LOCUS       NM_001039000            6334 bp    mRNA    linear   ROD 08-OCT-2024
DEFINITION  Mus musculus kinesin family member 5A (Kif5a), transcript variant
            1, mRNA.
ACCESSION   NM_001039000
VERSION     NM_001039000.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6334)
  AUTHORS   Cozzi,M., Magri,S., Tedesco,B., Patelli,G., Ferrari,V.,
            Casarotto,E., Chierichetti,M., Pramaggiore,P., Cornaggia,L.,
            Piccolella,M., Galbiati,M., Rusmini,P., Crippa,V., Mandrioli,J.,
            Pareyson,D., Pisciotta,C., D'Arrigo,S., Ratti,A., Nanetti,L.,
            Mariotti,C., Sarto,E., Pensato,V., Gellera,C., Di Bella,D.,
            Cristofani,R.M., Taroni,F. and Poletti,A.
  TITLE     Altered molecular and cellular mechanisms in KIF5A-associated
            neurodegenerative or neurodevelopmental disorders
  JOURNAL   Cell Death Dis 15 (9), 692 (2024)
   PUBMED   39333504
  REMARK    GeneRIF: Altered molecular and cellular mechanisms in
            KIF5A-associated neurodegenerative or neurodevelopmental disorders.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6334)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 6334)
  AUTHORS   Rich,K.A., Pino,M.G., Yalvac,M.E., Fox,A., Harris,H., Balch,M.H.H.,
            Arnold,W.D. and Kolb,S.J.
  TITLE     Impaired motor unit recovery and maintenance in a knock-in mouse
            model of ALS-associated Kif5a variant
  JOURNAL   Neurobiol Dis 182, 106148 (2023)
   PUBMED   37164288
  REMARK    GeneRIF: Impaired motor unit recovery and maintenance in a knock-in
            mouse model of ALS-associated Kif5a variant.
REFERENCE   4  (bases 1 to 6334)
  AUTHORS   Liu,J., Ke,P., Guo,H., Gu,J., Liu,Y., Tian,X., Wang,X. and Xiao,F.
  TITLE     Activation of TLR7-mediated autophagy increases epileptic
            susceptibility via reduced KIF5A-dependent GABAA receptor transport
            in a murine model
  JOURNAL   Exp Mol Med 55 (6), 1159-1173 (2023)
   PUBMED   37258573
  REMARK    GeneRIF: Activation of TLR7-mediated autophagy increases epileptic
            susceptibility via reduced KIF5A-dependent GABAA receptor transport
            in a murine model.
REFERENCE   5  (bases 1 to 6334)
  AUTHORS   Nakano,J., Chiba,K. and Niwa,S.
  TITLE     An ALS-associated KIF5A mutant forms oligomers and aggregates and
            induces neuronal toxicity
  JOURNAL   Genes Cells 27 (6), 421-435 (2022)
   PUBMED   35430760
  REMARK    GeneRIF: An ALS-associated KIF5A mutant forms oligomers and
            aggregates and induces neuronal toxicity.
REFERENCE   6  (bases 1 to 6334)
  AUTHORS   Wordeman,L. and Mitchison,T.J.
  TITLE     Identification and partial characterization of mitotic
            centromere-associated kinesin, a kinesin-related protein that
            associates with centromeres during mitosis
  JOURNAL   J Cell Biol 128 (1-2), 95-104 (1995)
   PUBMED   7822426
REFERENCE   7  (bases 1 to 6334)
  AUTHORS   Nangaku,M., Sato-Yoshitake,R., Okada,Y., Noda,Y., Takemura,R.,
            Yamazaki,H. and Hirokawa,N.
  TITLE     KIF1B, a novel microtubule plus end-directed monomeric motor
            protein for transport of mitochondria
  JOURNAL   Cell 79 (7), 1209-1220 (1994)
   PUBMED   7528108
REFERENCE   8  (bases 1 to 6334)
  AUTHORS   Aizawa,H., Sekine,Y., Takemura,R., Zhang,Z., Nangaku,M. and
            Hirokawa,N.
  TITLE     Kinesin family in murine central nervous system
  JOURNAL   J Cell Biol 119 (5), 1287-1296 (1992)
   PUBMED   1447303
REFERENCE   9  (bases 1 to 6334)
  AUTHORS   Justice,M.J., Gilbert,D.J., Kinzler,K.W., Vogelstein,B.,
            Buchberg,A.M., Ceci,J.D., Matsuda,Y., Chapman,V.M., Patriotis,C.,
            Makris,A. et al.
  TITLE     A molecular genetic linkage map of mouse chromosome 18 reveals
            extensive linkage conservation with human chromosomes 5 and 18
  JOURNAL   Genomics 13 (4), 1281-1288 (1992)
   PUBMED   1354644
REFERENCE   10 (bases 1 to 6334)
  AUTHORS   Navone,F., Niclas,J., Hom-Booher,N., Sparks,L., Bernstein,H.D.,
            McCaffrey,G. and Vale,R.D.
  TITLE     Cloning and expression of a human kinesin heavy chain gene:
            interaction of the COOH-terminal domain with cytoplasmic
            microtubules in transfected CV-1 cells
  JOURNAL   J Cell Biol 117 (6), 1263-1275 (1992)
   PUBMED   1607388
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK140769.1, BC058396.1, AK147707.1 and BC028563.1.
            
            On Apr 21, 2010 this sequence version replaced NM_001039000.3.
            
            Transcript Variant: This variant (1) represents the longer and the
            predominant transcript. Variants 1 and 2 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK220479.1, SRR1660813.12244.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164132 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1506              AK140769.1         2-1507
            1507-3584           BC058396.1         1224-3301
            3585-6307           AK147707.1         3316-6038
            6308-6334           BC028563.1         452-478
FEATURES             Location/Qualifiers
     source          1..6334
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 74.5 cM"
     gene            1..6334
                     /gene="Kif5a"
                     /gene_synonym="D10Bwg0738e; Khc; Kif5; Kns; mKIAA4086"
                     /note="kinesin family member 5A"
                     /db_xref="GeneID:16572"
                     /db_xref="MGI:MGI:109564"
     exon            1..596
                     /gene="Kif5a"
                     /gene_synonym="D10Bwg0738e; Khc; Kif5; Kns; mKIAA4086"
                     /inference="alignment:Splign:2.1.0"
     CDS             468..3551
                     /gene="Kif5a"
                     /gene_synonym="D10Bwg0738e; Khc; Kif5; Kns; mKIAA4086"
                     /note="NKHC; neuronal kinesin heavy chain; kinesin heavy
                     chain neuron-specific 1"
                     /codon_start=1
                     /product="kinesin heavy chain isoform 5A"
                     /protein_id="NP_001034089.1"
                     /db_xref="CCDS:CCDS24233.1"
                     /db_xref="GeneID:16572"
                     /db_xref="MGI:MGI:109564"
                     /translation="MAETNNECSIKVLCRFRPLNQAEILRGDKFIPIFQGDDSVIIGG
                     KPYVFDRVFPPNTTQEQVYHACAMQIVKDVLAGYNGTIFAYGQTSSGKTHTMEGKLHD
                     PQLMGIIPRIARDIFNHIYSMDENLEFHIKVSYFEIYLDKIRDLLDVTKTNLSVHEDK
                     NRVPFVKGCTERFVSSPEEILDVIDEGKSNRHVAVTNMNEHSSRSHSIFLINIKQENV
                     ETEQKLSGKLYLVDLAGSEKVSKTGAEGAVLDEAKNINKSLSALGNVISALAEGTKSY
                     VPYRDSKMTRILQDSLGGNCRTTMFICCSPSSYNDAETKSTLMFGQRAKTIKNTASVN
                     LELTAEQWKKKYEKEKEKTKAQKETIAKLEAELSRWRNGENVPETERLAGEDSALGAE
                     LCEETPVNDNSSIVVRIAPEERQKYEEEIRRLYKQLDDKDDEINQQSQLIEKLKQQML
                     DQEELLVSTRGDNEKVQRELSHLQSENDAAKDEVKEVLQALEELAVNYDQKSQEVEEK
                     SQQNQLLVDELSQKVATMLSLESELQRLQEVSGHQRKRIAEVLNGLMRDLSEFSVIVG
                     NGEIKLPVEISGAIEEEFTVARLYISKIKSEVKSVVKRCRQLENLQVECHRKMEVTGR
                     ELSSCQLLISQHEAKIRSLTEYMQTVELKKRHLEESYDSLSDELARLQAHETVHEVAL
                     KDKEPDTQDAEEVKKALELQMENHREAHHRQLARLRDEINEKQKTIDELKDLNQKLQL
                     ELEKLQADYERLKNEENEKSAKLQELTFLYERHEQSKQDLKGLEETVARELQTLHNLR
                     KLFVQDVTTRVKKSAEMEPEDSGGIHSQKQKISFLENNLEQLTKVHKQLVRDNADLRC
                     ELPKLEKRLRATAERVKALEGALKEAKEGAMKDKRRYQQEVDRIKEAVRYKSSGKRGH
                     SAQIAKPVRPGHYPASSPTNPYGTRSPECISYTNNLFQNYQNLHLQAAPSSTSDMYFA
                     SSGATSVAPLASYQKANMDNGNATDINDNRSDLPCGYEAEDQAKLFPLHQETAAS"
     exon            597..684
                     /gene="Kif5a"
                     /gene_synonym="D10Bwg0738e; Khc; Kif5; Kns; mKIAA4086"
                     /inference="alignment:Splign:2.1.0"
     exon            685..758
                     /gene="Kif5a"
                     /gene_synonym="D10Bwg0738e; Khc; Kif5; Kns; mKIAA4086"
                     /inference="alignment:Splign:2.1.0"
     exon            759..863
                     /gene="Kif5a"
                     /gene_synonym="D10Bwg0738e; Khc; Kif5; Kns; mKIAA4086"
                     /inference="alignment:Splign:2.1.0"
     exon            864..912
                     /gene="Kif5a"
                     /gene_synonym="D10Bwg0738e; Khc; Kif5; Kns; mKIAA4086"
                     /inference="alignment:Splign:2.1.0"
     exon            913..968
                     /gene="Kif5a"
                     /gene_synonym="D10Bwg0738e; Khc; Kif5; Kns; mKIAA4086"
                     /inference="alignment:Splign:2.1.0"
     exon            969..1056
                     /gene="Kif5a"
                     /gene_synonym="D10Bwg0738e; Khc; Kif5; Kns; mKIAA4086"
                     /inference="alignment:Splign:2.1.0"
     exon            1057..1181
                     /gene="Kif5a"
                     /gene_synonym="D10Bwg0738e; Khc; Kif5; Kns; mKIAA4086"
                     /inference="alignment:Splign:2.1.0"
     exon            1182..1286
                     /gene="Kif5a"
                     /gene_synonym="D10Bwg0738e; Khc; Kif5; Kns; mKIAA4086"
                     /inference="alignment:Splign:2.1.0"
     exon            1287..1435
                     /gene="Kif5a"
                     /gene_synonym="D10Bwg0738e; Khc; Kif5; Kns; mKIAA4086"
                     /inference="alignment:Splign:2.1.0"
     exon            1436..1584
                     /gene="Kif5a"
                     /gene_synonym="D10Bwg0738e; Khc; Kif5; Kns; mKIAA4086"
                     /inference="alignment:Splign:2.1.0"
     exon            1585..1760
                     /gene="Kif5a"
                     /gene_synonym="D10Bwg0738e; Khc; Kif5; Kns; mKIAA4086"
                     /inference="alignment:Splign:2.1.0"
     exon            1761..1829
                     /gene="Kif5a"
                     /gene_synonym="D10Bwg0738e; Khc; Kif5; Kns; mKIAA4086"
                     /inference="alignment:Splign:2.1.0"
     exon            1830..2036
                     /gene="Kif5a"
                     /gene_synonym="D10Bwg0738e; Khc; Kif5; Kns; mKIAA4086"
                     /inference="alignment:Splign:2.1.0"
     exon            2037..2183
                     /gene="Kif5a"
                     /gene_synonym="D10Bwg0738e; Khc; Kif5; Kns; mKIAA4086"
                     /inference="alignment:Splign:2.1.0"
     exon            2184..2372
                     /gene="Kif5a"
                     /gene_synonym="D10Bwg0738e; Khc; Kif5; Kns; mKIAA4086"
                     /inference="alignment:Splign:2.1.0"
     exon            2373..2490
                     /gene="Kif5a"
                     /gene_synonym="D10Bwg0738e; Khc; Kif5; Kns; mKIAA4086"
                     /inference="alignment:Splign:2.1.0"
     exon            2491..2555
                     /gene="Kif5a"
                     /gene_synonym="D10Bwg0738e; Khc; Kif5; Kns; mKIAA4086"
                     /inference="alignment:Splign:2.1.0"
     exon            2556..2665
                     /gene="Kif5a"
                     /gene_synonym="D10Bwg0738e; Khc; Kif5; Kns; mKIAA4086"
                     /inference="alignment:Splign:2.1.0"
     exon            2666..2767
                     /gene="Kif5a"
                     /gene_synonym="D10Bwg0738e; Khc; Kif5; Kns; mKIAA4086"
                     /inference="alignment:Splign:2.1.0"
     exon            2768..2828
                     /gene="Kif5a"
                     /gene_synonym="D10Bwg0738e; Khc; Kif5; Kns; mKIAA4086"
                     /inference="alignment:Splign:2.1.0"
     exon            2829..2900
                     /gene="Kif5a"
                     /gene_synonym="D10Bwg0738e; Khc; Kif5; Kns; mKIAA4086"
                     /inference="alignment:Splign:2.1.0"
     exon            2901..3005
                     /gene="Kif5a"
                     /gene_synonym="D10Bwg0738e; Khc; Kif5; Kns; mKIAA4086"
                     /inference="alignment:Splign:2.1.0"
     exon            3006..3222
                     /gene="Kif5a"
                     /gene_synonym="D10Bwg0738e; Khc; Kif5; Kns; mKIAA4086"
                     /inference="alignment:Splign:2.1.0"
     exon            3223..3376
                     /gene="Kif5a"
                     /gene_synonym="D10Bwg0738e; Khc; Kif5; Kns; mKIAA4086"
                     /inference="alignment:Splign:2.1.0"
     exon            3377..3444
                     /gene="Kif5a"
                     /gene_synonym="D10Bwg0738e; Khc; Kif5; Kns; mKIAA4086"
                     /inference="alignment:Splign:2.1.0"
     exon            3445..3472
                     /gene="Kif5a"
                     /gene_synonym="D10Bwg0738e; Khc; Kif5; Kns; mKIAA4086"
                     /inference="alignment:Splign:2.1.0"
     exon            3473..3584
                     /gene="Kif5a"
                     /gene_synonym="D10Bwg0738e; Khc; Kif5; Kns; mKIAA4086"
                     /inference="alignment:Splign:2.1.0"
     exon            3585..6311
                     /gene="Kif5a"
                     /gene_synonym="D10Bwg0738e; Khc; Kif5; Kns; mKIAA4086"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6290..6295
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Kif5a"
                     /gene_synonym="D10Bwg0738e; Khc; Kif5; Kns; mKIAA4086"
                     /note="hexamer: AATAAA"
     polyA_site      6311
                     /gene="Kif5a"
                     /gene_synonym="D10Bwg0738e; Khc; Kif5; Kns; mKIAA4086"
                     /note="major polyA site"
ORIGIN      
        1 attcctgtag gtggagtcta aggaggaaca gacaggtcgc gtgtagcaaa gtgagctgtg
       61 tggggaaggg gtgaggacaa ggttatttgc gagcctccaa atcaaggaac caggtgagcc
      121 taagccaaac tccacctttg ggtggtcgca gttcggagga tcacctcctg cgaaggaaac
      181 cccgcccccg cggctccggc gcgccccgcc caggcccgca gcgcggctgc agcgcgaggg
      241 gcggagaggc acagcgcggc gagaggacca gacgcccagg tcgcccgcat ccagtgccgc
      301 aggacaccga aagctcatct tccccgaggc gttccagctg ctcccttggc ctcagcgaca
      361 gatcacctgt ccactgcctc gacctcagcc cagcgtcccc ttcctccgga gtacacgcta
      421 cccttgcagt cggagacgct cccagcccct cgtcgtcgtc gaccaccatg gcggagacta
      481 acaacgaatg cagcatcaag gtgctttgcc gatttcggcc cctgaaccag gccgagattc
      541 tgcgggggga caagttcatc cccattttcc aaggggacga cagcgtcatt attgggggaa
      601 agccatatgt ctttgaccgc gtcttccccc caaacaccac tcaggagcag gtttaccacg
      661 cctgtgccat gcagatcgtc aaagacgtcc ttgctggtta caatggcaca atcttcgctt
      721 atggacagac atcctcaggg aaaacgcata ccatggaggg gaagctgcac gaccctcagc
      781 tgatgggcat cattccccgg atcgctcgag acatcttcaa ccacatctac tccatggatg
      841 agaaccttga attccacatt aaggtatctt acttcgagat ttacctggat aagatccgtg
      901 accttttgga tgtgaccaag acgaacctgt ccgtgcatga ggacaaaaac cgggtgccgt
      961 ttgtcaaggg ttgtaccgaa cgctttgtgt ccagcccaga ggagattctg gatgtgatcg
     1021 atgaggggaa gtccaaccgt cacgtagctg tcaccaacat gaacgagcac agttctcgga
     1081 gccacagcat cttcctcatc aacatcaagc aggagaacgt agagaccgag cagaagctca
     1141 gcgggaagct gtacctcgtg gatctggccg gaagcgagaa ggtcagcaag acaggggcag
     1201 agggagccgt tctggacgag gcaaagaata tcaacaagtc gctgtcggcc ctggggaacg
     1261 tgatctctgc actggcagag ggcaccaaaa gctacgtgcc gtaccgcgac agcaaaatga
     1321 cgaggattct ccaggactct ctgggaggga actgcaggac taccatgttc atctgctgct
     1381 cgccgtccag ctacaatgac gcagagacca agtccacgct catgtttgga cagcgggcga
     1441 agaccatcaa gaacactgcc tcagtgaatc tggagctgac tgctgagcag tggaagaaga
     1501 agtatgagaa ggagaaggag aagaccaagg cccagaagga gacaattgcg aagctagagg
     1561 ctgagcttag ccggtggcgc aatggagaga atgtgcctga gactgagcgc ctggctggag
     1621 aggactcagc tctgggagct gagctctgcg aggagacccc tgtgaatgac aactcatcca
     1681 ttgtggtacg catcgcacct gaggaaaggc agaaatatga ggaagagatc cgccgtctct
     1741 acaagcagct tgatgacaag gatgatgaga tcaaccagca gagccagctc attgagaagc
     1801 tgaagcagca gatgctggac caggaagagc tgctcgtgtc cactcgggga gacaacgaga
     1861 aggtccagcg ggagcttagc cacctgcagt ccgagaacga tgctgcgaag gacgaggtga
     1921 aggaagtgct gcaggcccta gaggagctgg cggtcaacta cgaccagaag tcccaggagg
     1981 tggaggagaa gagccagcag aaccagctgc tggtggacga gctgtcccag aaagtggcca
     2041 ccatgctgtc cctggagtcc gagctacagc ggctccagga ggtcagtgga caccagcgaa
     2101 agcggatcgc tgaggtgctg aatgggctga tgagggacct gagtgagttc agtgtcatcg
     2161 tgggcaacgg cgagattaag ctgcccgtgg agatcagtgg ggccatcgag gaggagttca
     2221 cggtggcccg gctctacatc agcaagatca agtcggaggt gaagtccgtg gttaagcgat
     2281 gtcggcagct ggagaacctc caggtggagt gtcatcgcaa gatggaggtg accggtaggg
     2341 agctgtcatc ttgccaactg ctcatctcac agcatgaggc caagatccgt tcactcacgg
     2401 agtacatgca gactgtggag ttgaagaaac ggcacctgga agagtcctac gactccctga
     2461 gcgatgagct tgccaggctc caggcgcacg aaactgtaca cgaggtagct ctgaaagaca
     2521 aggagccaga cacacaggac gcggaggagg tgaagaaggc cctggaacta cagatggaga
     2581 atcaccgtga ggcccatcac cggcagctgg cccgcctccg ggatgagatt aatgagaaac
     2641 agaaaaccat tgatgagctg aaagacctga accagaagct ccagttagag ctggagaagc
     2701 ttcaggccga ctatgagagg ctgaagaatg aagagaacga gaagagcgcc aagctccagg
     2761 agctgacatt tctgtatgag cgacatgagc agtccaagca ggacctcaag gggctggagg
     2821 agacagttgc ccgtgaactc cagaccctcc acaaccttcg caagctgttc gttcaagacg
     2881 tcacgactcg agtcaagaaa agtgcagaaa tggagcccga ggacagtggg gggattcatt
     2941 cccaaaagca gaagatctcc tttcttgaga acaacctgga acagcttaca aaggttcaca
     3001 aacagctggt acgtgacaat gcagatctgc gttgtgagct tcctaaattg gaaaaacgac
     3061 ttcgggctac ggctgagaga gttaaggccc tggagggtgc actgaaggag gccaaggagg
     3121 gcgctatgaa ggacaagcgt agataccagc aggaggtgga ccgcatcaaa gaagccgtgc
     3181 ggtacaagag ctccggcaag cggggccatt ctgcccagat cgctaagcct gtgaggcctg
     3241 gccactatcc tgcctcctca cccaccaacc cctacggcac ccggagcccc gagtgtatca
     3301 gctacaccaa caacctcttc cagaactacc agaacctgca cctgcaggct gcgcctagct
     3361 ccacttcaga tatgtacttt gccagcagcg gagccacatc tgttgccccc ttggcttcct
     3421 accagaaggc caacatggac aatggaaatg ccacagatat caacgacaac aggagtgacc
     3481 tgccgtgtgg ctatgaggct gaggaccagg ccaagctttt ccctctccac caagagacag
     3541 cagccagcta actcccaacc ctggccacat atctgcactt tcagtttcta agagggactg
     3601 aggcctcttc tctcagcatg ctgcaaaacc tgtggtctct gacactaact ccctccccag
     3661 cccgtgatgt tggactgttt gatgtctcct cctattccgt atctctttgt actctgtatc
     3721 tatctatcag aagctgctgc tgtctctcct ctctgtcctc ccctctaagt atctgatgat
     3781 gtatttagca gtttttaagc atagtctccc ttcctcgttg ggcgttaggg aggagggaat
     3841 atttcttctt tcttccatag actcgtttct tacaccgagt gatgtcagtc actgagtaga
     3901 ggtcacaaaa gataaaggaa aaatgggagc ggggaggctg cccttcttct ctctcacaaa
     3961 cacacgtgta cacgcacaca cgcatgcaca cacagtgtac atacaaagcc ttaagcagag
     4021 gaatgtctta gcatctacga aaagagagaa atagacccct tccctcttta cacagaacac
     4081 agaggaggcc ccagtggaag gttgcgacac cgctctctcc ctcacacata cgcatccctc
     4141 accggagtca gcacactgga ggcggtctcc tctgccctgt gaggtctgcc ttgtgctccc
     4201 ttccctggtt ggagagcatg gactactcaa gggactgttt ccctttctgg cccaagcctc
     4261 ttgtactttc cactccagat atcacaacca gaacttagag ttggtttaaa acatcttctg
     4321 aaaattcgag aaggcggact gctgagaaac cgctgctcac ctgtctgtgc caatagttat
     4381 acgcaggtgg agtcagaatg gttggctccc tggctctggg gagtgagcag gctgagggac
     4441 tactgtgtgc tactctgtca cagaaccctc aggttgaagc tccaagctcg ttctttctcc
     4501 catattgggc tgtgtgtgct tcccactcct gactttggtt tggggcttcc ggtttgttgg
     4561 cataatcgcc gtctctagat gccgtccctt cagaatggaa tctggcctgt tcccagtata
     4621 ccttcctccc ccaaacacag ttccttctgt aatctccatc tggtcccaag tgcactttaa
     4681 agacaggggt gggggagcag gttggagcat ggtggcaggc ggcctccctg acacaggaaa
     4741 aagctctgct gttgatccca gcactgcaaa agcaaaaaag cagaagctgg gtgtagtggc
     4801 tcacactttc gaatgttgct ctcaggaagc cgaggtagga aaattgctaa atttgaggct
     4861 atcctggact acacagttag atccaggaga gcttgtacta tgacgggagg aaatcctatc
     4921 tcagaatgaa ggaaagggaa gaaggaagag gaaggaagga aggaaggaaa agtaaggaaa
     4981 gggaggaagg aaggaaagaa aggaaggaag ggaggaaagg aaggaagtgg ggacaggaca
     5041 gtttttttcc gaactggcag gggctaagag catgaaatta atgctttccc cactgccatc
     5101 tcagctcagg tcccctcctg cccagcactg aagaggacgg acgttgcttt agttcagatg
     5161 gtcctgtcct cccatctgct aaggtatttt tccagacagc tgcagggatg aaggtcagta
     5221 ctcagcctaa gccaagaaaa acagttgagt atccagatac ccagtccatc ccaggatggg
     5281 agaccagggc tctccaacag agggcagcct gctgtccaga ccctgctagg cctgggagga
     5341 aaactccctg tgggtgacag ctggcaacta tgagctgtag tggctgtgac tccctcaagg
     5401 gaccgtttct gctctgtagg gagtgattga gatgaagaca gtatcagact ggcatgggag
     5461 aactcccaag tgacaatttt caaacacttc agaataaatc tgatgactaa gcagaaccta
     5521 gggctttgac catggcttag tggtaccatg cgaagacact tagtgtgaca agtctgaggg
     5581 ttcagtctat ctctggaacc gcaaacaaca cgaaacaacc aaaatggtaa agtaattcag
     5641 agcgaggaac gtttgttata atttctttct tttcataccc cctcacagtg gaaaatgctt
     5701 cattcattgg agggtcctga gatagcccta agagcttaga actcactcat ttgccagagg
     5761 ggtccagtct gctccccccc cccacacaca cacacactct ctaaaaccac aactcaaaag
     5821 aaaggtcagg aggtgcagac aaatcgcaca cctcagacac agtgggcaag gaaggaaaag
     5881 ggtgttccct gtggctcatg ctggcaggat gaggatgctt gggattctga gggagtttgc
     5941 atgatcttgt caccaaacga tccttttcaa aatacaagtg aggagatgtg gaggcgtgca
     6001 gcagagcaga tgaggagggg ggcggcagtg gccagccttc cctcctcggc aagatgtaag
     6061 ggacacggcc atttgctatg ctaaagaaac agcccttcac cggaaggttc tcaccacatc
     6121 ctccccctta ccttcactac atccctttca gagagccagg ccaccaccag ggcccctggc
     6181 ccgcccactt acatctgcca aagtgaaatg ttgcatgccg gcgtggaaga caaaaccaaa
     6241 ccgcacaaat cccagtgtgt atttacttgg tggacacaaa tatctttaaa ataaaataac
     6301 ttcgatgacg aaaaaaaaaa aaaaaaaaaa aaaa
//
