LOCUS       NM_008446               4691 bp    mRNA    linear   ROD 12-JUN-2024
DEFINITION  Mus musculus kinesin family member 4 (Kif4), mRNA.
ACCESSION   NM_008446 XM_982929
VERSION     NM_008446.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4691)
  AUTHORS   Wan,Y., Morikawa,M., Morikawa,M., Iwata,S., Naseer,M.I., Ahmed
            Chaudhary,A.G., Tanaka,Y. and Hirokawa,N.
  TITLE     KIF4 regulates neuronal morphology and seizure susceptibility via
            the PARP1 signaling pathway
  JOURNAL   J Cell Biol 222 (2) (2023)
   PUBMED   36482480
  REMARK    GeneRIF: KIF4 regulates neuronal morphology and seizure
            susceptibility via the PARP1 signaling pathway.
REFERENCE   2  (bases 1 to 4691)
  AUTHORS   He,P., Liu,F., Wang,Z., Gong,H., Zhang,M., Jia,Z. and Zhai,X.
  TITLE     CircKIF4A enhances osteosarcoma proliferation and metastasis by
            sponging MiR-515-5p and upregulating SLC7A11
  JOURNAL   Mol Biol Rep 49 (6), 4525-4535 (2022)
   PUBMED   35579738
  REMARK    GeneRIF: CircKIF4A enhances osteosarcoma proliferation and
            metastasis by sponging MiR-515-5p and upregulating SLC7A11.
REFERENCE   3  (bases 1 to 4691)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4691)
  AUTHORS   Gowans,L.J.J., Cameron-Christie,S., Slayton,R.L., Busch,T.,
            Romero-Bustillos,M., Eliason,S., Sweat,M., Sobreira,N., Yu,W.,
            Kantaputra,P.N., Wohler,E., Adeyemo,W.L., Lachke,S.A., Anand,D.,
            Campbell,C., Drummond,B.K., Markie,D.M., van Vuuren,W.J., van
            Vuuren,L.J., Casamassimo,P.S., Ettinger,R., Owais,A., van
            Staden,I., Amendt,B.A., Adeyemo,A.A., Murray,J.C., Robertson,S.P.
            and Butali,A.
  TITLE     Missense Pathogenic variants in KIF4A Affect Dental Morphogenesis
            Resulting in X-linked Taurodontism, Microdontia and
            Dens-Invaginatus
  JOURNAL   Front Genet 10, 800 (2019)
   PUBMED   31616463
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4691)
  AUTHORS   Luan,Y.J., Liu,S.H., Sun,Y.G., Qu,X., Wei,F.C., Xu,Y. and Yang,P.S.
  TITLE     Whole genome expression microarray reveals novel roles for Kif4 in
            monocyte/macrophage cells
  JOURNAL   Eur Rev Med Pharmacol Sci 23 (16), 7016-7023 (2019)
   PUBMED   31486502
  REMARK    GeneRIF: Whole genome expression microarray reveals novel roles for
            Kif4 in monocyte/macrophage cells.
REFERENCE   6  (bases 1 to 4691)
  AUTHORS   Oh,S., Hahn,H., Torrey,T.A., Shin,H., Choi,W., Lee,Y.M., Morse,H.C.
            and Kim,W.
  TITLE     Identification of the human homologue of mouse KIF4, a kinesin
            superfamily motor protein
  JOURNAL   Biochim Biophys Acta 1493 (1-2), 219-224 (2000)
   PUBMED   10978527
REFERENCE   7  (bases 1 to 4691)
  AUTHORS   Kim,W., Tang,Y., Okada,Y., Torrey,T.A., Chattopadhyay,S.K.,
            Pfleiderer,M., Falkner,F.G., Dorner,F., Choi,W., Hirokawa,N. and
            Morse,H.C. 3rd.
  TITLE     Binding of murine leukemia virus Gag polyproteins to KIF4, a
            microtubule-based motor protein
  JOURNAL   J Virol 72 (8), 6898-6901 (1998)
   PUBMED   9658142
REFERENCE   8  (bases 1 to 4691)
  AUTHORS   Lyu,M.S., Kim,W., Morse,H.C. 3rd and Kozak,C.A.
  TITLE     Genetic mapping in the mouse of Kif4, a gene encoding a
            kinesin-like motor protein
  JOURNAL   Mamm Genome 8 (7), 541 (1997)
   PUBMED   9196009
REFERENCE   9  (bases 1 to 4691)
  AUTHORS   Sekine,Y., Okada,Y., Noda,Y., Kondo,S., Aizawa,H., Takemura,R. and
            Hirokawa,N.
  TITLE     A novel microtubule-based motor protein (KIF4) for organelle
            transports, whose expression is regulated developmentally
  JOURNAL   J Cell Biol 127 (1), 187-201 (1994)
   PUBMED   7929562
REFERENCE   10 (bases 1 to 4691)
  AUTHORS   Aizawa,H., Sekine,Y., Takemura,R., Zhang,Z., Nangaku,M. and
            Hirokawa,N.
  TITLE     Kinesin family in murine central nervous system
  JOURNAL   J Cell Biol 119 (5), 1287-1296 (1992)
   PUBMED   1447303
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BX276129.7 and BX005480.12.
            
            On Jan 28, 2022 this sequence version replaced NM_008446.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC050946.1, AK171938.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849383, SAMN01164131
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-502               BX276129.7         18506-19007
            503-617             BX276129.7         19123-19237
            618-808             BX276129.7         26258-26448
            809-901             BX276129.7         28103-28195
            902-1068            BX276129.7         30703-30869
            1069-1163           BX276129.7         31096-31190
            1164-1280           BX276129.7         57155-57271
            1281-1456           BX276129.7         58092-58267
            1457-1518           BX276129.7         62328-62389
            1519-1651           BX276129.7         69706-69838
            1652-1710           BX276129.7         72265-72323
            1711-1816           BX276129.7         72428-72533
            1817-1873           BX005480.12        5859-5915
            1874-2059           BX005480.12        7315-7500
            2060-2163           BX005480.12        11672-11775
            2164-2308           BX005480.12        12799-12943
            2309-2419           BX005480.12        14232-14342
            2420-2503           BX005480.12        20843-20926
            2504-2617           BX005480.12        21591-21704
            2618-2773           BX005480.12        28593-28748
            2774-2874           BX005480.12        28863-28963
            2875-3004           BX005480.12        30679-30808
            3005-3175           BX005480.12        32382-32552
            3176-3283           BX005480.12        33072-33179
            3284-3361           BX005480.12        34132-34209
            3362-3460           BX005480.12        34738-34836
            3461-3637           BX005480.12        35295-35471
            3638-3754           BX005480.12        41443-41559
            3755-3877           BX005480.12        42929-43051
            3878-4691           BX005480.12        43260-44073
FEATURES             Location/Qualifiers
     source          1..4691
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 43.72 cM"
     gene            1..4691
                     /gene="Kif4"
                     /gene_synonym="D330050K22Rik; Kns4"
                     /note="kinesin family member 4"
                     /db_xref="GeneID:16571"
                     /db_xref="MGI:MGI:108389"
     exon            1..502
                     /gene="Kif4"
                     /gene_synonym="D330050K22Rik; Kns4"
                     /inference="alignment:Splign:2.1.0"
     exon            503..617
                     /gene="Kif4"
                     /gene_synonym="D330050K22Rik; Kns4"
                     /inference="alignment:Splign:2.1.0"
     exon            618..808
                     /gene="Kif4"
                     /gene_synonym="D330050K22Rik; Kns4"
                     /inference="alignment:Splign:2.1.0"
     exon            809..901
                     /gene="Kif4"
                     /gene_synonym="D330050K22Rik; Kns4"
                     /inference="alignment:Splign:2.1.0"
     exon            902..1068
                     /gene="Kif4"
                     /gene_synonym="D330050K22Rik; Kns4"
                     /inference="alignment:Splign:2.1.0"
     exon            1069..1163
                     /gene="Kif4"
                     /gene_synonym="D330050K22Rik; Kns4"
                     /inference="alignment:Splign:2.1.0"
     exon            1164..1280
                     /gene="Kif4"
                     /gene_synonym="D330050K22Rik; Kns4"
                     /inference="alignment:Splign:2.1.0"
     exon            1281..1456
                     /gene="Kif4"
                     /gene_synonym="D330050K22Rik; Kns4"
                     /inference="alignment:Splign:2.1.0"
     exon            1457..1518
                     /gene="Kif4"
                     /gene_synonym="D330050K22Rik; Kns4"
                     /inference="alignment:Splign:2.1.0"
     exon            1519..1651
                     /gene="Kif4"
                     /gene_synonym="D330050K22Rik; Kns4"
                     /inference="alignment:Splign:2.1.0"
     exon            1652..1710
                     /gene="Kif4"
                     /gene_synonym="D330050K22Rik; Kns4"
                     /inference="alignment:Splign:2.1.0"
     exon            1711..1816
                     /gene="Kif4"
                     /gene_synonym="D330050K22Rik; Kns4"
                     /inference="alignment:Splign:2.1.0"
     exon            1817..1873
                     /gene="Kif4"
                     /gene_synonym="D330050K22Rik; Kns4"
                     /inference="alignment:Splign:2.1.0"
     exon            1874..2059
                     /gene="Kif4"
                     /gene_synonym="D330050K22Rik; Kns4"
                     /inference="alignment:Splign:2.1.0"
     exon            2060..2163
                     /gene="Kif4"
                     /gene_synonym="D330050K22Rik; Kns4"
                     /inference="alignment:Splign:2.1.0"
     exon            2164..2308
                     /gene="Kif4"
                     /gene_synonym="D330050K22Rik; Kns4"
                     /inference="alignment:Splign:2.1.0"
     exon            2309..2419
                     /gene="Kif4"
                     /gene_synonym="D330050K22Rik; Kns4"
                     /inference="alignment:Splign:2.1.0"
     exon            2420..2503
                     /gene="Kif4"
                     /gene_synonym="D330050K22Rik; Kns4"
                     /inference="alignment:Splign:2.1.0"
     exon            2504..2617
                     /gene="Kif4"
                     /gene_synonym="D330050K22Rik; Kns4"
                     /inference="alignment:Splign:2.1.0"
     exon            2618..2773
                     /gene="Kif4"
                     /gene_synonym="D330050K22Rik; Kns4"
                     /inference="alignment:Splign:2.1.0"
     exon            2774..2874
                     /gene="Kif4"
                     /gene_synonym="D330050K22Rik; Kns4"
                     /inference="alignment:Splign:2.1.0"
     exon            2875..3004
                     /gene="Kif4"
                     /gene_synonym="D330050K22Rik; Kns4"
                     /inference="alignment:Splign:2.1.0"
     exon            3005..3175
                     /gene="Kif4"
                     /gene_synonym="D330050K22Rik; Kns4"
                     /inference="alignment:Splign:2.1.0"
     exon            3176..3283
                     /gene="Kif4"
                     /gene_synonym="D330050K22Rik; Kns4"
                     /inference="alignment:Splign:2.1.0"
     exon            3284..3361
                     /gene="Kif4"
                     /gene_synonym="D330050K22Rik; Kns4"
                     /inference="alignment:Splign:2.1.0"
     exon            3362..3460
                     /gene="Kif4"
                     /gene_synonym="D330050K22Rik; Kns4"
                     /inference="alignment:Splign:2.1.0"
     exon            3461..3637
                     /gene="Kif4"
                     /gene_synonym="D330050K22Rik; Kns4"
                     /inference="alignment:Splign:2.1.0"
     exon            3638..3754
                     /gene="Kif4"
                     /gene_synonym="D330050K22Rik; Kns4"
                     /inference="alignment:Splign:2.1.0"
     exon            3755..3877
                     /gene="Kif4"
                     /gene_synonym="D330050K22Rik; Kns4"
                     /inference="alignment:Splign:2.1.0"
     exon            3878..4691
                     /gene="Kif4"
                     /gene_synonym="D330050K22Rik; Kns4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4611..4616
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Kif4"
                     /gene_synonym="D330050K22Rik; Kns4"
                     /note="hexamer: AATAAA"
     polyA_site      4633
                     /gene="Kif4"
                     /gene_synonym="D330050K22Rik; Kns4"
                     /note="major polyA site"
     regulatory      4666..4671
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Kif4"
                     /gene_synonym="D330050K22Rik; Kns4"
                     /note="hexamer: AATAAA"
     polyA_site      4672
                     /gene="Kif4"
                     /gene_synonym="D330050K22Rik; Kns4"
     polyA_site      4691
                     /gene="Kif4"
                     /gene_synonym="D330050K22Rik; Kns4"
ORIGIN      
        1 gaaacttggc ggttaaagct ccggttggaa cagggcgcca gggaaggtcg gtgagaggga
       61 cgtttagttt ggtgagttac ccgggcaccg cgttagctcc gattctgcgc tttggagcac
      121 tttagggctt ggggtcgcgg ttgctgtctc tgctggagtt tccttattgc tgacgccgct
      181 tcgccctgca gtattgggac tgacaaacct ttaggcggtg gccaagagtg acaggacacc
      241 gtgatcccgc tgggagggag agtgcatcag cgagttccga gctctcccac cgcctgagaa
      301 gggcctttcc actcctgcca gcctccgggg gctcctggga gagccggctt cacccagcac
      361 ggacacctgc tgagctggta ccatgaaaga agaggtgaag gggattcccg taagagtggc
      421 actgcgttgt cgccccctcg tctcgaaaga gattaaggag ggctgccaga cgtgcctttc
      481 ctttgtgccc ggagagcctc aggtggtggt tggtaatgat aaatcattta cctacgattt
      541 tgtgtttgac ccctctactg aacaggaaga ggtctttaat acagcagtag ctccactcat
      601 aaaaggcgtg tttaaaggat acaatgcaac tgtcctggcc tatgggcaga ctggatctgg
      661 aaaaacgtat tcaatgggag gtgcatacac tgcagaacaa gaacatgact cagccattgg
      721 ggttattccc agggtaatac aactgctctt caaagaaatt aataaaaaga gtgacttcga
      781 atttactctg aaagtgtctt acttggagat ctataatgaa gaaattttgg accttctatg
      841 ttcatctcgt gagaaagcta ctcaaataaa tatccgggag gaccctaagg aaggcataaa
      901 gattgtggga ctgacagaga agactgtgct ggtggcctcg gacaccgttt cctgtctaga
      961 gcagggtaac aactccagga ctgtggcctc cacagctatg aactcccagt catctcgatc
     1021 tcatgccatc tttacaatct ccattgagca aaggaagaag aatgacaaaa atagcagctt
     1081 tcgttccaag ctgcatcttg tagacctcgc tggatcagaa agacagaaga aaaccaaggc
     1141 tgagggagat cgactgagag agggtattaa tattaatcga ggccttctgt gcttggggaa
     1201 tgtaatcagt gctcttggag atgataaaaa gggtaacttt gtgccctaca gagattccaa
     1261 gctgactcga ctgcttcaag attctctagg aggcaatagc cacactctta tgattgcctg
     1321 tgtgagtcct gctgattcca atctagaaga aacattaaat acccttcgct atgctgacag
     1381 agcaagaaaa atcaagaaca aacctattat taatattgat ccccaggcag ctgaactaaa
     1441 tcatcttaaa caacaggtcc aacagctgca gatcttgctg ctacaagccc atggaggcac
     1501 cttgcctgga gatataaatg tggaaccatc agaaaatctt cagtccctga tggagaagaa
     1561 tcagtctctg gtggaagaga atgaaaaatt aagtcgtggt ctgagtgagg cagctggtca
     1621 aacagcccag atgctggaga ggatcattct gacagagcaa gcaaatgaga aaatgaatgc
     1681 caagctagaa gaactcaggc ggcatgcggc ctgtaaagtg gatcttcaaa agctcgtgga
     1741 gacattggaa gaccaggagt taaaagaaaa catagagata atttgcaacc tacaacaagt
     1801 gattgcccag ctatctgatg aagctgctgc ttgcatgact gcaaccattg atactgcagg
     1861 ggaagcagac actcaagtgc aaagcagccc agataccagc aggtcttctg atgttttcag
     1921 cactcagcat gccctacgcc aagctcagat gtccaaggag ctgattgagt tgaataaagc
     1981 acttgcactg aaggaagccc tagctaagaa gatgactcag aatgacaacc aactccagcc
     2041 cattcagttc cagtaccagg ataatattaa aaatctagaa tcagaagtcc tcagtctaca
     2101 gagggaaaaa gaagaactgg ttcttgaact tcaaacagca aagaaggatg ccaaccaagc
     2161 caagttgagt gagcgccgtc gtaaacgtct tcaggaactg gagggtcaaa tagctgattt
     2221 gaaaaagaaa ctgcaagaac agtccaaact tctgaagctg aaggaatcca cagagcatac
     2281 tgtctccaag ctgaaccagg agattcggat gatgaaaaac cagcgagtcc agttaatgcg
     2341 tcaaatgaaa gaggatgctg agaagtttag gcaatggaag cagcaaaaag acaaagaagt
     2401 aatccagcta aaagaacggg atcgtaaaag gcaatatgag ctgctcaaac ttgaaagaaa
     2461 ctttcagaag cagtctaatg tgctcagacg taaaactgag gaggcagcag ctgccaacaa
     2521 acgtcttaag gatgctctgc aaaagcaaaa ggaggttgca gaaaaacgca aagagactca
     2581 gagccgtggg atggaaagca ctgcagctag aatgaagaat tggcttggaa atgaaattga
     2641 ggttatggtc agtactgagg aagccaagcg acatctgaat ggccttcttg aagagagaaa
     2701 gatcctggct caggatgtgg cacaactcaa agagaaaaga gaatctggag agaacccacc
     2761 tcttaaactc cgaaggcgca cattttccta cgatgaaata catggtcaag attcaggagc
     2821 agaggattct attgccaagc agattgaaag cctagagacc gaattggagc tcaggagtgc
     2881 gcagattgcg gacctacagc aaaagctgct ggatgctgaa agtgaagacc ggccgaaaca
     2941 gcgctgggag agtatcgcca caattctcga agccaaatgt gccataaagt atttagtggg
     3001 agagctcgtc tcctccaaaa tactggtgag caaactagaa agcagcctga atcagagcaa
     3061 ggccagctgt attgacgtgc agaagatgct gtttgaggag caaaatcatt ttgctaagat
     3121 agagacagag ttaaaagaag agctggtcaa agtggagcaa cagcaccaag aaaaggtgtt
     3181 gtaccttctc agccagctgc agcaatccca gatgacagag aagcagctgg aggagtcagt
     3241 tagtgaaaag gaacagcagc tgctgagcac actaaaatgt caggaggaag agcttaggaa
     3301 gatgcaagaa gtgtgtgagc aaaatcagca gcttctccaa gaaaacagtg ccatcaagca
     3361 gaaactgacc ctactccaag tagccagcaa acagaaaccc catctcacaa gaaatatctt
     3421 ccagtctcca gactcttcct ttgaatatat tccacctaag cccaaacctt gccgcattaa
     3481 ggaaaaatgc ctagagcaaa gcttcgccgt cgaggggctg cagtattatt cagagccttc
     3541 tgtggccgag caggacaatg aggacagtga cgaccatgct gatgaggagt ggatcccaac
     3601 aaaactagtc aaggtgtcca agaagagcat ccaagggtgt tcctgcaaag gttggtgcgg
     3661 gaacaagcaa tgtggatgca gaaagcaaaa gtcagactgt aatgtgtcct gcagctgtga
     3721 ccccacaaag tgtcgcaacc gccatcagaa ccaggacaat tcagatgcta ttgagctaaa
     3781 ccaagattct gaaaactctt tcaaactgga agatcccaca gaggtgacct caggcttaag
     3841 cttcttccac cctatctgtg caactcccag tagcaagatc ctaaaagaaa tgtgtgatgc
     3901 agatcaggtg cagctgaagc agcccgtgtt tgtctcttct tctgaccacc cagaactgaa
     3961 gtctatagcg tcagaatcac aagaaaataa ggccataggg aagaagaaga agcgagctct
     4021 ggccagcaat accagcttct tctctggctg ctctcctatc caagaagagt cccactgagt
     4081 ttagggccat tgtctcttct gtctgccgtg gacacagtcc gagggtgagg cacagagggg
     4141 aagagcacta atgacttcag tagttttagg tcttgctatt gagaaaatga gaaaagtgtc
     4201 cctgaaagga ggaggacctt ggctgagtgt tggcctttac tatctaagcc ttcaaacaac
     4261 tactttgctt ctctagaagg cattgagcct tctactggag agagaaccaa ctgacctgcc
     4321 tgataagtct agaggagcca gtccccagta cagtctagct cactctttgt gagcagttga
     4381 attgtctctt catggaacta aggccgacat gttcttcttt catgatcaca tcagcttaat
     4441 ggaagagtct cgagtaggat ggagacctgg ctcgactccc tcaccacacc tcatgaattg
     4501 ggcagggagc tttcctgctc cattccaacg ccagacttga caaacccttc aactgtctgt
     4561 cacacgtgtt actgaagtga atgtcacatt ttaaaaatgt taagaaaata aataaacctt
     4621 agttcatcta ctagttgaag gagatccttc tatgctagag gaagaaataa aattccaaca
     4681 tgttttcttc a
//
