LOCUS       NM_008444               5647 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus kinesin family member 3B (Kif3b), mRNA.
ACCESSION   NM_008444
VERSION     NM_008444.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5647)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 5647)
  AUTHORS   Wang,S., Tanaka,Y., Xu,Y., Takeda,S. and Hirokawa,N.
  TITLE     KIF3B promotes a PI3K signaling gradient causing changes in a Shh
            protein gradient and suppressing polydactyly in mice
  JOURNAL   Dev Cell 57 (19), 2273-2289 (2022)
   PUBMED   36220081
  REMARK    GeneRIF: KIF3B promotes a PI3K signaling gradient causing changes
            in a Shh protein gradient and suppressing polydactyly in mice.
REFERENCE   3  (bases 1 to 5647)
  AUTHORS   Ho,U.Y., Feng,C.A., Yeap,Y.Y., Bain,A.L., Wei,Z., Shohayeb,B.,
            Reichelt,M.E., Homer,H., Khanna,K.K., Bowles,J. and Ng,D.C.H.
  TITLE     WDR62 is required for centriole duplication in spermatogenesis and
            manchette removal in spermiogenesis
  JOURNAL   Commun Biol 4 (1), 645 (2021)
   PUBMED   34059773
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5647)
  AUTHORS   Yoshihara,S., Jiang,X., Morikawa,M., Ogawa,T., Ichinose,S.,
            Yabe,H., Kakita,A., Toyoshima,M., Kunii,Y., Yoshikawa,T., Tanaka,Y.
            and Hirokawa,N.
  TITLE     Betaine ameliorates schizophrenic traits by functionally
            compensating for KIF3-based CRMP2 transport
  JOURNAL   Cell Rep 35 (2), 108971 (2021)
   PUBMED   33852848
  REMARK    GeneRIF: Betaine ameliorates schizophrenic traits by functionally
            compensating for KIF3-based CRMP2 transport.
REFERENCE   5  (bases 1 to 5647)
  AUTHORS   Alsabban,A.H., Morikawa,M., Tanaka,Y., Takei,Y. and Hirokawa,N.
  TITLE     Kinesin Kif3b mutation reduces NMDAR subunit NR2A trafficking and
            causes schizophrenia-like phenotypes in mice
  JOURNAL   EMBO J 39 (1), e101090 (2020)
   PUBMED   31746486
  REMARK    GeneRIF: Kif3b mutation reduces NMDAR subunit NR2A trafficking and
            causes schizophrenia-like phenotypes.
REFERENCE   6  (bases 1 to 5647)
  AUTHORS   Marszalek,J.R., Ruiz-Lozano,P., Roberts,E., Chien,K.R. and
            Goldstein,L.S.
  TITLE     Situs inversus and embryonic ciliary morphogenesis defects in mouse
            mutants lacking the KIF3A subunit of kinesin-II
  JOURNAL   Proc Natl Acad Sci U S A 96 (9), 5043-5048 (1999)
   PUBMED   10220415
REFERENCE   7  (bases 1 to 5647)
  AUTHORS   Nonaka,S., Tanaka,Y., Okada,Y., Takeda,S., Harada,A., Kanai,Y.,
            Kido,M. and Hirokawa,N.
  TITLE     Randomization of left-right asymmetry due to loss of nodal cilia
            generating leftward flow of extraembryonic fluid in mice lacking
            KIF3B motor protein
  JOURNAL   Cell 95 (6), 829-837 (1998)
   PUBMED   9865700
  REMARK    Erratum:[Cell 1999 Oct 1;99(1):117]
REFERENCE   8  (bases 1 to 5647)
  AUTHORS   Yang,Z., Hanlon,D.W., Marszalek,J.R. and Goldstein,L.S.
  TITLE     Identification, partial characterization, and genetic mapping of
            kinesin-like protein genes in mouse
  JOURNAL   Genomics 45 (1), 123-131 (1997)
   PUBMED   9339368
REFERENCE   9  (bases 1 to 5647)
  AUTHORS   Nakagawa,T., Tanaka,Y., Matsuoka,E., Kondo,S., Okada,Y., Noda,Y.,
            Kanai,Y. and Hirokawa,N.
  TITLE     Identification and classification of 16 new kinesin superfamily
            (KIF) proteins in mouse genome
  JOURNAL   Proc Natl Acad Sci U S A 94 (18), 9654-9659 (1997)
   PUBMED   9275178
  REMARK    Erratum:[Proc Natl Acad Sci U S A 1999 Mar 30;96(7):4214]
REFERENCE   10 (bases 1 to 5647)
  AUTHORS   Yamazaki,H., Nakata,T., Okada,Y. and Hirokawa,N.
  TITLE     KIF3A/B: a heterodimeric kinesin superfamily protein that works as
            a microtubule plus end-directed motor for membrane organelle
            transport
  JOURNAL   J Cell Biol 130 (6), 1387-1399 (1995)
   PUBMED   7559760
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ089315.1, AK147467.1 and BC065132.1.
            
            On Apr 28, 2009 this sequence version replaced NM_008444.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK147467.1, AK122258.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-9                 CJ089315.1         4-12
            10-5627             AK147467.1         4-5621
            5628-5647           BC065132.1         3940-3959
FEATURES             Location/Qualifiers
     source          1..5647
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 75.41 cM"
     gene            1..5647
                     /gene="Kif3b"
                     /gene_synonym="mKIAA0359"
                     /note="kinesin family member 3B"
                     /db_xref="GeneID:16569"
                     /db_xref="MGI:MGI:107688"
     exon            1..89
                     /gene="Kif3b"
                     /gene_synonym="mKIAA0359"
                     /inference="alignment:Splign:2.1.0"
     exon            90..1557
                     /gene="Kif3b"
                     /gene_synonym="mKIAA0359"
                     /inference="alignment:Splign:2.1.0"
     CDS             154..2397
                     /gene="Kif3b"
                     /gene_synonym="mKIAA0359"
                     /EC_number="5.6.1.3"
                     /note="microtubule plus end-directed kinesin motor 3B"
                     /codon_start=1
                     /product="kinesin-like protein KIF3B"
                     /protein_id="NP_032470.3"
                     /db_xref="CCDS:CCDS16911.1"
                     /db_xref="GeneID:16569"
                     /db_xref="MGI:MGI:107688"
                     /translation="MSKLKSSESVRVVVRCRPMNGKEKAASYDKVVDVDVKLGQVSVK
                     NPKGTSHEMPKTFTFDAVYDWNAKQFELYDETFRPLVDSVLQGFNGTIFAYGQTGTGK
                     TYTMEGVRGDPEKRGVIPNSFDHIFTHISRSQNQQYLVRASYLEIYQEEIRDLLSKDQ
                     TKRLELKERPDTGVYVKDLSSFVTKSVKEIEHVMNVGNQNRSVGATNMNEHSSRSHAI
                     FVITIECSEVGLDGENHIRVGKLNLVDLAGSERQAKTGAQGERLKEATKINLSLSALG
                     NVISALVDGKSTHIPYRDSKLTRLLQDSLGGNAKTVMVANVGPASYNVEETLTTLRYA
                     NRAKNIKNKPRVNEDPKDALLREFQEEIARLKAQLEKRSIGRRKRREKRREGGGSGGG
                     GEEEEEEGEEGEEDGDDKDDYWREQQEKLEIEKRAIVEDHSLVAEEKMRLLKEKEKKM
                     EDLRREKDAAEMLGAKIKAMESKLLVGGKNIVDHTNEQQKILEQKRQEIAEQKRRERE
                     IQQQMESRDEETLELKETYTSLQQEVDIKTKKLKKLFSKLQAVKAEIHDLQEEHIKER
                     QELEQTQNELTRELKLKHLIIENFIPLEEKNKIMNRSFFDDEEDHWKLHPITRLENQQ
                     MMKRPVSAVGYKRPLSQHARMSMMIRPEPRYRAENIMLLELDMPSRTTRDYEGPAISP
                     KVQAALDAALQDEDEIQVDASSFESTASRKPKARPKSGRKSGSSSSSSGNPASQFYPQ
                     SRGLVPK"
     exon            1558..1659
                     /gene="Kif3b"
                     /gene_synonym="mKIAA0359"
                     /inference="alignment:Splign:2.1.0"
     exon            1660..1782
                     /gene="Kif3b"
                     /gene_synonym="mKIAA0359"
                     /inference="alignment:Splign:2.1.0"
     exon            1783..1901
                     /gene="Kif3b"
                     /gene_synonym="mKIAA0359"
                     /inference="alignment:Splign:2.1.0"
     exon            1902..2015
                     /gene="Kif3b"
                     /gene_synonym="mKIAA0359"
                     /inference="alignment:Splign:2.1.0"
     exon            2016..2121
                     /gene="Kif3b"
                     /gene_synonym="mKIAA0359"
                     /inference="alignment:Splign:2.1.0"
     exon            2122..2300
                     /gene="Kif3b"
                     /gene_synonym="mKIAA0359"
                     /inference="alignment:Splign:2.1.0"
     exon            2301..5632
                     /gene="Kif3b"
                     /gene_synonym="mKIAA0359"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3126..3131
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Kif3b"
                     /gene_synonym="mKIAA0359"
                     /note="hexamer: TATAAA"
     polyA_site      3150
                     /gene="Kif3b"
                     /gene_synonym="mKIAA0359"
     regulatory      5599..5604
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Kif3b"
                     /gene_synonym="mKIAA0359"
                     /note="hexamer: AATAAA"
     polyA_site      5632
                     /gene="Kif3b"
                     /gene_synonym="mKIAA0359"
                     /note="major polyA site"
ORIGIN      
        1 gagcgccgcg gtctctcccc atccggggca gctgggaatg gctgagcccc gggttcgccg
       61 ccgccgcccg ctctcggctg cggccgcaga accttagcat cctgagccat tttggatttg
      121 tagcccttga ggctaaactg gtcagagttc atcatgtcca agttaaaaag ctcagaatca
      181 gtccgggtgg tggtccgctg tcggcccatg aatggcaaag aaaaggctgc atcttatgac
      241 aaggtggtag atgtggatgt gaagctgggg caggtgtctg tgaagaaccc caaaggcaca
      301 tcccatgaga tgcccaagac cttcaccttc gacgctgtgt atgattggaa cgccaagcag
      361 tttgagctct atgatgagac gttccgacca ctcgtggact ctgtgctgca gggtttcaat
      421 ggcacaattt ttgcctatgg acaaacagga actgggaaaa cctataccat ggagggagtt
      481 cgtggtgacc ctgaaaaaag aggggtcatc cccaactcct ttgatcacat cttcacccac
      541 atctctcgat ctcagaatca gcagtacctg gtccgggcgt cttacttaga gatctatcaa
      601 gaagagattc gagacttgct ttcaaaggat cagaccaaaa ggctagagct caaagagaga
      661 ccagatacag gagtgtatgt aaaggatttg tcttcttttg tcacgaagag tgtgaaggag
      721 atagagcatg tgatgaatgt gggaaaccag aaccggtctg tcggtgctac aaacatgaat
      781 gagcacagct cacggtcgca tgcaatcttt gttatcacta ttgaatgcag cgaggtgggc
      841 ctggatggtg aaaaccacat ccgggtagga aagctgaatc ttgtagatct tgctggcagt
      901 gagcggcaag ccaagactgg agctcaaggg gaaagactga aggaagccac caagatcaac
      961 ctgtcccttt ccgccttggg taatgttatc tctgcccttg tagatggcaa aagcacccat
     1021 attccatata gagactcaaa gctgaccagg cttctccaag attcccttgg tggcaatgcc
     1081 aaaactgtga tggtagccaa tgtggggcct gcctcttaca atgtagaaga gaccctgacc
     1141 actctgagat atgccaaccg tgccaaaaac attaagaaca agccaagggt caatgaggac
     1201 ccaaaggatg ctctgcttcg agaattccaa gaagaaattg ctcggctcaa ggcccagctg
     1261 gaaaaacgtt ccattggcag gaggaagagg cgagagaagc ggagggaagg tggtggcagt
     1321 ggtgggggtg gggaagagga ggaggaggag ggagaagagg gtgaggagga cggggatgat
     1381 aaggatgatt actggcggga acagcaagaa aaactggaga ttgagaagcg ggccattgta
     1441 gaggaccaca gcttggttgc agaggagaag atgaggctgc tgaaggagaa ggagaaaaag
     1501 atggaggacc tgcggcgaga gaaggatgct gcagagatgc tgggtgccaa aatcaaggcc
     1561 atggagagta agctgcttgt cggaggaaaa aatatagtag atcatacaaa cgaacagcag
     1621 aagatcctgg agcaaaaacg ccaggagatc gcagagcaga aacgtcgaga aagagaaatc
     1681 cagcagcaaa tggagagtcg agatgaggag accctggaac tgaaagagac ttacacctca
     1741 ctgcagcagg aggtagacat caagaccaaa aagctcaaaa agctcttttc caagcttcag
     1801 gccgtgaagg ccgagatcca cgacctccaa gaagaacaca tcaaagagcg ccaggagctg
     1861 gagcagacgc agaatgaact cacccgggag ctaaagctca agcatcttat tatagaaaac
     1921 tttattccct tggaagagaa gaataaaatt atgaatagat ccttttttga tgatgaagaa
     1981 gaccattgga aattacatcc tataaccaga ctggaaaacc agcagatgat gaagcggcct
     2041 gtctctgctg tgggatacaa gagacctctg agccagcatg cacggatgtc catgatgatt
     2101 cggccagagc cccggtacag ggcggagaac atcatgctct tggagttaga tatgcccagc
     2161 cggacaacca gagactacga gggcccagcc atctctccca aggttcaggc tgcgctggat
     2221 gcagctctgc aggatgaaga tgagatacag gtggatgcct catcctttga aagtactgcc
     2281 agcagaaaac ccaaggccag gcccaagagt ggcaggaaat caggatcctc ctcttcctcc
     2341 tcaggaaacc ctgcatctca gttttaccca cagtctcggg ggctggttcc caagtaaccc
     2401 agcacccact cccaggatgg gaacagcatt gtcttctgag agaagagcga gcacaatact
     2461 gcagagatga cttgagccta aacgcagaac cattcccctg aggaggagtg atagcctctt
     2521 tgcagattag ctaacttaat ctgcccgaac atgctggtcc tgatgtggca ctcagttcct
     2581 ctgggaagtg tcctttaatt agcatctcag aatgcatggg taaggtaaac tgcaaagtcc
     2641 aagtggacag caagagaatg accatgacct tgctttcctt ctttctccct tccctcctca
     2701 ccctcccttc ctctcctctt ctctagcctc ttcttcacac cagcctccct tcttgttaaa
     2761 caatatggag acgaggcctc cttaggactg tgtgtggagc cttggcctta agtggcagtg
     2821 gggctgagaa atgaaagccc tagaacttga ataggtgcct gcctctgtca ggtaaaatga
     2881 gatatctcac ttggaaccaa gccccaggac ggcacgatga gagagcgatc cagcttccag
     2941 gcccctcagt aggagtagat ctacctggaa tcggttgaat ggggcagtgg cttccagttc
     3001 ctgttccaga aggacttggt gttggaagca atagaaaaga cattcccttt gccccctggg
     3061 agagtttggg gaaatagctt ttttaaaatc tcaaaaccat gaccatcctg ttaaagacct
     3121 aagtctataa accagtgcca tgtccatcta ccatgtcact ttactcattt gtcaccgtct
     3181 ttccccaagt acacatgctc tgtctgagtg gactcatgta gacccaccta cagagtgtgc
     3241 ctatagagtg tgcctggagg tggggaaggg gaagccagct ctgccttctc tgatgggagc
     3301 agagttgggg gaaggcatca gcagggcact tgtgaattgc ccacaagggt ccatactgtc
     3361 ctgggagcag aagagtgagg aggcagatgc agactagcag caagagactc agagcaggag
     3421 gaagggcaga tagcagtgga agcaaaggaa tcctgtctgc ctggagcaga agccactgac
     3481 ttctgcgagt gtggctcccc tgggtggaga ggagccgtag gtgctggcaa gaagaggctc
     3541 tgagtaggct cagaggggag tccacacctc ctgtttacat agactagttt ggtttataag
     3601 ttttagttct tcatgttacg gcacctcaag ctttgcttta tgttggtcat taggtgacag
     3661 ttactcattt tccccaagag aaataaatgc atgagtgtgt ggggctgcct gtgcacagta
     3721 gtgcctgtgc tctgggtgtg tctctaagag agactgaaaa cttgcccggt tttagaaata
     3781 ctccagcgtc cagtgtttgc ctttgtctgt gtgaaaggcc cacagaatga ctaatccagg
     3841 ctagaagcac gcacccccca tgaagtgtct tgagtccatg atccaaacct gaggggacag
     3901 tctgagtcct caagtctgcc acactggtgt accttgctgg catggtgcct caggaagatg
     3961 gcaactcagg tggctttgag atacgtttta actcagctac ttggtctcca ggtacatttc
     4021 tggacagagc ccatggaagg aggagtaacg tgcaatgtct tgacattctt tatcacatca
     4081 cggagatcca tggatcttct tggtagcttc ctttctgagc ccagagccct attcagttcc
     4141 taggatggaa tggaacctgt ctcatctttt cttggtctca aaccctgctt cttccttgtg
     4201 tcctaagagt ttgcttgttt gactaggaac caaatgagga gacatgtgct ctaaggtggc
     4261 tgtttgctgg tgacacttgt ctcttacatt tcctcacagc tagtctaaat tctggaggct
     4321 gaaaacattt gtgtaccaaa acaggggatt gcaaacttca ggtacgatca taccttaatg
     4381 ctggtgtcgt gaagtggtta atgttcgagt ggcgggggtt aagtgacgca tagaactttt
     4441 ccaagaagac aaaaggaaaa aaaaatctgg aagacatgat tattaaagca agcctgccct
     4501 gtcctctgct gggttcctac agtggtctgt ggacaccaag tggaaggcca cccatgtggt
     4561 gatgaagctg tcccttcccg ggcagcgtct ggtgcttctc ttttctcaat acggatccga
     4621 tactgaagag agcagatggt aaaaatgtct tgctgtcccc agaatgctgc tgctctgagt
     4681 tctgaattga gccaagagtc tagaggatat gacaagctca ctgagggacc aaagctttat
     4741 gctgttagtt atctagctga gattctggaa ggcctccatg cctgcagtag ctactgtagt
     4801 ctagaagcaa atctttaaaa ggatctaaga agaccatctg ggaggagttt gaggctgcgc
     4861 atacaatcct cttgggactc tcttcctctg ttcagtagaa tgtatctgaa attgtaacag
     4921 ctgacacaat ttccagatcc ttacactcag aatcagagtc cccaaaccat aggcatgaag
     4981 cactttgtaa gactgaccta cattgacttg ctccctgtct gatgcctgca tgctgcctga
     5041 attgttccac ctacatctcc atgaccatgg tgccagagtg cagtacagct caggcacagg
     5101 ccacttgtct gctcttccct gaagtcctcc ttcactgaat gtagactctg ccaagtttct
     5161 gagaagcgtc gaacccctgc taacgtaggc tatcagttct gcctcacttt ggcctctcga
     5221 atttgagggg tactgcgagc atcttggacc atccagacac catctgtgaa tgaaatgggc
     5281 tactgatgta ctccaaaagc cataatgaaa aaatctcaga gggatctagg taagaacgga
     5341 atgccccaca tttaccatgc aagtcttggt ctgatacttt aagattctag caccttcctc
     5401 tctgccctga tatgggcagg caggaggtgg gcggggcttg atggctcttt ggagttcctg
     5461 ttgatcttga ccttctcttt ggctgtcttt agatacagga tatgccagta cttgggactc
     5521 tctaagtttt acaattgata tttatttgta ttatctcttt gtctagcaat gtaaaagtga
     5581 ttctaaacta aaatgtgtaa taaaaatcaa tcaaatttat tgtatctaca aaaaaaaaaa
     5641 aaaaaaa
//
