LOCUS       NM_153103               6764 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Mus musculus kinesin family member 1C (Kif1c), mRNA.
ACCESSION   NM_153103
VERSION     NM_153103.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6764)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6764)
  AUTHORS   Kobayakawa,M., Matsubara,T., Mizokami,A., Hiura,F., Takakura,N.,
            Kokabu,S., Matsuda,M., Yasuda,H., Nakamura,I., Takei,Y., Honda,H.,
            Hosokawa,R. and Jimi,E.
  TITLE     Kif1c regulates osteoclastic bone resorption as a downstream
            molecule of p130Cas
  JOURNAL   Cell Biochem Funct 38 (3), 300-308 (2020)
   PUBMED   31887784
  REMARK    GeneRIF: Kif1c regulates osteoclastic bone resorption as a
            downstream molecule of p130Cas.
REFERENCE   3  (bases 1 to 6764)
  AUTHORS   Siddiqui,N., Zwetsloot,A.J., Bachmann,A., Roth,D., Hussain,H.,
            Brandt,J., Kaverina,I. and Straube,A.
  TITLE     PTPN21 and Hook3 relieve KIF1C autoinhibition and activate
            intracellular transport
  JOURNAL   Nat Commun 10 (1), 2693 (2019)
   PUBMED   31217419
  REMARK    GeneRIF: Study shows that the microtubule binding surface of Kif1c
            motor domain interacts with its stalk and that these autoinhibitory
            interactions are released upon binding of protein tyrosine
            phosphatase Ptpn21. The FERM domain of Ptpn21 stimulates dense core
            vesicle transport in primary hippocampal neurons and rescues
            integrin trafficking in Kif1c-depleted cells.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 6764)
  AUTHORS   Ishida,M., Marubashi,S. and Fukuda,M.
  TITLE     M-INK, a novel tool for visualizing melanosomes and melanocores
  JOURNAL   J Biochem 161 (4), 323-326 (2017)
   PUBMED   28096452
  REMARK    GeneRIF: The melanocore-interacting Kif1c-tail (M-INK) probe
            localize melanosomes in keratinocytes.
REFERENCE   5  (bases 1 to 6764)
  AUTHORS   Blehm,B.H., Schroer,T.A., Trybus,K.M., Chemla,Y.R. and Selvin,P.R.
  TITLE     In vivo optical trapping indicates kinesin's stall force is reduced
            by dynein during intracellular transport
  JOURNAL   Proc Natl Acad Sci U S A 110 (9), 3381-3386 (2013)
   PUBMED   23404705
  REMARK    Erratum:[Proc Natl Acad Sci U S A. 2013 Jun 4;110(23):9613]
REFERENCE   6  (bases 1 to 6764)
  AUTHORS   Watters,J.W. and Dietrich,W.F.
  TITLE     Genetic, physical, and transcript map of the Ltxs1 region of mouse
            chromosome 11
  JOURNAL   Genomics 73 (2), 223-231 (2001)
   PUBMED   11318612
  REMARK    Erratum:[Genomics 2002 Mar;79(3):462]
REFERENCE   7  (bases 1 to 6764)
  AUTHORS   Roberts,J.E., Watters,J.W., Ballard,J.D. and Dietrich,W.F.
  TITLE     Ltx1, a mouse locus that influences the susceptibility of
            macrophages to cytolysis caused by intoxication with Bacillus
            anthracis lethal factor, maps to chromosome 11
  JOURNAL   Mol Microbiol 29 (2), 581-591 (1998)
   PUBMED   9720874
REFERENCE   8  (bases 1 to 6764)
  AUTHORS   Brady,K.P., Rowe,L.B., Her,H., Stevens,T.J., Eppig,J.,
            Sussman,D.J., Sikela,J. and Beier,D.R.
  TITLE     Genetic mapping of 262 loci derived from expressed sequences in a
            murine interspecific cross using single-strand conformational
            polymorphism analysis
  JOURNAL   Genome Res 7 (11), 1085-1093 (1997)
   PUBMED   9371744
REFERENCE   9  (bases 1 to 6764)
  AUTHORS   Nakagawa,T., Tanaka,Y., Matsuoka,E., Kondo,S., Okada,Y., Noda,Y.,
            Kanai,Y. and Hirokawa,N.
  TITLE     Identification and classification of 16 new kinesin superfamily
            (KIF) proteins in mouse genome
  JOURNAL   Proc Natl Acad Sci U S A 94 (18), 9654-9659 (1997)
   PUBMED   9275178
  REMARK    Erratum:[Proc Natl Acad Sci U S A 1999 Mar 30;96(7):4214]
REFERENCE   10 (bases 1 to 6764)
  AUTHORS   Meeker,N.D., Hickey,W.F., Korngold,R., Hansen,W.K., Sudweeks,J.D.,
            Wardell,B.B., Griffith,J.S. and Teuscher,C.
  TITLE     Multiple loci govern the bone marrow-derived immunoregulatory
            mechanism controlling dominant resistance to autoimmune orchitis
  JOURNAL   Proc Natl Acad Sci U S A 92 (12), 5684-5688 (1995)
   PUBMED   7777570
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL596117.19, AK029250.1, AB074017.1 and AK046574.1.
            
            On Apr 27, 2007 this sequence version replaced NM_153103.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC029286.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-162               AL596117.19        67912-68073
            163-342             AL596117.19        69736-69915
            343-1535            AK029250.1         270-1462
            1536-2036           AB074017.1         1166-1666
            2037-2380           AK046574.1         1278-1621
            2381-2995           AL596117.19        93252-93866
            2996-6764           AL596117.19        95566-99334
FEATURES             Location/Qualifiers
     source          1..6764
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 43.21 cM"
     gene            1..6764
                     /gene="Kif1c"
                     /gene_synonym="B430105J22Rik; D11Bwg1349e; Ltxs1; Orch3"
                     /note="kinesin family member 1C"
                     /db_xref="GeneID:16562"
                     /db_xref="MGI:MGI:1098260"
     exon            1..162
                     /gene="Kif1c"
                     /gene_synonym="B430105J22Rik; D11Bwg1349e; Ltxs1; Orch3"
                     /inference="alignment:Splign:2.1.0"
     exon            163..342
                     /gene="Kif1c"
                     /gene_synonym="B430105J22Rik; D11Bwg1349e; Ltxs1; Orch3"
                     /inference="alignment:Splign:2.1.0"
     exon            343..476
                     /gene="Kif1c"
                     /gene_synonym="B430105J22Rik; D11Bwg1349e; Ltxs1; Orch3"
                     /inference="alignment:Splign:2.1.0"
     CDS             371..3673
                     /gene="Kif1c"
                     /gene_synonym="B430105J22Rik; D11Bwg1349e; Ltxs1; Orch3"
                     /note="kinesin superfamily protein 1C; lethal factor toxin
                     susceptibility 1; kinesin 1C; N-3 kinsin"
                     /codon_start=1
                     /product="kinesin-like protein KIF1C"
                     /protein_id="NP_694743.2"
                     /db_xref="CCDS:CCDS24965.1"
                     /db_xref="GeneID:16562"
                     /db_xref="MGI:MGI:1098260"
                     /translation="MAGASVKVAVRVRPFNARETSQDAKCVVSMQGNTTSIINPKQSK
                     DAPKSFTFDYSYWSHTSVEDPQFASQQQVYRDIGEEMLLHAFEGYNVCIFAYGQTGAG
                     KSYTMMGRQEPGQQGIVPQLCEDLFSRVNVNQSAQLSYSVEVSYMEIYCERVRDLLNP
                     KSRGSLRVREHPILGPYVQDLSKLAVTSYADIADLMDCGNKARTVAATNMNETSSRSH
                     AVFTIVFTQRSHDQLTGLDSEKVSKISLVDLAGSERADSSGARGMRLKEGANINKSLT
                     TLGKVISALADLQSKKRKSDFIPYRDSVLTWLLKENLGGNSRTAMIAALSPADINYEE
                     TLSTLRYADRTKQIRCNAVINEDPNARLIRELQEEVARLRDLLMAQGLSASALGGLKV
                     EEGSPGGVLPPASSPPAPASPSSPPPHNGELEPSFSPSAEPQIGPEEAMERLQETEKI
                     IAELNETWEEKLRKTEALRMEREALLAEMGVAVREDGGTVGVFSPKKTPHLVNLNEDP
                     LMSECLLYHIKDGVTRVGQVDVDIKLTGQFIREQHCLFRSIPQPDGEVMVTLEPCEGA
                     ETYVNGKLVTEPLVLKSGNRIVMGKNHVFRFNHPEQARLERERGVPPPPGPPSEPVDW
                     NFAQKELLEQQGIDIKLEMEKRLQDLENQYRKEKEEADLLLEQQRLYADSDSGEDSDK
                     RSCEESWRLISSLREQLPPTTVQNIVKRCGLPSSGKRRAPRRVYQIPQRRRLQGKDPR
                     WATMADLKMQAVKEICYEVALADFRHGRAEIEALAALKMRELCRTYGKPEGPGDAWRA
                     VARDVWDTVGEEEGCGGGGGGSEEGARGAEVEDLRAHIDKLTGILQEVKLQNSSKDRE
                     LQALRDRMLRMERVIPLTQDLEDDNDESGLVTWAPPEGPEAVEETVPNDHSPAVRPTS
                     PPLSSWERVSRLMEEDPAFRRGRLRWLKQEQLRLQGLQGAGGRGGGLRRPPARFVPPH
                     DCKLRFPFKSNPQHRESWPGMGSGEAPAPQPPEEVTVPPAPPNRRPPSPRRPHRSRRN
                     SLDGGSRSRGGGSTQPEPQHLRPQKHNGYPQQPQPSPAQRPGPRYPPYTTPPRMRRQR
                     SAPDLKESGAAV"
     exon            477..553
                     /gene="Kif1c"
                     /gene_synonym="B430105J22Rik; D11Bwg1349e; Ltxs1; Orch3"
                     /inference="alignment:Splign:2.1.0"
     exon            554..733
                     /gene="Kif1c"
                     /gene_synonym="B430105J22Rik; D11Bwg1349e; Ltxs1; Orch3"
                     /inference="alignment:Splign:2.1.0"
     exon            734..799
                     /gene="Kif1c"
                     /gene_synonym="B430105J22Rik; D11Bwg1349e; Ltxs1; Orch3"
                     /inference="alignment:Splign:2.1.0"
     exon            800..978
                     /gene="Kif1c"
                     /gene_synonym="B430105J22Rik; D11Bwg1349e; Ltxs1; Orch3"
                     /inference="alignment:Splign:2.1.0"
     exon            979..1090
                     /gene="Kif1c"
                     /gene_synonym="B430105J22Rik; D11Bwg1349e; Ltxs1; Orch3"
                     /inference="alignment:Splign:2.1.0"
     exon            1091..1168
                     /gene="Kif1c"
                     /gene_synonym="B430105J22Rik; D11Bwg1349e; Ltxs1; Orch3"
                     /inference="alignment:Splign:2.1.0"
     exon            1169..1234
                     /gene="Kif1c"
                     /gene_synonym="B430105J22Rik; D11Bwg1349e; Ltxs1; Orch3"
                     /inference="alignment:Splign:2.1.0"
     exon            1235..1310
                     /gene="Kif1c"
                     /gene_synonym="B430105J22Rik; D11Bwg1349e; Ltxs1; Orch3"
                     /inference="alignment:Splign:2.1.0"
     exon            1311..1389
                     /gene="Kif1c"
                     /gene_synonym="B430105J22Rik; D11Bwg1349e; Ltxs1; Orch3"
                     /inference="alignment:Splign:2.1.0"
     exon            1390..1535
                     /gene="Kif1c"
                     /gene_synonym="B430105J22Rik; D11Bwg1349e; Ltxs1; Orch3"
                     /inference="alignment:Splign:2.1.0"
     exon            1536..1705
                     /gene="Kif1c"
                     /gene_synonym="B430105J22Rik; D11Bwg1349e; Ltxs1; Orch3"
                     /inference="alignment:Splign:2.1.0"
     exon            1706..1785
                     /gene="Kif1c"
                     /gene_synonym="B430105J22Rik; D11Bwg1349e; Ltxs1; Orch3"
                     /inference="alignment:Splign:2.1.0"
     exon            1786..1861
                     /gene="Kif1c"
                     /gene_synonym="B430105J22Rik; D11Bwg1349e; Ltxs1; Orch3"
                     /inference="alignment:Splign:2.1.0"
     exon            1862..1941
                     /gene="Kif1c"
                     /gene_synonym="B430105J22Rik; D11Bwg1349e; Ltxs1; Orch3"
                     /inference="alignment:Splign:2.1.0"
     exon            1942..2036
                     /gene="Kif1c"
                     /gene_synonym="B430105J22Rik; D11Bwg1349e; Ltxs1; Orch3"
                     /inference="alignment:Splign:2.1.0"
     exon            2037..2120
                     /gene="Kif1c"
                     /gene_synonym="B430105J22Rik; D11Bwg1349e; Ltxs1; Orch3"
                     /inference="alignment:Splign:2.1.0"
     exon            2121..2307
                     /gene="Kif1c"
                     /gene_synonym="B430105J22Rik; D11Bwg1349e; Ltxs1; Orch3"
                     /inference="alignment:Splign:2.1.0"
     exon            2308..2380
                     /gene="Kif1c"
                     /gene_synonym="B430105J22Rik; D11Bwg1349e; Ltxs1; Orch3"
                     /inference="alignment:Splign:2.1.0"
     exon            2381..2995
                     /gene="Kif1c"
                     /gene_synonym="B430105J22Rik; D11Bwg1349e; Ltxs1; Orch3"
                     /inference="alignment:Splign:2.1.0"
     exon            2996..6764
                     /gene="Kif1c"
                     /gene_synonym="B430105J22Rik; D11Bwg1349e; Ltxs1; Orch3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4212..4217
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Kif1c"
                     /gene_synonym="B430105J22Rik; D11Bwg1349e; Ltxs1; Orch3"
                     /note="hexamer: AATAAA"
     polyA_site      4229
                     /gene="Kif1c"
                     /gene_synonym="B430105J22Rik; D11Bwg1349e; Ltxs1; Orch3"
                     /note="major polyA site"
     regulatory      4271..4276
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Kif1c"
                     /gene_synonym="B430105J22Rik; D11Bwg1349e; Ltxs1; Orch3"
                     /note="hexamer: AGTAAA"
     polyA_site      4291
                     /gene="Kif1c"
                     /gene_synonym="B430105J22Rik; D11Bwg1349e; Ltxs1; Orch3"
                     /note="major polyA site"
     regulatory      5199..5204
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Kif1c"
                     /gene_synonym="B430105J22Rik; D11Bwg1349e; Ltxs1; Orch3"
                     /note="hexamer: AATAAA"
     polyA_site      5218
                     /gene="Kif1c"
                     /gene_synonym="B430105J22Rik; D11Bwg1349e; Ltxs1; Orch3"
ORIGIN      
        1 ttctgctgcc gcccccgggg cgcgatccgc cgcccgccgc ccggggaccc ggcgaggggc
       61 gggggcagcc ccgaactggc ccccggtctc tccctcgccg gtcttaggca tcccagaaag
      121 tttgtccctt tgctctccgc cggggagtcc tgccgcgacg agaaccccag acagaccttt
      181 ggagctacag gtgcctcctg actactcttc ccccacaatc agggtttccc ttacagccct
      241 gctggtgtgg ccaggcccca agtgtaggat ggggctcccc atacgcgggc cggtggcagc
      301 cagaactgat acagccccgc tgatctgggg ccaggacacc agctgaggag ggcaggagat
      361 cctggaagct atggctggag cctccgtgaa agttgcagtg agggttcggc cctttaatgc
      421 ccgtgagacc agccaggatg ccaagtgtgt ggtcagcatg cagggcaaca ccacctccat
      481 cattaatccc aaacagagca aggatgcccc caaaagcttc accttcgact attcttactg
      541 gtcgcatact tcggtggagg atccgcagtt tgcatctcag cagcaggtgt accgagacat
      601 aggagaagag atgctactcc atgcctttga aggctacaat gtgtgcatct ttgcctacgg
      661 gcagacgggg gctgggaagt cctacaccat gatggggcgg caggagccgg ggcagcaggg
      721 cattgtgcct cagctctgtg aggacctctt ctctcgagtc aatgtgaacc agagtgccca
      781 gctttcctat tcagtagagg tgagctatat ggaaatctat tgcgagcgag tacgagacct
      841 cttgaacccc aagagtcggg gctctctgcg ggtccgggag caccccatcc taggcccgta
      901 cgtgcaagac ctgtctaaac tggctgtgac ttcctatgca gacattgccg acctcatgga
      961 ctgtggaaat aaggcaagaa ccgtggctgc caccaacatg aacgagacca gcagccgctc
     1021 ccatgccgtc tttactattg tctttaccca gcgatcccat gaccagctta ctggcctgga
     1081 ttcagaaaag gtcagtaaga tcagcttggt ggacctcgcc gggagtgagc gggctgactc
     1141 ctcaggggcc cgggggatgc gtctaaagga aggcgccaac atcaataagt ccctgactac
     1201 gcttgggaag gtgatctcag ccctggcaga tttgcaatca aagaagcgga agtcggattt
     1261 catcccctat agagactcag tgcttacctg gctgctcaag gagaatttgg gtgggaactc
     1321 tcgcacagca atgattgcag ccctgagtcc tgctgacatc aattacgagg agacactcag
     1381 cactctcagg tatgcagacc gcaccaagca gatccgatgc aatgctgtca tcaacgagga
     1441 ccccaatgcc cggcttatcc gggagctgca ggaggaggtg gcccggctgc gggacctgct
     1501 gatggctcag gggctgtcag cctctgctct aggaggtcta aaggtggaag aggggagtcc
     1561 tggaggtgtt ctgccccctg catcatctcc ccccgcccca gcttcaccct catctcctcc
     1621 cccacataat ggggagctgg agccctcatt ctcacccagt gccgagcccc agattgggcc
     1681 tgaggaggcc atggagaggc tgcaggaaac agagaagatc atagctgagc tgaatgagac
     1741 ttgggaggag aagcttcgga agacagaggc tctgagaatg gagagagaag cattgctggc
     1801 tgagatgggc gtggctgtcc gggaggatgg cggtactgtg ggtgtcttct ctccaaaaaa
     1861 gactccccac ctggtaaatc tgaatgagga ccccttgatg tctgaatgtc ttctctacca
     1921 catcaaagat ggcgtcacca gggttggcca agtagatgtg gacatcaagt tgactggcca
     1981 gttcatccgg gagcagcatt gcctcttccg cagcatccct cagcctgatg gagaagtgat
     2041 ggttactctg gagccttgtg aaggagctga gacatatgtc aatgggaagc tcgtgacgga
     2101 gccgctggtg ctgaagtcag gaaacaggat tgtaatgggc aagaaccatg ttttccgctt
     2161 caatcacccg gagcaggcgc ggctggaacg agaacgtggg gtccccccgc ccccaggacc
     2221 tccctcggag cctgtggact ggaactttgc tcagaaggag ctgctggagc agcaaggcat
     2281 agacatcaag ctggagatgg agaagaggct gcaggacttg gagaatcagt accggaaaga
     2341 gaaggaagag gctgaccttc tgctggagca gcagcggctg tatgcagact ctgacagcgg
     2401 ggaagactct gacaagcgtt cttgtgaaga aagctggcgg ctgatttcct ccttgcggga
     2461 gcagctgccc cctaccacag tacagaacat tgtcaagcgc tgtggcctgc ctagtagtgg
     2521 caagcgcagg gcccctcgaa gagtctatca gatccctcag cgacggcggc tccagggcaa
     2581 agacccccga tgggccacca tggctgacct gaagatgcag gcagtaaagg agatatgcta
     2641 tgaggtggcc ctagccgact tccgccacgg acgagcagaa attgaagccc tggctgctct
     2701 caagatgagg gagctgtgcc gaacctacgg caagccagag ggtcctggag atgcctggag
     2761 agccgtggcc agggatgtct gggatactgt gggtgaagaa gaaggatgtg gaggtggcgg
     2821 aggtggcagt gaggagggag cccgtggggc agaggtggag gacctccggg ctcacatcga
     2881 caagctgaca gggatcctgc aggaggtgaa gctccagaac agcagcaagg accgcgagct
     2941 gcaggccctg cgggaccgca tgctccgcat ggagagggtc atcccgctga ctcaggatct
     3001 tgaggatgat aatgacgagt ctggtttggt cacctgggcc ccaccggaag ggccagaagc
     3061 agtagaggag acagtgccca acgaccactc accagctgtc cggcccacct caccacctct
     3121 gtccagctgg gagcgggtgt cgagattgat ggaagaggac cctgccttcc gtcgcggccg
     3181 ccttcgctgg ctcaagcagg agcagctgcg gctgcaggga ctgcagggcg ctgggggccg
     3241 gggtggggga ctgcgcaggc ctccagcccg ctttgtgccc ccgcatgatt gcaagctgcg
     3301 cttccccttc aaaagcaacc ctcagcacag ggagtcctgg ccaggaatgg ggagtggaga
     3361 ggccccagct cctcagcccc ctgaagaggt cactgtcccc ccagcacccc ctaaccgtag
     3421 gcctccaagt ccccgaagac cccaccgttc tcgcaggaat tccctagatg gagggagccg
     3481 atctcgggga gggggttcta cacagccaga accccagcac ttacggcccc aaaagcacaa
     3541 cggttatccc caacagcccc agcccagccc agcccagcgg ccagggcccc gctacccacc
     3601 atacactacc cctccgcgaa tgcgacggca gcgctcagcc cctgacctca aagagagtgg
     3661 ggcagctgtg tgagtcccac atgatgggca gacagggcct agtggggccc ttgttaggag
     3721 gaaggtgccc actgcttccc caagaagccc tggggcaagg aggccagaaa gcagagagca
     3781 agagagaggg aaggtccgag taggtggtag aagatgccag agagtgtgct ggaggctgag
     3841 ggaaggaaga gggcgcggag ttgccaggag caaaccaaag tcaaggaggg tccgtaggga
     3901 gttgtcttgg ggctacccgt tgcagggggg agtcccacaa acgctgctat gggtgggtgg
     3961 gtgggctggg gtctgcatag ccagtgtttg actttctttt tgagtgggtg caacggggag
     4021 agaaccgaga gtgaggtggg ttctcctccc cagctcttgt ctgtccgtct atccgtctgt
     4081 ctgtggtgga tttctgtttc cagggaggtg tggtgggatc ctaagtcatt cccttcccct
     4141 tccaggcctc ctgctatatt taggggacct gtctggtttg gctggggtcc cacaaaaatg
     4201 tgggacctct taataaagga tagcaaacag cttgtggttg gtgggttttg gtagcggtta
     4261 aggttgtgca agtaaagtat cgttttacta agcgcgtcat cccacgtcat ttctgcatgt
     4321 gcgtgaccac ctcatcagcg ctccacgcag gcaatgctgc catcctattt tcttaagttg
     4381 gaaacctcct gttcttctct ccggggtaca cagcctgttc tttcatttct gtttgctctg
     4441 ggtctctgcc caggtcctgt accctcagtg tccttgacaa aggagggagg gctgtgaggg
     4501 gcagtggggt ctgtcagtct gtccgtgcct aggtgaagga tttggggttc tgcctcactg
     4561 actcacctca cttgtttgga aggtgtctgc tcggggagtg ttgatcgggc ttcctgcacc
     4621 acttgtgtat tctcatgtgt cacccgagtc acttgccctt cagcgggcca cagtcaacct
     4681 cctgagcagc attttaagac ttgctttcga agccaggcat tgtggtgcac attttgaatc
     4741 cccacaggaa taggcagatc tctgagttgg aggccagcct gatctacaga gtgagttcca
     4801 gtgtagccag ggctacacag agaaaccctg tctcgaaaaa acaaaaaaga aaatcacttt
     4861 ctagctaggc aggtatgtgt tgcccttctt tgaatgaagc attgggatgc tgagacaaga
     4921 aaattgacac aggttcaaga ccaacctaaa ctacacaaga cctggtttta aatgatcaca
     4981 cttcccacaa cccaaaatgg ttaaaacttt taaaaataac ttagatgatg aatgtgagtg
     5041 tgggtttgtg tgtatgagta ccatgccagt ggaggacaga acagtctcat ctacatggtg
     5101 cgatgctggt atccaactct ggttctcttc aagaagagaa tgtaccttta atcactgaac
     5161 tgtctgctca ccctagagtt taaaaaaaaa aaatcaataa taaaaattca gaaaattcgc
     5221 tgcctttgtc tttaactcta gtttgagtag cacgcttagg gatgccacgt gagaagcttg
     5281 caggttcacc tgtatcaagc atagccctga gcttgctgag tccctgagta actgtgcttt
     5341 tatcttgtta cttaaactgg gctgctactc tgcagggtcc tgaagccagt cagagttgtg
     5401 caagcagaca gattgaccca gatcctccga actgacccag ggctctgagc agggctagcg
     5461 tgccgtttgc agttggtttc ttcttccctc tgctactggc taccttgatt ttgacacttt
     5521 tgattgctgg gtttccagaa gcctgttgac tgtgactcgg gacctggagt gtaatggcta
     5581 gtttggtagc agtgtttact tgagcgggtt tatgatgtgg ttggggagaa taagtgtaag
     5641 caagaaaatg atagagtcca aaggtctctg cagtcagggt gagctgtgtg gtgcaacgta
     5701 ggagagtcca gatggggggt ggcggggaat gccagtctca gctaccactg ggtgaccttt
     5761 ctctaaggac tgtatcatgt aaataggtac tgcctttaaa aaattgaatt cagtcttcca
     5821 cttctgtctt taacaatgcg aatagacggg attttattca gagatttgcc catgagtgtc
     5881 atgtacacgt gccagcctgt gctctgcatc ccgtttcatc cttaaccctg ctcccatttc
     5941 agatggggag acaggtttga ttggaatgag ttgcctaagt gtgtagttct tcggtggtga
     6001 agttagggtt ctaacccagg ctaacctgga cttcatccag ccctccagga caggggtatt
     6061 gttctctcca ggggccacac tgccctgtcc cttggatcct tccaagtgta tcataagcct
     6121 gcccctagct tctggtctct cctgctttgt gctatgaacg agtgagtgag agccgctatt
     6181 tcaggagcct gctctaaaat caggggatgt tgcctgagca gttctccggc tttctggccc
     6241 tctcagtttt ggcactgcta caatgtctcc cttggtttcc ctggcaatgc agtttgcttt
     6301 tcttcctttg cctcttcaga ggtttcttct ggttagttgt acagactcgg gtgtcacctg
     6361 agctttttgt atcgtgaata catttaggga tcttctgctt ctttttgtcc cccatatttc
     6421 ccatcccttt atacactagg tttggtttga aattcttttc tcttcttttc tttttttttt
     6481 taaatggggt tttgttttgt tttaggtagg agacatttat atagtcagat tggcttcaaa
     6541 cttgtggttt tcctacccca gcctcacaaa ttcagggatt atggaggtta actaccacgt
     6601 ctagcattct ttgctgatgt tgtttgtttg tttgtttgtt tttgagacag agcctctctg
     6661 tatagcccta gctgacctgg aatctgctat gtagaccaag ctagtctcca attttcttgt
     6721 cttctgaagg aagctgagat taaaggcatg tgtcattact cctg
//
