LOCUS       NP_001361656             743 aa            linear   ROD 29-APR-2025
DEFINITION  kinesin-like protein KIF2A isoform 3 [Mus musculus].
ACCESSION   NP_001361656 XP_006517598
VERSION     NP_001361656.1
DBSOURCE    REFSEQ: accession NM_001374727.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 743)
  AUTHORS   Dey,S., Kovalenko,A. and Yaron,A.
  TITLE     Protocol for semiautomated analysis of sensory neuronal innervation
            of the mouse footpad skin
  JOURNAL   STAR Protoc 5 (4), 103312 (2024)
   PUBMED   39298322
REFERENCE   2  (residues 1 to 743)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (residues 1 to 743)
  AUTHORS   Dey,S., Barkai,O., Gokhman,I., Suissa,S., Haffner-Krausz,R.,
            Wigoda,N., Feldmesser,E., Ben-Dor,S., Kovalenko,A., Binshtok,A. and
            Yaron,A.
  TITLE     Kinesin family member 2A gates nociception
  JOURNAL   Cell Rep 42 (10), 113257 (2023)
   PUBMED   37851573
REFERENCE   4  (residues 1 to 743)
  AUTHORS   Ruiz-Reig,N., Garcia-Sanchez,D., Schakman,O., Gailly,P. and
            Tissir,F.
  TITLE     Inhibitory synapse dysfunction and epileptic susceptibility
            associated with KIF2A deletion in cortical interneurons
  JOURNAL   Front Mol Neurosci 15, 1110986 (2023)
   PUBMED   36733270
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 743)
  AUTHORS   Ruiz-Reig,N., Chehade,G., Hakanen,J., Aittaleb,M., Wierda,K., De
            Wit,J., Nguyen,L., Gailly,P. and Tissir,F.
  TITLE     KIF2A deficiency causes early-onset neurodegeneration
  JOURNAL   Proc Natl Acad Sci U S A 119 (46), e2209714119 (2022)
   PUBMED   36343267
  REMARK    GeneRIF: KIF2A deficiency causes early-onset neurodegeneration.
REFERENCE   6  (residues 1 to 743)
  AUTHORS   Miki,H., Setou,M., Kaneshiro,K. and Hirokawa,N.
  TITLE     All kinesin superfamily protein, KIF, genes in mouse and human
  JOURNAL   Proc Natl Acad Sci U S A 98 (13), 7004-7011 (2001)
   PUBMED   11416179
  REMARK    Review article
REFERENCE   7  (residues 1 to 743)
  AUTHORS   Santama,N., Krijnse-Locker,J., Griffiths,G., Noda,Y., Hirokawa,N.
            and Dotti,C.G.
  TITLE     KIF2beta, a new kinesin superfamily protein in non-neuronal cells,
            is associated with lysosomes and may be implicated in their
            centrifugal translocation
  JOURNAL   EMBO J 17 (20), 5855-5867 (1998)
   PUBMED   9774330
REFERENCE   8  (residues 1 to 743)
  AUTHORS   Nakagawa,T., Tanaka,Y., Matsuoka,E., Kondo,S., Okada,Y., Noda,Y.,
            Kanai,Y. and Hirokawa,N.
  TITLE     Identification and classification of 16 new kinesin superfamily
            (KIF) proteins in mouse genome
  JOURNAL   Proc Natl Acad Sci U S A 94 (18), 9654-9659 (1997)
   PUBMED   9275178
  REMARK    Erratum:[Proc Natl Acad Sci U S A 1999 Mar 30;96(7):4214]
REFERENCE   9  (residues 1 to 743)
  AUTHORS   Noda,Y., Sato-Yoshitake,R., Kondo,S., Nangaku,M. and Hirokawa,N.
  TITLE     KIF2 is a new microtubule-based anterograde motor that transports
            membranous organelles distinct from those carried by kinesin heavy
            chain or KIF3A/B
  JOURNAL   J Cell Biol 129 (1), 157-167 (1995)
   PUBMED   7535303
REFERENCE   10 (residues 1 to 743)
  AUTHORS   Aizawa,H., Sekine,Y., Takemura,R., Zhang,Z., Nangaku,M. and
            Hirokawa,N.
  TITLE     Kinesin family in murine central nervous system
  JOURNAL   J Cell Biol 119 (5), 1287-1296 (1992)
   PUBMED   1447303
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC154257.2 and AC154328.2.
            
            On Oct 10, 2019 this sequence version replaced XP_006517598.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7974084.18302.1,
                                           SRR7345562.1719579.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164139 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..743
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 58.06 cM"
     Protein         1..743
                     /product="kinesin-like protein KIF2A isoform 3"
                     /note="kinesin-like protein KIF2A; kinesin-2; kinesin
                     heavy chain member 2"
                     /calculated_mol_wt=83730
     Region          222..550
                     /region_name="KISc_KIF2_like"
                     /note="Kinesin motor domain, KIF2-like group; cd01367"
                     /db_xref="CDD:276818"
     Site            order(230,312,315,317..320,456)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:276818"
     Site            order(504,507,510)
                     /site_type="other"
                     /note="microtubule interaction site [polypeptide binding]"
                     /db_xref="CDD:276818"
     CDS             1..743
                     /gene="Kif2a"
                     /gene_synonym="C530030B14Rik; Kif2; Kns2; M-kinesin"
                     /coded_by="NM_001374727.1:281..2512"
                     /note="isoform 3 is encoded by transcript variant 3"
                     /db_xref="CCDS:CCDS88521.1"
                     /db_xref="GeneID:16563"
                     /db_xref="MGI:MGI:108390"
ORIGIN      
        1 matanfgkiq igiyveikrs dgrihqamvt slnednesvt vewiengdtk gkeidlesif
       61 slnpdlvpde diepspelpp psssskvnki vknrrtvaav kndppprdnr vvgsararps
      121 qlpeqsssaq qngsvsdisp vqaakkefgp psrrksncvk eveklqekre krrlqqqelr
      181 ekraqdvdat npnyeimcmi rdfrgsldyr plttadpide hricvcvrkr plnkketqmk
      241 dldvitipsk dvvmvhepkq kvdltrylen qtfrfdyafd dsapnemvyr ftarplveti
      301 fergmatcfa ygqtgsgkth tmggdfsgkn qdcskgiyal aardvflmlk kpnykklelq
      361 vyatffeiys gkvfdllnrk tklrvledgk qqvqvvglqe revkcvedvl klidignscr
      421 tsgqtsanah ssrshavfqi ilrrkgklhg kfslidlagn ergadtssad rqtrlegaei
      481 nksllalkec iralgrnkph tpfraskltq vlrdsfigen srtcmiatis pgmascentl
      541 ntlryanrvk efgispsdip fsqgggsrpd lspsydyddf spsitrvkel tvnpaaagdv
      601 hpimhhppsq iddletqwgv gsspqrddlk llceqneeev spqlftfhea vsqmvemeeq
      661 vvedhravfq esirwiedek allemteevd ydvdsyatql eaileqkidi ltelrdkvks
      721 fraalqeeeq askqinpkrp ral
//
