LOCUS       NM_001355123            5478 bp    mRNA    linear   ROD 18-DEC-2022
DEFINITION  Mus musculus kinesin family member 16B (Kif16b), transcript variant
            1, mRNA.
ACCESSION   NM_001355123 XM_006498817
VERSION     NM_001355123.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5478)
  AUTHORS   Farkhondeh A, Niwa S, Takei Y and Hirokawa N.
  TITLE     Characterizing KIF16B in neurons reveals a novel intramolecular
            'stalk inhibition' mechanism that regulates its capacity to
            potentiate the selective somatodendritic localization of early
            endosomes
  JOURNAL   J Neurosci 35 (12), 5067-5086 (2015)
   PUBMED   25810535
  REMARK    GeneRIF: the stalk domain of kinesin superfamily protein 16B
            determines the specific somatodendritic localization of Endosomes
            mediated by a novel intramolecular inhibitory mechanism.
REFERENCE   2  (bases 1 to 5478)
  AUTHORS   Ueno H, Huang X, Tanaka Y and Hirokawa N.
  TITLE     KIF16B/Rab14 molecular motor complex is critical for early
            embryonic development by transporting FGF receptor
  JOURNAL   Dev Cell 20 (1), 60-71 (2011)
   PUBMED   21238925
  REMARK    GeneRIF: The kinesin-3 motor KIF16B/Rab14 complex acts in
            biosynthetic Golgi-to-endosome traffic of the fibroblast growth
            factor receptor (FGFR) during early embryonic development.
REFERENCE   3  (bases 1 to 5478)
  AUTHORS   Trost M, English L, Lemieux S, Courcelles M, Desjardins M and
            Thibault P.
  TITLE     The phagosomal proteome in interferon-gamma-activated macrophages
  JOURNAL   Immunity 30 (1), 143-154 (2009)
   PUBMED   19144319
REFERENCE   4  (bases 1 to 5478)
  AUTHORS   Sheehan S, Tsaih SW, King BL, Stanton C, Churchill GA, Paigen B and
            DiPetrillo K.
  TITLE     Genetic analysis of albuminuria in a cross between C57BL/6J and
            DBA/2J mice
  JOURNAL   Am J Physiol Renal Physiol 293 (5), F1649-F1656 (2007)
   PUBMED   17804484
REFERENCE   5  (bases 1 to 5478)
  AUTHORS   Blatner NR, Wilson MI, Lei C, Hong W, Murray D, Williams RL and Cho
            W.
  TITLE     The structural basis of novel endosome anchoring activity of KIF16B
            kinesin
  JOURNAL   EMBO J 26 (15), 3709-3719 (2007)
   PUBMED   17641687
  REMARK    GeneRIF: The most salient structural feature of KIF16B-PX is that
            two neighboring residues, L1248 and F1249, on the membrane-binding
            surface form a protruding hydrophobic stalk with a large
            solvent-accessible surface area
REFERENCE   6  (bases 1 to 5478)
  AUTHORS   Okazaki N, Kikuno R, Ohara R, Inamoto S, Koseki H, Hiraoka S, Saga
            Y, Nagase T, Ohara O and Koga H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: III. the complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 10 (4), 167-180 (2003)
   PUBMED   14621295
REFERENCE   7  (bases 1 to 5478)
  AUTHORS   Stryke D, Kawamoto M, Huang CC, Johns SJ, King LA, Harper CA, Meng
            EC, Lee RE, Yee A, L'Italien L, Chuang PT, Young SG, Skarnes WC,
            Babbitt PC and Ferrin TE.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   8  (bases 1 to 5478)
  AUTHORS   Miki H, Setou M, Kaneshiro K and Hirokawa N.
  TITLE     All kinesin superfamily protein, KIF, genes in mouse and human
  JOURNAL   Proc Natl Acad Sci U S A 98 (13), 7004-7011 (2001)
   PUBMED   11416179
  REMARK    Review article
REFERENCE   9  (bases 1 to 5478)
  AUTHORS   Nakagawa T, Tanaka Y, Matsuoka E, Kondo S, Okada Y, Noda Y, Kanai Y
            and Hirokawa N.
  TITLE     Identification and classification of 16 new kinesin superfamily
            (KIF) proteins in mouse genome
  JOURNAL   Proc Natl Acad Sci U S A 94 (18), 9654-9659 (1997)
   PUBMED   9275178
  REMARK    Erratum:[Proc Natl Acad Sci U S A 1999 Mar 30;96(7):4214]
REFERENCE   10 (bases 1 to 5478)
  AUTHORS   Winter H, Siry P, Tobiasch E and Schweizer J.
  TITLE     Sequence and expression of murine type I hair keratins mHa2 and
            mHa3
  JOURNAL   Exp Cell Res 212 (2), 190-200 (1994)
   PUBMED   7514534
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL731712.6, AL929136.5 and AL731790.10.
            
            [WARNING] On May 18, 2023 this sequence was replaced by
            NM_001355123.2.
            
            On Sep 8, 2017 this sequence version replaced XM_006498817.3.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB610968.1, SRR10223969.3175.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-140               AL731712.6         155413-155552       c
            141-210             AL731712.6         119432-119501       c
            211-324             AL731712.6         116515-116628       c
            325-441             AL731712.6         111399-111515       c
            442-539             AL731712.6         108522-108619       c
            540-649             AL731712.6         107715-107824       c
            650-792             AL731712.6         103952-104094       c
            793-961             AL731712.6         102381-102549       c
            962-1093            AL731712.6         102079-102210       c
            1094-1269           AL731712.6         101017-101192       c
            1270-1335           AL731712.6         91605-91670         c
            1336-1395           AL731712.6         88165-88224         c
            1396-1515           AL731712.6         12878-12997         c
            1516-1567           AL731712.6         11985-12036         c
            1568-1705           AL731712.6         10177-10314         c
            1706-1788           AL929136.5         105785-105867       c
            1789-1877           AL929136.5         104399-104487       c
            1878-1910           AL929136.5         79938-79970         c
            1911-1964           AL929136.5         79555-79608         c
            1965-3308           AL929136.5         76571-77914         c
            3309-3461           AL929136.5         72135-72287         c
            3462-3558           AL929136.5         68818-68914         c
            3559-3609           AL929136.5         67499-67549         c
            3610-3732           AL929136.5         55455-55577         c
            3733-3822           AL929136.5         37165-37254         c
            3823-3906           AL929136.5         13304-13387         c
            3907-5478           AL731790.10        17209-18780
FEATURES             Location/Qualifiers
     source          1..5478
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2"
     gene            1..5478
                     /gene="Kif16b"
                     /gene_synonym="8430434E15Rik; mKIAA1590"
                     /note="kinesin family member 16B"
                     /db_xref="GeneID:16558"
                     /db_xref="MGI:MGI:1098240"
     exon            1..140
                     /gene="Kif16b"
                     /gene_synonym="8430434E15Rik; mKIAA1590"
                     /inference="alignment:Splign:2.1.0"
     CDS             94..4065
                     /gene="Kif16b"
                     /gene_synonym="8430434E15Rik; mKIAA1590"
                     /note="isoform 1 is encoded by transcript variant 1;
                     kinesin 16B; N-3 kinesin; kinesin-like protein KIF16B"
                     /codon_start=1
                     /product="kinesin-like protein KIF16B isoform 1"
                     /protein_id="NP_001342052.1"
                     /db_xref="CCDS:CCDS89559.1"
                     /db_xref="GeneID:16558"
                     /db_xref="MGI:MGI:1098240"
                     /translation="MASVKVAVRVRPMNRREKDLEAKFIIQMEKSKTTITNLKIPEGG
                     TGDSGRERTKTFTYDFSFYSADTKSPDYVSQEMVFKTLGTDVVKSAFEGYNACVFAYG
                     QTGSGKSYTMMGNSGDSGLIPRICEALFSRINETTRWDEASFRTEVSYLEIYNERVRD
                     LLRRKSSKTFNLRVREHPKEGPYVEDLSKHLVQNYSDVEELMDAGNINRTTAATGMND
                     VSSRSHAIFTIKFTQAKFDAEMPCETVSKIHLVDLAGSERADATGATGVRLKEGGNIN
                     KSLVTLGNVISALADLSQDAANPLVKKKQVFVPYRDSVLTWLLKDSLGGNSKTIMIAT
                     ISPADVNYGETLSTLRYANRAKNIINKPTINEDANVKLIRELRAEIARLKTLLAQGNQ
                     IALLDSPTALSMEEKLHQNEARVQELTKEWTNKWNETQNILKEQTLALRKEGIGVVLD
                     SELPHLIGIDDDLLSTGIILYHLKEGQTYVGREDASTEQDIVLHGLDLESEHCVFENA
                     GGTVTLIPLRGSQCSVNGVQIVDATQLNQGAVILLGRTNMFRFNHPKEAAKLREKRKS
                     GLLSSFSLSMTDLSKSCENLSAVMLYNPGLFPIKGPICLRLEFERQQREELEKLESKR
                     KLIEEMEEKQKSDKAELERMQQEVETRRKETEIVQRQIRKQEESLKRRSFHIENKLKD
                     LLAEKERFEEERLREQQGLEQQRRQEEESLFRIREELRKLQELNSHEQAEKVQIFQEL
                     DRLHQEQNAQSAKLRLEKRRLEEEEKEQVQRVAHLEEQLRKRQDTAPLLCPGEAQRAQ
                     EEKRELESIREALLQAKEMRAGGDHTCRDELERAQQYFLEFKRRQLVKLASLEKDLVQ
                     QKDLLSKEVQEEKVALEHVKCDAGGDPSFLATDDGNILGGPPDLDKIKTAETRLQSRE
                     HQLQDLLQNHLPALLEEKQRVLDALDSGVLGLDTTLCQVEKEVGEKEEQIAQYQANAS
                     QLQQLRATFEFTANVARQEEKVRRKEKEILESQEKQQREALEQAVAKLEQRRSALQRC
                     STLDLEIQEQRQKLGSLHTSEWSGWQASLETDGEALEMDPARLEHEIHQLKQKICEVD
                     GVQRPHHGILEGQAVLSSLPPSGGNSHLAPLMDARISAYIEEEVQRRLHDLHRAIGDA
                     NHTPADVMKSNEELHNGTTQRKLKYERMYSRSLGTNRDDLKDPIKISIPRYVLCGQGK
                     DEHFEFEVKISVLDETWTVFRRYSRFREMHKTLKLKYAELAALEFPPKKLFGNKDERV
                     VAERRTHLEKYLREFFSVMLQSETSPLHINKVGLTLSKHTICEFSPFFKKGVFDYSSH
                     GTG"
     exon            141..210
                     /gene="Kif16b"
                     /gene_synonym="8430434E15Rik; mKIAA1590"
                     /inference="alignment:Splign:2.1.0"
     exon            211..324
                     /gene="Kif16b"
                     /gene_synonym="8430434E15Rik; mKIAA1590"
                     /inference="alignment:Splign:2.1.0"
     exon            325..441
                     /gene="Kif16b"
                     /gene_synonym="8430434E15Rik; mKIAA1590"
                     /inference="alignment:Splign:2.1.0"
     exon            442..539
                     /gene="Kif16b"
                     /gene_synonym="8430434E15Rik; mKIAA1590"
                     /inference="alignment:Splign:2.1.0"
     exon            540..649
                     /gene="Kif16b"
                     /gene_synonym="8430434E15Rik; mKIAA1590"
                     /inference="alignment:Splign:2.1.0"
     exon            650..792
                     /gene="Kif16b"
                     /gene_synonym="8430434E15Rik; mKIAA1590"
                     /inference="alignment:Splign:2.1.0"
     exon            793..961
                     /gene="Kif16b"
                     /gene_synonym="8430434E15Rik; mKIAA1590"
                     /inference="alignment:Splign:2.1.0"
     exon            962..1093
                     /gene="Kif16b"
                     /gene_synonym="8430434E15Rik; mKIAA1590"
                     /inference="alignment:Splign:2.1.0"
     exon            1094..1269
                     /gene="Kif16b"
                     /gene_synonym="8430434E15Rik; mKIAA1590"
                     /inference="alignment:Splign:2.1.0"
     exon            1270..1335
                     /gene="Kif16b"
                     /gene_synonym="8430434E15Rik; mKIAA1590"
                     /inference="alignment:Splign:2.1.0"
     exon            1336..1395
                     /gene="Kif16b"
                     /gene_synonym="8430434E15Rik; mKIAA1590"
                     /inference="alignment:Splign:2.1.0"
     exon            1396..1515
                     /gene="Kif16b"
                     /gene_synonym="8430434E15Rik; mKIAA1590"
                     /inference="alignment:Splign:2.1.0"
     exon            1516..1567
                     /gene="Kif16b"
                     /gene_synonym="8430434E15Rik; mKIAA1590"
                     /inference="alignment:Splign:2.1.0"
     exon            1568..1705
                     /gene="Kif16b"
                     /gene_synonym="8430434E15Rik; mKIAA1590"
                     /inference="alignment:Splign:2.1.0"
     exon            1706..1788
                     /gene="Kif16b"
                     /gene_synonym="8430434E15Rik; mKIAA1590"
                     /inference="alignment:Splign:2.1.0"
     exon            1789..1877
                     /gene="Kif16b"
                     /gene_synonym="8430434E15Rik; mKIAA1590"
                     /inference="alignment:Splign:2.1.0"
     exon            1878..1910
                     /gene="Kif16b"
                     /gene_synonym="8430434E15Rik; mKIAA1590"
                     /inference="alignment:Splign:2.1.0"
     exon            1911..1964
                     /gene="Kif16b"
                     /gene_synonym="8430434E15Rik; mKIAA1590"
                     /inference="alignment:Splign:2.1.0"
     exon            1965..3308
                     /gene="Kif16b"
                     /gene_synonym="8430434E15Rik; mKIAA1590"
                     /inference="alignment:Splign:2.1.0"
     exon            3309..3461
                     /gene="Kif16b"
                     /gene_synonym="8430434E15Rik; mKIAA1590"
                     /inference="alignment:Splign:2.1.0"
     exon            3462..3558
                     /gene="Kif16b"
                     /gene_synonym="8430434E15Rik; mKIAA1590"
                     /inference="alignment:Splign:2.1.0"
     exon            3559..3609
                     /gene="Kif16b"
                     /gene_synonym="8430434E15Rik; mKIAA1590"
                     /inference="alignment:Splign:2.1.0"
     exon            3610..3732
                     /gene="Kif16b"
                     /gene_synonym="8430434E15Rik; mKIAA1590"
                     /inference="alignment:Splign:2.1.0"
     exon            3733..3822
                     /gene="Kif16b"
                     /gene_synonym="8430434E15Rik; mKIAA1590"
                     /inference="alignment:Splign:2.1.0"
     exon            3823..3906
                     /gene="Kif16b"
                     /gene_synonym="8430434E15Rik; mKIAA1590"
                     /inference="alignment:Splign:2.1.0"
     exon            3907..5478
                     /gene="Kif16b"
                     /gene_synonym="8430434E15Rik; mKIAA1590"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gggggcgcgg gcacgggcac agtcgctgga gtggccggcg gccgcggggc gcaggcctgt
       61 tggaagcccc cgcgggccgg gccgggatga gctatggcat cggtcaaggt ggccgtgaga
      121 gtccggccca tgaatcgcag ggaaaaggac ctggaggcca agttcatcat tcaaatggag
      181 aaaagcaaaa cgacaatcac aaacttaaag ataccagaag gaggaactgg ggattcaggc
      241 agagaacgga ccaagacctt cacctatgac ttctcttttt attctgctga caccaagagt
      301 ccagattatg tctcacaaga aatggttttc aaaactctgg gtacagatgt tgtgaaatct
      361 gcatttgaag gttacaatgc ttgtgtcttt gcatatgggc aaactggatc tggaaagtcc
      421 tacaccatga tgggaaattc tggcgattct ggcttaatac ctcggatctg tgaagctctc
      481 ttcagtcgga tcaatgaaac cactagatgg gatgaagcct ctttcaggac agaagtcagc
      541 tacttagaaa tttataatga acgtgtgaga gacctactta ggcggaagtc atctaagacc
      601 ttcaatttaa gagtccgtga gcatcccaaa gaaggaccgt acgttgagga tttatccaag
      661 catttagtcc agaactacag tgatgtggag gaactcatgg acgcaggaaa tatcaatcgc
      721 accaccgcag cgacggggat gaatgatgtc agtagcaggt cccacgccat cttcaccatc
      781 aagttcactc aggcaaaatt cgacgctgaa atgccatgtg aaactgtgag caagatccac
      841 ctcgtcgatc ttgctggaag tgagcgggca gatgccaccg gtgccactgg ggtcagactc
      901 aaggaagggg gcaatataaa caagtccctt gtgactctgg gaaatgtcat ttctgcctta
      961 gctgatttat ctcaggatgc agccaaccct cttgtgaaga agaagcaagt ttttgtgcct
     1021 tacagggatt cagttttgac ttggctgttg aaagacagcc ttggaggaaa ctctaaaacc
     1081 atcatgattg ccaccatttc acctgctgat gtcaattatg gagaaaccct aagtaccctt
     1141 cgctatgcaa atagagccaa aaacatcatc aacaagccta ccattaatga ggatgccaac
     1201 gtcaaactca tccgtgagct gagagctgaa atagccaggc tgaaaaccct gctcgctcaa
     1261 gggaaccaga ttgccctctt ggactcccct acagctttaa gtatggagga aaaacttcac
     1321 cagaatgaag caagagtcca agaattgacc aaggaatgga caaacaagtg gaatgaaacc
     1381 cagaatattt tgaaagagca aactctagcc ctcaggaaag agggcattgg tgtggtgctg
     1441 gactcggagc tgccgcacct aattggcatt gatgatgatc ttctgagcac tggaatcatc
     1501 ttgtatcact tgaaggaggg tcagacttac gtcggcagag aagatgcttc aacagagcaa
     1561 gatattgtcc ttcatggcct tgacttggag agtgagcact gtgtctttga gaacgccggg
     1621 ggaacagtga ctctgatacc cctgagaggg tcccaatgct ctgtgaatgg tgttcagatt
     1681 gtggatgcca cgcagctaaa tcaaggtgct gtgatactct tgggaagaac caacatgttc
     1741 cgctttaacc atccgaagga agccgccaag cttagggaga agaggaagag tggcctcctg
     1801 tcctccttca gcttgtctat gaccgacctc tcaaagtcct gtgagaacct gtctgcagtc
     1861 atgttgtata accctggtct tttccctata aaaggaccca tctgtctaag acttgagttt
     1921 gagagacaac agcgtgaaga acttgaaaaa ctcgaaagta aaaggaaact cattgaggag
     1981 atggaggaaa agcagaagtc ggacaaggca gaactagagc gaatgcagca ggaggtagag
     2041 accaggcgca aggaaacaga gattgtgcag cggcaaatcc gcaagcagga ggaaagcctc
     2101 aaacgccgca gcttccacat tgaaaacaag ctcaaggacc tgctggctga gaaggaaagg
     2161 tttgaggaag agaggcttcg ggagcagcag ggactcgagc agcagaggag gcaggaggaa
     2221 gagagcttat tccgcatcag agaagagctt cgcaaactcc aagagctcaa cagccacgaa
     2281 caagctgaga aggtccagat attccaggag ctggaccgat tgcaccaaga gcaaaatgcc
     2341 cagagtgcca agctgcggtt ggagaaaagg aggctggagg aggaggagaa ggagcaggtg
     2401 cagcgggtgg cacacctgga ggagcagctt cggaagaggc aggacactgc tcctctgctg
     2461 tgtcctggag aggcccagcg ggcccaagag gaaaagaggg aactggaaag catccgggaa
     2521 gcccttttgc aggccaaaga gatgagagct ggaggggacc atacctgtag ggatgaactg
     2581 gaaagggctc agcagtactt cttagagttc aagagaaggc agcttgtcaa gctagcaagc
     2641 ctggagaagg acctggtcca acagaaagac ctcctaagca aagaagtcca agaagagaaa
     2701 gtagctctgg agcatgtaaa atgtgacgca gggggtgacc cgagcttctt ggcaacagat
     2761 gatggcaaca ttctcggtgg gcctccagat ctagacaaaa taaagactgc agagaccagg
     2821 ctacagagca gagagcacca gctacaggac cttctgcaaa atcatttgcc agctctgctg
     2881 gaagaaaagc agagagtgct tgatgccctt gacagtggtg tcctaggcct agacaccact
     2941 ctctgccaag tagagaaaga agtgggagag aaagaagagc agatcgcaca gtaccaggct
     3001 aatgctagcc agctgcaaca gctccgggcc accttcgagt tcacagctaa cgtggccaga
     3061 caggaagaga aggtgagaag aaaggaaaag gaaatactgg agtcccagga gaaacagcaa
     3121 agagaggcat tggagcaggc tgtggctaag ctagagcaga ggcgctctgc cctgcagcgg
     3181 tgctccaccc tggacctgga gatccaggag cagaggcaga aacttggctc tctccacacc
     3241 agtgaatggt cagggtggca ggccagtctg gagactgatg gagaagcact tgagatggac
     3301 cctgcaaggt tagaacatga aatccatcag ctgaagcaga agatctgtga agtagatggt
     3361 gttcagagac ctcatcatgg gattttagag gggcaggccg ttctctccag cttgccaccc
     3421 agtgggggaa actctcacct ggctccactg atggatgcca ggatcagtgc ttacattgaa
     3481 gaagaagtcc agagacgcct tcatgatttg cacagggcaa ttggtgatgc caaccataca
     3541 cctgctgatg tgatgaagag taatgaggaa cttcacaatg gcaccactca acgtaagcta
     3601 aagtatgagc ggatgtattc tcgctctttg ggaacaaatc gagacgacct gaaggacccc
     3661 attaagatta gtattcctcg ctatgtcctg tgtggccaag ggaaggacga gcacttcgag
     3721 tttgaagtga agatttctgt cctagatgag acatggactg tattcaggcg ctacagtcgt
     3781 tttcgagaaa tgcataaaac attgaagcta aagtatgcag agctcgctgc tcttgaattc
     3841 cccccaaaga agctgtttgg aaacaaagac gagcgggtag ttgctgagcg gcggacacac
     3901 ttagagaaat acctcaggga gtttttcagt gtgatgctcc agtccgagac atctcccctt
     3961 cacatcaaca aagtgggact gaccctgtcc aagcacacca tttgtgaatt ctcaccattc
     4021 ttcaagaaag gagtttttga ctacagcagc catgggacag ggtagagctg tggcgaccaa
     4081 ggaaccacca acacagtgcc ttctcatcaa atagactctg atgcagagtg gactcctgca
     4141 ccaggattcc agcttgcctc ctccagttgt ggcaacatgc agcagccagc ccagaccacc
     4201 tctcacacca tatctagtgc ctgagtttgg gagtgggtgc ttgcctgcca agggcaactc
     4261 tgattgacag ttgttactgt acctctgcac ttgaacgtgg cctttcccat agtacagcaa
     4321 gtcaatcccc tgtggcagga tggatgtgtg gcttgcttat ctagggactc ctagagccaa
     4381 gccaacttgg gacttcccat tgtgggtggc ttaccagacc acccttaagt gactttcatc
     4441 tggtttcctt tttcaccaaa atatgctttt ttttttatac ttcttccatg tggctggcta
     4501 ggtttcaaag atgttttaag ttatgtcata ttgttttgtt catttggatt tggatttaat
     4561 aatatctaaa tactgacgtt tacatagaat gtcctgttca gtaaaaagga tctgtaggcc
     4621 aatcatgaga agagtcttcc atgcctgaca aattggatgt aggcaacatt gcagaaactt
     4681 gcagaaatcc ctacaaataa gacattgttt aaccttcact atttgagggc attttcccaa
     4741 acctcaaagg ctgttgttca ttttttagct ttttctgcat aaaacaagtg caaagctgga
     4801 tgcaatcttt taaatatcct ttgtccatgt tttagtacag aaccttcaag atcattaact
     4861 aaaaagagag agagaatttt cagtagttta ttaataatcc ctcaattact caggacataa
     4921 tgtagcattt cacatcgtgt acagtgaaac tgcttccttt atcaaaagaa aattgtgagt
     4981 aggaaaaatc tgtggtatat attgaaatgt acataattca acatatagat ttatatgtat
     5041 acactcctgt acaatagtat atcaggctat atgatcattc acaccaaatt tattaaaggt
     5101 gtttgctttt tcaactgtta aattgagctg ctatcaatat taaatgaagt catgtgctat
     5161 accctgtagt tcagtttaag tttgtaatat gatcatttct actggtctgt ttaacaattg
     5221 acctgatatg cttagaaaga ggcatattgt acaatttagc atttatgttg cagaaaatgc
     5281 agttatgatt gaagtcacaa atgaatggat aacaaaacat gcttgcattc agtcttctag
     5341 aacatgcccg cacagcagat ctctccaagc tcacaagaat gttggaagat gcagctagcc
     5401 ctataaggag gagactaata ttcaattaat taaatatcat agcttagcat gaaaaaataa
     5461 aacggactct ttatttaa
//
