LOCUS       NM_001290995           10288 bp    mRNA    linear   ROD 28-JUL-2024
DEFINITION  Mus musculus kinesin family member 1B (Kif1b), transcript variant
            3, mRNA.
ACCESSION   NM_001290995 XM_006535912 XM_006538589
VERSION     NM_001290995.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 10288)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 10288)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 10288)
  AUTHORS   Nakano,Y., Wiechert,S., Fritzsch,B. and Banfi,B.
  TITLE     Inhibition of a transcriptional repressor rescues hearing in a
            splicing factor-deficient mouse
  JOURNAL   Life Sci Alliance 3 (12), e202000841 (2020)
   PUBMED   33087486
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 10288)
  AUTHORS   Nakano,Y., Wiechert,S. and Banfi,B.
  TITLE     Overlapping Activities of Two Neuronal Splicing Factors Switch the
            GABA Effect from Excitatory to Inhibitory by Regulating REST
  JOURNAL   Cell Rep 27 (3), 860-871 (2019)
   PUBMED   30995482
REFERENCE   5  (bases 1 to 10288)
  AUTHORS   Xu,F., Takahashi,H., Tanaka,Y., Ichinose,S., Niwa,S., Wicklund,M.P.
            and Hirokawa,N.
  TITLE     KIF1Bbeta mutations detected in hereditary neuropathy impair IGF1R
            transport and axon growth
  JOURNAL   J Cell Biol 217 (10), 3480-3496 (2018)
   PUBMED   30126838
  REMARK    GeneRIF: These data have supported the relevance of KIF1Bbeta in
            IGF1R transport, which may give new clue to the neuropathic
            pathogenesis.
REFERENCE   6  (bases 1 to 10288)
  AUTHORS   Gong,T.L., Burmeister,M. and Lomax,M.I.
  TITLE     The novel gene D4Mil1e maps to mouse chromosome 4 and human
            chromosome 1p36
  JOURNAL   Mamm Genome 7 (10), 790-791 (1996)
   PUBMED   8854876
REFERENCE   7  (bases 1 to 10288)
  AUTHORS   Okada,Y., Yamazaki,H., Sekine-Aizawa,Y. and Hirokawa,N.
  TITLE     The neuron-specific kinesin superfamily protein KIF1A is a unique
            monomeric motor for anterograde axonal transport of synaptic
            vesicle precursors
  JOURNAL   Cell 81 (5), 769-780 (1995)
   PUBMED   7539720
REFERENCE   8  (bases 1 to 10288)
  AUTHORS   Nangaku,M., Sato-Yoshitake,R., Okada,Y., Noda,Y., Takemura,R.,
            Yamazaki,H. and Hirokawa,N.
  TITLE     KIF1B, a novel microtubule plus end-directed monomeric motor
            protein for transport of mitochondria
  JOURNAL   Cell 79 (7), 1209-1220 (1994)
   PUBMED   7528108
REFERENCE   9  (bases 1 to 10288)
  AUTHORS   Matthews,R.H., Sardovia,M., Lewis,N.J. and Zand,R.
  TITLE     Biphasic kinetic plots and specific analogs distinguishing and
            describing amino acid transport sites in S37 ascites tumor cells
  JOURNAL   Biochim Biophys Acta 394 (2), 182-192 (1975)
   PUBMED   1138929
REFERENCE   10 (bases 1 to 10288)
  AUTHORS   Beaven,D.W.
  TITLE     Morals and ethics in medical research
  JOURNAL   N Z Med J 81 (541), 519-524 (1975)
   PUBMED   1057104
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK134946.1, CJ104954.1, AF131865.1, BE952257.1, CF746574.1,
            BC059901.1 and AI848477.1.
            
            On or before Mar 21, 2014 this sequence version replaced
            XM_006535912.1, XM_006538589.1.
            
            Transcript Variant: This variant (3) represents the longest
            transcript and encodes the longest isoform (c).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF131865.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164138
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-42                AK134946.1         2-43
            43-287              CJ104954.1         3-247
            288-723             AF131865.1         206-641
            724-737             BE952257.1         528-541
            738-5196            AF131865.1         656-5114
            5197-5210           CF746574.1         161-174
            5211-5825           AF131865.1         5129-5743
            5826-10272          BC059901.1         474-4920
            10273-10288         AI848477.1         1-16                c
FEATURES             Location/Qualifiers
     source          1..10288
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 79.05 cM"
     gene            1..10288
                     /gene="Kif1b"
                     /gene_synonym="A530096N05Rik; D4Mil1e; KIF1Bp130;
                     KIF1Bp204"
                     /note="kinesin family member 1B"
                     /db_xref="GeneID:16561"
                     /db_xref="MGI:MGI:108426"
     exon            1..305
                     /gene="Kif1b"
                     /gene_synonym="A530096N05Rik; D4Mil1e; KIF1Bp130;
                     KIF1Bp204"
                     /inference="alignment:Splign:2.1.0"
     exon            306..480
                     /gene="Kif1b"
                     /gene_synonym="A530096N05Rik; D4Mil1e; KIF1Bp130;
                     KIF1Bp204"
                     /inference="alignment:Splign:2.1.0"
     CDS             375..5825
                     /gene="Kif1b"
                     /gene_synonym="A530096N05Rik; D4Mil1e; KIF1Bp130;
                     KIF1Bp204"
                     /EC_number="5.6.1.3"
                     /note="isoform c is encoded by transcript variant 3;
                     kinesin-like protein KIF1B; kinesin heavy chain member 1B;
                     N-3 kinesin"
                     /codon_start=1
                     /product="kinesin-like protein KIF1B isoform c"
                     /protein_id="NP_001277924.1"
                     /db_xref="CCDS:CCDS71521.1"
                     /db_xref="GeneID:16561"
                     /db_xref="MGI:MGI:108426"
                     /translation="MSGASVKVAVRVRPFNSRETSKESKCIIQMQGNSTSIINPKNPK
                     EAPKSFSFDYSYWSHTSPEDPCFASQNRVYNDIGKEMLLHAFEGYNVCIFAYGQTGAG
                     KSYTMMGKQEESQAGIIPQLCEELFEKINDNCNEEMSYSVEVSYMEIYCERVRDLLNP
                     KNKGNLRVREHPLLGPYVEDLSKLAVTSYTDIADLMDAGNKARTVAATNMNETSSRSH
                     AVFTIVFTQKKQDPETNLSTEKVSKISLVDLAGSERADSTGAKGTRLKEGANINKSLT
                     TLGKVISALAEVDNCTSKSKKKKKTDFIPYRDSVLTWLLRENLGGNSRTAMVAALSPA
                     DINYDETLSTLRYADRAKQIKCNAVINEDPNAKLVRELKEEVTRLKDLLRAQGLGDII
                     DIDPLIDDYSGSGGKYLKDFQNNKHRYLLASENQRPGNFSTASMGSLTSSPSSCSLNS
                     QVGLTSVTSIQERIMSTPGGEEAIERLKESEKIIAELNETWEEKLRKTEAIRMEREAL
                     LAEMGVAIREDGGTLGVFSPKKTPHLVNLNEDPLMSECLLYYIKDGITRVGQADAERR
                     QDIVLSGAHIKEEHCLFRSERSNTGEVIVTLEPCERSETYVNGKRVAHPVQLRSGNRI
                     IMGKNHVFRFNHPEQARAEREKTPSAETPSEPVDWTFAQRELLEKQGIDMKQEMEKRL
                     QEMEILYKKEKEEADLLLEQQRLDYESKLQALQRQVETRSLAAETTEEEEEEEEVPWT
                     QHEFELAQWAFRKWKSHQFTSLRDLLWGNAVYLKEANAISVELKKKVQFQFVLLTDTL
                     YSPVPPELLPSEMEKTHEDRPFPRTVVAVEVQDLKNGATHYWSLDKLKQRLDLMREMY
                     DRAGEVASSAQDDSETTMTGSDPFYDRFHWFKLVGSSPIFHGCVNERLADRTPSPTFS
                     TADSDITELADEQQDAMEDFDDEAFVDDTGSDAGTEEGSELFSDGHDPFYDRSPWFIL
                     VGRAFVYLSNLLYPVPLIHRVAIVSEKGEVRGFLRVAVQAIAADEEAPDYGSGIRQSG
                     TAKISFDNEYFNQSDFSSAAMTRSGLSLEELRIVEGQGQSSEVISPPEEVNRMNDLDL
                     KSGTLLDGKMVMEGFSEEIGNHLKLGSAFTFRVTVLQASGILPEYADIFCQFNFLHRH
                     DEAFSTEPLKNNGRGSPLGFYHVQNIAVEVTESFVDYIKTKPIVFEVFGHYQQHPLHL
                     QGQDLNSPPQPSRRFFPPPMPLSKPVPATKLNTMNKTTLGQSMSKYDLLVWFEISELE
                     PTGEYIPAVVDHTAGLPCQGTFLLHQGIQRRITVTIIHEKGSELHWKDVRELVVGRIR
                     NKPEVDEAAVDAVLSLNIISAKSLKAAHSSSRTFYRFEAVWDSSLHNSLLLNRVTPYG
                     EKIYMTLSAYLELDHCIQPAVITKDVCMVFYSRDAKISPPRSLRNLFGSGYSKSPDSN
                     RVTGIYELSLCKMADTGSPGMQRRRRKVLDTSVAYVRGEENLAGWRPRGDSLILEHQW
                     ELEKLELLHEVEKTRHFLLLRERLGDSVPKSLSDSLSPSLSSGTLSTSTSISSQISTT
                     TFESAITPSESSGYDSADVESLVDREKELATKCLQLLTHTFNREFSQVHGSISDCKLS
                     DISPIGRDPSVSSFSSSTLTPSSTCPSLVDSRSSSMDQKTPEANSRASSPCQEFEQFQ
                     IVPTVETPYLARAGKNEFLNLVPDIEEVRAGSVVSKKGYLHFKEPLSSNWAKHFVVVR
                     RPYVFIYNSDKDPVERGIINLSTAQVEYSEDQQAMVKTPNTFAVCTKHRGVLLQALND
                     KDMNDWLYAFNPLLAGTIRSKLSRRCPSQPKY"
     exon            481..557
                     /gene="Kif1b"
                     /gene_synonym="A530096N05Rik; D4Mil1e; KIF1Bp130;
                     KIF1Bp204"
                     /inference="alignment:Splign:2.1.0"
     exon            558..737
                     /gene="Kif1b"
                     /gene_synonym="A530096N05Rik; D4Mil1e; KIF1Bp130;
                     KIF1Bp204"
                     /inference="alignment:Splign:2.1.0"
     exon            738..803
                     /gene="Kif1b"
                     /gene_synonym="A530096N05Rik; D4Mil1e; KIF1Bp130;
                     KIF1Bp204"
                     /inference="alignment:Splign:2.1.0"
     exon            804..982
                     /gene="Kif1b"
                     /gene_synonym="A530096N05Rik; D4Mil1e; KIF1Bp130;
                     KIF1Bp204"
                     /inference="alignment:Splign:2.1.0"
     exon            983..1094
                     /gene="Kif1b"
                     /gene_synonym="A530096N05Rik; D4Mil1e; KIF1Bp130;
                     KIF1Bp204"
                     /inference="alignment:Splign:2.1.0"
     exon            1095..1172
                     /gene="Kif1b"
                     /gene_synonym="A530096N05Rik; D4Mil1e; KIF1Bp130;
                     KIF1Bp204"
                     /inference="alignment:Splign:2.1.0"
     exon            1173..1238
                     /gene="Kif1b"
                     /gene_synonym="A530096N05Rik; D4Mil1e; KIF1Bp130;
                     KIF1Bp204"
                     /inference="alignment:Splign:2.1.0"
     exon            1239..1256
                     /gene="Kif1b"
                     /gene_synonym="A530096N05Rik; D4Mil1e; KIF1Bp130;
                     KIF1Bp204"
                     /inference="alignment:Splign:2.1.0"
     exon            1257..1332
                     /gene="Kif1b"
                     /gene_synonym="A530096N05Rik; D4Mil1e; KIF1Bp130;
                     KIF1Bp204"
                     /inference="alignment:Splign:2.1.0"
     exon            1333..1411
                     /gene="Kif1b"
                     /gene_synonym="A530096N05Rik; D4Mil1e; KIF1Bp130;
                     KIF1Bp204"
                     /inference="alignment:Splign:2.1.0"
     exon            1412..1554
                     /gene="Kif1b"
                     /gene_synonym="A530096N05Rik; D4Mil1e; KIF1Bp130;
                     KIF1Bp204"
                     /inference="alignment:Splign:2.1.0"
     exon            1555..1596
                     /gene="Kif1b"
                     /gene_synonym="A530096N05Rik; D4Mil1e; KIF1Bp130;
                     KIF1Bp204"
                     /inference="alignment:Splign:2.1.0"
     exon            1597..1808
                     /gene="Kif1b"
                     /gene_synonym="A530096N05Rik; D4Mil1e; KIF1Bp130;
                     KIF1Bp204"
                     /inference="alignment:Splign:2.1.0"
     exon            1809..1888
                     /gene="Kif1b"
                     /gene_synonym="A530096N05Rik; D4Mil1e; KIF1Bp130;
                     KIF1Bp204"
                     /inference="alignment:Splign:2.1.0"
     exon            1889..1964
                     /gene="Kif1b"
                     /gene_synonym="A530096N05Rik; D4Mil1e; KIF1Bp130;
                     KIF1Bp204"
                     /inference="alignment:Splign:2.1.0"
     exon            1965..2044
                     /gene="Kif1b"
                     /gene_synonym="A530096N05Rik; D4Mil1e; KIF1Bp130;
                     KIF1Bp204"
                     /inference="alignment:Splign:2.1.0"
     exon            2045..2151
                     /gene="Kif1b"
                     /gene_synonym="A530096N05Rik; D4Mil1e; KIF1Bp130;
                     KIF1Bp204"
                     /inference="alignment:Splign:2.1.0"
     exon            2152..2235
                     /gene="Kif1b"
                     /gene_synonym="A530096N05Rik; D4Mil1e; KIF1Bp130;
                     KIF1Bp204"
                     /inference="alignment:Splign:2.1.0"
     exon            2236..2416
                     /gene="Kif1b"
                     /gene_synonym="A530096N05Rik; D4Mil1e; KIF1Bp130;
                     KIF1Bp204"
                     /inference="alignment:Splign:2.1.0"
     exon            2417..2489
                     /gene="Kif1b"
                     /gene_synonym="A530096N05Rik; D4Mil1e; KIF1Bp130;
                     KIF1Bp204"
                     /inference="alignment:Splign:2.1.0"
     exon            2490..2583
                     /gene="Kif1b"
                     /gene_synonym="A530096N05Rik; D4Mil1e; KIF1Bp130;
                     KIF1Bp204"
                     /inference="alignment:Splign:2.1.0"
     exon            2584..2732
                     /gene="Kif1b"
                     /gene_synonym="A530096N05Rik; D4Mil1e; KIF1Bp130;
                     KIF1Bp204"
                     /inference="alignment:Splign:2.1.0"
     exon            2733..2911
                     /gene="Kif1b"
                     /gene_synonym="A530096N05Rik; D4Mil1e; KIF1Bp130;
                     KIF1Bp204"
                     /inference="alignment:Splign:2.1.0"
     exon            2912..3049
                     /gene="Kif1b"
                     /gene_synonym="A530096N05Rik; D4Mil1e; KIF1Bp130;
                     KIF1Bp204"
                     /inference="alignment:Splign:2.1.0"
     exon            3050..3298
                     /gene="Kif1b"
                     /gene_synonym="A530096N05Rik; D4Mil1e; KIF1Bp130;
                     KIF1Bp204"
                     /inference="alignment:Splign:2.1.0"
     exon            3299..3417
                     /gene="Kif1b"
                     /gene_synonym="A530096N05Rik; D4Mil1e; KIF1Bp130;
                     KIF1Bp204"
                     /inference="alignment:Splign:2.1.0"
     exon            3418..3503
                     /gene="Kif1b"
                     /gene_synonym="A530096N05Rik; D4Mil1e; KIF1Bp130;
                     KIF1Bp204"
                     /inference="alignment:Splign:2.1.0"
     exon            3504..3633
                     /gene="Kif1b"
                     /gene_synonym="A530096N05Rik; D4Mil1e; KIF1Bp130;
                     KIF1Bp204"
                     /inference="alignment:Splign:2.1.0"
     exon            3634..3796
                     /gene="Kif1b"
                     /gene_synonym="A530096N05Rik; D4Mil1e; KIF1Bp130;
                     KIF1Bp204"
                     /inference="alignment:Splign:2.1.0"
     exon            3797..3887
                     /gene="Kif1b"
                     /gene_synonym="A530096N05Rik; D4Mil1e; KIF1Bp130;
                     KIF1Bp204"
                     /inference="alignment:Splign:2.1.0"
     exon            3888..4006
                     /gene="Kif1b"
                     /gene_synonym="A530096N05Rik; D4Mil1e; KIF1Bp130;
                     KIF1Bp204"
                     /inference="alignment:Splign:2.1.0"
     exon            4007..4062
                     /gene="Kif1b"
                     /gene_synonym="A530096N05Rik; D4Mil1e; KIF1Bp130;
                     KIF1Bp204"
                     /inference="alignment:Splign:2.1.0"
     exon            4063..4171
                     /gene="Kif1b"
                     /gene_synonym="A530096N05Rik; D4Mil1e; KIF1Bp130;
                     KIF1Bp204"
                     /inference="alignment:Splign:2.1.0"
     exon            4172..4238
                     /gene="Kif1b"
                     /gene_synonym="A530096N05Rik; D4Mil1e; KIF1Bp130;
                     KIF1Bp204"
                     /inference="alignment:Splign:2.1.0"
     exon            4239..4323
                     /gene="Kif1b"
                     /gene_synonym="A530096N05Rik; D4Mil1e; KIF1Bp130;
                     KIF1Bp204"
                     /inference="alignment:Splign:2.1.0"
     exon            4324..4429
                     /gene="Kif1b"
                     /gene_synonym="A530096N05Rik; D4Mil1e; KIF1Bp130;
                     KIF1Bp204"
                     /inference="alignment:Splign:2.1.0"
     exon            4430..4544
                     /gene="Kif1b"
                     /gene_synonym="A530096N05Rik; D4Mil1e; KIF1Bp130;
                     KIF1Bp204"
                     /inference="alignment:Splign:2.1.0"
     exon            4545..4678
                     /gene="Kif1b"
                     /gene_synonym="A530096N05Rik; D4Mil1e; KIF1Bp130;
                     KIF1Bp204"
                     /inference="alignment:Splign:2.1.0"
     exon            4679..4740
                     /gene="Kif1b"
                     /gene_synonym="A530096N05Rik; D4Mil1e; KIF1Bp130;
                     KIF1Bp204"
                     /inference="alignment:Splign:2.1.0"
     exon            4741..4886
                     /gene="Kif1b"
                     /gene_synonym="A530096N05Rik; D4Mil1e; KIF1Bp130;
                     KIF1Bp204"
                     /inference="alignment:Splign:2.1.0"
     exon            4887..5126
                     /gene="Kif1b"
                     /gene_synonym="A530096N05Rik; D4Mil1e; KIF1Bp130;
                     KIF1Bp204"
                     /inference="alignment:Splign:2.1.0"
     exon            5127..5198
                     /gene="Kif1b"
                     /gene_synonym="A530096N05Rik; D4Mil1e; KIF1Bp130;
                     KIF1Bp204"
                     /inference="alignment:Splign:2.1.0"
     exon            5199..5320
                     /gene="Kif1b"
                     /gene_synonym="A530096N05Rik; D4Mil1e; KIF1Bp130;
                     KIF1Bp204"
                     /inference="alignment:Splign:2.1.0"
     exon            5321..5470
                     /gene="Kif1b"
                     /gene_synonym="A530096N05Rik; D4Mil1e; KIF1Bp130;
                     KIF1Bp204"
                     /inference="alignment:Splign:2.1.0"
     exon            5471..5663
                     /gene="Kif1b"
                     /gene_synonym="A530096N05Rik; D4Mil1e; KIF1Bp130;
                     KIF1Bp204"
                     /inference="alignment:Splign:2.1.0"
     exon            5664..5782
                     /gene="Kif1b"
                     /gene_synonym="A530096N05Rik; D4Mil1e; KIF1Bp130;
                     KIF1Bp204"
                     /inference="alignment:Splign:2.1.0"
     exon            5783..10274
                     /gene="Kif1b"
                     /gene_synonym="A530096N05Rik; D4Mil1e; KIF1Bp130;
                     KIF1Bp204"
                     /inference="alignment:Splign:2.1.0"
     regulatory      10249..10254
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Kif1b"
                     /gene_synonym="A530096N05Rik; D4Mil1e; KIF1Bp130;
                     KIF1Bp204"
                     /note="hexamer: AATAAA"
     polyA_site      10274
                     /gene="Kif1b"
                     /gene_synonym="A530096N05Rik; D4Mil1e; KIF1Bp130;
                     KIF1Bp204"
                     /note="major polyA site"
ORIGIN      
        1 ggcttcgggc ggagtttggc gagcagcgtc gcggtgtagt cagacggcag tggtcccggg
       61 aggcgacagc tcggatccgg gcttctctct gttcctccgc cgcatccaca gccgcgcccc
      121 ggcctcccgc caatcctcga tgcagagctg ggcggccgcg tgatggggct gcggagcggc
      181 gccctgcggc tcgcggcggc cgctgcctgc gctgaggtgc gtcggtgccc ggcctcccgc
      241 gcccctgcgc gcctcggcgt cttctgactc ggccggctcg cccgtctgtc cgcagcgcgg
      301 ctgaggaacc ttgaacacaa cttcaaaaga agatttgatt tttacttctg gactgcatat
      361 ataaggccat cagaatgtcg ggagcctctg tgaaggtcgc tgttcgagtg aggcccttca
      421 attctcgaga gaccagcaag gagtccaagt gcatcattca gatgcaaggc aactcgacca
      481 gtattattaa cccaaagaac ccaaaggaag caccaaagtc cttcagcttt gactactcct
      541 actggtccca cacctcgcct gaagatccct gttttgcatc gcagaatcgt gtgtacaatg
      601 acattggaaa ggaaatgctc ttacatgcct ttgaaggtta taatgtctgt atctttgcct
      661 atgggcagac tggtgctggg aaatcctaca cgatgatggg gaaacaagaa gagagccaag
      721 ctggaatcat cccacagttg tgtgaagaac tctttgagaa gatcaatgac aattgtaatg
      781 aagaaatgtc ttactctgta gaggtgagct acatggaaat ttactgtgag agagtacgag
      841 atttactgaa tcccaaaaac aagggtaact tgcgtgtgcg tgaacacccg cttcttggac
      901 cctatgtgga ggatctgtcc aagctggcgg tcacctccta cactgacatc gctgacctga
      961 tggatgctgg gaacaaagcc aggactgtgg cagctaccaa catgaatgag acaagcagcc
     1021 gttctcacgc tgtgttcacc attgtcttta cccagaagaa acaggatcct gagacgaacc
     1081 tttctactga gaaggtcagt aaaatcagct tggtggatct agcaggaagt gaacgggctg
     1141 attcaactgg tgccaaagga actcgattaa aggaaggtgc aaatatcaat aagtccctta
     1201 caactttggg caaagtcatt tcggccttgg cagaggtgga taactgcaca agcaagagta
     1261 aaaagaagaa gaaaactgat tttattcctt atagggattc tgtacttact tggctccttc
     1321 gagaaaatct cggtggcaac tcccgaactg caatggttgc tgctctgagc ccagccgaca
     1381 tcaactacga tgaaactttg agcacactga gatacgcaga tcgtgcaaaa caaattaaat
     1441 gcaatgctgt tatcaatgag gacccgaatg ccaagctggt tcgggagttg aaggaggaag
     1501 tgacccgact gaaggacctt cttcgtgctc agggactggg agatattatt gatattgacc
     1561 cattgatcga tgattactct ggaagtggag gcaaatatct gaaagatttt cagaacaata
     1621 agcataggta cttgctagcc tctgagaatc aacgccctgg caatttttcc acagcatcca
     1681 tggggtccct cacttcatct ccatcttcat gctcacttaa tagtcaggtg ggcttaacat
     1741 ctgtgaccag tattcaggag aggatcatgt ctacacctgg aggggaggaa gccattgaac
     1801 gtctgaagga gtcagagaag atcattgctg agttgaatga aacctgggaa gagaaacttc
     1861 gtaaaacaga ggccatcaga atggagagag aagccttgtt ggctgagatg ggagttgcca
     1921 tacgggaaga tggggggaca cttggagttt tctctcctaa aaagacccca catcttgtta
     1981 acctcaatga agacccatta atgtcggagt gtttgctcta ttacatcaag gatggaatta
     2041 caagggttgg ccaggcagat gctgagcggc gccaggacat agtgctgagt ggggcccaca
     2101 ttaaagagga gcattgtctc tttcggagtg agaggagcaa cactggtgaa gttattgtga
     2161 ccttggagcc ctgtgagcgc tcagaaacat acgtgaatgg caagagggtg gctcatcctg
     2221 ttcagctgcg ctcagggaac cgtatcatca tgggtaaaaa ccatgttttt cgttttaacc
     2281 accctgaaca agcgcgagca gaaagggaaa agactccctc agctgagacc ccctctgagc
     2341 ctgtggactg gacctttgct cagagagagc ttctcgaaaa acaaggaatt gatatgaaac
     2401 aggagatgga aaagaggctt caggaaatgg agatccttta caaaaaggag aaggaggaag
     2461 ccgatcttct cctggagcag cagagactgg actacgagag taaattgcag gccttgcaga
     2521 ggcaggttga gactcgatct ctggctgcag agacaacgga agaggaggaa gaggaggagg
     2581 aagttccttg gacacagcat gaatttgagt tggcccagtg ggcgttccgg aaatggaagt
     2641 ctcaccagtt tacttcatta agggacttac tctggggcaa tgcggtgtac ctgaaggaag
     2701 ccaatgccat cagtgtggaa ctaaagaaaa aggtgcagtt ccagtttgtt ctgctgactg
     2761 acacgctgta ctcccctgtg cctcctgaac tgcttccctc ggagatggag aagacgcacg
     2821 aggacagacc tttccctcgg actgtggtgg cggtggaggt ccaggatctg aagaatggag
     2881 caacacatta ttggtctttg gataaactca agcagagact ggatctgatg cgagagatgt
     2941 atgacagggc aggggaggtg gcctccagtg cccaagatga cagcgagacg accatgaccg
     3001 gcagcgaccc attctacgat cggttccact ggttcaaact tgtgggaagc tcccctattt
     3061 tccacggctg tgtgaatgag cgccttgccg accgcacacc ctcccccact ttttccacgg
     3121 ccgattccga catcactgaa ctggctgacg agcagcagga tgccatggag gactttgatg
     3181 atgaggcatt cgtggatgac accggctctg acgcagggac ggaagaggga tcagagctct
     3241 tcagtgatgg gcatgaccca ttttacgacc gatccccttg gttcatttta gtaggaaggg
     3301 catttgtgta cttgagcaac ctgctgtatc cggtgcccct gattcacagg gtggccattg
     3361 tcagtgagaa gggggaagtc cggggatttc ttcgtgtggc tgtgcaggcc attgcagcgg
     3421 atgaagaagc ccctgattat ggctctggaa tccggcagtc gggaacagct aaaatatctt
     3481 ttgataatga atactttaat cagagtgact tctcgtcagc tgcaatgact cgttctggtc
     3541 tgtccttgga ggagctgagg attgtggaag gtcagggcca gagttctgaa gtcatcagtc
     3601 ctccagaaga agtcaatcga atgaacgacc tggatttgaa gtcaggcact ttgctggatg
     3661 ggaagatggt gatggaaggg ttttctgaag agattggtaa ccacctgaag ctgggcagtg
     3721 ccttcacttt ccgagtcact gtgctccaag ccagcgggat ccttccagag tatgcagaca
     3781 tcttctgtca gttcaacttt ttgcatcggc atgatgaagc gttctccact gaacccctca
     3841 agaacaatgg aagaggaagt cccctgggct tctaccatgt acagaacatt gcggtggagg
     3901 tcacagagtc gtttgtggac tacatcaaaa ccaagcccat tgtattcgag gtctttgggc
     3961 actaccagca gcacccactc catctgcaag gacaagatct taacagtcca cctcagccat
     4021 ctcggagatt cttcccccca cccatgccac tctccaagcc agttccagct actaagttaa
     4081 acaccatgaa caaaaccacc cttgggcaaa gcatgagcaa gtacgacctt ctggtttggt
     4141 ttgagatcag tgaactggag cctactggag agtatattcc agctgtggtt gaccatactg
     4201 caggcctgcc ctgccagggg acatttttgc tgcaccaggg catccagcga cggatcacag
     4261 tgactatcat ccacgagaag ggcagtgagc tccactggaa agatgtccgt gagctggtgg
     4321 taggtcggat taggaataaa ccggaggtag atgaagctgc agttgatgct gttctttccc
     4381 tgaacatcat ctctgctaag tccctgaagg ctgcccacag ctccagcagg accttctacc
     4441 gtttcgaggc agtatgggac agctccctac ataactccct ccttctgaac cgagtgacac
     4501 cctatggaga aaagatctac atgaccttat ctgcttatct ggagttggat cattgcatcc
     4561 agccggccgt catcactaag gatgtgtgca tggtcttcta ttcccgagat gccaagatct
     4621 caccaccgcg ttctctgcga aacctctttg gtagtggcta ctcaaagtca ccagactcca
     4681 accgagtgac tgggatctat gagctgagct tatgcaaaat ggcagatact ggaagcccag
     4741 gcatgcagag gcggaggaga aaagtcttgg atacctcagt ggcatatgtg cggggagagg
     4801 agaacctagc gggctggcga cctcgtggag acagcctcat tctggaacac cagtgggagc
     4861 tggagaagct ggagctgctg catgaggtgg aaaaaactcg ccacttcttg ctgcttcggg
     4921 agagacttgg tgacagcgtc cctaagtctc tgagtgactc actgtccccc agcctgagca
     4981 gtggaaccct tagcacctcc accagcatct cctctcagat ctcaaccacc acctttgaaa
     5041 gcgccatcac accgagcgag agcagtggct acgactcggc agacgttgaa agcctggtcg
     5101 accgggagaa agagctggct acaaagtgcc tgcagcttct cacccacact ttcaaccgag
     5161 aattcagcca ggtgcacggc agcatcagtg actgtaagtt gtctgacatc tctccaattg
     5221 gacgggaccc ctctgtgtcc agtttcagca gttccaccct cacgccctcc tccacttgcc
     5281 cctccttggt ggactccagg agcagctcta tggatcagaa gaccccagaa gccaactctc
     5341 gtgcctccag tccctgccaa gaatttgaac agtttcagat cgtcccaact gtggagacac
     5401 cctatttggc ccgagcaggg aagaatgaat ttctcaatct tgttccagac attgaagaag
     5461 tcagagcggg atcagtggta tctaagaaag gatacctgca tttcaaagag ccactttcca
     5521 gtaactgggc taaacatttc gttgtggttc gtcgccctta cgtcttcatc tataacagtg
     5581 acaaagaccc agtagagcgt ggcatcatta acctgtctac agcacaggtg gagtacagcg
     5641 aggaccagca ggccatggtg aagacaccta atacttttgc tgtatgcaca aagcaccgtg
     5701 gggtccttct gcaagctctc aatgacaaag acatgaatga ctggttatat gcctttaacc
     5761 cacttctggc tggcacaata aggtcaaaac tctctcgcag atgcccgagc cagccaaagt
     5821 actgagcgtt ctcctgagcc ttgctcacct tcgacagata aagaaagtgt tacctctcat
     5881 tctctttgtg attcttgaca gttattcttg tatgtaatcc tgtggcttaa cgacttttcc
     5941 ctcctcaccc tgcacttctc tagctctctg ttccctctcc atggctctga ctcttcttat
     6001 tcttgtgcta agacttgtag catgtggcct aacaagggga acaaaaccac tacacgtcca
     6061 tacacactca cactcacact cacccacacc cgaggggacc cagcacatct ccaaatgatt
     6121 ctcctgtgtg cttcagcttc ctttggatgt taggtcccct tcacggtcac tgtccgactg
     6181 ttgtctccgt agctctggtt ttcagggtaa cttctctgtc tctctttttc tttccccttt
     6241 gtttatgata atcttctttt ttctgggtgg tttagagact aagggaggag acatttggta
     6301 ttgtcagcca ggagaagaaa acttgttaac ttgtttctct ctctctctct ctcttcctct
     6361 ctctctctct tctctctctc tctctctctc tgtctctttt tctctcagtg tctgtctctg
     6421 tctatttgtg tgtgtgtctg gtgtctgtct gtctctctct gtgtctgtct ctgactctct
     6481 ctctttctct gtatgtgtgt gtgtgtgtgt ctgtctgtct ctgtctctct ttctctttct
     6541 ctttggtggc taatccatgt gtttccattc agggaaagca ctgtgggaag ctcagaaatg
     6601 ggatttaaat tctctgtcta aatcagggct cggagcatgg atgtatagag tggaagatgc
     6661 agaggggcct tgtgattggc ctgcaacaga ggctgctgct agccctttaa gactcgggct
     6721 gctgcagtag attgggcagt gggtcacaag ggtgactgta gctccttaca gcagggtcca
     6781 gcaggcttgt ctcctccctg ggaaggagcg tttgtctagg agtttcccaa ctctagtctc
     6841 agtgtcactg tttggaatta ggtgatgtca tgaacagatt tcccacaaga gggactgggg
     6901 agtgtttgac tttctggtga tatggaccat tgttgctttg agagtgctga gtgcagcttg
     6961 tgattgttgt cgctcccttt gatcaaagac ttgtagcttc agcataaatc ttgaggtctc
     7021 catctaaatc cagtggccat ttccagtagt tctcgtctcc atatgaacaa acatggcatt
     7081 gttttctgga tgccagaact gaccagtcct taccaccact ccaaacaaat cagaaggcat
     7141 ttagagtcga aaaagattgt ctcccagcag tttgctactg gattgtgaaa tgcctcctct
     7201 gtgacatgcc cccttccccc actgtcctca tctggtttgg aaatactccc ttaggaagaa
     7261 tttccctgct accagtttct gtggcttcta acaaaccagg cctccgggtt taagaggtta
     7321 tagaaaataa cgctcttcct ccaccggcca gtaagtgtcg gggactgagt ggggcacaga
     7381 atgcccgctg gggctacttg agttgctgtg ccagtgactt ggggagcatt cacactgctg
     7441 tttcctggcc ttgccagcct gtttcagcat cactcacgca cacaggaagg catctgctca
     7501 cctccagtct gcgaaggctc ctggctacct gagggtagag aaggaatgga tttccttctg
     7561 gtggagagcc catctccact gcagagcagc cactagggag gcgagcatgc agccccttgc
     7621 ttctctctga agaacaggac tcccagcttc ctttgttaca gttgccttgc aaagaaagga
     7681 aaagtggacc atggagaaaa ggaaaggaaa ggaaagaaag caaaagaaaa gaaaggaaaa
     7741 ggcagaaatc agactgttct tatctaaaag atgctcagct ctggtggatt tttaaaactt
     7801 tctttctctc cttaaagtat aggttactaa ctgtaatgtt acttgttttc taaacatatc
     7861 tatgagattt ttaatgtagt tagaagtctc tgttgtctaa tggacacagc atgtccttct
     7921 ggtgtatact caaattcagc agactctgtc tatgcctgta gacagtttcc tggaccggaa
     7981 ctaaatctaa tttcagggaa acgaagatca aaggtcgctt ttaaactgaa tcactgatgt
     8041 tgctgctgtt aggaaggtag gcagaaggat ccatgtctgt gccgagaggt gtgacgcctg
     8101 ggggagggtg gcagtgtgcg gcacactaaa ccctgagata acttgttttc ttttaactca
     8161 aacaaaactg gtttagaaag tctttgcttt gcaaatatca aatgttagca tgagccaaac
     8221 tggaccccgc cttcatcaga ggccccttaa ggagacctca ttagaaagcc agggaaagta
     8281 aggttggagc ttgggcacct gtgcctctcc ctgctgtcac tgggacccct cctactgtaa
     8341 agcccaggat caggtcagaa tcggagcatt tgggggcttt atattctgtt tccagacaag
     8401 gtcacctgct ccgaagctct gaaagagaaa gggttttatg gcaggacctg ttcatgagat
     8461 ttttgtgatt gccatagtag caggaaagtt aagagaacta atctttaaaa taagtatttt
     8521 taagattttt ttttaaattt tcaaagcact cctttaaaca aacaaacaaa caaacaaaca
     8581 aaaaacctac aaggaaaaca tacaaattac agaaaagtga gtgctggtta aaatgaatta
     8641 gtctccccct tcctttatgt ctttatcctc cttcctccca agcagatata gcctcataac
     8701 tgtcccccgc cagtgctcag gcctcgcctg cttctgggag acgaccctgg gagtcagtca
     8761 gctctcagtc ccagactgtc agggaccagg cagtccctgc acaaggcgag gtgggagcac
     8821 aggccagact gcttctgagc aggccctgat ctccagtcca taaatgagaa acttgatgag
     8881 gtgagagctg aaggttcttc agctaagaaa ccattatttt tttttctctt cagctatgtg
     8941 gaatttgtat atctatcaat ttttcaggtt tttttttttt ttatcttgtt tagatgaagg
     9001 aatgaatggt tgtgaaaggt gtttggggtc taaaacatga tttttcctgg cacatatttc
     9061 aaagcataga ctttgttacc tgctgcttct tgtctaattt acagggatat ttaattttgt
     9121 aaggtatttg tatatttata caactgtaat gaattgcaca ttggactgaa aggggaaggc
     9181 tctgccctgt gtggctcctg ctgggactct aggttgctgt gctttgactt tcctgaacaa
     9241 taccaggggg gtgtggtttg tttagcgtgg gtccatcact tttcatttgg gttccttttg
     9301 gaaaatgtaa tctttaactt gctctgtgag aagaaaagaa tgattgtgtt gctgctcttg
     9361 gaaggtctgc tgaatgcttt tgagtgacct ctggcactgt gtactgcctg tgatccacca
     9421 agagtgagta agaccacgac cgtggagcaa gtcagagatc gtcagccgag agattattgc
     9481 tgttactgtt caaaaggcca tttatgaagt agatatttga gctctttaaa aaaaaaaatt
     9541 taagagagcc cctaattact taaaaaagaa atttaagaaa gaaattaaga gttgatacag
     9601 aaccggtgtt aaaaactcac agccagaggt taggggtgtt ggttagtggt agggcacttg
     9661 gcaactatat gtgatgccat tggttcagtc ccggttctga gatcagacag aaagcctcac
     9721 ggtagatagc tgctcagaca aagtccaggc agaggttggt cttgtgccaa accctggatg
     9781 ttctatgttg tcatgtcctt aactgattct tttcatgctg tgtattctga catcaattca
     9841 ccgaagggac ccaccagcct cctcatgttt aagcattgtc gtagactttg tggctctgac
     9901 atacttgtct gttgagagtg gcgtctcctg tcaccatccc catgctataa cagaatccat
     9961 gaagcataag tggccttttt gaaccaagac tttgcaaact gatctctccc cagggaagga
    10021 gttgagcaca agcaacaatg tacattatta attttggatt tcattttcat gttttatttt
    10081 gtaaatatct aatgtttgga gcttgagtat acaaaatgta aatacagttc ttgtatttgt
    10141 actaatcctg attcttttgc tgtatagccc tagatgtgta atgcagacat tatctaactg
    10201 tgtatggtaa ccttgcatca cagaactgct agtgaacgag gtaaaaataa taaaggtaca
    10261 accagtgcat cacaaaaaaa aaaaaaaa
//
