LOCUS       NM_145588               2053 bp    mRNA    linear   ROD 07-AUG-2024
DEFINITION  Mus musculus kinesin family member 22 (Kif22), transcript variant
            1, mRNA.
ACCESSION   NM_145588
VERSION     NM_145588.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2053)
  AUTHORS   Kawaue,H., Matsubara,T., Nagano,K., Ikedo,A., Rojasawasthien,T.,
            Yoshimura,A., Nakatomi,C., Imai,Y., Kakuta,Y., Addison,W.N. and
            Kokabu,S.
  TITLE     KIF22 regulates mitosis and proliferation of chondrocyte cells
  JOURNAL   iScience 27 (7), 110151 (2024)
   PUBMED   38989461
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2053)
  AUTHORS   Li,C., Zhang,Y., Shen,J., Bao,H., Zhao,Y., Li,D., Li,S., Liu,Y.,
            Yang,J., Zhou,Z., Gao,K., Zhao,L., Pei,Y., Lu,Y., Pan,Z. and Cai,B.
  TITLE     Cfp1 Controls Cardiomyocyte Maturation by Modifying Histone H3K4me3
            of Structural, Metabolic, and Contractile Related Genes
  JOURNAL   Adv Sci (Weinh) 11 (11), e2305992 (2024)
   PUBMED   38196272
REFERENCE   3  (bases 1 to 2053)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2053)
  AUTHORS   Farini,D., Cesari,E., Weatheritt,R.J., La Sala,G., Naro,C.,
            Pagliarini,V., Bonvissuto,D., Medici,V., Guerra,M., Di Pietro,C.,
            Rizzo,F.R., Musella,A., Carola,V., Centonze,D., Blencowe,B.J.,
            Marazziti,D. and Sette,C.
  TITLE     A Dynamic Splicing Program Ensures Proper Synaptic Connections in
            the Developing Cerebellum
  JOURNAL   Cell Rep 31 (9), 107703 (2020)
   PUBMED   32492419
REFERENCE   5  (bases 1 to 2053)
  AUTHORS   Bizzotto,S., Uzquiano,A., Dingli,F., Ershov,D., Houllier,A.,
            Arras,G., Richards,M., Loew,D., Minc,N., Croquelois,A., Houdusse,A.
            and Francis,F.
  TITLE     Eml1 loss impairs apical progenitor spindle length and soma shape
            in the developing cerebral cortex
  JOURNAL   Sci Rep 7 (1), 17308 (2017)
   PUBMED   29229923
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2053)
  AUTHORS   Soeda,S., Yamada-Nomoto,K. and Ohsugi,M.
  TITLE     The microtubule-binding and coiled-coil domains of Kid are required
            to turn off the polar ejection force at anaphase
  JOURNAL   J Cell Sci 129 (19), 3609-3619 (2016)
   PUBMED   27550518
  REMARK    GeneRIF: phosphorylation of Thr463 switches the mitotic chromosome
            movement from an anti-poleward direction to a poleward direction by
            converting the Kid functional mode from polar-ejection-force-ON to
            -OFF during the metaphase-anaphase transition.
REFERENCE   7  (bases 1 to 2053)
  AUTHORS   Ohsugi,M., Adachi,K., Horai,R., Kakuta,S., Sudo,K., Kotaki,H.,
            Tokai-Nishizumi,N., Sagara,H., Iwakura,Y. and Yamamoto,T.
  TITLE     Kid-mediated chromosome compaction ensures proper nuclear envelope
            formation
  JOURNAL   Cell 132 (5), 771-782 (2008)
   PUBMED   18329364
  REMARK    GeneRIF: These data suggest that Kid-mediated anaphase/telophase
            chromosome compaction prevents formation of multinucleated cells.
REFERENCE   8  (bases 1 to 2053)
  AUTHORS   Shiroguchi,K., Ohsugi,M., Edamatsu,M., Yamamoto,T. and
            Toyoshima,Y.Y.
  TITLE     The second microtubule-binding site of monomeric kid enhances the
            microtubule affinity
  JOURNAL   J Biol Chem 278 (25), 22460-22465 (2003)
   PUBMED   12692123
REFERENCE   9  (bases 1 to 2053)
  AUTHORS   Dickins,R.A., Frew,I.J., House,C.M., O'Bryan,M.K., Holloway,A.J.,
            Haviv,I., Traficante,N., de Kretser,D.M. and Bowtell,D.D.
  TITLE     The ubiquitin ligase component Siah1a is required for completion of
            meiosis I in male mice
  JOURNAL   Mol Cell Biol 22 (7), 2294-2303 (2002)
   PUBMED   11884614
REFERENCE   10 (bases 1 to 2053)
  AUTHORS   Yang,Z., Hanlon,D.W., Marszalek,J.R. and Goldstein,L.S.
  TITLE     Identification, partial characterization, and genetic mapping of
            kinesin-like protein genes in mouse
  JOURNAL   Genomics 45 (1), 123-131 (1997)
   PUBMED   9339368
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC122863.4.
            
            On Apr 1, 2022 this sequence version replaced NM_145588.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC003427.1, AK084310.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164134, SAMN01164138
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-64                AC122863.4         183078-183141       c
            65-257              AC122863.4         176482-176674       c
            258-385             AC122863.4         174858-174985       c
            386-540             AC122863.4         174612-174766       c
            541-750             AC122863.4         174203-174412       c
            751-981             AC122863.4         173896-174126       c
            982-1135            AC122863.4         173616-173769       c
            1136-1271           AC122863.4         173363-173498       c
            1272-1440           AC122863.4         171663-171831       c
            1441-1606           AC122863.4         170069-170234       c
            1607-1668           AC122863.4         169649-169710       c
            1669-1881           AC122863.4         168804-169016       c
            1882-1941           AC122863.4         168665-168724       c
            1942-2053           AC122863.4         168463-168574       c
FEATURES             Location/Qualifiers
     source          1..2053
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 69.29 cM"
     gene            1..2053
                     /gene="Kif22"
                     /gene_synonym="Kid; Kif22a"
                     /note="kinesin family member 22"
                     /db_xref="GeneID:110033"
                     /db_xref="MGI:MGI:109233"
     exon            1..64
                     /gene="Kif22"
                     /gene_synonym="Kid; Kif22a"
                     /inference="alignment:Splign:2.1.0"
     CDS             7..1989
                     /gene="Kif22"
                     /gene_synonym="Kid; Kif22a"
                     /note="isoform 1 is encoded by transcript variant 1;
                     kinesin-like protein KIF22; kinesin family member 22A"
                     /codon_start=1
                     /product="kinesin-like protein KIF22 isoform 1"
                     /protein_id="NP_663563.1"
                     /db_xref="CCDS:CCDS21855.1"
                     /db_xref="GeneID:110033"
                     /db_xref="MGI:MGI:109233"
                     /translation="MSLRAKTCPQRREMASATSGPGRCVSKGGLGRRPPLARVRVAVR
                     LRPFMDGETEAKELPCVRAIDSCSLEVANWKKYQETLKYQFDAFYGEKSTQQEVYVGS
                     VQPILRHLLEGQNASVLAYGPTGAGKTHTMLGSPEQPGVIPRALMDLLQLAREESAEG
                     RPWDVSVAMSYLEIYQEKVLDLLDPASGDLVIREDCRGNILIPGLTQKPITSFSDFEQ
                     HFLPASRNRAVGATRLNQRSSRSHAVLLVKVDQRERLTPFRQREGKLYLIDLAGSEDN
                     RRTGNQGIRLKESGAINTSLFVLGKVVDALNQGLPRIPYRDSKLTRLLQDSLGGSAHS
                     ILIANIAPERRFYQDTISALNFTARSKEVINRPFTNESLQPHALAPVKLSQKELLGPS
                     EAKKAKGPEEESTGSPESTAAPASASQKLSLLQKLSNMDPAMLENLLSMERLLGSQGS
                     QGTPLLNTPKRERMVLMKTVEEKNLEIERLKMKQKELEAKVLAQEAPDPREKENTPTI
                     LQPPASYSGTVAKPLKKAVVMPLQRIQKQRESSNQIQLLKKGPKRKLEPSPESEAVEK
                     DEDYWEVQISPELLAHGRKKLLDLLNEGSARELRSLQRIGQKKAQLIVGWRELHGPFS
                     EVEDLEQVEGISGKQVESFLKANLLSLAASQHSGPS"
     exon            65..257
                     /gene="Kif22"
                     /gene_synonym="Kid; Kif22a"
                     /inference="alignment:Splign:2.1.0"
     exon            258..385
                     /gene="Kif22"
                     /gene_synonym="Kid; Kif22a"
                     /inference="alignment:Splign:2.1.0"
     exon            386..540
                     /gene="Kif22"
                     /gene_synonym="Kid; Kif22a"
                     /inference="alignment:Splign:2.1.0"
     exon            541..750
                     /gene="Kif22"
                     /gene_synonym="Kid; Kif22a"
                     /inference="alignment:Splign:2.1.0"
     exon            751..981
                     /gene="Kif22"
                     /gene_synonym="Kid; Kif22a"
                     /inference="alignment:Splign:2.1.0"
     exon            982..1135
                     /gene="Kif22"
                     /gene_synonym="Kid; Kif22a"
                     /inference="alignment:Splign:2.1.0"
     exon            1136..1271
                     /gene="Kif22"
                     /gene_synonym="Kid; Kif22a"
                     /inference="alignment:Splign:2.1.0"
     exon            1272..1440
                     /gene="Kif22"
                     /gene_synonym="Kid; Kif22a"
                     /inference="alignment:Splign:2.1.0"
     exon            1441..1606
                     /gene="Kif22"
                     /gene_synonym="Kid; Kif22a"
                     /inference="alignment:Splign:2.1.0"
     exon            1607..1668
                     /gene="Kif22"
                     /gene_synonym="Kid; Kif22a"
                     /inference="alignment:Splign:2.1.0"
     exon            1669..1881
                     /gene="Kif22"
                     /gene_synonym="Kid; Kif22a"
                     /inference="alignment:Splign:2.1.0"
     exon            1882..1941
                     /gene="Kif22"
                     /gene_synonym="Kid; Kif22a"
                     /inference="alignment:Splign:2.1.0"
     exon            1942..2053
                     /gene="Kif22"
                     /gene_synonym="Kid; Kif22a"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2034..2039
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Kif22"
                     /gene_synonym="Kid; Kif22a"
                     /note="hexamer: AATACA"
     polyA_site      2053
                     /gene="Kif22"
                     /gene_synonym="Kid; Kif22a"
                     /note="major polyA site"
ORIGIN      
        1 aaggctatga gcttaagggc taagacgtgt ccgcagcgac gggagatggc gtcggccacc
       61 tcaggacctg gccgctgtgt aagcaaagga gggcttggcc ggcgtccgcc tctagctcga
      121 gtaagggtgg ctgtgcggct gcgcccgttt atggatggag agacagaagc gaaggagctc
      181 ccctgtgtcc gagccataga cagctgctct cttgaagtgg ctaactggaa gaaataccag
      241 gagacgctca aatatcagtt tgatgccttc tatggcgaga agagcactca gcaggaagtc
      301 tatgtaggtt cagtacagcc catcctaagg cacttgctgg aagggcagaa tgccagtgta
      361 cttgcctatg ggcctactgg ggcagggaag acacacacaa tgctgggcag cccagagcaa
      421 cctggagtga ttcctcgggc tctcatggac ctcctgcaac tagcaaggga agagagtgct
      481 gagggacggc catgggacgt ttctgttgct atgtcctatt tagagatcta ccaggaaaag
      541 gtattagacc tcttggatcc tgcatcagga gacctcgtga tccgcgaaga ctgccgaggg
      601 aacatcctga tcccaggcct cacacagaag cccatcacca gcttctctga cttcgagcag
      661 cacttccttc cagccagtag aaatcgagct gtaggagcca cccggcttaa ccagcgctct
      721 tcccgtagtc acgcagtgct cttggtcaag gtagatcagc gtgaacgttt gactccattt
      781 cgccagcggg aaggaaaact ctaccttatt gatttggctg gttcagagga caaccgtcgc
      841 acaggcaacc agggcattcg gctcaaagag agcggagcca tcaacacctc cctctttgta
      901 ctgggcaaag tggtggatgc attaaaccag ggcctccctc gcataccata ccgggacagc
      961 aagctcactc gtctgctgca ggactctctg ggaggctcag ctcatagcat cctcattgcc
     1021 aacattgctc ctgaaagacg tttttaccag gatacaattt cagcattgaa cttcactgct
     1081 aggtccaagg aggtgattaa ccggcctttc accaatgaga gtctacagcc tcatgccttg
     1141 gcacctgtta agctgtctca gaaagaactg ctaggcccgt cagaggcaaa gaaggccaaa
     1201 ggccctgaag aagaatcaac tgggagccct gagtctacag cagctccagc gtctgcctcc
     1261 cagaaactaa gcctcttaca gaagctaagc aatatggatc cagccatgtt ggagaacctc
     1321 ctgagtatgg aacgtttgct gggttcccag ggaagccaag ggacccccct actgaatacc
     1381 ccaaagcgag aacgaatggt gctcatgaag acagtggagg aaaagaactt agagattgag
     1441 aggcttaaga tgaagcaaaa agaactggaa gccaaggtgt tggcccagga ggcaccggat
     1501 ccaagggaaa aagagaacac tcccacaatt ctccagccgc ctgcctctta tagtggcaca
     1561 gtggcaaagc ccctgaaaaa ggctgtagtg atgcccctgc aacggattca gaagcagcga
     1621 gagtcctcaa accaaatcca gctcctgaag aaaggcccca aaaggaagct ggagccatcc
     1681 cctgagtcag aagctgtgga aaaggatgag gactactggg aggtacagat tagcccagag
     1741 ttactggcac atgggcgcaa aaaattattg gatctgctga atgaaggctc agctcgggaa
     1801 ctgcgcagcc tgcagcgcat tggccagaag aaagcccagc tcatcgtggg ctggagggag
     1861 ctccacggcc ccttcagtga ggtggaggac ttggaacagg tggaaggcat ctctgggaag
     1921 caggtggagt ctttcctgaa ggcgaatctc ttgagcttgg ccgccagcca gcacagcggt
     1981 ccctcttgac actaccttct tttaaaaatc cttgtatagt gacgtgttgt gtaaatacag
     2041 tttttattcc atg
//
