LOCUS       NM_001418960            3285 bp    mRNA    linear   ROD 15-OCT-2024
DEFINITION  Mus musculus kinesin family member 18A (Kif18a), transcript variant
            2, mRNA.
ACCESSION   NM_001418960 XM_006499259
VERSION     NM_001418960.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3285)
  AUTHORS   Mihajlovic,A.I., Byers,C., Reinholdt,L. and FitzHarris,G.
  TITLE     Spindle assembly checkpoint insensitivity allows meiosis-II despite
            chromosomal defects in aged eggs
  JOURNAL   EMBO Rep 24 (11), e57227 (2023)
   PUBMED   37795949
REFERENCE   2  (bases 1 to 3285)
  AUTHORS   Mora-Bermudez,F., Kanis,P., Macak,D., Peters,J., Naumann,R.,
            Xing,L., Sarov,M., Winkler,S., Oegema,C.E., Haffner,C.,
            Wimberger,P., Riesenberg,S., Maricic,T., Huttner,W.B. and Paabo,S.
  TITLE     Longer metaphase and fewer chromosome segregation errors in modern
            human than Neanderthal brain development
  JOURNAL   Sci Adv 8 (30), eabn7702 (2022)
   PUBMED   35905187
REFERENCE   3  (bases 1 to 3285)
  AUTHORS   Sepaniac,L.A., Martin,W., Dionne,L.A., Stearns,T.M., Reinholdt,L.G.
            and Stumpff,J.
  TITLE     Micronuclei in Kif18a mutant mice form stable micronuclear
            envelopes and do not promote tumorigenesis
  JOURNAL   J Cell Biol 220 (11) (2021)
   PUBMED   34515734
  REMARK    GeneRIF: Micronuclei in Kif18a mutant mice form stable micronuclear
            envelopes and do not promote tumorigenesis.
REFERENCE   4  (bases 1 to 3285)
  AUTHORS   Kim,S., Cho,Y.B., Song,C.U., Eyun,S.I. and Seo,Y.J.
  TITLE     Kinesin family member KIF18A is a critical cellular factor that
            regulates the differentiation and activation of dendritic cells
  JOURNAL   Genes Genomics 42 (1), 41-46 (2020)
   PUBMED   31677127
  REMARK    GeneRIF: phylogenetic analysis revealed that the KIF18A gene family
            is remarkably conserved across vertebrates.
REFERENCE   5  (bases 1 to 3285)
  AUTHORS   Fonseca,C.L., Malaby,H.L.H., Sepaniac,L.A., Martin,W., Byers,C.,
            Czechanski,A., Messinger,D., Tang,M., Ohi,R., Reinholdt,L.G. and
            Stumpff,J.
  TITLE     Mitotic chromosome alignment ensures mitotic fidelity by promoting
            interchromosomal compaction during anaphase
  JOURNAL   J Cell Biol 218 (4), 1148-1163 (2019)
   PUBMED   30733233
REFERENCE   6  (bases 1 to 3285)
  AUTHORS   Favor,J., Bradley,A., Conte,N., Janik,D., Pretsch,W., Reitmeir,P.,
            Rosemann,M., Schmahl,W., Wienberg,J. and Zaus,I.
  TITLE     Analysis of Pax6 contiguous gene deletions in the mouse, Mus
            musculus, identifies regions distinct from Pax6 responsible for
            extreme small-eye and belly-spotting phenotypes
  JOURNAL   Genetics 182 (4), 1077-1088 (2009)
   PUBMED   19474196
REFERENCE   7  (bases 1 to 3285)
  AUTHORS   Reinholdt,L.G., Munroe,R.J., Kamdar,S. and Schimenti,J.C.
  TITLE     The mouse gcd2 mutation causes primordial germ cell depletion
  JOURNAL   Mech Dev 123 (7), 559-569 (2006)
   PUBMED   16822657
REFERENCE   8  (bases 1 to 3285)
  AUTHORS   Ward,J.O., Reinholdt,L.G., Hartford,S.A., Wilson,L.A., Munroe,R.J.,
            Schimenti,K.J., Libby,B.J., O'Brien,M., Pendola,J.K., Eppig,J. and
            Schimenti,J.C.
  TITLE     Toward the genetics of mammalian reproduction: induction and
            mapping of gametogenesis mutants in mice
  JOURNAL   Biol Reprod 69 (5), 1615-1625 (2003)
   PUBMED   12855593
REFERENCE   9  (bases 1 to 3285)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   10 (bases 1 to 3285)
  AUTHORS   Miki,H., Setou,M., Kaneshiro,K. and Hirokawa,N.
  TITLE     All kinesin superfamily protein, KIF, genes in mouse and human
  JOURNAL   Proc Natl Acad Sci U S A 98 (13), 7004-7011 (2001)
   PUBMED   11416179
  REMARK    Review article
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL691430.6.
            
            On Mar 24, 2023 this sequence version replaced XM_006499259.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR17253014.1540959.1,
                                           SRR7345562.3338716.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849384, SAMN01164131
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-74                AL691430.6         35935-36008
            75-444              AL691430.6         42912-43281
            445-602             AL691430.6         44794-44951
            603-707             AL691430.6         47180-47284
            708-818             AL691430.6         48086-48196
            819-1016            AL691430.6         50054-50251
            1017-1193           AL691430.6         51735-51911
            1194-1268           AL691430.6         53190-53264
            1269-1381           AL691430.6         53452-53564
            1382-1544           AL691430.6         57918-58080
            1545-1709           AL691430.6         61965-62129
            1710-1831           AL691430.6         65662-65783
            1832-2067           AL691430.6         72990-73225
            2068-2479           AL691430.6         88371-88782
            2480-2587           AL691430.6         89436-89543
            2588-2693           AL691430.6         93682-93787
            2694-3285           AL691430.6         96273-96864
FEATURES             Location/Qualifiers
     source          1..3285
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 56.55 cM"
     gene            1..3285
                     /gene="Kif18a"
                     /gene_synonym="B130001M12Rik; gcd2"
                     /note="kinesin family member 18A"
                     /db_xref="GeneID:228421"
                     /db_xref="MGI:MGI:2446977"
     exon            1..74
                     /gene="Kif18a"
                     /gene_synonym="B130001M12Rik; gcd2"
                     /inference="alignment:Splign:2.1.0"
     exon            75..444
                     /gene="Kif18a"
                     /gene_synonym="B130001M12Rik; gcd2"
                     /inference="alignment:Splign:2.1.0"
     CDS             120..2879
                     /gene="Kif18a"
                     /gene_synonym="B130001M12Rik; gcd2"
                     /note="isoform 2 is encoded by transcript variant 2;
                     kinesin superfamily protein 18A; kinesin-like protein
                     KIF18A; N-8 kinesin"
                     /codon_start=1
                     /product="kinesin-like protein KIF18A isoform 2"
                     /protein_id="NP_001405889.1"
                     /db_xref="GeneID:228421"
                     /db_xref="MGI:MGI:2446977"
                     /translation="MSGTEEDLCHRMKVVVRVRPENTKEKAVQFCKVVHVVDKHILSF
                     DPKQEEISFFHRKKTTNFDITKRQNKDLKFVFDAVFDETSTQMEVFEHTTKPILHSFL
                     NGYNCTVFAYGATGSGKTHTMLGSAAEPGVMYLTMLDLFKCIDEIKEEKECSTAVSYL
                     EVYNEQIRDLLTNSGPLAVREDSQKGVVVQGLTLHQPKSSEEILQLLDNGNKNRTQHP
                     TDVNAVSSRSHAVFQIYLRQQDKTASINQNVRIAKMSLIDLAGSERASVSGAKGSRFV
                     EGTNINKSLLALGNVINALANTKRRNQHIPYRNSKLTRLLKDSLGGNCQTIMIAAVSP
                     SSLFYDDTYNTLKYANRAKEIKSSLKSNVLNLNSHISQYVKICNMQKAEILMLKEKLK
                     AYEEQKALSDRNDCAKLVHSNPEDRETERFQEILNCLFQNREGIRQEYLKLEMLLKAN
                     ALKSSYHQQCHKQIEMMCSEDKVEKATCKRDHRLEKLKTNSCFLEKKKEEVSKQFDEN
                     TNWLHRVENEMRLLGQNGDIPEALNKELHCHHLHLQNKELKTQMAHMTALACLQEQQH
                     KQTEAVLNALLPVLRKQYWKLKETGLSNAAFDSDFKDIEHLVERKKVVAWADQTNEHS
                     NRNDLPGISLLMTFPQLEPIQSISCCTSVSDPNVLKLTPQRRTRRKIIPSPLKVQHTQ
                     KSALSESTQLNDSFSKELQPIVYTPEDCKKAQDLFPSLTRTSSQSANVMNDNSQKALC
                     RIESPLSRTECKQGLYSTSTLCDSIRGLKNKWPEQEPLASSKSSVHRIESSSFSTKDS
                     MPESAGVPSYMAMTTAAKRKWKQMSSTSNASIKSDESCGFAKRIRRDNSSVKPMQENR
                     LKAIKEIPTKQIQTCLENLEETLQKKMYNKKNQCPCVVFMPLEMYFKSGKEGHLLLKY
                     FQQAK"
     exon            445..602
                     /gene="Kif18a"
                     /gene_synonym="B130001M12Rik; gcd2"
                     /inference="alignment:Splign:2.1.0"
     exon            603..707
                     /gene="Kif18a"
                     /gene_synonym="B130001M12Rik; gcd2"
                     /inference="alignment:Splign:2.1.0"
     exon            708..818
                     /gene="Kif18a"
                     /gene_synonym="B130001M12Rik; gcd2"
                     /inference="alignment:Splign:2.1.0"
     exon            819..1016
                     /gene="Kif18a"
                     /gene_synonym="B130001M12Rik; gcd2"
                     /inference="alignment:Splign:2.1.0"
     exon            1017..1193
                     /gene="Kif18a"
                     /gene_synonym="B130001M12Rik; gcd2"
                     /inference="alignment:Splign:2.1.0"
     exon            1194..1268
                     /gene="Kif18a"
                     /gene_synonym="B130001M12Rik; gcd2"
                     /inference="alignment:Splign:2.1.0"
     exon            1269..1381
                     /gene="Kif18a"
                     /gene_synonym="B130001M12Rik; gcd2"
                     /inference="alignment:Splign:2.1.0"
     exon            1382..1544
                     /gene="Kif18a"
                     /gene_synonym="B130001M12Rik; gcd2"
                     /inference="alignment:Splign:2.1.0"
     exon            1545..1709
                     /gene="Kif18a"
                     /gene_synonym="B130001M12Rik; gcd2"
                     /inference="alignment:Splign:2.1.0"
     exon            1710..1831
                     /gene="Kif18a"
                     /gene_synonym="B130001M12Rik; gcd2"
                     /inference="alignment:Splign:2.1.0"
     exon            1832..2067
                     /gene="Kif18a"
                     /gene_synonym="B130001M12Rik; gcd2"
                     /inference="alignment:Splign:2.1.0"
     exon            2068..2479
                     /gene="Kif18a"
                     /gene_synonym="B130001M12Rik; gcd2"
                     /inference="alignment:Splign:2.1.0"
     exon            2480..2587
                     /gene="Kif18a"
                     /gene_synonym="B130001M12Rik; gcd2"
                     /inference="alignment:Splign:2.1.0"
     exon            2588..2693
                     /gene="Kif18a"
                     /gene_synonym="B130001M12Rik; gcd2"
                     /inference="alignment:Splign:2.1.0"
     exon            2694..3285
                     /gene="Kif18a"
                     /gene_synonym="B130001M12Rik; gcd2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3263..3268
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Kif18a"
                     /gene_synonym="B130001M12Rik; gcd2"
                     /note="hexamer: ATTAAA"
     polyA_site      3285
                     /gene="Kif18a"
                     /gene_synonym="B130001M12Rik; gcd2"
                     /note="major polyA site"
ORIGIN      
        1 gggtttgaat ttgtggctgt gtttggagcg cctggaagcc aactctgcca agttgtgacg
       61 gtcacttctt gtaggaaaat tcccaggtat tcatgtaaca ggaattgagg taactaagaa
      121 tgtctggcac tgaagaagac ttatgtcacc gcatgaaagt agttgtccgt gtacgtcctg
      181 agaacacaaa agaaaaggcg gtgcagttct gtaaagtggt tcatgtagtg gataaacata
      241 tactcagttt tgatccgaaa caagaagaaa tcagtttttt tcacagaaag aaaactacaa
      301 attttgatat tactaaaagg caaaataaag atctgaagtt tgtatttgat gctgtctttg
      361 atgaaacttc aactcaaatg gaagtttttg aacacacaac caagccaatc cttcatagtt
      421 ttctgaatgg atacaattgc acagtatttg catatggtgc cactggatct gggaaaactc
      481 acacaatgct aggatcagct gctgaacctg gggtcatgta cctgacaatg ctggaccttt
      541 tcaaatgcat cgatgagatt aaagaagaga aagagtgtag cactgccgtg tcatacctgg
      601 aggtatataa tgaacagatc cgtgacctct tgacaaactc aggaccactt gctgtccggg
      661 aagattccca aaaaggagtg gttgttcagg gtcttactct acaccagcct aaatcttcag
      721 aggaaatatt acagctacta gacaatggaa acaaaaacag gacccagcat cccactgacg
      781 tgaatgcagt gtcttctcgt tcccatgctg ttttccagat ttatttgcga caacaagaca
      841 aaacagcgag catcaatcaa aatgtccgta tagccaaaat gtcactcatc gacctcgcag
      901 gatctgagag ggccagtgtt tcgggtgcta aagggtcacg atttgtagaa ggcacaaata
      961 ttaacaaatc tcttttagct cttgggaatg tcatcaatgc cttagcaaat acaaagagaa
     1021 gaaatcagca tattccttac agaaatagta agcttactcg tttgctgaag gattctcttg
     1081 gaggaaactg tcaaactata atgatagctg ctgttagtcc ttcctcttta ttttatgatg
     1141 acacatataa cactcttaag tatgctaatc gtgcaaagga aattaaatct tctttgaaga
     1201 gcaatgttct taatctcaac agtcacatat ctcagtatgt aaagatatgt aatatgcaga
     1261 aagcagagat tttaatgttg aaagaaaaac taaaggccta tgaagaacag aaagccctgt
     1321 ctgacagaaa tgactgtgct aaattagtac attcaaaccc agaagacaga gaaactgaaa
     1381 gatttcaaga aattctgaac tgcttgttcc agaatcgaga aggaatcagg caagagtatc
     1441 tgaagttaga aatgttactt aaggcaaatg cgctaaagtc atcctatcac caacagtgcc
     1501 ataaacagat agagatgatg tgttctgaag acaaagtgga aaaggccact tgcaaacgag
     1561 atcacagact tgaaaagttg aaaaccaaca gctgttttct agagaaaaag aaagaagagg
     1621 tgtcgaaaca atttgatgaa aatactaatt ggctacatcg tgttgaaaac gaaatgcgac
     1681 tcttgggtca aaatggtgat attccagagg cactcaataa agagcttcac tgtcaccatt
     1741 tacacctcca gaacaaagaa ctgaaaacac aaatggcaca catgacagct ctagcttgtc
     1801 tccaggaaca gcagcacaag caaactgagg cagtattgaa tgctttgctt ccagtactaa
     1861 gaaaacagta ttggaaattg aaagaaactg gcctgtcaaa tgctgctttt gattctgact
     1921 tcaaagatat tgaacattta gtagagagaa aaaaggtggt ggcttgggct gaccaaacta
     1981 atgaacattc aaaccgaaat gatcttccag ggatttctct tcttatgacc ttcccacagc
     2041 ttgaaccaat tcagtctatt tcttgttgca catctgtgag tgatcctaac gtgcttaaac
     2101 ttactccaca acgaagaacc agaagaaaaa taattccttc tcccttgaaa gtacaacata
     2161 ctcagaagtc tgcactgtct gaaagtacac agctcaatga ttctttcagc aaagaacttc
     2221 agcctattgt ttatacgcca gaggactgca aaaaagctca agacctgttt ccatccttaa
     2281 cgagaacttc atcgcagtct gcaaatgtaa tgaatgacaa ttcccagaaa gcactgtgta
     2341 gaatagagtc tcctctcagc agaactgagt gcaaacaggg tttgtactct acatctactc
     2401 tgtgtgatag catcagaggc ttgaagaata aatggcctga acaagaacca ctagcaagca
     2461 gcaaaagcag tgtgcacagg atagagtctt cttcattttc aacaaaggat tctatgcctg
     2521 aatcagcagg tgtgccgtcc tacatggcaa tgactactgc tgcaaagagg aaatggaaac
     2581 aaatgagttc tacatcaaat gcttcaatca aatctgatga aagttgtgga tttgccaaac
     2641 gcattcgacg ggataattca agcgttaagc ctatgcaaga aaacagactg aaagctataa
     2701 aagaaatacc aacaaaacaa attcaaacat gcttagaaaa tttagaagaa acacttcaaa
     2761 agaaaatgta caataagaag aatcaatgtc cttgtgtggt atttatgcct ttagaaatgt
     2821 atttcaagtc tgggaaagaa ggccatcttt tgctcaaata ttttcagcaa gcaaaatgaa
     2881 acttcttttg tatttaaaat aaatatcaaa ttacaacagg gtatttttcc catttctcaa
     2941 atatttggta tgcttgaaaa tctctaagtc accatgatgc caatttactc atactttact
     3001 acaacttgat tcgaacattg tagaaaacat agtaaattaa attgccctta ttattttcaa
     3061 aaataaggag actttagaag tcatagttat ggccaagatg tatttggtct tctgctgtgt
     3121 gtcaatatgt tggtttaatc atacatgtca ttttactttc taaaacattg gtgtaaaaat
     3181 gtagatacat atgtccattg cattgtaaat attgtttaaa taccttccat aaataatgtg
     3241 ctaatatttt attacttggt atattaaaga tgtagatttt aaaca
//
