LOCUS       NP_077203               1356 aa            linear   ROD 14-FEB-2025
DEFINITION  kinesin-like protein KIF24 [Mus musculus].
ACCESSION   NP_077203
VERSION     NP_077203.2
DBSOURCE    REFSEQ: accession NM_024241.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 1356)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (residues 1 to 1356)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 1356)
  AUTHORS   Ding,W., Wu,Q., Sun,L., Pan,N.C. and Wang,X.
  TITLE     Cenpj Regulates Cilia Disassembly and Neurogenesis in the
            Developing Mouse Cortex
  JOURNAL   J Neurosci 39 (11), 1994-2010 (2019)
   PUBMED   30626697
REFERENCE   4  (residues 1 to 1356)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643.. PMID: 29144450]
REFERENCE   5  (residues 1 to 1356)
  AUTHORS   Kobayashi,T., Kim,S., Lin,Y.C., Inoue,T. and Dynlacht,B.D.
  TITLE     The CP110-interacting proteins Talpid3 and Cep290 play overlapping
            and distinct roles in cilia assembly
  JOURNAL   J Cell Biol 204 (2), 215-229 (2014)
   PUBMED   24421332
REFERENCE   6  (residues 1 to 1356)
  AUTHORS   Taniwaki,T., Haruna,K., Nakamura,H., Sekimoto,T., Oike,Y.,
            Imaizumi,T., Saito,F., Muta,M., Soejima,Y., Utoh,A., Nakagata,N.,
            Araki,M., Yamamura,K. and Araki,K.
  TITLE     Characterization of an exchangeable gene trap using pU-17 carrying
            a stop codon-beta geo cassette
  JOURNAL   Dev Growth Differ 47 (3), 163-172 (2005)
   PUBMED   15840001
REFERENCE   7  (residues 1 to 1356)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   8  (residues 1 to 1356)
  AUTHORS   Miki,H., Setou,M., Kaneshiro,K. and Hirokawa,N.
  TITLE     All kinesin superfamily protein, KIF, genes in mouse and human
  JOURNAL   Proc Natl Acad Sci U S A 98 (13), 7004-7011 (2001)
   PUBMED   11416179
  REMARK    Review article
REFERENCE   9  (residues 1 to 1356)
  AUTHORS   Araki,K., Imaizumi,T., Sekimoto,T., Yoshinobu,K., Yoshimuta,J.,
            Akizuki,M., Miura,K., Araki,M. and Yamamura,K.
  TITLE     Exchangeable gene trap using the Cre/mutated lox system
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 45 (5), 737-750 (1999)
   PUBMED   10512203
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BX470237.7 and AL807823.6.
            
            On Aug 3, 2007 this sequence version replaced NP_077203.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC067395.1, SRR9219380.29160.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164143 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1356
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 21.51 cM"
     Protein         1..1356
                     /product="kinesin-like protein KIF24"
                     /calculated_mol_wt=150076
     Region          3..62
                     /region_name="SAM_KIF24-like"
                     /note="SAM domain of KIF24-like subfamily; cd09541"
                     /db_xref="CDD:188940"
     Region          93..119
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6NWW5.2)"
     Site            102
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q5T7B8; propagated from
                     UniProtKB/Swiss-Prot (Q6NWW5.2)"
     Region          218..539
                     /region_name="KISc_KIF2_like"
                     /note="Kinesin motor domain, KIF2-like group; cd01367"
                     /db_xref="CDD:276818"
     Site            order(226,308,311,313..316,446)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:276818"
     Region          473..702
                     /region_name="Interaction with MPHOSPH9.
                     /evidence=ECO:0000250|UniProtKB:Q5T7B8"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6NWW5.2)"
     Site            473
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q5T7B8; propagated from
                     UniProtKB/Swiss-Prot (Q6NWW5.2)"
     Site            order(494,497,500)
                     /site_type="other"
                     /note="microtubule interaction site [polypeptide binding]"
                     /db_xref="CDD:276818"
     Region          552..581
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6NWW5.2)"
     Site            579
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q6NWW5.2)"
     Region          597..664
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6NWW5.2)"
     Site            615
                     /site_type="phosphorylation"
                     /note="Phosphothreonine, by NEK2.
                     /evidence=ECO:0000250|UniProtKB:Q5T7B8; propagated from
                     UniProtKB/Swiss-Prot (Q6NWW5.2)"
     Site            616
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by NEK2.
                     /evidence=ECO:0000250|UniProtKB:Q5T7B8; propagated from
                     UniProtKB/Swiss-Prot (Q6NWW5.2)"
     Site            640
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q6NWW5.2)"
     Region          788..840
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6NWW5.2)"
     Site            817
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q6NWW5.2)"
     Site            820
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q6NWW5.2)"
     Region          897..947
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6NWW5.2)"
     Region          964..998
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6NWW5.2)"
     Site            1008
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q5T7B8; propagated from
                     UniProtKB/Swiss-Prot (Q6NWW5.2)"
     Region          1109..1140
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6NWW5.2)"
     CDS             1..1356
                     /gene="Kif24"
                     /gene_synonym="4933425J19Rik; 9430029L23Rik"
                     /coded_by="NM_024241.3:193..4263"
                     /db_xref="CCDS:CCDS18060.2"
                     /db_xref="GeneID:109242"
                     /db_xref="MGI:MGI:1918345"
ORIGIN      
        1 maswlyeclc eaelaqyyph ftalglqkid elakvtmkdy srlgvhdmnd rkrlfqliki
       61 ikimqeedka lgipehplqa sslytkpref rsgprrqlhf dspsaskdkm annetgslsn
      121 fsvdeqksty lkvlehmlpd dsqcqtkira pdasaadasm qtetnaplfs snyfspqlgn
      181 cdipviqrvs hvsgynygip hscvrqitse npwtemekir vcvrkrplgv revrrgevnv
      241 itvedketll vhekkeavdl tqyilqhvfy fdevfgeacs nqdvylktah pliqhifngg
      301 satcfaygqt gagktytmig thqnpglyal aakdifrqlk vsqsrrnlfv wisfyeiycg
      361 qlydllnrrk rlfaredskh vvqiaglrel qvdsvelllq vilkgskers tgatgvnads
      421 srshaiiqiq ikdsakrtfg risfidlags eraadardsd rqtkmegaei nqsllalkec
      481 iraldqehth tpfrqskltq vlkdsfigna ktcmianisp shiatehtln tlryadrvke
      541 lkkgvkccas atsqnqtsan aspkriqssp vtlpgdkcsp kkvklglqqs ltvapgptkv
      601 kahplashvp nvpftsgpkt pgkksssrgs ptpewdmkas prkgttrsgh sikkgaesap
      661 lcseksqigs kiavgwegra sdpgegllrv rlptrgkkvq pvqpvqkqll srprllansh
      721 hleatqdskv gtpaglapea wtnpilqqke reehlrfyhq qfqqppllkq klnyqplqrl
      781 lcqhrpsegr lqsetgfplh snpenrdgaq aedlddsdfs edsfshgssq pamkqgstal
      841 ersgssfflh qdrehspeeq aaerqqcllf ssetdgskkr padswvysrd piishrrgal
      901 sqshspsmvc pdwskeedsa ssgpspkdnr aqkpsssqvd fvhhqkpgea qvsdirleaf
      961 tsevpeqaeg slsspspeng lsfplshvav sgspdqrdrv ctplrevsen rvthtpgrvn
     1021 sstpfqedsg eqiqmcsana sglmapltms lletpchedl ssleqiaqdg agygfmaeiv
     1081 ggpaaghtvp sydqeaalpv ssateclwls ssppdnrpsg dlpalspspi hqhspdklpg
     1141 reayqtrrpi llpenhmgsk lyddraeete lggsltfprk pssnihagvp ystpfltsct
     1201 gssngvgrpw aqerkhptgv scqelvsstd snkphynedi awlrhrpisr cldsdspvvp
     1261 scsskalrty cpltpeqaqq viirahkeql demaeldlke etlmtqmdsn dfedfvtqld
     1321 eimalksrci qslrsqlqly ltshrpaaap ertvvs
//
