LOCUS       NM_008448               6030 bp    mRNA    linear   ROD 24-DEC-2024
DEFINITION  Mus musculus kinesin family member 5B (Kif5b), mRNA.
ACCESSION   NM_008448
VERSION     NM_008448.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6030)
  AUTHORS   Dias,A.P., Rehmani,T., Salih,M. and Tuana,B.
  TITLE     Tail-anchored membrane protein SLMAP3 is essential for targeting
            centrosomal proteins to the nuclear envelope in skeletal myogenesis
  JOURNAL   Open Biol 14 (10), 240094 (2024)
   PUBMED   39378988
REFERENCE   2  (bases 1 to 6030)
  AUTHORS   Fok,A.H.K., Huang,Y., So,B.W.L., Zheng,Q., Tse,C.S.C., Li,X.,
            Wong,K.K., Huang,J., Lai,K.O. and Lai,C.S.W.
  TITLE     KIF5B plays important roles in dendritic spine plasticity and
            dendritic localization of PSD95 and FMRP in the mouse cortex in
            vivo
  JOURNAL   Cell Rep 43 (3), 113906 (2024)
   PUBMED   38451812
  REMARK    GeneRIF: KIF5B plays important roles in dendritic spine plasticity
            and dendritic localization of PSD95 and FMRP in the mouse cortex in
            vivo.
REFERENCE   3  (bases 1 to 6030)
  AUTHORS   Marom,R., Zhang,B., Washington,M.E., Song,I.W., Burrage,L.C.,
            Rossi,V.C., Berrier,A.S., Lindsey,A., Lesinski,J., Nonet,M.L.,
            Chen,J., Baldridge,D., Silverman,G.A., Sutton,V.R., Rosenfeld,J.A.,
            Tran,A.A., Hicks,M.J., Murdock,D.R., Dai,H., Weis,M.,
            Jhangiani,S.N., Muzny,D.M., Gibbs,R.A., Caswell,R., Pottinger,C.,
            Cilliers,D., Stals,K., Eyre,D., Krakow,D., Schedl,T., Pak,S.C. and
            Lee,B.H.
  CONSRTM   Undiagnosed Diseases Network
  TITLE     Dominant negative variants in KIF5B cause osteogenesis imperfecta
            via down regulation of mTOR signaling
  JOURNAL   PLoS Genet 19 (11), e1011005 (2023)
   PUBMED   37934770
  REMARK    GeneRIF: Dominant negative variants in KIF5B cause osteogenesis
            imperfecta via down regulation of mTOR signaling.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 6030)
  AUTHORS   Longe,C., Bratti,M., Kurowska,M., Vibhushan,S., David,P.,
            Desmeure,V., Huang,J.D., Fischer,A., de Saint Basile,G.,
            Sepulveda,F.E., Blank,U. and Menasche,G.
  TITLE     Rab44 regulates murine mast cell-driven anaphylaxis through
            kinesin-1-dependent secretory granule translocation
  JOURNAL   J Allergy Clin Immunol 150 (3), 676-689 (2022)
   PUBMED   35469841
REFERENCE   5  (bases 1 to 6030)
  AUTHORS   Shah,S.H., Schiapparelli,L.M., Ma,Y., Yokota,S., Atkins,M., Xia,X.,
            Cameron,E.G., Huang,T., Saturday,S., Sun,C.B., Knasel,C.,
            Blackshaw,S., Yates,J.R., Cline,H.T. and Goldberg,J.L.
  TITLE     Quantitative transportomics identifies Kif5a as a major regulator
            of neurodegeneration
  JOURNAL   Elife 11, e68148 (2022)
   PUBMED   35259089
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 6030)
  AUTHORS   Tanaka,Y., Kanai,Y., Okada,Y., Nonaka,S., Takeda,S., Harada,A. and
            Hirokawa,N.
  TITLE     Targeted disruption of mouse conventional kinesin heavy chain,
            kif5B, results in abnormal perinuclear clustering of mitochondria
  JOURNAL   Cell 93 (7), 1147-1158 (1998)
   PUBMED   9657148
REFERENCE   7  (bases 1 to 6030)
  AUTHORS   Rahman,A., Friedman,D.S. and Goldstein,L.S.
  TITLE     Two kinesin light chain genes in mice. Identification and
            characterization of the encoded proteins
  JOURNAL   J Biol Chem 273 (25), 15395-15403 (1998)
   PUBMED   9624122
  REMARK    Erratum:[J Biol Chem 1998 Sep 11;273(37):24280]
REFERENCE   8  (bases 1 to 6030)
  AUTHORS   Nakagawa,T., Tanaka,Y., Matsuoka,E., Kondo,S., Okada,Y., Noda,Y.,
            Kanai,Y. and Hirokawa,N.
  TITLE     Identification and classification of 16 new kinesin superfamily
            (KIF) proteins in mouse genome
  JOURNAL   Proc Natl Acad Sci U S A 94 (18), 9654-9659 (1997)
   PUBMED   9275178
  REMARK    Erratum:[Proc Natl Acad Sci U S A 1999 Mar 30;96(7):4214]
REFERENCE   9  (bases 1 to 6030)
  AUTHORS   Meng,Y.X., Wilson,G.W., Avery,M.C., Varden,C.H. and Balczon,R.
  TITLE     Suppression of the expression of a pancreatic beta-cell form of the
            kinesin heavy chain by antisense oligonucleotides inhibits insulin
            secretion from primary cultures of mouse beta-cells
  JOURNAL   Endocrinology 138 (5), 1979-1987 (1997)
   PUBMED   9112396
REFERENCE   10 (bases 1 to 6030)
  AUTHORS   Gudkov,A.V., Kazarov,A.R., Thimmapaya,R., Axenovich,S.A., Mazo,I.A.
            and Roninson,I.B.
  TITLE     Cloning mammalian genes by expression selection of genetic
            suppressor elements: association of kinesin with drug resistance
            and cell immortalization
  JOURNAL   Proc Natl Acad Sci U S A 91 (9), 3744-3748 (1994)
   PUBMED   8170981
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AI788274.1, BC090841.1, AK014590.1, AV316286.1 and AC113003.9.
            
            On Jan 13, 2010 this sequence version replaced NM_008448.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC090841.1, U86090.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164134
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-24                AI788274.1         1-24
            25-3711             BC090841.1         1-3687
            3712-4824           BC090841.1         3689-4801
            4825-5931           AK014590.1         1721-2827
            5932-6013           AV316286.1         138-219
            6014-6030           AC113003.9         65504-65520
FEATURES             Location/Qualifiers
     source          1..6030
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 4.46 cM"
     gene            1..6030
                     /gene="Kif5b"
                     /gene_synonym="Khc; Khcs; Kns1; Ukhc"
                     /note="kinesin family member 5B"
                     /db_xref="GeneID:16573"
                     /db_xref="MGI:MGI:1098268"
     exon            1..543
                     /gene="Kif5b"
                     /gene_synonym="Khc; Khcs; Kns1; Ukhc"
                     /inference="alignment:Splign:2.1.0"
     CDS             418..3309
                     /gene="Kif5b"
                     /gene_synonym="Khc; Khcs; Kns1; Ukhc"
                     /note="conventional kinesin heavy chain; ubiquitous
                     kinesin heavy chain; kinesin heavy chain member 5B,
                     ubiquitous"
                     /codon_start=1
                     /product="kinesin-1 heavy chain"
                     /protein_id="NP_032474.2"
                     /db_xref="CCDS:CCDS37724.1"
                     /db_xref="GeneID:16573"
                     /db_xref="MGI:MGI:1098268"
                     /translation="MADPAECNIKVMCRFRPLNESEVNRGDKYVAKFQGEDTVMIASK
                     PYAFDRVFQSSTSQEQVYNDCAKKIVKDVLEGYNGTIFAYGQTSSGKTHTMEGKLHDP
                     EGMGIIPRIVQDIFNYIYSMDENLEFHIKVSYFEIYLDKIRDLLDVSKTNLSVHEDKN
                     RVPYVKGCTERFVCSPDEVMDTIDEGKSNRHVAVTNMNEHSSRSHSIFLINVKQENTQ
                     TEQKLSGKLYLVDLAGSEKVSKTGAEGAVLDEAKNINKSLSALGNVISALAEGSTYVP
                     YRDSKMTRILQDSLGGNCRTTIVICCSPSSYNESETKSTLLFGQRAKTIKNTVCVNVE
                     LTAEQWKKKYEKEKEKNKTLRNTIQWLENELNRWRNGETVPIDEQFDKEKANLEAFTA
                     DKDIAITSDKPAAAVGMAGSFTDAERRKCEEELAKLYKQLDDKDEEINQQSQLVEKLK
                     TQMLDQEELLASTRRDQDNMQAELNRLQAENDASKEEVKEVLQALEELAVNYDQKSQE
                     VEDKTKEYELLSDELNQKSATLASIDAELQKLKEMTNHQKKRAAEMMASLLKDLAEIG
                     IAVGNNDVKQPEGTGMIDEEFTVARLYISKMKSEVKTMVKRCKQLESTQTESNKKMEE
                     NEKELAACQLRISQHEAKIKSLTEYLQNVEQKKRQLEESVDSLGEELVQLRAQEKVHE
                     MEKEHLNKVQTANEVKQAVEQQIQSHRETHQKQISSLRDEVEAKEKLITDLQDQNQKM
                     VLEQERLRVEHERLKATDQEKSRKLHELTVMQDRREQARQDLKGLEETVAKELQTLHN
                     LRKLFVQDLATRVKKSAEVDSDDTGGSAAQKQKISFLENNLEQLTKVHKQLVRDNADL
                     RCELPKLEKRLRATAERVKALESALKEAKENASRDRKRYQQEVDRIKEAVRSKNMARR
                     GHSAQIAKPIRPGQHPAASPTHPGTVRGGGSFVQNNQPVGLRGGGGKQS"
     exon            544..631
                     /gene="Kif5b"
                     /gene_synonym="Khc; Khcs; Kns1; Ukhc"
                     /inference="alignment:Splign:2.1.0"
     exon            632..705
                     /gene="Kif5b"
                     /gene_synonym="Khc; Khcs; Kns1; Ukhc"
                     /inference="alignment:Splign:2.1.0"
     exon            706..810
                     /gene="Kif5b"
                     /gene_synonym="Khc; Khcs; Kns1; Ukhc"
                     /inference="alignment:Splign:2.1.0"
     exon            811..859
                     /gene="Kif5b"
                     /gene_synonym="Khc; Khcs; Kns1; Ukhc"
                     /inference="alignment:Splign:2.1.0"
     exon            860..915
                     /gene="Kif5b"
                     /gene_synonym="Khc; Khcs; Kns1; Ukhc"
                     /inference="alignment:Splign:2.1.0"
     exon            916..1003
                     /gene="Kif5b"
                     /gene_synonym="Khc; Khcs; Kns1; Ukhc"
                     /inference="alignment:Splign:2.1.0"
     exon            1004..1128
                     /gene="Kif5b"
                     /gene_synonym="Khc; Khcs; Kns1; Ukhc"
                     /inference="alignment:Splign:2.1.0"
     exon            1129..1233
                     /gene="Kif5b"
                     /gene_synonym="Khc; Khcs; Kns1; Ukhc"
                     /inference="alignment:Splign:2.1.0"
     exon            1234..1379
                     /gene="Kif5b"
                     /gene_synonym="Khc; Khcs; Kns1; Ukhc"
                     /inference="alignment:Splign:2.1.0"
     exon            1380..1528
                     /gene="Kif5b"
                     /gene_synonym="Khc; Khcs; Kns1; Ukhc"
                     /inference="alignment:Splign:2.1.0"
     exon            1529..1722
                     /gene="Kif5b"
                     /gene_synonym="Khc; Khcs; Kns1; Ukhc"
                     /inference="alignment:Splign:2.1.0"
     exon            1723..1791
                     /gene="Kif5b"
                     /gene_synonym="Khc; Khcs; Kns1; Ukhc"
                     /inference="alignment:Splign:2.1.0"
     exon            1792..1998
                     /gene="Kif5b"
                     /gene_synonym="Khc; Khcs; Kns1; Ukhc"
                     /inference="alignment:Splign:2.1.0"
     exon            1999..2142
                     /gene="Kif5b"
                     /gene_synonym="Khc; Khcs; Kns1; Ukhc"
                     /inference="alignment:Splign:2.1.0"
     exon            2143..2331
                     /gene="Kif5b"
                     /gene_synonym="Khc; Khcs; Kns1; Ukhc"
                     /inference="alignment:Splign:2.1.0"
     exon            2332..2449
                     /gene="Kif5b"
                     /gene_synonym="Khc; Khcs; Kns1; Ukhc"
                     /inference="alignment:Splign:2.1.0"
     exon            2450..2511
                     /gene="Kif5b"
                     /gene_synonym="Khc; Khcs; Kns1; Ukhc"
                     /inference="alignment:Splign:2.1.0"
     exon            2512..2621
                     /gene="Kif5b"
                     /gene_synonym="Khc; Khcs; Kns1; Ukhc"
                     /inference="alignment:Splign:2.1.0"
     exon            2622..2723
                     /gene="Kif5b"
                     /gene_synonym="Khc; Khcs; Kns1; Ukhc"
                     /inference="alignment:Splign:2.1.0"
     exon            2724..2784
                     /gene="Kif5b"
                     /gene_synonym="Khc; Khcs; Kns1; Ukhc"
                     /inference="alignment:Splign:2.1.0"
     exon            2785..2856
                     /gene="Kif5b"
                     /gene_synonym="Khc; Khcs; Kns1; Ukhc"
                     /inference="alignment:Splign:2.1.0"
     exon            2857..2961
                     /gene="Kif5b"
                     /gene_synonym="Khc; Khcs; Kns1; Ukhc"
                     /inference="alignment:Splign:2.1.0"
     exon            2962..3178
                     /gene="Kif5b"
                     /gene_synonym="Khc; Khcs; Kns1; Ukhc"
                     /inference="alignment:Splign:2.1.0"
     exon            3179..3327
                     /gene="Kif5b"
                     /gene_synonym="Khc; Khcs; Kns1; Ukhc"
                     /inference="alignment:Splign:2.1.0"
     exon            3328..6030
                     /gene="Kif5b"
                     /gene_synonym="Khc; Khcs; Kns1; Ukhc"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5110..5115
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Kif5b"
                     /gene_synonym="Khc; Khcs; Kns1; Ukhc"
                     /note="hexamer: AATAAA"
     polyA_site      5141
                     /gene="Kif5b"
                     /gene_synonym="Khc; Khcs; Kns1; Ukhc"
                     /note="major polyA site"
     regulatory      5526..5531
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Kif5b"
                     /gene_synonym="Khc; Khcs; Kns1; Ukhc"
                     /note="hexamer: CATAAA"
     polyA_site      5552
                     /gene="Kif5b"
                     /gene_synonym="Khc; Khcs; Kns1; Ukhc"
                     /note="major polyA site"
ORIGIN      
        1 gtttgccgcc ggcctgggca ctaaggcctt tggagggtgc gcgcgtcagc tggccgggaa
       61 gccggcgagc tgccgggaca ggatagtggg ccgagcccta ggcctcggct gtccttcccg
      121 aaaagaaaag aaggagccgc tcgccagtcc ccgcagcctg tggaggccgg tgagggagac
      181 gccgaggagc atcgaggctc tgtgggcgcc gccgccttgg ccgccatgat ggagcggaag
      241 tgaacttcgg gcgcaggctg ccggcgacag cgcttcggtc tagctgcccg gggtgcacgg
      301 cgctgcggag cccggacctt ccggtcctcg cgacccctgc ctcttggctc ccctcgctta
      361 ccccaagact gagcggcttg aagaggcgcc cggcctgcgg tcccggcttc cagaaagatg
      421 gcggacccgg cggagtgcaa catcaaagtg atgtgtcgct tcagacctct caacgaatct
      481 gaagtgaacc gcggcgataa gtacgtcgcc aaattccagg gagaagacac ggtgatgatc
      541 gcgtccaagc cttatgcctt tgatcgtgtg ttccagtcaa gcacatctca agagcaagta
      601 tacaacgact gtgcaaaaaa gattgttaaa gatgttcttg agggctataa tggaacaata
      661 tttgcatatg gacaaacatc atctgggaag acccacacga tggagggtaa acttcatgat
      721 ccagaaggca tgggaattat tccaagaata gtgcaagata tttttaatta tatttactcc
      781 atggatgaaa atttggaatt tcatattaag gtttcatatt ttgaaatata tttggataag
      841 ataagggact tgttagatgt ttcaaagact aacctttcag tccatgaaga caaaaaccgt
      901 gttccctatg taaaggggtg cacagaacgt ttcgtgtgta gtccagatga agtcatggat
      961 accatagatg aagggaaatc caacagacat gtcgcagtta caaatatgaa tgaacatagc
     1021 tctaggagtc acagcatatt tcttattaat gtaaaacaag agaatacaca aacggaacag
     1081 aaactcagtg gaaagcttta tctggttgat ttagctggca gtgagaaggt tagtaagact
     1141 ggggctgaag gtgctgtgct ggatgaagct aagaacatca acaagtcact ttctgcactt
     1201 ggaaatgtca tttctgcttt ggcagagggc agtacctatg ttccttatcg agatagtaaa
     1261 atgaccagaa ttcttcaaga ttcattaggt ggcaactgta ggaccactat tgtcatatgc
     1321 tgctctccat catcatacaa tgagtctgag acaaagtcaa cactcctctt tggtcaaagg
     1381 gccaaaacaa ttaagaacac agtctgtgtc aatgtagagt taactgcgga gcagtggaaa
     1441 aagaagtatg aaaaagaaaa ggaaaaaaat aaaactctac ggaacactat tcagtggctg
     1501 gaaaacgagc taaaccgttg gcgtaacggg gagacagtgc ctattgatga gcagtttgac
     1561 aaagagaaag ctaatttgga agccttcaca gcggataaag atattgctat taccagtgat
     1621 aaaccagctg ctgcagtcgg aatggctggt agttttaccg atgctgaaag aagaaagtgt
     1681 gaagaagaac ttgctaaatt gtataaacaa cttgatgaca aggatgaaga gattaaccaa
     1741 caaagccaat tggtagagaa attgaagaca caaatgctgg atcaggaaga gcttctggca
     1801 tcaaccagaa gggatcaaga taatatgcaa gctgaactga atcgcctcca agcagaaaat
     1861 gatgcttcta aagaagaagt caaagaagtt ttacaggcct tagaggaact ggctgttaat
     1921 tatgatcaga agtctcagga agttgaagac aaaacaaagg aatatgaatt gcttagtgat
     1981 gaattgaatc aaaaatctgc aactttagca agtattgatg ctgagcttca gaagctgaag
     2041 gaaatgacca accaccagaa gaaacgagca gctgaaatga tggcatcatt attaaaagac
     2101 cttgcagaaa taggaattgc tgtggggaat aacgatgtga agcaaccaga aggaactggt
     2161 atgatagatg aagagtttac tgttgcaaga ctctacatta gcaaaatgaa atcagaagta
     2221 aagaccatgg tgaaacgctg caaacagcta gaaagcacac agactgagag caacaaaaaa
     2281 atggaagaaa atgagaaaga gttagcagca tgccagcttc ggatctccca acatgaagcc
     2341 aaaatcaagt cactgactga gtaccttcag aatgtagaac aaaagaagag gcagctggag
     2401 gagtctgttg attcccttgg tgaggagcta gtccaactcc gagcacaaga gaaagtccat
     2461 gaaatggaaa aagagcactt gaacaaggtt cagactgcaa atgaagtcaa gcaagctgtt
     2521 gagcagcaga tccagagtca cagagaaacc caccaaaaac aaatcagtag tttgcgagat
     2581 gaagtggagg caaaggaaaa gctaatcact gacctccaag accaaaacca gaagatggtg
     2641 ttggagcagg aacggctaag ggtggagcat gagaggctga aggctacaga ccaagagaag
     2701 agcaggaagc tgcacgagct cacggttatg caagacagac gagaacaagc aagacaagac
     2761 ttgaagggtt tggaggagac cgtggcaaaa gaacttcaga ctttacacaa cctgcgtaag
     2821 ctctttgttc aggacttggc taccagggtg aaaaagagcg ccgaggtcga ctctgacgac
     2881 actggcggca gtgctgcaca gaagcagaaa atctccttcc ttgaaaacaa ccttgaacag
     2941 ctcaccaaag tgcacaagca gttggtacgc gataatgcag atcttcgctg tgagcttcct
     3001 aagttagaga aacggcttag agctactgca gaaagagtga aagctttgga gtcagccctg
     3061 aaagaagcca aagaaaatgc atctcgagac cgtaaacgct atcagcaaga agtagaccgg
     3121 ataaaggaag cagtcaggtc aaagaacatg gccagaaggg gacattctgc ccagattgca
     3181 aagccgatcc gtcctggaca gcatccagcg gcctcgccaa ctcacccggg cacagttcgt
     3241 ggaggaggct catttgttca gaacaaccag ccagtggggc ttcgtggtgg tggaggcaag
     3301 cagtcgtaaa cacttgacac attgcaggtg ttgaaaagta attgaagttt gaagaggaca
     3361 taaaatcagt ctttcactaa ctaacctcta ttccttggga ttgtagaaat ttaatttttt
     3421 aatgtgtaaa ttactcctac cctgtacagc tgtttcctac ccactcttgt aaactctgct
     3481 gcttcccaac actagagtgc aatgttgatg tcctagaagg gaaacgacag tttacaactg
     3541 cggccctgtt tgttacacgg tgtgtccttc gtgtcttcac tgtgctgagt aactgtgttg
     3601 agggactctg ctccttgatt tgcctttctg tgagtgtgta atcttggttt acattacata
     3661 gctgctattg cttttcattt tcccttttct actaaaatgt cttttttttt taaaggaaat
     3721 atggaacatt tagattaaat gtcttaaatt ttactactta taacactact tgccacaaaa
     3781 tatatcaggt cagtcagtac tgtattttaa aaatccctca agcaaggtat ggtggcacgc
     3841 atctctactc ccaggcagag gcagatggat ggctgtcagc ttgagttcag cctgctttcc
     3901 aggacagcca gggctatata gggagaccct gtctcaaaaa taaatcaaaa aataaaaaat
     3961 taacttaaaa ataaatttaa aaatcccttg atatgttgct ggtatagtct ctgaagcttg
     4021 cctctgaaaa cgttgagctt tgagaccagg agttcgagac tgaacaggct ctttctatta
     4081 tatcattagc tcatgagatg ccttttgaat acaaatatct tacatatcaa aaatggatct
     4141 catgttaaat ggatttggaa gtactatacc ccttctttct acttctgcac ttaaacatag
     4201 cttaatgtgc tctgctttgt tctgttatat cttcctgcta aagtaagaat tgagcagagc
     4261 taatgtcatc tttaatatta ggaaataagt ggactaagac attatagaat taaataattt
     4321 tcaaatgtta aataattgta ttgactgata aatttatagc ctctgaaaaa tgagaaaaaa
     4381 attgtgaaca ggacagatga agtataaatt taaaactaca tggttaattt tgctctgaaa
     4441 tcctataggt ggttttcacc tgttatacta aatcatacac tataatttgt ttagttagaa
     4501 atagtaaact gtttgcaagt cactagtaat tctcaaaaaa atattgttgg ccatagtgaa
     4561 taatttttaa attagaacta agtgtgtacc tatttttggc acttattttt caaataatta
     4621 agctcaatca agtatatttt aaggatctat aaaagtgaca ggaagaccgg gtgtggtggc
     4681 gcacaccttt aatcccagca cttgggaggc agaggcaggc ggatttctga gttcgaggcc
     4741 agcctggtct acaaagtgag ttccaagaca gccagggcta cacagagaaa ccttgtctcg
     4801 aaaaaccaaa aaaaaaaaaa aaaagtgaca ggaagggtct cagcacctgc atcctcagtg
     4861 cttggggcag ctgtagccgg aagcaaagac ccacaggaaa tgcagtgtct ggggatcttt
     4921 gataagtaga caagcttttg aagttctggg ttagaatctg gctggcagaa tctttggaaa
     4981 agttttatat acagatattt gtattattaa atttggagcc atagtcagaa gactcagatc
     5041 ataattggct tatttttcta tttccttaac tattgtaatt tccactttta taataatttt
     5101 gatttgaaaa ataaatttat ttattttttt aacagtcaaa atctttgctg ttgtagtctg
     5161 cagcctttaa tgattgtgtt gcttttatga ttgaaagaag cactccacaa attgaagaga
     5221 gcgtgatgca gcgaggtgta agtcgtggtt agtgacgtgt atggctcctg tgctcatcgc
     5281 tgtctctgcg aggcatctgg ctgcatctaa aggacattcg ttccaaatga aaatttgctt
     5341 ttctggcagt tttcataatg gaaaaaaaat tctcctttgt ctgagtatag aagttttaag
     5401 atgtatcatg ggtatcggtg cttgtataac acacaatgaa ttgtaactag catgttgtta
     5461 agaaaacaca ttgttagttt tttttaatct taaatgtttc ttttctattt ataatttcaa
     5521 cctttcataa agtatactaa gaatttcaca aatttctttt cagtgaactg aactcttttt
     5581 tgcaatgata ggccattaaa tatagcattc acacaaaatg gacattttta atcacctaga
     5641 atattgaaaa tattttaatt tgcagtgtct ttttttgtga ctggatatat taatgttcct
     5701 ctgagtagta ttgataattg gttcagaaga gaaactcaat gaaataagaa tagtatttat
     5761 tcatggtgat caattaaatt atttgcctaa tttaaggaaa ctaaatacta tgcataactg
     5821 aatttatttg caattctcag tttgatttga ggtaacagag gagagtctag gtctacctgt
     5881 ggaatatgtt gttttatttt cagtgtttag ggttacattt aaacatagtt ggtttgggaa
     5941 aatgacatat aattttaagt taacctgcat gctgtaaatg tgtttaaata aaggaaaatc
     6001 ttttttgaaa tgtaatgaca catttgaacc
//
