LOCUS       NM_010623               3915 bp    mRNA    linear   ROD 07-MAY-2024
DEFINITION  Mus musculus kinesin family member 17 (Kif17), transcript variant
            1, mRNA.
ACCESSION   NM_010623 XM_011251932
VERSION     NM_010623.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3915)
  AUTHORS   Waas,B., Carpenter,B.S., Franks,N.E., Merchant,O.Q., Verhey,K.J.
            and Allen,B.L.
  TITLE     Dual and opposing roles for the kinesin-2 motor, KIF17, in
            Hedgehog-dependent cerebellar development
  JOURNAL   Sci Adv 10 (17), eade1650 (2024)
   PUBMED   38669326
  REMARK    GeneRIF: Dual and opposing roles for the kinesin-2 motor, KIF17, in
            Hedgehog-dependent cerebellar development.
REFERENCE   2  (bases 1 to 3915)
  AUTHORS   Liu,Y., Tian,X., Ke,P., Gu,J., Ma,Y., Guo,Y., Xu,X., Chen,Y.,
            Yang,M., Wang,X. and Xiao,F.
  TITLE     KIF17 Modulates Epileptic Seizures and Membrane Expression of the
            NMDA Receptor Subunit NR2B
  JOURNAL   Neurosci Bull 38 (8), 841-856 (2022)
   PUBMED   35678994
  REMARK    GeneRIF: KIF17 Modulates Epileptic Seizures and Membrane Expression
            of the NMDA Receptor Subunit NR2B.
REFERENCE   3  (bases 1 to 3915)
  AUTHORS   Wang,H.H., Zhang,Y., Tang,F., Pan,M.H., Wan,X., Li,X.H. and
            Sun,S.C.
  TITLE     Rab23/Kif17 regulate meiotic progression in oocytes by modulating
            tubulin acetylation and actin dynamics
  JOURNAL   Development 146 (3) (2019)
   PUBMED   30696709
  REMARK    GeneRIF: results demonstrate that the Rab23-Kif17-cargo complex
            regulates tubulin acetylation for spindle organization and drives
            actin-mediated spindle migration during meiosis.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3915)
  AUTHORS   Lewis,T.R., Kundinger,S.R., Link,B.A., Insinna,C. and Besharse,J.C.
  TITLE     Kif17 phosphorylation regulates photoreceptor outer segment
            turnover
  JOURNAL   BMC Cell Biol 19 (1), 25 (2018)
   PUBMED   30458707
  REMARK    GeneRIF: phosphorylation of KIF17 promotes its photoreceptor outer
            segment localization and disc shedding, a process essential for
            photoreceptor maintenance and homeostasis.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3915)
  AUTHORS   Lewis,T.R., Kundinger,S.R., Pavlovich,A.L., Bostrom,J.R., Link,B.A.
            and Besharse,J.C.
  TITLE     Cos2/Kif7 and Osm-3/Kif17 regulate onset of outer segment
            development in zebrafish photoreceptors through distinct mechanisms
  JOURNAL   Dev Biol 425 (2), 176-190 (2017)
   PUBMED   28341548
REFERENCE   6  (bases 1 to 3915)
  AUTHORS   Wong,R.W., Setou,M., Teng,J., Takei,Y. and Hirokawa,N.
  TITLE     Overexpression of motor protein KIF17 enhances spatial and working
            memory in transgenic mice
  JOURNAL   Proc Natl Acad Sci U S A 99 (22), 14500-14505 (2002)
   PUBMED   12391294
  REMARK    GeneRIF: KIF17 contributes to neuronal events required for learning
            and memory by trafficking fundamental N-methyl-d-aspartate-type
            glutamate receptor, NR2A.
REFERENCE   7  (bases 1 to 3915)
  AUTHORS   Miki,H., Setou,M., Kaneshiro,K. and Hirokawa,N.
  TITLE     All kinesin superfamily protein, KIF, genes in mouse and human
  JOURNAL   Proc Natl Acad Sci U S A 98 (13), 7004-7011 (2001)
   PUBMED   11416179
  REMARK    Review article
REFERENCE   8  (bases 1 to 3915)
  AUTHORS   Zhao,C., Takita,J., Tanaka,Y., Setou,M., Nakagawa,T., Takeda,S.,
            Yang,H.W., Terada,S., Nakata,T., Takei,Y., Saito,M., Tsuji,S.,
            Hayashi,Y. and Hirokawa,N.
  TITLE     Charcot-Marie-Tooth disease type 2A caused by mutation in a
            microtubule motor KIF1Bbeta
  JOURNAL   Cell 105 (5), 587-597 (2001)
   PUBMED   11389829
  REMARK    Erratum:[Cell 2001 Jul 13;106(1):127]
REFERENCE   9  (bases 1 to 3915)
  AUTHORS   Setou,M., Nakagawa,T., Seog,D.H. and Hirokawa,N.
  TITLE     Kinesin superfamily motor protein KIF17 and mLin-10 in NMDA
            receptor-containing vesicle transport
  JOURNAL   Science 288 (5472), 1796-1802 (2000)
   PUBMED   10846156
REFERENCE   10 (bases 1 to 3915)
  AUTHORS   Nakagawa,T., Tanaka,Y., Matsuoka,E., Kondo,S., Okada,Y., Noda,Y.,
            Kanai,Y. and Hirokawa,N.
  TITLE     Identification and classification of 16 new kinesin superfamily
            (KIF) proteins in mouse genome
  JOURNAL   Proc Natl Acad Sci U S A 94 (18), 9654-9659 (1997)
   PUBMED   9275178
  REMARK    Erratum:[Proc Natl Acad Sci U S A 1999 Mar 30;96(7):4214]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL807249.8.
            
            On or before Feb 15, 2015 this sequence version replaced
            XM_011251932.1, NM_010623.3.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from genomic sequence
            data to make the sequence consistent with the reference genome
            assembly. The genomic coordinates used for the transcript record
            were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB008867.1, SRR13422600.559466.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-483               AL807249.8         46780-47262
            484-630             AL807249.8         53474-53620
            631-732             AL807249.8         54375-54476
            733-922             AL807249.8         59496-59685
            923-1375            AL807249.8         62325-62777
            1376-1485           AL807249.8         65886-65995
            1486-1639           AL807249.8         70961-71114
            1640-2196           AL807249.8         72458-73014
            2197-2280           AL807249.8         73770-73853
            2281-2510           AL807249.8         75898-76127
            2511-2742           AL807249.8         76643-76874
            2743-3001           AL807249.8         78241-78499
            3002-3069           AL807249.8         80724-80791
            3070-3190           AL807249.8         82735-82855
            3191-3915           AL807249.8         85778-86502
FEATURES             Location/Qualifiers
     source          1..3915
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 70.07 cM"
     gene            1..3915
                     /gene="Kif17"
                     /gene_synonym="5930435E01Rik; Kif17b; mKIAA1405"
                     /note="kinesin family member 17"
                     /db_xref="GeneID:16559"
                     /db_xref="MGI:MGI:1098229"
     exon            1..483
                     /gene="Kif17"
                     /gene_synonym="5930435E01Rik; Kif17b; mKIAA1405"
                     /inference="alignment:Splign:2.1.0"
     CDS             253..3369
                     /gene="Kif17"
                     /gene_synonym="5930435E01Rik; Kif17b; mKIAA1405"
                     /note="isoform 1 is encoded by transcript variant 1;
                     kinesin-like protein KIF17; kinesin 17; N-4 kinesin"
                     /codon_start=1
                     /product="kinesin-like protein KIF17 isoform 1"
                     /protein_id="NP_034753.1"
                     /db_xref="CCDS:CCDS18823.1"
                     /db_xref="GeneID:16559"
                     /db_xref="MGI:MGI:1098229"
                     /translation="MASESVKVVVRCRPMNKRERELSCQSVVTVDSARGQCFIQNPGA
                     ADEPPKQFTFDGAYYIEHFTEQIYNEIAYPLVEGVTEGYNGTIFAYGQTGSGKSFTMQ
                     GLPDPPCQRGIIPRAFEHVFESVQCAENTKFLVRASYLEIYNEDVHDLLGADTKQRLE
                     LKEHPEKGVYVKGLSMHTVHNVAQCERVMETGWKNRAVGYTLMNKDSSRSHSIFTINI
                     EIYAVDERGKDHLRAGKLNLVDLAGSERQSKTGATGERLKEATKINLSLSALGNVISA
                     LVDGRCKHIPYRDSKLTRLLQDSLGGNTKTLMVACLSPADNNYDETLSTLRYANRAKN
                     IKNKPRINEDPKDALLREYQEEIKRLKAILAQQMGPGNLSALLSTQTPPGPVQSEEKL
                     LSPTTVQQDTEAEKQLIREEYEERLARLKADYEAEQESRVRLQEDITAMRNSYDVKLS
                     TLQENLRKEKETEAILKAEVLCKTEVMSRAELASGPEYSPPLQYETAVKPTILSMPDM
                     PPSGKVTKSQAPLAFEEPHGETSRSEFSFESNECSTLEDSATSEAFPGPEEFSNMEFS
                     MAAALTESRYLPEEYLGGQEAAASPLEAERYVQENEPSLEPLRILASLQDPFAEVEAK
                     LARLSSTVAMSDSSQTVVPQIPKQPSSADLLEPSDTKSEADVAVADNVVLGTEPDVNL
                     RVAEEVVSEAETGVWMESEAQVAHVAQVSEEAQPQPLLAMVSVRRESVGVEVAVLTEE
                     ELQPVDQQQVLARLQLLEQQVVGGEQAKNKDLREKHKRRKRYADERKKQLVAALQNSD
                     EDGGDWVLLNVYDSIQEEVRAKSKLLEKMQRKLRAAEVEIKDLQSEFQLEKIDYLATI
                     RRQERDSMLFQQLLEQVQPLIRRDCNYSNLEKIRRESSWDEDNGFWKIPDPIILKTSL
                     PVVPTGTQNKPARKTSAVDSGEPHMQEEDRYKLMLSRSDSENIASNYFRSKRASQILS
                     TDPMKSLTYHNSPPGLNSSLSNNSALPPTQTPEMPQPRPFRLESLDIPFSKAKRKKSK
                     NSFGGEPL"
     exon            484..630
                     /gene="Kif17"
                     /gene_synonym="5930435E01Rik; Kif17b; mKIAA1405"
                     /inference="alignment:Splign:2.1.0"
     exon            631..732
                     /gene="Kif17"
                     /gene_synonym="5930435E01Rik; Kif17b; mKIAA1405"
                     /inference="alignment:Splign:2.1.0"
     exon            733..922
                     /gene="Kif17"
                     /gene_synonym="5930435E01Rik; Kif17b; mKIAA1405"
                     /inference="alignment:Splign:2.1.0"
     exon            923..1375
                     /gene="Kif17"
                     /gene_synonym="5930435E01Rik; Kif17b; mKIAA1405"
                     /inference="alignment:Splign:2.1.0"
     exon            1376..1485
                     /gene="Kif17"
                     /gene_synonym="5930435E01Rik; Kif17b; mKIAA1405"
                     /inference="alignment:Splign:2.1.0"
     exon            1486..1639
                     /gene="Kif17"
                     /gene_synonym="5930435E01Rik; Kif17b; mKIAA1405"
                     /inference="alignment:Splign:2.1.0"
     exon            1640..2196
                     /gene="Kif17"
                     /gene_synonym="5930435E01Rik; Kif17b; mKIAA1405"
                     /inference="alignment:Splign:2.1.0"
     exon            2197..2280
                     /gene="Kif17"
                     /gene_synonym="5930435E01Rik; Kif17b; mKIAA1405"
                     /inference="alignment:Splign:2.1.0"
     exon            2281..2510
                     /gene="Kif17"
                     /gene_synonym="5930435E01Rik; Kif17b; mKIAA1405"
                     /inference="alignment:Splign:2.1.0"
     exon            2511..2742
                     /gene="Kif17"
                     /gene_synonym="5930435E01Rik; Kif17b; mKIAA1405"
                     /inference="alignment:Splign:2.1.0"
     exon            2743..3001
                     /gene="Kif17"
                     /gene_synonym="5930435E01Rik; Kif17b; mKIAA1405"
                     /inference="alignment:Splign:2.1.0"
     exon            3002..3069
                     /gene="Kif17"
                     /gene_synonym="5930435E01Rik; Kif17b; mKIAA1405"
                     /inference="alignment:Splign:2.1.0"
     exon            3070..3190
                     /gene="Kif17"
                     /gene_synonym="5930435E01Rik; Kif17b; mKIAA1405"
                     /inference="alignment:Splign:2.1.0"
     exon            3191..3915
                     /gene="Kif17"
                     /gene_synonym="5930435E01Rik; Kif17b; mKIAA1405"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3893..3898
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Kif17"
                     /gene_synonym="5930435E01Rik; Kif17b; mKIAA1405"
                     /note="hexamer: AATAAA"
     polyA_site      3915
                     /gene="Kif17"
                     /gene_synonym="5930435E01Rik; Kif17b; mKIAA1405"
                     /note="major polyA site"
ORIGIN      
        1 gtcgtgcggc ggcgcctgca gcgcggatcc cccgttcccc gcccgggccc ggcctcaggg
       61 acgggcgagc ccgggcgcgg gaggcggcgg cccgggttcc agcccgcaca cttgtccgcc
      121 gagcccctgc cacacccagt gcgccccgcg gggagtcccg gccccctggt gcggccccgc
      181 ccccgccgcc aggccccgcc ccgcgcgggc tctggctcca ccccctggac cgggccacgc
      241 ccccgggcag ccatggcctc ggagtcagtg aaagtggtcg tgcgctgccg acccatgaac
      301 aagcgcgagc gcgagctgag ctgccagtcg gtggtgacgg tggacagtgc gcgcggccaa
      361 tgcttcattc agaacccggg agcggcggac gaacccccaa agcagttcac cttcgatggc
      421 gcctactaca tagaacactt caccgagcag atctacaacg agatcgccta cccgctggtg
      481 gagggtgtca ccgaaggcta caatgggacc atttttgcct atggccagac aggcagtggg
      541 aagtctttca ccatgcaggg actgccagat cccccctgcc agaggggcat cattcccaga
      601 gccttcgagc acgtgtttga gagcgttcag tgtgcagaga acaccaagtt cttagtgcgg
      661 gcttcctatc tggagatcta caacgaagat gtccatgacc tgctgggcgc tgacaccaag
      721 cagaggcttg agctgaagga gcatcccgag aagggagtgt atgtcaaggg gctgtccatg
      781 cacacggtac acaacgtggc ccagtgcgag cgcgtcatgg agaccggctg gaagaaccgt
      841 gcggttggct acaccctgat gaataaggac tcctcccgtt cccactccat ctttaccatc
      901 aacatcgaga tctatgccgt ggatgaacgg ggtaaggacc atcttcgtgc aggcaagctc
      961 aacctggtag acctggccgg cagtgagcgg caatccaaga ctggggccac aggggaaagg
     1021 ctgaaggagg ccaccaaaat taacctgtca ctgtcggcgc tgggcaacgt catctcggca
     1081 ctggtggatg ggcgctgcaa gcacattcct taccgggact cgaagctgac ccgactgctt
     1141 caggactcac tgggtggcaa caccaagact ctgatggtgg cttgcctgtc tcccgcagac
     1201 aacaattacg atgagaccct cagtacgctg cgctatgcta acagggccaa gaacatcaag
     1261 aacaagccac gcattaatga agaccccaag gatgccctgc ttcgagagta ccaggaagag
     1321 atcaagaggc taaaggctat cctcgcccag cagatgggcc ctggcaacct gtcagccctg
     1381 ctgtccactc agacaccccc aggcccagtc cagtctgagg agaagctgct gtccccaact
     1441 actgtccagc aggacacgga ggctgagaag cagttgatcc gagaggagta tgaggagcgc
     1501 ctggcccgcc tgaaggctga ctacgaggca gagcaagagt ctcgggtccg gctgcaggag
     1561 gacattactg ccatgcgtaa ctcgtatgac gtgaagctgt ccacactgca ggagaatctg
     1621 cgcaaggaga aggagacaga ggccattctc aaggcggaag tcctgtgtaa gacggaggtc
     1681 atgtccaggg ccgagttagc cagcgggccc gagtactcac ctcctttgca gtatgagact
     1741 gcggtgaagc ccaccatcct ctccatgccc gacatgccac ccagtggcaa ggtcaccaag
     1801 agccaagcgc ccctcgcttt cgaggaacca cacggggaga cctccaggtc cgagttttcc
     1861 tttgagtcca atgagtgttc cactctcgaa gactctgcca catcagaggc cttccctggg
     1921 ccagaggagt tttccaacat ggagttctcc atggctgcgg cactgaccga gagcaggtac
     1981 cttcctgagg agtatctcgg cggccaggag gctgctgcat ctccgctgga ggcagagcgc
     2041 tatgtccagg agaacgagcc atcgctggag cccctgcgga tactggcaag cctgcaggat
     2101 ccttttgctg aagtggaggc caagctggcc agactgtcct ctactgtggc catgtcggac
     2161 tcatcccaga ccgtcgtccc ccagatccct aagcagccat cctcggctga cctgctggag
     2221 cccagcgaca ccaagtcaga agctgatgtg gctgtggctg acaacgtcgt cctcgggact
     2281 gagcctgatg taaacctgag agtggctgag gaggtggttt ctgaggcaga gactggcgtg
     2341 tggatggagt ctgaagccca ggtggcccat gtggcccagg tgtctgagga ggcccagcct
     2401 cagcccttgc tggccatggt gagcgtgagg agggaaagtg tgggtgtaga agtggctgtg
     2461 ttgacggagg aggagctgca gcctgtggat caacagcagg tgctggcccg cttgcagttg
     2521 ctggagcagc aggtggtggg gggcgagcag gctaaaaaca aggacctgag ggagaagcac
     2581 aagcggcgga agcggtacgc agatgagcgc aagaagcagc tggtggccgc actgcagaac
     2641 tcggatgagg atggcgggga ctgggtgctg ctcaacgtct atgactctat ccaggaggaa
     2701 gtgagggcca agagcaagct gctggagaag atgcagagga agctccgggc agcagaggta
     2761 gaaatcaagg acctgcagtc agagttccag ctggagaaga ttgattacct ggcaaccatc
     2821 cgccggcagg agcgggactc catgctcttc cagcaactcc tggagcaggt gcagcctctc
     2881 atccgcagag actgtaacta tagcaacctg gagaagatca ggcgagagtc gagctgggat
     2941 gaggataatg gcttctggaa gatcccagat cccatcatac tgaaaaccag cctcccagta
     3001 gttccaactg ggacacagaa caagccagct cgaaaaacct ctgcagtaga cagtggggag
     3061 ccacacatgc aggaggaaga caggtataag ctgatgctca gccgaagcga cagtgagaat
     3121 atcgctagca actacttccg ctccaagcgg gccagccaga tcctcagcac ggaccccatg
     3181 aagagcctca catatcacaa ctcaccaccg gggctaaatt cctctctgag caacaactct
     3241 gccttgccgc ccacccagac cccggaaatg ccccagcccc ggcccttccg cctagagtcc
     3301 cttgacatcc ccttctccaa agccaagcgt aaaaaaagca aaaacagctt cggtggtgag
     3361 cctctgtgat ccagctgcct gctgctatct gctttcaaga aacttccgag tcctctctgc
     3421 aaagccccaa ccaggcctct tctctcctac tccacagtgt ccccaagccc aaggggatct
     3481 tagccctggg aagacacgtt cccttcccta ttccctagag aactcccttt ggcccagggc
     3541 ctgagctttg tggaagttgg actacacttc tcagagagag gcctgctcca gctattcaca
     3601 ggagccaatg tccctactga cttgcctgcc actgagccta cactagccag tgtgggtcta
     3661 cctccacggg ctcagatgcc caccgatctc cccaggcatt ctcatacaga gcacagaagc
     3721 tgccaaccac acggacaaaa ctcaacatct tggtgactta agatttgggc ctctgtgatt
     3781 ggccccttcc aagggaacct gtgacacaca gtggacctgg agacagctgc tgtgcctagc
     3841 ctacccttgg ctggacagca gtccagagaa ggtgatttac agaaagctgc ccaataaact
     3901 gccttttgga ataag
//
