LOCUS       NM_001291222            4564 bp    mRNA    linear   ROD 09-JUN-2024
DEFINITION  Mus musculus kinesin family member 7 (Kif7), transcript variant 1,
            mRNA.
ACCESSION   NM_001291222 XM_006540664
VERSION     NM_001291222.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4564)
  AUTHORS   Yue,Y., Engelke,M.F., Blasius,T.L. and Verhey,K.J.
  TITLE     Hedgehog-induced ciliary trafficking of kinesin-4 motor KIF7
            requires intraflagellar transport but not KIF7's microtubule
            binding
  JOURNAL   Mol Biol Cell 33 (1), br1 (2022)
   PUBMED   34705483
  REMARK    GeneRIF: Hedgehog-induced ciliary trafficking of kinesin-4 motor
            KIF7 requires intraflagellar transport but not KIF7's microtubule
            binding.
REFERENCE   2  (bases 1 to 4564)
  AUTHORS   Xu,M.F., Yang,Y.H., Wei,Y.L., Zhang,J.L., Lin,X., Lin,X.Y., Chen,H.
            and She,Z.Y.
  TITLE     Functional Assessment of Kinesin-7 CENP-E in Spermatocytes using In
            Vivo Inhibition, Immunofluorescence and Flow Cytometry
  JOURNAL   J Vis Exp (2021)
   PUBMED   35037651
  REMARK    GeneRIF: Functional Assessment of Kinesin-7 CENP-E in Spermatocytes
            using In Vivo Inhibition, Immunofluorescence and Flow Cytometry.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4564)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4564)
  AUTHORS   Ferent,J., Constable,S., Gigante,E.D., Yam,P.T., Mariani,L.E.,
            Legue,E., Liem,K.F. Jr., Caspary,T. and Charron,F.
  TITLE     The Ciliary Protein Arl13b Functions Outside of the Primary Cilium
            in Shh-Mediated Axon Guidance
  JOURNAL   Cell Rep 29 (11), 3356-3366 (2019)
   PUBMED   31825820
REFERENCE   5  (bases 1 to 4564)
  AUTHORS   Putoux,A., Baas,D., Paschaki,M., Morle,L., Maire,C.,
            Attie-Bitach,T., Thomas,S. and Durand,B.
  TITLE     Altered GLI3 and FGF8 signaling underlies acrocallosal syndrome
            phenotypes in Kif7 depleted mice
  JOURNAL   Hum Mol Genet 28 (6), 877-887 (2019)
   PUBMED   30445565
REFERENCE   6  (bases 1 to 4564)
  AUTHORS   Cheung,H.O., Zhang,X., Ribeiro,A., Mo,R., Makino,S., Puviindran,V.,
            Law,K.K., Briscoe,J. and Hui,C.C.
  TITLE     The kinesin protein Kif7 is a critical regulator of Gli
            transcription factors in mammalian hedgehog signaling
  JOURNAL   Sci Signal 2 (76), ra29 (2009)
   PUBMED   19549984
  REMARK    GeneRIF: The kinesin protein Kif7 is a critical regulator of Gli
            transcription factors in mammalian hedgehog signaling.
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 4564)
  AUTHORS   Kenney-Hunt,J.P., Vaughn,T.T., Pletscher,L.S., Peripato,A.,
            Routman,E., Cothran,K., Durand,D., Norgard,E., Perel,C. and
            Cheverud,J.M.
  TITLE     Quantitative trait loci for body size components in mice
  JOURNAL   Mamm Genome 17 (6), 526-537 (2006)
   PUBMED   16783635
REFERENCE   8  (bases 1 to 4564)
  AUTHORS   Varjosalo,M., Li,S.P. and Taipale,J.
  TITLE     Divergence of hedgehog signal transduction mechanism between
            Drosophila and mammals
  JOURNAL   Dev Cell 10 (2), 177-186 (2006)
   PUBMED   16459297
REFERENCE   9  (bases 1 to 4564)
  AUTHORS   Nakagawa,T., Tanaka,Y., Matsuoka,E., Kondo,S., Okada,Y., Noda,Y.,
            Kanai,Y. and Hirokawa,N.
  TITLE     Identification and classification of 16 new kinesin superfamily
            (KIF) proteins in mouse genome
  JOURNAL   Proc Natl Acad Sci U S A 94 (18), 9654-9659 (1997)
   PUBMED   9275178
  REMARK    Erratum:[Proc Natl Acad Sci U S A 1999 Mar 30;96(7):4214]
REFERENCE   10 (bases 1 to 4564)
  AUTHORS   Winter,H., Siry,P., Tobiasch,E. and Schweizer,J.
  TITLE     Sequence and expression of murine type I hair keratins mHa2 and
            mHa3
  JOURNAL   Exp Cell Res 212 (2), 190-200 (1994)
   PUBMED   7514534
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC158582.2.
            
            On or before Apr 17, 2020 this sequence version replaced
            XM_006540664.1, NM_001291222.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMN00849374, SAMN00849375
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-43                AC158582.2         42252-42294
            44-395              AC158582.2         43777-44128
            396-596             AC158582.2         46346-46546
            597-990             AC158582.2         46863-47256
            991-1510            AC158582.2         47395-47914
            1511-1627           AC158582.2         48677-48793
            1628-1846           AC158582.2         49319-49537
            1847-2004           AC158582.2         50282-50439
            2005-2120           AC158582.2         50855-50970
            2121-2273           AC158582.2         51071-51223
            2274-2476           AC158582.2         53130-53332
            2477-2674           AC158582.2         54983-55180
            2675-2800           AC158582.2         55381-55506
            2801-2977           AC158582.2         55677-55853
            2978-3193           AC158582.2         56795-57010
            3194-3400           AC158582.2         57571-57777
            3401-3599           AC158582.2         58374-58572
            3600-3746           AC158582.2         58663-58809
            3747-4564           AC158582.2         59044-59861
FEATURES             Location/Qualifiers
     source          1..4564
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 45.09 cM"
     gene            1..4564
                     /gene="Kif7"
                     /note="kinesin family member 7"
                     /db_xref="GeneID:16576"
                     /db_xref="MGI:MGI:1098239"
     exon            1..43
                     /gene="Kif7"
                     /inference="alignment:Splign:2.1.0"
     exon            44..395
                     /gene="Kif7"
                     /inference="alignment:Splign:2.1.0"
     CDS             68..4114
                     /gene="Kif7"
                     /note="isoform 1 is encoded by transcript variant 1;
                     kinesin-like protein KIF7; kinesin 7"
                     /codon_start=1
                     /product="kinesin-like protein KIF7 isoform 1"
                     /protein_id="NP_001278151.1"
                     /db_xref="CCDS:CCDS80739.1"
                     /db_xref="GeneID:16576"
                     /db_xref="MGI:MGI:1098239"
                     /translation="MGLEAQRLPGAEEAPVRVALRVRPLLPKELLHGHQSCLRVEPER
                     GRITLGRDRHFGFHVVLGEDTGQEAVYQACVQPLLEAFFEGFNATVFAYGQTGSGKTY
                     TMGEASVASLHEDEQGIIPRAMAEAFKLIDENDLLDCLVHVSYLELYKEEFRDLLEVG
                     TASRDIQLREDDRGNVVLCGVKEVDVEGLDEVLSLLEMGNAARHTGATHFNRLSSRSH
                     TVFTVTLEQRGRTPSRLPRPAAGHLLVSKFHFVDLAGSERVLKTGSTGERLKESIQIN
                     STLLALGNVISALGDPQRRGSHIPYRDSKITRILKDSLGGNAKTVMIACVSPSSSDFD
                     ETLNTLNYASRAQNIRNRATVNWRPEAERVPEEQAAGARGPPRHRSETRIIHRGRRVP
                     CPAVGSAAVAAGLGAECARCRARTSAAYSLLRELQAEPGLPGAAARKVRDWLCAVEGE
                     RSTLSSASGPDSGIESAPAEDQAAQGTSGRKGDEGTQQLLTLQSQVARLEEENRDFLA
                     ALEDAMEQYKLQSDRLREQQEEMVELRLRLELAQPGWGAPGLLQGLPPGSFVPRPHTA
                     PLGGAHTHMLGMMPSTCLPGEEVSSEQQVVSGKEVKAEVLAQADKLRSASSTTSEEEG
                     EEEEEEEEEEEEPPRRTLYLRRNGISNWSQRAGLSPGSPPDRKGPEVCPEEPAAAIPA
                     PQAVGSGKVPVQTRQAPAAMASEWRLAQAQQKIRELAINIRMKEELIGELVRTGKAAQ
                     ALNRQHSQRIRELEQEAERVRAELCEGQRQLRELEGREPQDASERSRLQEFRKRVAAA
                     QSQVQVLKEKKQATERLVSLSAQSETRLQELERNVQLMRRQQGQLQRRLREETEQKRR
                     LETEMNKRQHRVKELELKHEQQQKILKIKTEEIAAFQRKRRSGSNGSVVSLEQQQKIE
                     EQKKWLDQEMEKVLQQRRALEELGEELRKREVILAKKEALMQEKTGLESKRLRSSQAL
                     NEDIVRVSSRLEHLEKELSEKSGQLRQGSAQNQQQIRGEIDTLRQEKDSLLKQRLEID
                     SKLRQGSLLSPEEERTLFQLDEAIEALDAAIEYKNEAITCRQRVLRASASLLSQCEMN
                     LMAKLSYLSSSETRALLCKYFDKVVTLREEQHQQQIAFSELEMQLEEQQRLVYWLEVA
                     LERQRLEMDRQLTLQQKEHEQNVQLLLQQGRDHLGEGLADSKRQYEARIHALEKELGR
                     HMWINQELKQKLSAGSTAGQSRGCERRSLCLENRQCLGNEDGLHPAAPEPLWQSSLLE
                     GVSRVWDESRDLVHAPLPLTWKRSSLCSEQGSSEESRVRETTEPPVGRVLPMGEVGLS
                     WNFGPLPKPRWEPRRTSPGMIDVRKNPL"
     exon            396..596
                     /gene="Kif7"
                     /inference="alignment:Splign:2.1.0"
     exon            597..990
                     /gene="Kif7"
                     /inference="alignment:Splign:2.1.0"
     exon            991..1510
                     /gene="Kif7"
                     /inference="alignment:Splign:2.1.0"
     exon            1511..1627
                     /gene="Kif7"
                     /inference="alignment:Splign:2.1.0"
     exon            1628..1846
                     /gene="Kif7"
                     /inference="alignment:Splign:2.1.0"
     exon            1847..2004
                     /gene="Kif7"
                     /inference="alignment:Splign:2.1.0"
     exon            2005..2120
                     /gene="Kif7"
                     /inference="alignment:Splign:2.1.0"
     exon            2121..2273
                     /gene="Kif7"
                     /inference="alignment:Splign:2.1.0"
     exon            2274..2476
                     /gene="Kif7"
                     /inference="alignment:Splign:2.1.0"
     exon            2477..2674
                     /gene="Kif7"
                     /inference="alignment:Splign:2.1.0"
     exon            2675..2800
                     /gene="Kif7"
                     /inference="alignment:Splign:2.1.0"
     exon            2801..2977
                     /gene="Kif7"
                     /inference="alignment:Splign:2.1.0"
     exon            2978..3193
                     /gene="Kif7"
                     /inference="alignment:Splign:2.1.0"
     exon            3194..3400
                     /gene="Kif7"
                     /inference="alignment:Splign:2.1.0"
     exon            3401..3599
                     /gene="Kif7"
                     /inference="alignment:Splign:2.1.0"
     exon            3600..3746
                     /gene="Kif7"
                     /inference="alignment:Splign:2.1.0"
     exon            3747..4564
                     /gene="Kif7"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4545..4550
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Kif7"
                     /note="hexamer: AATAAA"
     polyA_site      4564
                     /gene="Kif7"
                     /note="major polyA site"
ORIGIN      
        1 gagcttggct gcgcgtcccg ggactgcgct cgcactctgg cagattccgt agctgctgtc
       61 cttcaagatg gggctggagg cccagaggct gcctggggct gaggaggccc ccgtgagggt
      121 ggcccttcga gttcgcccat tgctgcccaa ggagctgctg catggtcatc agagttgcct
      181 gcgtgtggag cctgagcggg gtcgaatcac cctggggcgg gaccgacact ttgggttcca
      241 tgtggtcctg ggagaggaca ctgggcaaga ggctgtgtac caggcttgcg tgcagcccct
      301 cctcgaggct ttctttgagg gcttcaatgc caccgtcttt gcctatggtc agacaggctc
      361 tgggaagaca tataccatgg gggaggccag tgtggcctcc ctgcatgaag atgaacaagg
      421 tatcatccca agggccatgg ctgaggcctt caagctcatt gatgagaatg acctgctgga
      481 ctgcctggtg catgtatcct acctggaact ctacaaggaa gagttccgag atctgctaga
      541 agttggcact gccagccggg acatccagct tcgggaagat gatcggggaa atgttgtgct
      601 ctgtggggtg aaagaagtgg atgtagaagg cctggacgag gtgctgagcc tcctagagat
      661 gggcaatgct gcgcgccaca caggcgccac acacttcaac cgcctctcca gccgctcaca
      721 cacagtcttc actgtgaccc tggagcagcg gggacggact cctagccgct tgcctcgacc
      781 cgccgctggc cacctgctgg tctccaaatt ccacttcgtg gacctggcag gctccgagag
      841 ggttctgaag accggcagca ccggagaacg gctcaaagag agcatccaga ttaacagcac
      901 cctgctggcg ctgggaaatg tcattagcgc cctgggggac ccccagcgcc gaggcagcca
      961 catcccttac cgtgattcca agatcacccg gatcctcaaa gactctctgg gagggaatgc
     1021 caagacagtg atgatcgcct gcgtcagccc ctcctcctcc gacttcgatg agaccctcaa
     1081 caccctaaac tacgccagcc gtgctcagaa catccgcaat cgcgccacag tcaactggcg
     1141 tccagaggcc gagcgcgtcc ctgaggaaca ggcggcgggt gcgcgcgggc cgccgcgaca
     1201 ccgctcggaa acgcgcatca tccatcgcgg ccggcgcgtg ccctgccctg cagtgggctc
     1261 cgcggcagtc gctgcgggcc tgggggccga gtgcgcgcgc tgccgggccc gcaccagcgc
     1321 cgcctacagc ctcctgcgag agcttcaggc cgagcccggg ctgcctggcg ctgccgcccg
     1381 caaagtgcgg gactggctgt gcgcggtgga gggcgagcgc agcaccttga gctctgcctc
     1441 cggacccgac agcggcatcg aaagcgctcc agccgaggac caggcggcac aggggaccag
     1501 cgggagaaag ggagatgagg ggacccagca gctgttgacc ctgcagagcc aggtggcccg
     1561 gctagaggag gagaatcgag atttcctggc ggctttggag gacgccatgg agcagtacaa
     1621 actgcagagt gaccgcctgc gggagcagca ggaagagatg gtagaactgc ggctacgcct
     1681 agagctggca cagcctggct ggggtgcacc ggggctcctg cagggcttgc caccgggatc
     1741 ctttgtgccc cggcctcaca cagcccccct ggggggtgcc cacactcaca tgctgggcat
     1801 gatgccctcg acatgtcttc ctggagaaga agttagctct gagcagcagg tggtgagtgg
     1861 caaggaagtc aaagcagagg tgttggccca ggcggacaaa ttgaggagtg cctcttccac
     1921 tacatcagag gaggaagggg aggaggagga ggaagaggag gaagaagaag aggagccacc
     1981 caggcggacc ttatacttgc gcagaaatgg gatcagcaac tggagtcaga gggcagggtt
     2041 gagtccaggg agcccacctg acaggaaggg cccagaggtc tgcccagaag agccagctgc
     2101 tgccatccca gcaccacaag cagtcggtag cggcaaggtc ccagttcaga cccgccaggc
     2161 cccagctgcc atggcctctg agtggcgact ggcccaggcc caacagaaaa tccgggaact
     2221 ggccatcaac atccgcatga aggaggagct cattggtgag ctggtccgga cagggaaggc
     2281 ggcccaggcc ctgaaccgtc aacacagcca gcgcatccgg gagctggagc aggaggctga
     2341 gcgtgtgcgg gcggagctgt gtgaagggca gaggcagctt cgagagctgg agggcaggga
     2401 gccccaagat gccagcgaga ggtccaggct ccaggaattc cgtaagagag tggctgcagc
     2461 ccaaagccag gtgcaggtgc tgaaggagaa gaagcaggca acagagcgac tggtgtcact
     2521 gtcggctcaa agtgagactc ggctacagga gctggagagg aatgtgcagc tcatgcggcg
     2581 acagcagggg cagctgcaga ggcggctccg tgaggagaca gagcagaagc ggcgcctaga
     2641 gacggagatg aacaagcggc agcatcgcgt caaggagctg gaactgaagc acgagcaaca
     2701 gcaaaagatc ctgaaaatca agacagaaga gattgcagcc ttccagagga agaggcgcag
     2761 tggcagcaat ggctctgtgg tgagcctgga gcagcagcag aagatcgagg agcagaagaa
     2821 gtggctggac caggagatgg aaaaggtgct gcagcagcgg cgggcgctgg aggagttggg
     2881 agaggagctt cgcaagcggg aggtcatcct ggccaagaag gaggccctga tgcaggagaa
     2941 gacggggctt gagagcaagc gcctgaggtc cagccaggcc ctaaatgaag acattgtgcg
     3001 tgtgtccagc cgcctagaac acctggagaa ggagctatct gagaagagtg ggcagctgcg
     3061 gcaaggcagc gcccagaacc agcagcagat cagaggggag atagacaccc tgcgccaaga
     3121 gaaggactca ctgttgaagc aacgcctgga gattgatagc aagctgaggc agggaagcct
     3181 gctgtcacct gaggaagaga ggacactgtt ccagctggat gaagccatcg aggccctgga
     3241 cgctgccatc gagtacaaga atgaggctat cacatgccgc cagcgggtgc tacgggcttc
     3301 ggcctccttg ctgtcccagt gtgagatgaa tctcatggca aagctcagct acctttcctc
     3361 ctcagagacc agagccctgc tgtgcaagta ttttgacaag gtggtgacac tccgagagga
     3421 gcaacaccag caacagattg ccttctcgga gctggagatg cagctggagg agcagcagcg
     3481 gctggtgtac tggctggagg tggccctgga gcggcagcgc ctggagatgg accggcagct
     3541 gaccctgcag cagaaggagc acgagcagaa tgtacagctg ctcctccagc agggccgaga
     3601 ccaccttggc gaggggttag cagacagcaa gaggcagtat gaggcccgga ttcacgctct
     3661 ggagaaggaa ctaggtcgac acatgtggat aaaccaggag ctgaagcaga agctcagtgc
     3721 aggaagcact gcaggccaga gccggggttg tgagaggaga agcctctgcc tggaaaacag
     3781 acaatgcctt ggaaatgaag atgggctcca tcccgcagct cctgaacctc tctggcagtc
     3841 ctcccttctg gagggggtgt cccgtgtgtg ggatgagtcc cgggacttgg tccatgcccc
     3901 actacccctg acatggaaac gctcaagctt gtgcagcgag cagggctcct ctgaggagtc
     3961 tagggtccgg gagacaactg aacccccagt agggcgggtg ctacctatgg gtgaagtggg
     4021 cctctcctgg aactttggac ccttgcccaa gccccggtgg gaaccccgaa gaaccagccc
     4081 agggatgatc gacgtcagga aaaacccctt gtaggccttg gtcagaccct gcttcagatt
     4141 ccagtcctgc tgagaggaga gactgcctgt tttgcttcta tgaaggacag tccttacctc
     4201 acactgtaaa tccagagtct catctttaca ccaactggag tccgaaaatt tgggtcacac
     4261 cccaaagaac tggattttcc ccactatggt gcttagcagt cttttttttt tttttttttt
     4321 tgtaatctat gcaaattcct tcagctataa tacttgactg ctcctttttc atttgtggga
     4381 cagttctgac tttaagcctg tgtgcccaga gttctggaga taatccaagg cttgtcacaa
     4441 aacagtcagt ggcaaggggg tcacagcttt caatggtgtt atacagatgg gagaactggg
     4501 aaagtaataa gcatttttag aatttttaaa aaataccatt taataataaa caggagtaat
     4561 ctca
//
