            splicing results in multiple transcript variants encoding different
            isoforms. [provided by RefSeq, Mar 2015].
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (KAP3A, PMID:8710890).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC049100.1, D50366.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-208               AK013954.1         2-209
            209-806             BC040362.1         1-598
            807-3940            AK133957.1         538-3671
            3941-3961           BU701040.1         1-21                c
FEATURES             Location/Qualifiers
     source          1..3961
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 71.08 cM"
     gene            1..3961
                     /gene="Kifap3"
                     /gene_synonym="KAP-3; KAP3; SMAP"
                     /note="kinesin-associated protein 3"
                     /db_xref="GeneID:16579"
                     /db_xref="MGI:MGI:107566"
     exon            1..320
                     /gene="Kifap3"
                     /gene_synonym="KAP-3; KAP3; SMAP"
                     /inference="alignment:Splign:2.1.0"
     CDS             289..2670
                     /gene="Kifap3"
                     /gene_synonym="KAP-3; KAP3; SMAP"
                     /note="isoform KAP3A is encoded by transcript variant 1"
                     /codon_start=1
                     /product="kinesin-associated protein 3 isoform KAP3A"
                     /protein_id="NP_001292572.1"
                     /db_xref="CCDS:CCDS78729.1"
                     /db_xref="GeneID:16579"
                     /db_xref="MGI:MGI:107566"
                     /translation="MQGEDARYLKRKVKGGNIDVHPSEKALIVQYEVEATILGEMGDP
                     MLGERKECQKIIRLKSLNANTDITSLARKVVEECKLIHPSKLSEVEQLLYYLQNRRDS
                     LPGKEKKEKSSKPKDPPPFEGMEIDEVANINDMDEYIELLYEDIPDKVRGSALILQLA
                     RNPDNLEELLLNETALGALARVLREDWKQSVELATNIIYIFFCFSSFSHFHGLITHYK
                     IGALCMNIIDHELKRHELWQEELSKKKKAVDEDLENQTLRKDYDKTFKKYQGLVVKQE
                     QLLRVALYLLLNLAEDTRTELKMRNKNIVHMLVKALDRDNFELLILVVSFLKKLSIFM
                     ENKNDMVEMDIVEKLVKMIPCEHEDLLNITLRLLLNLSFDTGLRNKMVQVGLLPKLTA
                     LLGNENYKQIAMCVLYHISMDDRFKSMFAYTDCIPQLMKMLFECSDERIDLELISFCI
                     NLAANKRNVQLICEGNGLKMLMKRALKLKDPLLMKMIRNISQHDGPTKNLFIDYVGDL
                     AAQISSDEEEEFVIECLGTLANLTIPDLDWELVLKEYKLVPFLKDKLKPGAAEDDLVL
                     EVVIMIGTVSMDDSCAALLAKSGIIPALIELLNAQQEDDEFVCQIIYVFYQMVFHQAT
                     RDVIIKETQAPAYLIDLMHDKNNEIRKVCDNTLDIIAEYDEEWAKKIQSEKFRWHNSQ
                     WLEMVESRQLDESEQYLYGDDRIEPYIHEGDILERPDLFYNSDGLITSEGAISPDFFN
                     DFHLQNGDVVGQHAFPGSLGMDGFGQPLGILGRPATAYGFRPDEPYYYSFGSR"
     exon            321..452
                     /gene="Kifap3"
                     /gene_synonym="KAP-3; KAP3; SMAP"
                     /inference="alignment:Splign:2.1.0"
     exon            453..607
                     /gene="Kifap3"
                     /gene_synonym="KAP-3; KAP3; SMAP"
                     /inference="alignment:Splign:2.1.0"
     exon            608..663
                     /gene="Kifap3"
                     /gene_synonym="KAP-3; KAP3; SMAP"
                     /inference="alignment:Splign:2.1.0"
     exon            664..805
                     /gene="Kifap3"
                     /gene_synonym="KAP-3; KAP3; SMAP"
                     /inference="alignment:Splign:2.1.0"
     exon            806..905
                     /gene="Kifap3"
                     /gene_synonym="KAP-3; KAP3; SMAP"
                     /inference="alignment:Splign:2.1.0"
     exon            906..1030
                     /gene="Kifap3"
                     /gene_synonym="KAP-3; KAP3; SMAP"
                     /inference="alignment:Splign:2.1.0"
     exon            1031..1129
                     /gene="Kifap3"
                     /gene_synonym="KAP-3; KAP3; SMAP"
                     /inference="alignment:Splign:2.1.0"
     exon            1130..1308
                     /gene="Kifap3"
                     /gene_synonym="KAP-3; KAP3; SMAP"
                     /inference="alignment:Splign:2.1.0"
     exon            1309..1471
                     /gene="Kifap3"
                     /gene_synonym="KAP-3; KAP3; SMAP"
                     /inference="alignment:Splign:2.1.0"
     exon            1472..1572
                     /gene="Kifap3"
                     /gene_synonym="KAP-3; KAP3; SMAP"
                     /inference="alignment:Splign:2.1.0"
     exon            1573..1681
                     /gene="Kifap3"
                     /gene_synonym="KAP-3; KAP3; SMAP"
                     /inference="alignment:Splign:2.1.0"
     exon            1682..1794
                     /gene="Kifap3"
                     /gene_synonym="KAP-3; KAP3; SMAP"
                     /inference="alignment:Splign:2.1.0"
     exon            1795..1960
                     /gene="Kifap3"
                     /gene_synonym="KAP-3; KAP3; SMAP"
                     /inference="alignment:Splign:2.1.0"
     exon            1961..2086
                     /gene="Kifap3"
                     /gene_synonym="KAP-3; KAP3; SMAP"
                     /inference="alignment:Splign:2.1.0"
     exon            2087..2185
                     /gene="Kifap3"
                     /gene_synonym="KAP-3; KAP3; SMAP"
                     /inference="alignment:Splign:2.1.0"
     exon            2186..2271
                     /gene="Kifap3"
                     /gene_synonym="KAP-3; KAP3; SMAP"
                     /inference="alignment:Splign:2.1.0"
     exon            2272..2461
                     /gene="Kifap3"
                     /gene_synonym="KAP-3; KAP3; SMAP"
                     /inference="alignment:Splign:2.1.0"
     exon            2462..2561
                     /gene="Kifap3"
                     /gene_synonym="KAP-3; KAP3; SMAP"
                     /inference="alignment:Splign:2.1.0"
     exon            2562..3944
                     /gene="Kifap3"
                     /gene_synonym="KAP-3; KAP3; SMAP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3917..3922
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Kifap3"
                     /gene_synonym="KAP-3; KAP3; SMAP"
                     /note="hexamer: ATTAAA"
     polyA_site      3941
                     /gene="Kifap3"
                     /gene_synonym="KAP-3; KAP3; SMAP"
                     /note="major polyA site"
ORIGIN      
        1 gtgagcgcat gcgccttgcg gagagttcgg ccctgacggc tctgggcggg tctgggctgc
       61 tccagtgttt tggggcccag gagcagtggg aggagccggc gggttcaccg tggtaaccgc
      121 tgcgccgccg ccgccgccac cgccaccgcc accgccgccc cgccttgcag gccttgggac
      181 tgtcaccgct ctgctttgag ggtactttgg ccgggtctcc ggaagtagcc ctcccagatt
      241 ctcagacact cccattctcc ccacgccgct gccgccgccg ccgccgccat gcaaggcgag
      301 gacgccagat acctcaaaag gaaagttaaa ggggggaata ttgatgtaca tccatcagaa
      361 aaagctctca ttgttcagta tgaagtggaa gctaccattc ttggagaaat gggagatccc
      421 atgttgggag aacgaaagga atgccaaaaa atcatccgtc tgaagagtct caatgctaac
      481 acagacatca cctctctggc ccggaaggtg gttgaggaat gtaagctcat ccatccctca
      541 aagctaagcg aggtggagca gcttttgtac tatctacaga accgccgaga ctcattgccg
      601 ggaaaagaaa aaaaagaaaa atcaagcaag cctaaagacc cacctccttt tgaagggatg
      661 gagattgacg aagtggccaa cattaatgac atggacgaat acattgagct cttgtatgaa
      721 gacattccag ataaggttcg gggttctgcc ttgatcctac agcttgctcg aaatcctgat
      781 aacctggaag agctattatt aaatgaaact gccctgggtg cgctagcaag agtcctgaga
      841 gaagactgga aacaaagtgt tgagttagct acaaacatca tttatatctt cttttgcttt
      901 tctagctttt ctcattttca tggactcatc actcactaca aaattggagc actgtgtatg
      961 aatatcattg atcatgagtt aaaaagacac gagctttggc aagaagaact ctctaagaag
     1021 aagaaagctg ttgatgaaga ccttgaaaat caaacattga gaaaggatta tgacaaaacc
     1081 tttaaaaaat accaaggact tgtggtaaaa caagagcagc tactgagagt tgctctctac
     1141 ttgcttttga atcttgcgga ggacacacgt acagaactga agatgaggaa caagaatatc
     1201 gttcacatgt tggtgaaggc tcttgatcgg gacaattttg agctgctgat tctggtcgtg
     1261 tcattcttaa agaaactgag tatttttatg gagaataaaa atgacatggt agagatggat
     1321 attgttgaaa aactggtaaa aatgataccc tgtgagcatg aagatctcct gaatatcacc
     1381 ctccggctcc tcttaaacct ctcgtttgac acaggcctga ggaacaagat ggtacaagtt
     1441 gggcttctcc caaagctcac tgcactcctg ggcaatgaaa actacaaaca aatagcaatg
     1501 tgtgtgcttt accatataag catggatgac cgctttaagt caatgtttgc atatactgac
     1561 tgcataccac agttaatgaa gatgctcttt gaatgttcag atgaacgaat tgacttggag
     1621 ctgatttctt tctgcattaa tcttgctgct aacaagagaa atgtccagct catctgtgaa
     1681 ggaaatgggc tgaaaatgct catgaaaaga gctctgaagc tcaaggaccc actgctgatg
     1741 aagatgatca gaaacatctc ccagcatgat gggcccacta agaatttgtt cattgattat
     1801 gttggggacc ttgcagccca gatttccagt gatgaagagg aggagtttgt aatcgagtgt
     1861 ttgggaacgc tggcaaatct gacaatccca gatctagact gggaactggt cctgaaggag
     1921 tacaagctgg ttccattcct caaagacaaa ctaaagccag gtgccgcaga ggatgacctt
     1981 gttttagaag tggttatcat gattgggacg gtgtctatgg atgactcttg tgctgcccta
     2041 ctggccaaat ctgggataat cccagccctc atcgagctgc tgaacgctca acaagaagat
     2101 gatgaatttg tgtgtcaaat aatctatgtc ttctaccaga tggtgttcca tcaggccaca
     2161 agagatgtca taatcaagga aacacaagct ccagcatatc tcattgacct gatgcatgat
     2221 aaaaataatg aaatccggaa agtctgtgat aacacattag atatcatcgc agagtatgat
     2281 gaagagtggg ccaagaaaat tcagagtgag aagtttcgct ggcataactc tcagtggctg
     2341 gagatggtgg agagccgtca gctggatgag agcgagcagt acttgtatgg tgatgatcgc
     2401 attgagccgt acatccatga aggggacatt cttgaaaggc ctgacctttt ctacaactca
     2461 gacggactaa ttacctctga aggagccata agtccagact tcttcaatga ttttcacctc
     2521 cagaatggag atgtggtggg gcaacacgca tttcctggca gcctcgggat ggatggcttc
     2581 gggcagccac tggggatcct tggacgtcct gccaccgcgt atggattccg ccctgacgaa
     2641 ccttactact acagctttgg gtctcgataa aatcacccct cccatgtgga cactcagctt
     2701 aggagagatc tgtgtgctgt gggttaacct tgaatcttga cttaataatg catgttatac
     2761 tcctatgggg ctgtgttgct tatttctcca cgttgttagc ttcaggttaa ctctaaccct
     2821 catgtctttt gttaaatacg gttgatgctc cactgttcac tcgtccagcc acatctcgag
     2881 gtgaataaca tttcccgtga gtctgttgca aaactgctag actggaaaag cagatactac
     2941 attatgtact ttaagtgact aatttctatt ggaaaaaaaa agtggcatac atgcaaagga
     3001 atgagccgaa gtcatgtgtt catacttact gtggttcata ggaaacactc atgtacatgg
     3061 gagaaacata cttttttttt taactttctc tttctactta taaacttctt agtgtttcat
     3121 gtgagccatg ctatctttaa actttaagtg aacctcaagc tttttatccc atgctgtgtc
     3181 tggaagtttc tttcacaaag ttagtaactg tacaagcttt ttaactagca gtgagcatat
     3241 gctgtaagta atgttatgca ttagcatagt ctactgagcg acccacgctc atgccatgtt
     3301 aactgcagca gaacaccggg cagcggaacc ctctgtagat ggagcacgag catcactgag
     3361 cttctaagtc cgggtcttcc aaaatgtgca atatcaaatg tgaggatgct gattattttt
     3421 gccttaccta agaaaattaa ggaaaggact ctctgtttgt tcacttaaga tagaagtggg
     3481 tagtgggaaa ttgaaaggga taggatgatt aataatgagt tttggaaata attcattgat
     3541 tgtaagatat tgaaaacttt acttgagaaa ccaagcaaat gaattcagta tgggcaaaga
     3601 ttgttgcttg atcatctcct actgaaggaa acctaagctt ccgaacactg cagatcaaag
     3661 ggaagacttc tgctcttaac tttaggagcc cactgatcta agtgtactag ttacctcagt
     3721 tcacacgttt agcacaaagt actggagctc gggaggtcct ttggacaata cagtccatct
     3781 gctggagaaa tgtaaatcta gccaacaggt atgttcttac ctgatacata aatgacctga
     3841 gacattgttt atgtttgtga attcacaatc tgaaagcatg cagttattgt ctttgtttcc
     3901 cttttaccca taaaatatta aagccagaaa ggtttgaacc agcaaaaaaa aaaaaaaaaa
     3961 a
//
