LOCUS       NM_177052               3528 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus kinesin family member 6 (Kif6), mRNA.
ACCESSION   NM_177052 XM_001001635 XM_001003897
VERSION     NM_177052.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3528)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3528)
  AUTHORS   Konjikusic,M.J., Yeetong,P., Boswell,C.W., Lee,C., Roberson,E.C.,
            Ittiwut,R., Suphapeetiporn,K., Ciruna,B., Gurnett,C.A.,
            Wallingford,J.B., Shotelersuk,V. and Gray,R.S.
  TITLE     Mutations in Kinesin family member 6 reveal specific role in
            ependymal cell ciliogenesis and human neurological development
  JOURNAL   PLoS Genet 14 (11), e1007817 (2018)
   PUBMED   30475797
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3528)
  AUTHORS   Falnikar,A., Tole,S., Liu,M., Liu,J.S. and Baas,P.W.
  TITLE     Polarity in migrating neurons is related to a mechanism analogous
            to cytokinesis
  JOURNAL   Curr Biol 23 (13), 1215-1220 (2013)
   PUBMED   23791725
REFERENCE   4  (bases 1 to 3528)
  AUTHORS   Hameed,A., Bennett,E., Ciani,B., Hoebers,L.P., Milner,R.,
            Lawrie,A., Francis,S.E. and Grierson,A.J.
  TITLE     No evidence for cardiac dysfunction in Kif6 mutant mice
  JOURNAL   PLoS One 8 (1), e54636 (2013)
   PUBMED   23355886
  REMARK    GeneRIF: that dysfunction of Kif6 is linked to other more complex
            biological/biochemical parameters or is unlikely to be of material
            consequence in cardiac function.
REFERENCE   5  (bases 1 to 3528)
  AUTHORS   Nakagawa,T., Tanaka,Y., Matsuoka,E., Kondo,S., Okada,Y., Noda,Y.,
            Kanai,Y. and Hirokawa,N.
  TITLE     Identification and classification of 16 new kinesin superfamily
            (KIF) proteins in mouse genome
  JOURNAL   Proc Natl Acad Sci U S A 94 (18), 9654-9659 (1997)
   PUBMED   9275178
  REMARK    Erratum:[Proc Natl Acad Sci U S A 1999 Mar 30;96(7):4214]
REFERENCE   6  (bases 1 to 3528)
  AUTHORS   Winter,H., Siry,P., Tobiasch,E. and Schweizer,J.
  TITLE     Sequence and expression of murine type I hair keratins mHa2 and
            mHa3
  JOURNAL   Exp Cell Res 212 (2), 190-200 (1994)
   PUBMED   7514534
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC124748.5, AC114824.5 and AK084082.1.
            
            [WARNING] On Jul 9, 2024 this sequence was replaced by NM_177052.4.
            
            On or before Aug 30, 2007 this sequence version replaced
            XM_001003897.2, XM_001001635.2, NM_177052.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN00849384,
                              SAMN01164131 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-131               AC124748.5         109062-109192       c
            132-241             AC124748.5         103662-103771       c
            242-316             AC124748.5         99838-99912         c
            317-464             AC124748.5         53184-53331         c
            465-574             AC124748.5         48978-49087         c
            575-704             AC124748.5         37844-37973         c
            705-911             AC124748.5         16648-16854         c
            912-1055            AC124748.5         10226-10369         c
            1056-1142           AC124748.5         9214-9300           c
            1143-1246           AC124748.5         2020-2123           c
            1247-1352           AC114824.5         186475-186580       c
            1353-1488           AC114824.5         185166-185301       c
            1489-1704           AC114824.5         181765-181980       c
            1705-1813           AC114824.5         108153-108261       c
            1814-1869           AC114824.5         101195-101250       c
            1870-1920           AC114824.5         69458-69508         c
            1921-2005           AC114824.5         50314-50398         c
            2006-2141           AC114824.5         48577-48712         c
            2142-3151           AK084082.1         1943-2952
            3152-3306           AK084082.1         2954-3108
            3307-3528           AK084082.1         3110-3331
FEATURES             Location/Qualifiers
     source          1..3528
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 25.78 cM"
     gene            1..3528
                     /gene="Kif6"
                     /gene_synonym="D130004B10Rik; D130084M03Rik"
                     /note="kinesin family member 6"
                     /db_xref="GeneID:319991"
                     /db_xref="MGI:MGI:1098238"
     exon            1..131
                     /gene="Kif6"
                     /gene_synonym="D130004B10Rik; D130084M03Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             66..2474
                     /gene="Kif6"
                     /gene_synonym="D130004B10Rik; D130084M03Rik"
                     /note="kinesin 6"
                     /codon_start=1
                     /product="kinesin-like protein KIF6"
                     /protein_id="NP_796026.2"
                     /db_xref="CCDS:CCDS50144.1"
                     /db_xref="GeneID:319991"
                     /db_xref="MGI:MGI:1098238"
                     /translation="MVKQTIQIFARVKPTVRKQQQGIYSIDEDEKLTHSLEIVLPRDL
                     ADGFVNNKRESYKFKFQRIFDQEAKQEIIFEIIAKPVAESTLAGYNGTIFAYGQTGSG
                     KTFTITGGAERYSDRGIIPRTLSYIFEQLQKDSSKIYTTHISYLEIYNECGYDLLDPR
                     HEASKLEDLPKVTILEDPDQNIHLKNLSLHQATTEEEALNLLFLGDTNRMIAETPMNQ
                     ASTRSHCIFTVHLSSKEPGSATVRHAKLHLVDLAGSERVSKTGVGGLLLTEAKYINLS
                     LHYLEQVIIALSEKHRTHIPYRNSMMTSVLRDSLGGNCMTTMIATLSLEKRNIDESIS
                     TCRFAQRVALIKNEAILNEEIDPRLMIVRLQKEIEDLKAELAMATGEQRTEALTEAEL
                     LQLEKLIASYLEDQDPESRLEVGADMRKIHHCFHHFKKLLNDKKTLENTVSSESTRQA
                     CQEPLRDEEYTKLLGLLKQRDNEINILVNMLKKEKKKTQDALQNSSLEKSDTRPPQNS
                     PFIAGSPAVPRTPFSSAPSHTQDLSICRHRSSLLHKKTGMREEMSLGRQEAFEIFKRD
                     HADSVTIEDNKQVLKQRFSEAKALGESINEARSKIGQLKDAINQRHLQQVALGISENT
                     VPASTPDPQEEKLRAQLEEEKGRYKTAFMHLKALKVEIEHLQLLMDKAKVKLQKEFEA
                     WWAEEATSLQVNSPATNLQDAVKPFPQQDQAQLLSKKSSRDLEVENGAGRLEVCDRNA
                     RRILPSPCPNQQSQEPSGSRVLVQDRPLSSIPLTGDSQTDSDILAFIKARQSILQKKC
                     LGSN"
     exon            132..241
                     /gene="Kif6"
                     /gene_synonym="D130004B10Rik; D130084M03Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            242..316
                     /gene="Kif6"
                     /gene_synonym="D130004B10Rik; D130084M03Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            317..464
                     /gene="Kif6"
                     /gene_synonym="D130004B10Rik; D130084M03Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            465..574
                     /gene="Kif6"
                     /gene_synonym="D130004B10Rik; D130084M03Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            575..704
                     /gene="Kif6"
                     /gene_synonym="D130004B10Rik; D130084M03Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            705..911
                     /gene="Kif6"
                     /gene_synonym="D130004B10Rik; D130084M03Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            912..1055
                     /gene="Kif6"
                     /gene_synonym="D130004B10Rik; D130084M03Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1056..1142
                     /gene="Kif6"
                     /gene_synonym="D130004B10Rik; D130084M03Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1143..1246
                     /gene="Kif6"
                     /gene_synonym="D130004B10Rik; D130084M03Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1247..1352
                     /gene="Kif6"
                     /gene_synonym="D130004B10Rik; D130084M03Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1353..1488
                     /gene="Kif6"
                     /gene_synonym="D130004B10Rik; D130084M03Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1489..1704
                     /gene="Kif6"
                     /gene_synonym="D130004B10Rik; D130084M03Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1705..1813
                     /gene="Kif6"
                     /gene_synonym="D130004B10Rik; D130084M03Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1814..1869
                     /gene="Kif6"
                     /gene_synonym="D130004B10Rik; D130084M03Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1870..1920
                     /gene="Kif6"
                     /gene_synonym="D130004B10Rik; D130084M03Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1921..2005
                     /gene="Kif6"
                     /gene_synonym="D130004B10Rik; D130084M03Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2006..2141
                     /gene="Kif6"
                     /gene_synonym="D130004B10Rik; D130084M03Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2142..2224
                     /gene="Kif6"
                     /gene_synonym="D130004B10Rik; D130084M03Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2225..2272
                     /gene="Kif6"
                     /gene_synonym="D130004B10Rik; D130084M03Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2273..2362
                     /gene="Kif6"
                     /gene_synonym="D130004B10Rik; D130084M03Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2363..2457
                     /gene="Kif6"
                     /gene_synonym="D130004B10Rik; D130084M03Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2458..3528
                     /gene="Kif6"
                     /gene_synonym="D130004B10Rik; D130084M03Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3506..3511
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Kif6"
                     /gene_synonym="D130004B10Rik; D130084M03Rik"
                     /note="hexamer: AATAAA"
     polyA_site      3527
                     /gene="Kif6"
                     /gene_synonym="D130004B10Rik; D130084M03Rik"
                     /note="major polyA site"
ORIGIN      
        1 aataggaagt tttaggtggt ccggactcgg aaaggtcaag ggtcagtgcg gagtctccgc
       61 tggtgatggt gaagcagacg atccagattt tcgctagggt gaagcccacc gtgcggaagc
      121 agcagcaagg gatttactcc atagatgaag atgaaaaatt aacgcatagc ttggaaattg
      181 tcttaccccg agacctggca gatggattcg taaacaacaa acgagaaagc tacaagttta
      241 agtttcaaag gatttttgac caagaggcta agcaagagat cattttcgag atcattgcca
      301 aaccagtcgc cgagagtacc ttggcaggtt acaatggcac catcttcgca tatgggcaga
      361 cgggcagtgg caagacattc accatcacag gcggggcaga gcgctacagt gacagaggca
      421 tcatcccaag gaccctgtcg tacatttttg agcagttgca aaaggacagc agcaagatct
      481 acacgacaca catttcttac ttggaaatct acaacgaatg tggctatgac ctgctggatc
      541 ccagacacga agcctccaaa ctggaagatc tgccgaaagt gacaatattg gaggaccctg
      601 atcagaacat tcacctgaaa aacctgtctc tgcatcaggc aacaactgag gaggaagctc
      661 tgaacctgct cttcttgggg gacaccaaca ggatgatcgc tgagactcct atgaatcaag
      721 cttcaacccg gtcacactgt attttcactg tgcacttgag cagcaaggag ccaggttctg
      781 ccaccgtccg acatgctaag ctccatctgg ttgacctggc agggtcagag cgtgtctcga
      841 agactggagt cgggggcctg cttctgacag aggccaaata catcaacttg tccctacact
      901 acctggagca ggtcatcatt gccctttcgg aaaaacaccg tacacacatc ccttacagga
      961 actccatgat gaccagcgtg ctcagagaca gtctgggagg gaactgcatg accaccatga
     1021 ttgcaaccct gtctttggag aagaggaaca ttgatgagtc tatctccacc tgcagatttg
     1081 ctcagcgagt ggccctaatt aaaaacgaag ccattctcaa cgaagagatt gatcccaggc
     1141 tgatgattgt tcgcttgcaa aaggagattg aagacttgaa ggcagagttg gccatggcca
     1201 caggagagca gaggacagag gccctcacgg aagcagagct ccttcagttg gaaaaactaa
     1261 tagcatccta tttggaagac caagatccag agagtcgact ggaagttggc gctgatatgc
     1321 gtaaaatcca tcactgtttt catcatttta agaagctgtt gaatgacaag aagaccctag
     1381 agaatactgt ctcctctgaa agcacacggc aagcatgcca agaaccattg agagatgaag
     1441 aatatacaaa gctcctaggt cttctcaagc agagggacaa cgagatcaat atcctggtca
     1501 atatgttaaa aaaggaaaag aagaaaactc aggatgccct ccagaattca agcctagaga
     1561 aaagcgatac caggccacct cagaactcgc ccttcatcgc tgggagccca gcggtcccaa
     1621 ggaccccatt ctcctcagcc ccgagccaca cccaggacct cagcatctgc aggcacagat
     1681 ccagcttgct ccacaaaaaa acagggatga gagaggagat gtcactggga cgccaggagg
     1741 cttttgagat tttcaagagg gaccacgctg acagtgtcac catcgaggac aacaaacagg
     1801 ttctgaagca gagattttct gaagcaaaag ctctgggaga aagtataaat gaagcaagaa
     1861 gtaaaattgg tcagctgaaa gatgccatca accagcggca cctacagcaa gtagctcttg
     1921 gaatctcaga gaacactgtc ccagcctcca cgcctgaccc ccaggaggag aaactgcgag
     1981 cacagctgga ggaggagaag ggcaggtaca aaacggcctt tatgcacctg aaggccctga
     2041 aggtggagat agagcacctg cagctgctca tggacaaagc caaggtcaag ctgcagaaag
     2101 agttcgaggc ctggtgggca gaggaggcca ccagcctgca ggtaaactcc ccggccacga
     2161 acctccagga tgctgtgaag ccgtttcccc agcaggacca ggcacagctt ctctccaaga
     2221 aaagttctcg agacttggaa gttgaaaatg gagctggcag gctggaggtc tgcgatagga
     2281 atgccagaag aatccttccc tccccctgcc ccaaccagca aagccaagag cccagtggct
     2341 ccagggtcct ggtgcaagat aggcccctat catccatccc tctcactgga gacagccaga
     2401 cagactccga catcctagca ttcatcaagg ccagacagag cattctacag aagaaatgcc
     2461 tgggaagcaa ctgactttct gatgggagtc caaccctgcc ctgcagacag aatggctact
     2521 gagaagatga agaacctgcc cctccctcac tcgtgacctc acattcgatg gaaagactcc
     2581 ccaggaagca gctggcaaat ctgaggccag aggaggagcc ctttacccag aagatctgag
     2641 cagcaccctc gtgcccctgg catgcgatcc aaactttagg cagctgaact atgggtgctc
     2701 aaacacagac ttaaatctgt gtgtctagga tggaactcaa gactgattct tcttaaagac
     2761 taatttcaaa gtgtgtgact acttcttaga ggatggtgtc taggagggca tgcagggctg
     2821 acaggaagtc ctgacagagt tgctgacagg gtgggcacta ccaagaagct ggaggccagc
     2881 caggactcac tgacaggttt tggagaaccc tggagatggt gcagtgcacc atcatgatac
     2941 acaggtgggg acattccagg cagtgcaatg caggaggatg atagcccatt atttattgat
     3001 aactacttgc caaccattac ccaaggctac ccctggctta caagcccagg aatggccgtg
     3061 gcaagccagg caggcctcca aagtcctaga taagaatgta gggcacctta agtgccaccg
     3121 taccagccca aaccatcacc cacttgcccc gtcttcaggg agctatgtac tctgcagtct
     3181 gaggacctca cagtaccaga aagcagtggg aagctactca gagctctaca gctcgcagtt
     3241 ccctgagcca tcaccccacc aagttgcatg gggctctaca aaactaaggc ctaaactccc
     3301 tgtcccacgg gggaacatag ttgcccaatg atcttgcctc agtgaccctc ccggcatctg
     3361 gcaacctggc ccagtgtctt gggctaagtg gacacaaaag agaggggagc acagtcagta
     3421 gatacctgtg ttggggtccc aacccaacta cagttggggg ggcagtggag gtgcagaaat
     3481 aggtgcccag aaataattac agctgaataa aaataccttc caaatgct
//
