LOCUS       NM_001408925            8534 bp    mRNA    linear   ROD 11-MAR-2025
DEFINITION  Mus musculus kinesin family member 1A (Kif1a), transcript variant
            6, mRNA.
ACCESSION   NM_001408925 XM_006529158
VERSION     NM_001408925.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 8534)
  AUTHORS   Tran,K.M., Kwang,N.E., Butler,C.A., Gomez-Arboledas,A.,
            Kawauchi,S., Mar,C., Chao,D., Barahona,R.A., Da Cunha,C.,
            Tsourmas,K.I., Shi,Z., Wang,S., Collins,S., Walker,A., Shi,K.X.,
            Alcantara,J.A., Neumann,J., Duong,D.M., Seyfried,N.T., Tenner,A.J.,
            LaFerla,F.M., Hohsfield,L.A., Swarup,V., MacGregor,G.R. and
            Green,K.N.
  TITLE     APOE Christchurch enhances a disease-associated microglial response
            to plaque but suppresses response to tau pathology
  JOURNAL   Mol Neurodegener 20 (1), 9 (2025)
   PUBMED   39844286
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 8534)
  AUTHORS   Vitet,H., Bruyere,J., Xu,H., Seris,C., Brocard,J., Abada,Y.S.,
            Delatour,B., Scaramuzzino,C., Venance,L. and Saudou,F.
  TITLE     Huntingtin recruits KIF1A to transport synaptic vesicle precursors
            along the mouse axon to support synaptic transmission and motor
            skill learning
  JOURNAL   Elife 12, e81011 (2023)
   PUBMED   37431882
  REMARK    GeneRIF: Huntingtin recruits KIF1A to transport synaptic vesicle
            precursors along the mouse axon to support synaptic transmission
            and motor skill learning.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 8534)
  AUTHORS   Pedersen,T.J., Keil,S.A., Han,W., Wang,M.X. and Iliff,J.J.
  TITLE     The effect of aquaporin-4 mis-localization on Abeta deposition in
            mice
  JOURNAL   Neurobiol Dis 181, 106100 (2023)
   PUBMED   36990365
REFERENCE   4  (bases 1 to 8534)
  AUTHORS   Rierola,M., Trushina,N.I., Holtmannspotter,M., Kurre,R. and
            Bakota,L.
  TITLE     Lattice light-sheet microscopy and evaluation of dendritic
            transport in cultured hippocampal tissue reveal high variability in
            mobility of the KIF1A motor domain and entry into dendritic spines
  JOURNAL   Brain Res Bull 194, 13-22 (2023)
   PUBMED   36626968
  REMARK    GeneRIF: Lattice light-sheet microscopy and evaluation of dendritic
            transport in cultured hippocampal tissue reveal high variability in
            mobility of the KIF1A motor domain and entry into dendritic spines.
            Review article
REFERENCE   5  (bases 1 to 8534)
  AUTHORS   Liao,P., Yuan,Y., Liu,Z., Hou,X., Li,W., Wen,J., Zhang,K., Jiao,B.,
            Shen,L., Jiang,H., Guo,J., Tang,B., Zhang,Z., Hu,Z. and Wang,J.
  TITLE     Association of variants in the KIF1A gene with amyotrophic lateral
            sclerosis
  JOURNAL   Transl Neurodegener 11 (1), 46 (2022)
   PUBMED   36284339
  REMARK    GeneRIF: Association of variants in the KIF1A gene with amyotrophic
            lateral sclerosis.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 8534)
  AUTHORS   Yonekawa,Y., Harada,A., Okada,Y., Funakoshi,T., Kanai,Y., Takei,Y.,
            Terada,S., Noda,T. and Hirokawa,N.
  TITLE     Defect in synaptic vesicle precursor transport and neuronal cell
            death in KIF1A motor protein-deficient mice
  JOURNAL   J Cell Biol 141 (2), 431-441 (1998)
   PUBMED   9548721
REFERENCE   7  (bases 1 to 8534)
  AUTHORS   Nakagawa,T., Tanaka,Y., Matsuoka,E., Kondo,S., Okada,Y., Noda,Y.,
            Kanai,Y. and Hirokawa,N.
  TITLE     Identification and classification of 16 new kinesin superfamily
            (KIF) proteins in mouse genome
  JOURNAL   Proc Natl Acad Sci U S A 94 (18), 9654-9659 (1997)
   PUBMED   9275178
  REMARK    Erratum:[Proc Natl Acad Sci U S A 1999 Mar 30;96(7):4214]
REFERENCE   8  (bases 1 to 8534)
  AUTHORS   Saito,N., Okada,Y., Noda,Y., Kinoshita,Y., Kondo,S. and Hirokawa,N.
  TITLE     KIFC2 is a novel neuron-specific C-terminal type kinesin
            superfamily motor for dendritic transport of multivesicular
            body-like organelles
  JOURNAL   Neuron 18 (3), 425-438 (1997)
   PUBMED   9115736
REFERENCE   9  (bases 1 to 8534)
  AUTHORS   Okada,Y., Yamazaki,H., Sekine-Aizawa,Y. and Hirokawa,N.
  TITLE     The neuron-specific kinesin superfamily protein KIF1A is a unique
            monomeric motor for anterograde axonal transport of synaptic
            vesicle precursors
  JOURNAL   Cell 81 (5), 769-780 (1995)
   PUBMED   7539720
REFERENCE   10 (bases 1 to 8534)
  AUTHORS   Aizawa,H., Sekine,Y., Takemura,R., Zhang,Z., Nangaku,M. and
            Hirokawa,N.
  TITLE     Kinesin family in murine central nervous system
  JOURNAL   J Cell Biol 119 (5), 1287-1296 (1992)
   PUBMED   1447303
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC110247.9 and AC119846.14.
            
            On Jul 1, 2022 this sequence version replaced XM_006529158.5.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN01164131
                              [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-100               AC110247.9         49621-49720
            101-265             AC110247.9         69003-69167
            266-342             AC110247.9         72646-72722
            343-522             AC110247.9         73616-73795
            523-588             AC110247.9         74376-74441
            589-767             AC110247.9         75154-75332
            768-879             AC110247.9         76416-76527
            880-957             AC110247.9         77598-77675
            958-1023            AC110247.9         78379-78444
            1024-1041           AC110247.9         79158-79175
            1042-1117           AC110247.9         82923-82998
            1118-1196           AC110247.9         84349-84427
            1197-1339           AC110247.9         85294-85436
            1340-1366           AC110247.9         85905-85931
            1367-1500           AC110247.9         87201-87334
            1501-1580           AC110247.9         88537-88616
            1581-1656           AC110247.9         88908-88983
            1657-1736           AC110247.9         90666-90745
            1737-1843           AC110247.9         91180-91286
            1844-1927           AC110247.9         92586-92669
            1928-2108           AC110247.9         95203-95383
            2109-2181           AC110247.9         95454-95526
            2182-2275           AC110247.9         95705-95798
            2276-2424           AC110247.9         96519-96667
            2425-2603           AC110247.9         97045-97223
            2604-2741           AC110247.9         98922-99059
            2742-3020           AC110247.9         99802-100080
            3021-3139           AC110247.9         104713-104831
            3140-3225           AC110247.9         107809-107894
            3226-3364           AC110247.9         108729-108867
            3365-3533           AC110247.9         108972-109140
            3534-3624           AC110247.9         109308-109398
            3625-3743           AC110247.9         109791-109909
            3744-3799           AC110247.9         110809-110864
            3800-3908           AC110247.9         111630-111738
            3909-3975           AC110247.9         112200-112266
            3976-4060           AC110247.9         112364-112448
            4061-4166           AC110247.9         114532-114637
            4167-4281           AC110247.9         125748-125862
            4282-4415           AC110247.9         126771-126904
            4416-4477           AC110247.9         127963-128024
            4478-4623           AC110247.9         128412-128557
            4624-4824           AC110247.9         128962-129162
            4825-4902           AC110247.9         129680-129757
            4903-5027           AC110247.9         130146-130270
            5028-5180           AC110247.9         130873-131025
            5181-5373           AC110247.9         131484-131676
            5374-5492           AC110247.9         132413-132531
            5493-6970           AC110247.9         132984-134461
            6971-8534           AC119846.14        1-1564
FEATURES             Location/Qualifiers
     source          1..8534
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 46.74 cM"
     gene            1..8534
                     /gene="Kif1a"
                     /gene_synonym="ATSV; C630002N23Rik; Gm1626; Kns1"
                     /note="kinesin family member 1A"
                     /db_xref="GeneID:16560"
                     /db_xref="MGI:MGI:108391"
     exon            1..100
                     /gene="Kif1a"
                     /gene_synonym="ATSV; C630002N23Rik; Gm1626; Kns1"
                     /inference="alignment:Splign:2.1.0"
     exon            101..265
                     /gene="Kif1a"
                     /gene_synonym="ATSV; C630002N23Rik; Gm1626; Kns1"
                     /inference="alignment:Splign:2.1.0"
     CDS             160..5535
                     /gene="Kif1a"
                     /gene_synonym="ATSV; C630002N23Rik; Gm1626; Kns1"
                     /note="isoform f is encoded by transcript variant 6;
                     kinesin-like protein KIF1A; axonal transporter of synaptic
                     vesicles; kinesin heavy chain member 1A; N-3 kinesin"
                     /codon_start=1
                     /product="kinesin-like protein KIF1A isoform f"
                     /protein_id="NP_001395854.1"
                     /db_xref="GeneID:16560"
                     /db_xref="MGI:MGI:108391"
                     /translation="MAGASVKVAVRVRPFNSREMSRDSKCIIQMSGSTTTIVNPKQPK
                     ETPKSFSFDYSYWSHTSPEDINYASQKQVYRDIGEEMLQHAFEGYNVCIFAYGQTGAG
                     KSYTMMGKQEKDQQGIIPQLCEDLFSRINDTTNDNMSYSVEVSYMEIYCERVRDLLNP
                     KNKGNLRVREHPLLGPYVEDLSKLAVTSYNDIQDLMDSGNKARTVAATNMNETSSRSH
                     AVFNIIFTQKRHDAETNITTEKVSKISLVDLAGSERADSTGAKGTRLKEGANINKSLT
                     TLGKVISALAEMDSGPNKNKKKKKTDFIPYRDSVLTWLLRENLGGNSRTAMVAALSPA
                     DINYDETLSTLRYADRAKQIRCNAIINEDPNNKLIRELKDEVTRLRDLLYAQGLGDIT
                     DTNTVPGGPKLTNALVGMSPSSSLSALSSRAASVSSLHERILFAPGSEEAIERLKETE
                     KIIAELNETWEEKLRRTEAIRMEREALLAEMGVAMREDGGTLGVFSPKKTPHLVNLNE
                     DPLMSECLLYYIKDGVTRVGREDAERRQDIVLSGHFIKEEHCIFRSDSRGGGEAVVTL
                     EPCEGADTYVNGKKVTEPSILRSGNRIIMGKSHVFRFNHPEQARQERERTPCAETPAE
                     PVDWAFAQRELLEKQGIDMKQEMEQRLQELEDQYRREREEATYLLEQQRLDYESKLEA
                     LQKQMDSRYYPEVNEEEEEPEDEVQWTERECELALWAFRKWKWYQFTSLRDLLWGNAI
                     FLKEANAISVELKKKVQFQFVLLTDTLYSPLPPDLLPPEAAKDRETRPFPRTIVAVEV
                     QDQKNGATHYWTLEKLRQRLDLMREMYDRAAEVPSSVVEDCDNVVTGGDPFYDRFPWF
                     RLVGSSVISGCNSYPLLNTCMSERMAALTPSPTFSSPDSDTTEPAEEQSVGEEEEEEE
                     EEEEEEEEEDLEDDVFPEHTLCDGQDPFYDRPPLFSLVGRAFVYLSNLLYPVPLVHRV
                     AIVSEKGEVKGFLRVAVQAISADEEAPDYGSGVRQSGTAKISFDDQHFEKFQSESCPV
                     VGMSRSGTSQEELRIVEGQGQGADAGPSADEVNNNTCSAVPPEGLMDSPEKAALDGPL
                     DTALDHLRLGSTFTFRVTVLQASSISAEYADIFCQFNFIHRHDEAFSTEPLKNTGRGP
                     PLGFYHVQNIAVEVTKSFIEYIKSQPIVFEVFGHYQQHPFPPLCKDVLSPLRPSRRHF
                     PRVMPLSKPVPATKLSTMTRPSPGPCHCKYDLLVYFEICELEANGDYIPAVVDHRGGM
                     PCMGTFLLHQGIQRRITVTLLHETGSHIRWKEVRELVVGRIRNTPETDEALIDPNILS
                     LNILSSGYVHPAQDDRTFYQFEAAWDSSMHNSLLLNRVTPYREKIYMTLSAYIEMENC
                     TQPAVITKDFCMVFYSRDAKLPASRSIRNLFGSGSLRATEGNRVTGVYELSLCHVADA
                     GSPGMQRRRRRVLDTSVAYVRGEENLAGWRPRSDSLILDHQWELEKLSLLQEVEKTRH
                     YLLLREKLETTQRPGPEVLSPASSEDSESRSSSGASSPLSAEGQPSPLEAPNERQREL
                     AVKCLRLLMHTFNREYTHSHVCISASESKLSEMSVTLMRDPSMSPLGAATLTPSSTCP
                     SLIEGRYGATDVRTPQPCSRPASPEPELLPELDSKKTPSPVRATETEKEPQRLLVPDI
                     QEIRVSPIVSKKGYLHFLEPHTAGWAKRFVVVRRPYAYMYNSDKDTVERFVLNLSTAQ
                     VEYSEDQQAMLKTPNTFAVCTEHRGILLQANSDKDMHDWLYAFNPLLAGTIRSKLSRR
                     RSAQMRV"
     exon            266..342
                     /gene="Kif1a"
                     /gene_synonym="ATSV; C630002N23Rik; Gm1626; Kns1"
                     /inference="alignment:Splign:2.1.0"
     exon            343..522
                     /gene="Kif1a"
                     /gene_synonym="ATSV; C630002N23Rik; Gm1626; Kns1"
                     /inference="alignment:Splign:2.1.0"
     exon            523..588
                     /gene="Kif1a"
                     /gene_synonym="ATSV; C630002N23Rik; Gm1626; Kns1"
                     /inference="alignment:Splign:2.1.0"
     exon            589..767
                     /gene="Kif1a"
                     /gene_synonym="ATSV; C630002N23Rik; Gm1626; Kns1"
                     /inference="alignment:Splign:2.1.0"
     exon            768..879
                     /gene="Kif1a"
                     /gene_synonym="ATSV; C630002N23Rik; Gm1626; Kns1"
                     /inference="alignment:Splign:2.1.0"
     exon            880..957
                     /gene="Kif1a"
                     /gene_synonym="ATSV; C630002N23Rik; Gm1626; Kns1"
                     /inference="alignment:Splign:2.1.0"
     exon            958..1023
                     /gene="Kif1a"
                     /gene_synonym="ATSV; C630002N23Rik; Gm1626; Kns1"
                     /inference="alignment:Splign:2.1.0"
     exon            1024..1041
                     /gene="Kif1a"
                     /gene_synonym="ATSV; C630002N23Rik; Gm1626; Kns1"
                     /inference="alignment:Splign:2.1.0"
     exon            1042..1117
                     /gene="Kif1a"
                     /gene_synonym="ATSV; C630002N23Rik; Gm1626; Kns1"
                     /inference="alignment:Splign:2.1.0"
     exon            1118..1196
                     /gene="Kif1a"
                     /gene_synonym="ATSV; C630002N23Rik; Gm1626; Kns1"
                     /inference="alignment:Splign:2.1.0"
     exon            1197..1339
                     /gene="Kif1a"
                     /gene_synonym="ATSV; C630002N23Rik; Gm1626; Kns1"
                     /inference="alignment:Splign:2.1.0"
     exon            1340..1366
                     /gene="Kif1a"
                     /gene_synonym="ATSV; C630002N23Rik; Gm1626; Kns1"
                     /inference="alignment:Splign:2.1.0"
     exon            1367..1500
                     /gene="Kif1a"
                     /gene_synonym="ATSV; C630002N23Rik; Gm1626; Kns1"
                     /inference="alignment:Splign:2.1.0"
     exon            1501..1580
                     /gene="Kif1a"
                     /gene_synonym="ATSV; C630002N23Rik; Gm1626; Kns1"
                     /inference="alignment:Splign:2.1.0"
     exon            1581..1656
                     /gene="Kif1a"
                     /gene_synonym="ATSV; C630002N23Rik; Gm1626; Kns1"
                     /inference="alignment:Splign:2.1.0"
     exon            1657..1736
                     /gene="Kif1a"
                     /gene_synonym="ATSV; C630002N23Rik; Gm1626; Kns1"
                     /inference="alignment:Splign:2.1.0"
     exon            1737..1843
                     /gene="Kif1a"
                     /gene_synonym="ATSV; C630002N23Rik; Gm1626; Kns1"
                     /inference="alignment:Splign:2.1.0"
     exon            1844..1927
                     /gene="Kif1a"
                     /gene_synonym="ATSV; C630002N23Rik; Gm1626; Kns1"
                     /inference="alignment:Splign:2.1.0"
     exon            1928..2108
                     /gene="Kif1a"
                     /gene_synonym="ATSV; C630002N23Rik; Gm1626; Kns1"
                     /inference="alignment:Splign:2.1.0"
     exon            2109..2181
                     /gene="Kif1a"
                     /gene_synonym="ATSV; C630002N23Rik; Gm1626; Kns1"
                     /inference="alignment:Splign:2.1.0"
     exon            2182..2275
                     /gene="Kif1a"
                     /gene_synonym="ATSV; C630002N23Rik; Gm1626; Kns1"
                     /inference="alignment:Splign:2.1.0"
     exon            2276..2424
                     /gene="Kif1a"
                     /gene_synonym="ATSV; C630002N23Rik; Gm1626; Kns1"
                     /inference="alignment:Splign:2.1.0"
     exon            2425..2603
                     /gene="Kif1a"
                     /gene_synonym="ATSV; C630002N23Rik; Gm1626; Kns1"
                     /inference="alignment:Splign:2.1.0"
     exon            2604..2741
                     /gene="Kif1a"
                     /gene_synonym="ATSV; C630002N23Rik; Gm1626; Kns1"
                     /inference="alignment:Splign:2.1.0"
     exon            2742..3020
                     /gene="Kif1a"
                     /gene_synonym="ATSV; C630002N23Rik; Gm1626; Kns1"
                     /inference="alignment:Splign:2.1.0"
     exon            3021..3139
                     /gene="Kif1a"
                     /gene_synonym="ATSV; C630002N23Rik; Gm1626; Kns1"
                     /inference="alignment:Splign:2.1.0"
     exon            3140..3225
                     /gene="Kif1a"
                     /gene_synonym="ATSV; C630002N23Rik; Gm1626; Kns1"
                     /inference="alignment:Splign:2.1.0"
     exon            3226..3364
                     /gene="Kif1a"
                     /gene_synonym="ATSV; C630002N23Rik; Gm1626; Kns1"
                     /inference="alignment:Splign:2.1.0"
     exon            3365..3533
                     /gene="Kif1a"
                     /gene_synonym="ATSV; C630002N23Rik; Gm1626; Kns1"
                     /inference="alignment:Splign:2.1.0"
     exon            3534..3624
                     /gene="Kif1a"
                     /gene_synonym="ATSV; C630002N23Rik; Gm1626; Kns1"
                     /inference="alignment:Splign:2.1.0"
     exon            3625..3743
                     /gene="Kif1a"
                     /gene_synonym="ATSV; C630002N23Rik; Gm1626; Kns1"
                     /inference="alignment:Splign:2.1.0"
     exon            3744..3799
                     /gene="Kif1a"
                     /gene_synonym="ATSV; C630002N23Rik; Gm1626; Kns1"
                     /inference="alignment:Splign:2.1.0"
     exon            3800..3908
                     /gene="Kif1a"
                     /gene_synonym="ATSV; C630002N23Rik; Gm1626; Kns1"
                     /inference="alignment:Splign:2.1.0"
     exon            3909..3975
                     /gene="Kif1a"
                     /gene_synonym="ATSV; C630002N23Rik; Gm1626; Kns1"
                     /inference="alignment:Splign:2.1.0"
     exon            3976..4060
                     /gene="Kif1a"
                     /gene_synonym="ATSV; C630002N23Rik; Gm1626; Kns1"
                     /inference="alignment:Splign:2.1.0"
     exon            4061..4166
                     /gene="Kif1a"
                     /gene_synonym="ATSV; C630002N23Rik; Gm1626; Kns1"
                     /inference="alignment:Splign:2.1.0"
     exon            4167..4281
                     /gene="Kif1a"
                     /gene_synonym="ATSV; C630002N23Rik; Gm1626; Kns1"
                     /inference="alignment:Splign:2.1.0"
     exon            4282..4415
                     /gene="Kif1a"
                     /gene_synonym="ATSV; C630002N23Rik; Gm1626; Kns1"
                     /inference="alignment:Splign:2.1.0"
     exon            4416..4477
                     /gene="Kif1a"
                     /gene_synonym="ATSV; C630002N23Rik; Gm1626; Kns1"
                     /inference="alignment:Splign:2.1.0"
     exon            4478..4623
                     /gene="Kif1a"
                     /gene_synonym="ATSV; C630002N23Rik; Gm1626; Kns1"
                     /inference="alignment:Splign:2.1.0"
     exon            4624..4824
                     /gene="Kif1a"
                     /gene_synonym="ATSV; C630002N23Rik; Gm1626; Kns1"
                     /inference="alignment:Splign:2.1.0"
     exon            4825..4902
                     /gene="Kif1a"
                     /gene_synonym="ATSV; C630002N23Rik; Gm1626; Kns1"
                     /inference="alignment:Splign:2.1.0"
     exon            4903..5027
                     /gene="Kif1a"
                     /gene_synonym="ATSV; C630002N23Rik; Gm1626; Kns1"
                     /inference="alignment:Splign:2.1.0"
     exon            5028..5180
                     /gene="Kif1a"
                     /gene_synonym="ATSV; C630002N23Rik; Gm1626; Kns1"
                     /inference="alignment:Splign:2.1.0"
     exon            5181..5373
                     /gene="Kif1a"
                     /gene_synonym="ATSV; C630002N23Rik; Gm1626; Kns1"
                     /inference="alignment:Splign:2.1.0"
     exon            5374..5492
                     /gene="Kif1a"
                     /gene_synonym="ATSV; C630002N23Rik; Gm1626; Kns1"
                     /inference="alignment:Splign:2.1.0"
     exon            5493..8534
                     /gene="Kif1a"
                     /gene_synonym="ATSV; C630002N23Rik; Gm1626; Kns1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      8507..8512
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Kif1a"
                     /gene_synonym="ATSV; C630002N23Rik; Gm1626; Kns1"
                     /note="hexamer: AATAAA"
     polyA_site      8534
                     /gene="Kif1a"
                     /gene_synonym="ATSV; C630002N23Rik; Gm1626; Kns1"
                     /note="major polyA site"
ORIGIN      
        1 acagcaccag gagcaggcag taagaagcat cagttccagg atcggggacc ctccccggtg
       61 ccagtgccca tgcacggcta tccccagtga cgcctgagag gtgactctgt cctctctggg
      121 gcaactgcag ctgctgaact accaaccaac tccacagaaa tggccggggc ctctgtgaag
      181 gtggcggtgc gtgtccgccc cttcaactcc cgggaaatga gccgagactc caagtgcatc
      241 attcagatgt ctggaagcac caccactatt gtcaacccca aacagcccaa ggagacaccc
      301 aagagcttca gctttgatta ctcctactgg tcacatacct cgccggagga catcaactat
      361 gcctctcaga agcaggtcta cagggacatt ggggaagaga tgctacagca tgcctttgag
      421 ggctacaatg tgtgcatctt tgcctatggg cagacggggg ccggcaagtc ctacaccatg
      481 atggggaaac aggagaagga ccagcaaggc atcattccac agctctgcga agacctcttc
      541 tctcgaatca acgacaccac caacgacaac atgtcctact ctgtggaggt cagctacatg
      601 gagatttact gtgagcgagt ccgtgacctc ctgaacccca agaacaaagg caacctgcgt
      661 gtgagggagc accctctgct ggggccttat gtggaggacc tctccaagct ggctgtaacc
      721 tcctacaatg acatccagga cctcatggac tcagggaaca aggccaggac tgtggcggcc
      781 acaaacatga atgagaccag cagccgttct cacgcagtct tcaacatcat ctttacccag
      841 aagcgccatg atgcagagac caacatcacc acagagaaag tgagcaaaat cagcctggtg
      901 gacctggcag gcagtgaacg agccgactcc acaggagcca agggcacgcg actcaaggag
      961 ggggccaaca tcaacaagtc tttgaccacc ctgggaaagg tcatctctgc tctggctgaa
     1021 atggactctg gacccaacaa gaacaagaaa aagaagaaga cagatttcat cccttaccga
     1081 gactccgtat tgacatggct tctccgggaa aacctcggtg gcaactcaag gacagccatg
     1141 gtggcagccc tgagccctgc ggacatcaac tatgatgaga ccctcagcac actgagatat
     1201 gcagatcggg ccaaacaaat ccgctgcaat gccatcatca atgaagaccc caacaacaag
     1261 ctgattagag aactgaagga tgaggtgacc aggctgagag acctgctgta tgcccaaggt
     1321 cttggcgata tcactgacac caacactgtg cccggaggac ccaaattgac caatgccctg
     1381 gtgggcatga gcccctcatc ttcactctca gccctgtcca gccgtgcagc ctctgtgtcc
     1441 agtctccatg agcgcatctt gtttgctcca ggcagcgagg aggctattga aaggctgaag
     1501 gaaacagaga agatcattgc tgaactcaat gagacctggg aggagaagct gcggcggaca
     1561 gaagccatcc ggatggagag ggaagccttg ctggctgaga tgggtgtggc catgagggaa
     1621 gatggtggta ccttgggtgt gttttctccc aaaaagactc ctcatcttgt caacctgaat
     1681 gaggaccctt tgatgtccga atgcctcctt tactacatca aagatggcgt caccagagtg
     1741 ggcagagaag atgcagagag gcggcaagac attgtcctga gtggacactt catcaaagag
     1801 gagcactgca tcttccggag tgactcccga ggaggcggag aagctgtggt gaccctggag
     1861 ccctgtgaag gagcagacac atatgtcaac ggcaagaaag tcactgagcc cagcatccta
     1921 cggtcaggaa accgcatcat catgggaaaa agccacgtgt tccggtttaa ccaccctgag
     1981 caggcccgtc aggagcgtga gcgaacacct tgtgcagaga cacctgctga gccagtggac
     2041 tgggcctttg cccagcggga actgctggag aagcaaggca ttgacatgaa gcaggagatg
     2101 gagcagaggc tccaggagtt ggaggaccag taccggaggg agcgggagga ggccacatac
     2161 cttctggagc agcagaggct ggactatgag agtaagctgg aggccctaca gaaacagatg
     2221 gactccaggt actacccaga ggtgaacgag gaggaagaag agccagagga tgaagtccaa
     2281 tggacagaac gagaatgtga gctggcattg tgggccttcc ggaagtggaa gtggtaccag
     2341 tttacttctc tgcgggacct gctgtggggc aatgccatct tcctgaagga ggccaacgcc
     2401 atcagtgtgg agctaaagaa gaaggtccag ttccagtttg tcctcctcac ggacaccctg
     2461 tactccccac tgccgccaga cctactgccc ccagaagccg ccaaagaccg agagacacga
     2521 cccttcccca ggaccattgt ggcagtggag gtccaggacc agaagaatgg ggccacccac
     2581 tactggacac tggagaaact caggcaacgc ctggacctga tgcgggaaat gtacgacagg
     2641 gctgcagagg ttccctccag cgtcgttgag gactgtgaca acgtggtgac cggcggggac
     2701 cccttctatg accgcttccc ctggttccga ctggtgggca gttcagtcat ctctggctgc
     2761 aacagctacc ctcttctcaa cacatgcatg agcgagcgca tggctgctct caccccctcc
     2821 cccaccttct caagtcccga ctccgacacc accgagcctg ccgaggagca gagcgtgggg
     2881 gaggaggagg aggaggagga ggaggaggag gaggaggagg aggaggagga cctggaggac
     2941 gacgtctttc cggagcacac gctgtgcgac ggccaggacc cgttttacga ccggcccccc
     3001 ctgttcagtt tagtaggaag ggccttcgta tacctgagca acctgctgta ccctgtgccc
     3061 ctggtgcacc gagtggcaat cgtcagcgaa aagggagagg tgaaaggctt cctccgtgtg
     3121 gcggtgcagg ccatctcagc tgatgaagag gctccggatt atggctcggg tgtccgtcag
     3181 tcaggaactg ctaaaatctc ctttgatgac cagcattttg aaaagttcca atctgagtcc
     3241 tgccctgtgg tggggatgtc ccgctcagga acttcccaag aggagctgcg cattgtagaa
     3301 ggccagggtc agggggctga tgctgggcct tcagctgatg aagttaacaa caacacctgt
     3361 tcagctgtgc ctcctgaagg cctcatggat agcccagaga aggctgccct ggatgggcct
     3421 ctggacacag ccctggacca cctccgtcta ggcagtacct tcaccttccg ggtgacagtc
     3481 ctgcaggcgt ccagtatctc tgctgaatac gctgacatct tctgccagtt caactttatc
     3541 caccgccacg atgaggcctt ctccactgaa cccctgaaga acactggcag aggaccccct
     3601 cttggcttct accatgtcca aaatattgcg gtagaggtga ccaagtcctt catcgaatac
     3661 atcaagagcc agcccattgt gttcgaggtc tttgggcact accagcagca cccgttccca
     3721 cctctttgca aggatgtcct cagccccctg agaccctcac gtcgccactt ccccagggtc
     3781 atgccgttat ccaagccagt gcccgccact aagctcagca cgatgacacg gccttcccca
     3841 ggtccctgcc attgcaagta tgacctgctg gtctacttcg agatctgcga gctggaagcc
     3901 aatggcgatt acatccctgc tgtggtggac caccgtggtg gcatgccgtg catggggact
     3961 ttccttctcc atcagggcat ccagagacgg ataactgtga cactgttaca tgagacagga
     4021 agccacatcc gctggaagga agtgcgcgag ctagttgtgg gtcgcatccg aaacacccca
     4081 gaaactgacg aagctctgat tgaccccaac atcttgtccc tcaacatcct ctcatcagga
     4141 tacgtccatc cagcccagga tgaccggacc ttctaccagt ttgaagcagc ctgggacagt
     4201 tccatgcata actctctcct gctgaatcgt gtcacccctt accgggagaa aatctacatg
     4261 acgctctctg cctacattga gatggagaac tgtacccagc cagctgtcat caccaaggac
     4321 ttctgcatgg ttttctactc tcgggacgcc aagctacccg cctcacgctc cattcgcaac
     4381 ctgtttggca gtggcagcct gcgggccaca gaaggcaacc gtgtgactgg tgtgtatgag
     4441 ctcagccttt gccacgtggc cgacgcaggc agcccaggga tgcagcgtcg gcgccggcgg
     4501 gtgctggaca catcagtagc ctatgtccgg ggtgaggaga acctggctgg ctggaggccc
     4561 cgaagtgaca gcctgatcct agatcaccag tgggaactgg agaaactgag cctcttacag
     4621 gaggtggaaa agaccaggca ctacctgctc cttcgggaga agctggagac gacccagcgc
     4681 cctggccctg aggtgctgtc cccagcctcc agtgaggact ctgagtcccg tagttcttca
     4741 ggtgcctctt ccccattgtc agccgagggt cagccgtcac ctctggaggc tcccaacgag
     4801 aggcagaggg agctggctgt caagtgctta cgactcctca tgcacacatt caacagggaa
     4861 tacacccaca gccacgtctg tatcagcgcc agcgagagca agctctctga gatgtctgtc
     4921 accctgatgc gggacccatc catgtcccct ctgggtgctg ctacactcac tccctcctcc
     4981 acttgcccct ctctgatcga aggacgatac ggtgccactg acgtgaggac cccccagccc
     5041 tgctcccggc ccgccagccc agagcccgag ctcctgccag aacttgactc taagaagact
     5101 ccctcccctg ttcgggcaac agagacagag aaggagcccc agcgactgct ggtccctgac
     5161 atccaagaga tccgagtcag cccaatcgtc tccaagaagg gatacctgca tttcctggag
     5221 ccacacacgg ctggctgggc caagcgcttt gtggtggtga ggcgtcccta cgcctacatg
     5281 tacaacagtg acaaggacac ggtggagaga tttgtgctca acctctccac tgcgcaggtg
     5341 gagtacagcg aggaccagca ggccatgctc aagacaccca acacattcgc tgtgtgcacg
     5401 gagcaccgag gcatcctgct gcaggccaac agtgacaagg acatgcacga ctggctgtat
     5461 gccttcaacc cgctcctggc tgggaccatc cggtccaagc tctctcgaag gagatctgcg
     5521 cagatgcggg tctgagttga aagccttccg gacttccagt ggcccagacc actcccctgt
     5581 ccttaccatc tgttctgtca tctgccactc agcccttccc ccctacccac caccagggga
     5641 cacctgtgct gggcccagca accctacctc tggagggagg cctataccac atgacgaatt
     5701 gtgctccccc cagaggttgt gcgtgttgtg gtttcttcca aaattgctct ggtgggaagt
     5761 tcggaatgcc aggaaggtca gagggcccga gacccagggt attgccgctg ttctaatatt
     5821 tttttaagca tagacagact tataattaat atacattagt tagtggcgtt gaaacagtcc
     5881 tctgagacat taactataag actgtgttct gtttataagt atttatttct aatgcctcca
     5941 ggtagggctg taaggttcat gtggagctac cttctcctat ccccccttca gcctggccct
     6001 gttggttccc acctgtatct ccagcctgca aggggcagag ggagggaggg acgtgaacaa
     6061 accatggctc ctcacagcct ggcacaggga aactccgtcc tggccagttt tgtctgagat
     6121 gcaccttgca tggtacgtgt gtgagaggtt gtgcaagttc tgagacttag acaattcaga
     6181 agtcaccctt ctgagggaac agttcccaaa atggagcaat aaaggtggtg tgagcagttt
     6241 catctcagag cgaggaggat caggtgaggg gtatgatcca acctcgctag gcagactggc
     6301 tccagctgag ctgtgtccag gctgttgggt aggcggctgc gtttacacac ggctgtgggt
     6361 gacagaggcc atgggtgttc agagtggggc ctctgactgt agccttgggt gtcaatgagc
     6421 agaggaatgg atatgtagct ctgggaagtt ccgtgatcag tgatcccagt ctgcccaggg
     6481 gtggcgctcc tgtaaatctc agcaagagag cacaggaggg tgacctcgtg gtggtcttgg
     6541 taaagggact cttctgtacc ttctgtacct ggggactttt cataccactg gtccatttgg
     6601 aaagccagaa accaaacctc aagtccccag gacccatcag gagcagttac actcagcatc
     6661 cagctattcc aggaatctct ctccaccttg gtcagcccct cccccttctg gatcagctga
     6721 tggatctaag ctccccatca gctcagactg tgtccacatg gcactgacat gacctggata
     6781 ctcttgtgac caatgttcac agcatcccta ctgtctggaa ggtcatagaa ggttctggct
     6841 tcaaggtccc ttggcatagt tatcaaaggt cctgctcttt gtccaggcat caagattcag
     6901 ggtagtggca gggctcatgc tgaaagtagt gtgtgcaccc gccagccagt gtgagtccag
     6961 tggaaactga gaattcaccc atcactgggg tcaggtgcca tatgggtagc caccctcatg
     7021 catggccacc ctcatcccca ggacttgagc taatagtcat tagcatcaag tgccagggaa
     7081 ccctctccat gaagtataga ataagactca ttcccaagaa tccaaatcaa ggtgcccatc
     7141 ccagagcaag attaaactag aaaccaggtg acctgagctg tccgcggtgg actgtggagg
     7201 caggaggttg agatacaaag tggggagaag acacctgtgt taagaagctc actctggtgc
     7261 tcatgaccag gagggaagga gcgggttgct tcaatttctt ggttcccaag ggccacacag
     7321 cccccagcag gcagaaaggc agtcatggct tgccacactc gctcaggtca accagcctga
     7381 agctgaggcc ttgcaagagt ccagctccac ccaggaggtg ggtgtctgag gccagccaac
     7441 ctccagagca cctgtgcctg ggtcgggtta tagaaaggtt gggagctcta gtgcccaccc
     7501 cacccccatt caggggccat gccatactgg ctgtcctggc attgtctacg aaccaagatg
     7561 ggctctcggc ttttgtgggg gtcctgagtc agaacctagt aaccagaact gatggaccaa
     7621 gaaatctgtc cacagctcag gaaacctgat ttcttcatgc cccaccccct tgcccaaaat
     7681 tacctgtatt atgccagctg aaggtcattt gtccaacagc tgtgacgtgg agggatgaca
     7741 tgaggactag ggataaccta gctgaggccc gtttcctgct tggtgcagaa agtgagatga
     7801 atctagaaac ccacctccac agacgttttg gttttgatac ttaatgttgc tcaggctgtg
     7861 acctcaactt agtttgggat aatcatcaac tttcctggag aaggggagtt gtttctgcat
     7921 ccggggtggg gcggggccgt gctgtgttgg gttcctgtga gaccctgctt atgcctggat
     7981 aacacttcta atgcctcttg tcccaagcaa tcatgccagc accttattca acacacacac
     8041 acacacacac acacacacac acacacacac acaaatgtac taaatgattc tcctcctctc
     8101 tcctggtacc tggagacccc tggctatcat gggattactg aatgtggctg atgttacaga
     8161 tgtgaacaag actaagatgg ttctctgctc cactcagcat ggggacttca taagacacat
     8221 tcctttatcc ctgggaccgg agccatgcag tccctcagga tggacagata tggctgacct
     8281 gagtctctcc ttgagcctgg acctcctgtg gtttgtctat accgaggggc ccctgcaact
     8341 cagaggctgt ttccctgacc tgtacatatg tggttgctgt gggctccccc tggcccctgt
     8401 gtcataacca cctgacgtaa tgactagtat cctgctgttt acacccgagt gttagctgta
     8461 ggctcctgta ctgtttgtgt gcacttaggg ctctgtccaa ttaagaaata aatgtggctc
     8521 tcatgcaaca caca
//
