LOCUS       NP_032470                747 aa            linear   ROD 30-APR-2024
DEFINITION  kinesin-like protein KIF3B [Mus musculus].
ACCESSION   NP_032470
VERSION     NP_032470.3
DBSOURCE    REFSEQ: accession NM_008444.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 747)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (residues 1 to 747)
  AUTHORS   Wang,S., Tanaka,Y., Xu,Y., Takeda,S. and Hirokawa,N.
  TITLE     KIF3B promotes a PI3K signaling gradient causing changes in a Shh
            protein gradient and suppressing polydactyly in mice
  JOURNAL   Dev Cell 57 (19), 2273-2289 (2022)
   PUBMED   36220081
  REMARK    GeneRIF: KIF3B promotes a PI3K signaling gradient causing changes
            in a Shh protein gradient and suppressing polydactyly in mice.
REFERENCE   3  (residues 1 to 747)
  AUTHORS   Ho,U.Y., Feng,C.A., Yeap,Y.Y., Bain,A.L., Wei,Z., Shohayeb,B.,
            Reichelt,M.E., Homer,H., Khanna,K.K., Bowles,J. and Ng,D.C.H.
  TITLE     WDR62 is required for centriole duplication in spermatogenesis and
            manchette removal in spermiogenesis
  JOURNAL   Commun Biol 4 (1), 645 (2021)
   PUBMED   34059773
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 747)
  AUTHORS   Yoshihara,S., Jiang,X., Morikawa,M., Ogawa,T., Ichinose,S.,
            Yabe,H., Kakita,A., Toyoshima,M., Kunii,Y., Yoshikawa,T., Tanaka,Y.
            and Hirokawa,N.
  TITLE     Betaine ameliorates schizophrenic traits by functionally
            compensating for KIF3-based CRMP2 transport
  JOURNAL   Cell Rep 35 (2), 108971 (2021)
   PUBMED   33852848
  REMARK    GeneRIF: Betaine ameliorates schizophrenic traits by functionally
            compensating for KIF3-based CRMP2 transport.
REFERENCE   5  (residues 1 to 747)
  AUTHORS   Alsabban,A.H., Morikawa,M., Tanaka,Y., Takei,Y. and Hirokawa,N.
  TITLE     Kinesin Kif3b mutation reduces NMDAR subunit NR2A trafficking and
            causes schizophrenia-like phenotypes in mice
  JOURNAL   EMBO J 39 (1), e101090 (2020)
   PUBMED   31746486
  REMARK    GeneRIF: Kif3b mutation reduces NMDAR subunit NR2A trafficking and
            causes schizophrenia-like phenotypes.
REFERENCE   6  (residues 1 to 747)
  AUTHORS   Marszalek,J.R., Ruiz-Lozano,P., Roberts,E., Chien,K.R. and
            Goldstein,L.S.
  TITLE     Situs inversus and embryonic ciliary morphogenesis defects in mouse
            mutants lacking the KIF3A subunit of kinesin-II
  JOURNAL   Proc Natl Acad Sci U S A 96 (9), 5043-5048 (1999)
   PUBMED   10220415
REFERENCE   7  (residues 1 to 747)
  AUTHORS   Nonaka,S., Tanaka,Y., Okada,Y., Takeda,S., Harada,A., Kanai,Y.,
            Kido,M. and Hirokawa,N.
  TITLE     Randomization of left-right asymmetry due to loss of nodal cilia
            generating leftward flow of extraembryonic fluid in mice lacking
            KIF3B motor protein
  JOURNAL   Cell 95 (6), 829-837 (1998)
   PUBMED   9865700
  REMARK    Erratum:[Cell 1999 Oct 1;99(1):117]
REFERENCE   8  (residues 1 to 747)
  AUTHORS   Yang,Z., Hanlon,D.W., Marszalek,J.R. and Goldstein,L.S.
  TITLE     Identification, partial characterization, and genetic mapping of
            kinesin-like protein genes in mouse
  JOURNAL   Genomics 45 (1), 123-131 (1997)
   PUBMED   9339368
REFERENCE   9  (residues 1 to 747)
  AUTHORS   Nakagawa,T., Tanaka,Y., Matsuoka,E., Kondo,S., Okada,Y., Noda,Y.,
            Kanai,Y. and Hirokawa,N.
  TITLE     Identification and classification of 16 new kinesin superfamily
            (KIF) proteins in mouse genome
  JOURNAL   Proc Natl Acad Sci U S A 94 (18), 9654-9659 (1997)
   PUBMED   9275178
  REMARK    Erratum:[Proc Natl Acad Sci U S A 1999 Mar 30;96(7):4214]
REFERENCE   10 (residues 1 to 747)
  AUTHORS   Yamazaki,H., Nakata,T., Okada,Y. and Hirokawa,N.
  TITLE     KIF3A/B: a heterodimeric kinesin superfamily protein that works as
            a microtubule plus end-directed motor for membrane organelle
            transport
  JOURNAL   J Cell Biol 130 (6), 1387-1399 (1995)
   PUBMED   7559760
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ089315.1, AK147467.1 and BC065132.1.
            
            On Apr 28, 2009 this sequence version replaced NP_032470.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK147467.1, AK122258.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..747
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 75.41 cM"
     Protein         1..747
                     /product="kinesin-like protein KIF3B"
                     /EC_number="5.6.1.3"
                     /note="microtubule plus end-directed kinesin motor 3B"
                     /calculated_mol_wt=85157
     Site            1
                     /site_type="acetylation"
                     /note="N-acetylmethionine.
                     /evidence=ECO:0000250|UniProtKB:O15066; propagated from
                     UniProtKB/Swiss-Prot (Q61771.1)"
     Site            2
                     /site_type="acetylation"
                     /note="N-acetylserine, in Kinesin-like protein KIF3B,
                     N-terminally processed.
                     /evidence=ECO:0000250|UniProtKB:O15066; propagated from
                     UniProtKB/Swiss-Prot (Q61771.1)"
     Region          8..340
                     /region_name="KISc_KIF3"
                     /note="Kinesin motor domain, kinesins II or KIF3_like
                     proteins; cd01371"
                     /db_xref="CDD:276822"
     Site            order(17,96,99,101..104,245)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:276822"
     Site            order(293,296,299)
                     /site_type="other"
                     /note="microtubule interaction site [polypeptide binding]"
                     /db_xref="CDD:276822"
     Region          <355..>581
                     /region_name="Smc"
                     /note="Chromosome segregation ATPase Smc [Cell cycle
                     control, cell division, chromosome partitioning]; COG1196"
                     /db_xref="CDD:440809"
     Region          374..412
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q61771.1)"
     Region          580..747
                     /region_name="Globular"
                     /note="propagated from UniProtKB/Swiss-Prot (Q61771.1)"
     Region          698..747
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q61771.1)"
     CDS             1..747
                     /gene="Kif3b"
                     /gene_synonym="mKIAA0359"
                     /coded_by="NM_008444.4:154..2397"
                     /db_xref="CCDS:CCDS16911.1"
                     /db_xref="GeneID:16569"
                     /db_xref="MGI:MGI:107688"
ORIGIN      
        1 msklkssesv rvvvrcrpmn gkekaasydk vvdvdvklgq vsvknpkgts hempktftfd
       61 avydwnakqf elydetfrpl vdsvlqgfng tifaygqtgt gktytmegvr gdpekrgvip
      121 nsfdhifthi srsqnqqylv rasyleiyqe eirdllskdq tkrlelkerp dtgvyvkdls
      181 sfvtksvkei ehvmnvgnqn rsvgatnmne hssrshaifv itiecsevgl dgenhirvgk
      241 lnlvdlagse rqaktgaqge rlkeatkinl slsalgnvis alvdgksthi pyrdskltrl
      301 lqdslggnak tvmvanvgpa synveetltt lryanrakni knkprvnedp kdallrefqe
      361 eiarlkaqle krsigrrkrr ekrregggsg gggeeeeeeg eegeedgddk ddywreqqek
      421 leiekraive dhslvaeekm rllkekekkm edlrrekdaa emlgakikam eskllvggkn
      481 ivdhtneqqk ileqkrqeia eqkrrereiq qqmesrdeet lelketytsl qqevdiktkk
      541 lkklfsklqa vkaeihdlqe ehikerqele qtqneltrel klkhliienf ipleeknkim
      601 nrsffddeed hwklhpitrl enqqmmkrpv savgykrpls qharmsmmir pepryraeni
      661 mlleldmpsr ttrdyegpai spkvqaalda alqdedeiqv dassfestas rkpkarpksg
      721 rksgssssss gnpasqfypq srglvpk
//
