LOCUS       NM_008443               5450 bp    mRNA    linear   ROD 10-OCT-2024
DEFINITION  Mus musculus kinesin family member 3A (Kif3a), transcript variant
            1, mRNA.
ACCESSION   NM_008443
VERSION     NM_008443.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5450)
  AUTHORS   Liu,J.C., Pan,Z.N., Ju,J.Q., Zou,Y.J., Pan,M.H., Wang,Y., Wu,X. and
            Sun,S.C.
  TITLE     Kinesin KIF3A regulates meiotic progression and spindle assembly in
            oocyte meiosis
  JOURNAL   Cell Mol Life Sci 81 (1), 168 (2024)
   PUBMED   38587639
  REMARK    GeneRIF: Kinesin KIF3A regulates meiotic progression and spindle
            assembly in oocyte meiosis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5450)
  AUTHORS   Yang,J., Zhu,L., Pan,H., Ueharu,H., Toda,M., Yang,Q., Hallett,S.A.,
            Olson,L.E. and Mishina,Y.
  TITLE     A BMP-controlled metabolic/epigenetic signaling cascade directs
            midfacial morphogenesis
  JOURNAL   J Clin Invest 134 (8), e165787 (2024)
   PUBMED   38466355
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5450)
  AUTHORS   Ho,K.H., Candat,A., Scarpetta,V., Faucourt,M., Weill,S., Salio,C.,
            D'Este,E., Meschkat,M., Wurm,C.A., Kneussel,M., Janke,C.,
            Magiera,M.M., Genovesio,A., Meunier,A., Sassoe-Pognetto,M.,
            Brill,M.S., Spassky,N. and Patrizi,A.
  TITLE     Choroid plexuses carry nodal-like cilia that undergo axoneme
            regression from early adult stage
  JOURNAL   Dev Cell 58 (23), 2641-2651 (2023)
   PUBMED   37890489
REFERENCE   4  (bases 1 to 5450)
  AUTHORS   Paul,C., Tang,R., Longobardi,C., Lattanzio,R., Eguether,T.,
            Turali,H., Bremond,J., Maurizy,C., Gabola,M., Poupeau,S.,
            Turtoi,A., Denicolai,E., Cufaro,M.C., Svrcek,M., Seksik,P.,
            Castronovo,V., Delvenne,P., de Laurenzi,V., Da Costa,Q.,
            Bertucci,F., Lemmers,B., Pieragostino,D., Mamessier,E., Janke,C.,
            Pinet,V. and Hahne,M.
  TITLE     Loss of primary cilia promotes inflammation and carcinogenesis
  JOURNAL   EMBO Rep 23 (12), e55687 (2022)
   PUBMED   36281991
REFERENCE   5  (bases 1 to 5450)
  AUTHORS   Chen,J., Cheng,N.C., Boland,J.A., Liu,K., Kench,J.G., Watkins,D.N.,
            Ferreira-Gonzalez,S., Forbes,S.J. and McCaughan,G.W.
  TITLE     Deletion of kif3a in CK19 positive cells leads to primary cilia
            loss, biliary cell proliferation and cystic liver lesions in
            TAA-treated mice
  JOURNAL   Biochim Biophys Acta Mol Basis Dis 1868 (4), 166335 (2022)
   PUBMED   34973373
REFERENCE   6  (bases 1 to 5450)
  AUTHORS   Frazer,K.A., Ueda,Y., Zhu,Y., Gifford,V.R., Garofalo,M.R.,
            Mohandas,N., Martin,C.H., Palazzolo,M.J., Cheng,J.F. and Rubin,E.M.
  TITLE     Computational and biological analysis of 680 kb of DNA sequence
            from the human 5q31 cytokine gene cluster region
  JOURNAL   Genome Res 7 (5), 495-512 (1997)
   PUBMED   9149945
REFERENCE   7  (bases 1 to 5450)
  AUTHORS   Saito,N., Okada,Y., Noda,Y., Kinoshita,Y., Kondo,S. and Hirokawa,N.
  TITLE     KIFC2 is a novel neuron-specific C-terminal type kinesin
            superfamily motor for dendritic transport of multivesicular
            body-like organelles
  JOURNAL   Neuron 18 (3), 425-438 (1997)
   PUBMED   9115736
REFERENCE   8  (bases 1 to 5450)
  AUTHORS   Yamazaki,H., Nakata,T., Okada,Y. and Hirokawa,N.
  TITLE     KIF3A/B: a heterodimeric kinesin superfamily protein that works as
            a microtubule plus end-directed motor for membrane organelle
            transport
  JOURNAL   J Cell Biol 130 (6), 1387-1399 (1995)
   PUBMED   7559760
REFERENCE   9  (bases 1 to 5450)
  AUTHORS   Kondo,S., Sato-Yoshitake,R., Noda,Y., Aizawa,H., Nakata,T.,
            Matsuura,Y. and Hirokawa,N.
  TITLE     KIF3A is a new microtubule-based anterograde motor in the nerve
            axon
  JOURNAL   J Cell Biol 125 (5), 1095-1107 (1994)
   PUBMED   7515068
REFERENCE   10 (bases 1 to 5450)
  AUTHORS   Aizawa,H., Sekine,Y., Takemura,R., Zhang,Z., Nangaku,M. and
            Hirokawa,N.
  TITLE     Kinesin family in murine central nervous system
  JOURNAL   J Cell Biol 119 (5), 1287-1296 (1992)
   PUBMED   1447303
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ157264.1, BC052707.1, BB752635.1, AK053412.1, AK084748.1,
            AK149180.1 and AV356644.1.
            
            On Mar 20, 2014 this sequence version replaced NM_008443.3.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC052707.1, D12645.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849384, SAMN01164131
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-34                CJ157264.1         2-35
            35-3158             BC052707.1         1-3124
            3159-3322           BB752635.1         267-430
            3323-4228           AK053412.1         196-1101
            4229-5438           AK084748.1         1082-2291
            5439-5448           AK149180.1         2370-2379
            5449-5450           AV356644.1         239-240
FEATURES             Location/Qualifiers
     source          1..5450
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 31.97 cM"
     gene            1..5450
                     /gene="Kif3a"
                     /gene_synonym="Kif3; Kifl; Kns3"
                     /note="kinesin family member 3A"
                     /db_xref="GeneID:16568"
                     /db_xref="MGI:MGI:107689"
     exon            1..163
                     /gene="Kif3a"
                     /gene_synonym="Kif3; Kifl; Kns3"
                     /inference="alignment:Splign:2.1.0"
     CDS             158..2263
                     /gene="Kif3a"
                     /gene_synonym="Kif3; Kifl; Kns3"
                     /note="isoform 1 is encoded by transcript variant 1;
                     kinesin-like protein KIF3A; microtubule plus end-directed
                     kinesin motor 3A; kinesin-II subunit; N-4 kinesin"
                     /codon_start=1
                     /product="kinesin-like protein KIF3A isoform 1"
                     /protein_id="NP_032469.2"
                     /db_xref="CCDS:CCDS48795.1"
                     /db_xref="GeneID:16568"
                     /db_xref="MGI:MGI:107689"
                     /translation="MPINKSEKPESCDNVKVVVRCRPLNEREKSMCYRQAVSVDEMRG
                     TITVHKTDSSNEPPKTFTFDTVFGPESKQLDVYNLTARPIIDSVLEGYNGTIFAYGQT
                     GTGKTFTMEGVRAVPGLRGVIPNSFAHIFGHIAKAEGDTRFLVRVSYLEIYNEEVRDL
                     LGKDQTQRLEVKERPDVGVYIKDLSAYVVNNADDMDRIMTLGHKNRSVGATNMNEHSS
                     RSHAIFTITIECSEKGVDGNMHVRMGKLHLVDLAGSERQAKTGATGQRLKEATKINLS
                     LSTLGNVISALVDGKSTHVPYRNSKLTRLLQDSLGGNSKTMMCANIGPADYNYDETIS
                     TLRYANRAKNIKNKARINEDPKDALLRQFQKEIEELKKKLEEGEEVSGSDISGSEEDD
                     EEGELGEDGEKKKKRRDQAGKKKVSPDKMVEMQAKIDEERKALETKLDMEEEERNKAR
                     AELERREKDLLKAQQEHQSLLEKLSALEKKVIVGGVDLLAKAEEQEKLLEESNMELEE
                     RRRRAEQLRKELEEKEQERLDIEEKYTSLQEEAQGKTKKLKKVWTMLMAAKSEMADLQ
                     QEHQREIEGLLENIRQLSRELRLQMLIIDNFIPQDYQEMIENYVHWNEDIGEWQLKCV
                     AYTGNNMRKQTPVPDKKERDPFEVDLSHVYLAYTEESLRQSLMKLERPRTSKGKARPK
                     MGRRKRSAKPETVIDSLLQ"
     exon            164..437
                     /gene="Kif3a"
                     /gene_synonym="Kif3; Kifl; Kns3"
                     /inference="alignment:Splign:2.1.0"
     exon            438..582
                     /gene="Kif3a"
                     /gene_synonym="Kif3; Kifl; Kns3"
                     /inference="alignment:Splign:2.1.0"
     exon            583..667
                     /gene="Kif3a"
                     /gene_synonym="Kif3; Kifl; Kns3"
                     /inference="alignment:Splign:2.1.0"
     exon            668..773
                     /gene="Kif3a"
                     /gene_synonym="Kif3; Kifl; Kns3"
                     /inference="alignment:Splign:2.1.0"
     exon            774..913
                     /gene="Kif3a"
                     /gene_synonym="Kif3; Kifl; Kns3"
                     /inference="alignment:Splign:2.1.0"
     exon            914..1111
                     /gene="Kif3a"
                     /gene_synonym="Kif3; Kifl; Kns3"
                     /inference="alignment:Splign:2.1.0"
     exon            1112..1286
                     /gene="Kif3a"
                     /gene_synonym="Kif3; Kifl; Kns3"
                     /inference="alignment:Splign:2.1.0"
     exon            1287..1382
                     /gene="Kif3a"
                     /gene_synonym="Kif3; Kifl; Kns3"
                     /inference="alignment:Splign:2.1.0"
     exon            1383..1391
                     /gene="Kif3a"
                     /gene_synonym="Kif3; Kifl; Kns3"
                     /inference="alignment:Splign:2.1.0"
     exon            1392..1548
                     /gene="Kif3a"
                     /gene_synonym="Kif3; Kifl; Kns3"
                     /inference="alignment:Splign:2.1.0"
     exon            1549..1729
                     /gene="Kif3a"
                     /gene_synonym="Kif3; Kifl; Kns3"
                     /inference="alignment:Splign:2.1.0"
     exon            1730..1840
                     /gene="Kif3a"
                     /gene_synonym="Kif3; Kifl; Kns3"
                     /inference="alignment:Splign:2.1.0"
     exon            1841..1966
                     /gene="Kif3a"
                     /gene_synonym="Kif3; Kifl; Kns3"
                     /inference="alignment:Splign:2.1.0"
     exon            1967..2020
                     /gene="Kif3a"
                     /gene_synonym="Kif3; Kifl; Kns3"
                     /inference="alignment:Splign:2.1.0"
     exon            2021..2089
                     /gene="Kif3a"
                     /gene_synonym="Kif3; Kifl; Kns3"
                     /inference="alignment:Splign:2.1.0"
     exon            2090..2214
                     /gene="Kif3a"
                     /gene_synonym="Kif3; Kifl; Kns3"
                     /inference="alignment:Splign:2.1.0"
     exon            2215..5450
                     /gene="Kif3a"
                     /gene_synonym="Kif3; Kifl; Kns3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2287..2292
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Kif3a"
                     /gene_synonym="Kif3; Kifl; Kns3"
                     /note="hexamer: AATAAA"
     polyA_site      2307
                     /gene="Kif3a"
                     /gene_synonym="Kif3; Kifl; Kns3"
                     /note="major polyA site"
     regulatory      4205..4210
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Kif3a"
                     /gene_synonym="Kif3; Kifl; Kns3"
                     /note="hexamer: ATTAAA"
     polyA_site      4231
                     /gene="Kif3a"
                     /gene_synonym="Kif3; Kifl; Kns3"
                     /note="major polyA site"
ORIGIN      
        1 agagtgcgcc tgcgcactgc cctctgtagc tgtgtgagcc gcagtctctg gagcgctaag
       61 gtgttgcggt cgcctgtggc cagcctcgcc cccaaacccg gtgttgttgg gctgcatccg
      121 gagtggggac gttggcggag caccggacgc ggccaccatg ccgatcaata agtcggagaa
      181 gccggaaagc tgcgataatg tgaaggtggt ggttaggtgc cggcctctca atgagagaga
      241 gaagtcaatg tgctatagac aggccgtcag cgtggatgaa atgaggggaa ctatcaccgt
      301 ccataagacc gattcctcca acgaacctcc aaagacattt actttcgata ctgtttttgg
      361 accagaaagt aaacaacttg atgtgtataa cttaactgca agaccaatta ttgattctgt
      421 tctggaaggc tacaatggga ccatctttgc atatggacag actgggacag gcaagacttt
      481 caccatggaa ggcgttcgag cagtaccggg gctcagaggg gtcatcccca actcatttgc
      541 tcacatattt ggtcacatcg caaaagcaga gggcgacaca aggtttttgg ttcgagtgtc
      601 atacttggag atatataatg aagaagttcg agaccttttg ggtaaagatc agacccagag
      661 gttagaggtt aaagaaaggc ctgatgtggg agtatatatc aaagacttat cagcatatgt
      721 agtcaacaac gctgacgaca tggatagaat catgactcta ggccacaaaa accgttctgt
      781 cggtgcgact aatatgaacg agcacagctc ccgatcccac gccatcttta caattactat
      841 agagtgcagt gagaaaggcg tggacgggaa catgcacgtc aggatgggca agctccacct
      901 tgtggatctg gctgggtcag aaagacaagc aaaaactgga gccacaggac agcgcctcaa
      961 ggaagctacc aaaatcaacc tttcattgtc taccctgggc aacgttattt ctgccttggt
     1021 ggatggaaaa agcactcacg tgccgtatcg gaactccaaa ctgacccgtc tcctgcagga
     1081 ctccttagga gggaactcaa aaaccatgat gtgtgcaaat attgggccag cagattataa
     1141 ttatgatgaa actatcagca ccttgcggta tgccaaccgc gccaagaaca ttaaaaacaa
     1201 agcgagaatc aatgaggacc caaaggatgc tctgctccgc cagtttcaga aagaaatcga
     1261 agagctgaag aaaaagcttg aggaagggga agaagtgtca ggctctgaca tcagtgggtc
     1321 agaggaggat gacgaggagg gtgaacttgg agaagatgga gaaaaaaaga aaaagagaag
     1381 ggaccaagca ggtaaaaaga aagtttcccc agataagatg gtggaaatgc aagcgaaaat
     1441 tgacgaggag agaaaagcac tggaaaccaa acttgacatg gaagaagaag aaagaaacaa
     1501 ggctagagct gaactagaga gacgggagaa ggaccttctg aaagcccaac aagagcatca
     1561 gtctttgctg gaaaagctgt ctgctttgga aaagaaggtc attgtcggcg gcgtggacct
     1621 gctggccaag gctgaggagc aagagaagct tctggaggag tccaacatgg agctggagga
     1681 gaggaggaga cgagctgagc agcttcggaa agagctggag gaaaaggagc aagaacgctt
     1741 ggacatcgag gaaaaatata ccagtctgca agaggaggca caaggaaaga ccaagaaatt
     1801 aaagaaagtc tggaccatgc tgatggctgc aaagtcagag atggctgatc tccagcagga
     1861 gcatcagagg gagatcgaag gcctcctgga gaacatccgg cagctcagcc gggagctccg
     1921 tcttcagatg ctcatcattg ataacttcat acctcaggat taccaggaaa tgattgaaaa
     1981 ctacgtccac tggaatgaag acataggaga atggcagcta aaatgtgtgg cctacacagg
     2041 aaataacatg aggaaacaaa ctccagtccc tgacaagaag gagagagacc catttgaagt
     2101 cgacctttcc cacgtgtacc tcgcctatac agaggagagt ctgcgtcagt ctctgatgaa
     2161 gttagaaagg ccacggacct ccaaggggaa agcaaggcca aagatggggc gaagaaagcg
     2221 ttctgcaaag cctgagaccg taattgattc tttacttcag taaatgtaca gaattaaagt
     2281 taaaataata aaaagagtgc tgtcccatgc ctggagagaa ctccttaatt aagacacgag
     2341 gacaactgta tggttcacat aatggaagct gtaaagcatg gagagagact ggaaatagca
     2401 attttcctaa tatcttttag actctttaag tgtctgtaac atgtaagtgc gccgcagctc
     2461 atggtcgttg ggcatggcgc actgtgtctg tcacactgct ctgcaggaag taagggttcc
     2521 gttgttgtac gtgaatgtgc gtttcttagc tatgtattca actaccgtgg ctctagacaa
     2581 gcagaatctc agactagaac caagtctgtc ttgtttgcac acaacatata gcagatcacc
     2641 ttgtcctgtg tcctgtgtcc tgtgtcctgt gccagtctgg gctgcccatc taagcagtga
     2701 cttgattctg tacctgcctg acctgtctaa atgcagtcca actttacact catcctgact
     2761 gcatctaagt gtgcaatgac taccttgatt gatctcctgt ggaaaactat aaaatctgac
     2821 agctctgcag gcttacattc tgaagatgca gtttgtgtgc tcgcctgtgc accctccact
     2881 tctgtagctc tgactccaca ttcagccatt gttgttacta agttggctcc ccacttctcc
     2941 tgaagccagc attagccact tacccttgct cacacacaca ttctaaaaca ttccctggac
     3001 atacagctta caaacacttc cttgtctgaa ttttaagttt gatggaaata actataaaaa
     3061 atgagaccag gggttgggga tttagctcag tggtaaagtg cttgcctagc aagcccaagg
     3121 ccctgggttc ggtcctcagc tccggaaaaa agaaaaaaga aaaaaaaaaa aataaaaaaa
     3181 aaaaaataaa aaaaaaaaat aaaaaatgag accagtctca tttttcagaa aatgaaacaa
     3241 agtaaaaaaa aaaaaacctt ttaattttct ttattgtata tataaatttt atatataaaa
     3301 atactcttct ggatttcttg cattgattaa tccagttaga tggaattcct ctacataaaa
     3361 acgttaatac tcactgtata gtagggtaac ttgtaataga gaagttttgg ttttgttgtt
     3421 tacgtatata attttttgaa ggtcatgtgc ttcctaaacc caagtttgaa gttatacaat
     3481 caactctgag ctattgattc caaaagtttt gagacttccc acgtgaggat aaattaaatt
     3541 gctatgattt taacaagttt ggataaatac tgacttacag ctacattgct ctgtgtggct
     3601 gcggatgact gatcagaggg gcatccctgg cgagaggtgg aaaacatggc cggacagttt
     3661 taggctctcc tgaattagag ccctgagtat cctggatgtg caggctgctg gtgttagcat
     3721 ggcgtgcggc agcatcttct attgtgagtg tggcctgctg tgactcaatg agctctgtgt
     3781 gtgtgtgtgt gtgtgtgtct tgcaaaggct catgtgagct gagcatcttg gtgacgtcaa
     3841 atttcgcaat gatgtaaatt tacatgttag taattagaag aatctatatg ccttcatttt
     3901 aaaagtccat gtttctatca tttagcagtt cagttggcct agaaggaata tctgctgtga
     3961 attaagctaa aacatgagag aaattaaatc tagttaaatc agtaacacaa gtaactccat
     4021 aaaactaaca atttagaagc ttctctaagc atcttgactt agtaatttta tttgcttgct
     4081 tgtttttttg agacagggtc tctgtgttag cccaggctgg cctgggactc gtcgtaatcc
     4141 ttctgcctca gcctcccagg tgctgagaat gcagatgcat gttatcatac caagccatat
     4201 gtttattaaa gcattgatgt taaaactcta atcaggtgga cattgttcat tttctgaaaa
     4261 accaaattcg attctcacca ggtggggagg tctgttgaag aaggtaggaa gcccacttct
     4321 gccacagcca tgctgtggct gcttctcatg gactctgtct tcatctgcaa atggaatcat
     4381 tttcagtgtt aattccatga atggatagag atgtaggaca aacttaatgt ttaaaataaa
     4441 tgtacagatt tacatgagtg gaacagatct ataaataggc tattgataca tagccctttt
     4501 tctttgattt aaaaggtagt atttatttat ttgaactgta tagtgtgtta tggctggctt
     4561 tgcatttaca taccctgaca gttaggctct ctccactcag tgtccactgt gatcttaagt
     4621 cttggcttaa aggaaggctc tgcagctgct gtttgccccc agaatcctct ggtaagctgt
     4681 ctcatttata ttctggaaaa ggtgattttc aaatttatgt ttttggcagc cagaacatca
     4741 gggttagttt ggaaggagag ggggaagtgt tacttcatct gcaacatgtt ttaaagtgat
     4801 aattatagtt tcagcgattt tatttccatt ttaagtttat gtggcccatc ccccttttct
     4861 ctttgaactc ttaacacaag gaacaccttt tttccttata gagctgtgaa ttaaggaatg
     4921 ggcagagttt acatttacac acacctgtgt ctgcccagtt tctcctctct cccctcttcc
     4981 attttgaaat agagtccaat gtagtccagg ctggccacaa accctctgtg tagcccaggt
     5041 tggcctttaa gctccttatc ctcctacctc catctaacag ttgctgggat catacttatg
     5101 caccagccac cacactgagc tttgcctcca ccccttctta acatacataa ttgttctctg
     5161 tcttcctttt tcttaaaata ctagaaccca tagttcttct tagtgccttt gagctgaccc
     5221 tgcagtctga ctaattagaa tcagtgaaac cctgagtagt gttactgtaa tgctgttacc
     5281 gaccaggaaa caaactgtac agaaagttgg ctgtgttaat tcaaaatcca cacttgagct
     5341 gtatttaatg tataaattgt acttgtccaa gctgtatata tcaatgctgt gtgtacgtgc
     5401 agcccaggag gatgagaaat aaatgcctcc ccatgcctaa tgtcttttaa
//
