LOCUS       NP_034750               1387 aa            linear   ROD 04-AUG-2024
DEFINITION  kinesin-like protein KIF15 [Mus musculus].
ACCESSION   NP_034750 XP_135231
VERSION     NP_034750.1
DBSOURCE    REFSEQ: accession NM_010620.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 1387)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (residues 1 to 1387)
  AUTHORS   Wang,J., Tu,Q., Zhang,S., He,X., Ma,C., Qian,X., Wu,R., Shi,X.,
            Yang,Z., Liu,Y., Dong,Z. and Liu,M.
  TITLE     Kif15 deficiency contributes to depression-like behavior in mice
  JOURNAL   Metab Brain Dis 38 (7), 2369-2381 (2023)
   PUBMED   37256467
  REMARK    GeneRIF: Kif15 deficiency contributes to depression-like behavior
            in mice.
REFERENCE   3  (residues 1 to 1387)
  AUTHORS   Zhang,S., Tu,Q., Qian,X., Wang,J., Ma,C., Yang,L., Liu,Y., Wu,R.
            and Liu,M.
  TITLE     Deficiency of Kif15 gene inhibits tumor growth due to host CD8+T
            lymphocytes increase
  JOURNAL   Biochem Biophys Res Commun 655, 110-117 (2023)
   PUBMED   36934586
  REMARK    GeneRIF: Deficiency of Kif15 gene inhibits tumor growth due to host
            CD8[+]T lymphocytes increase.
REFERENCE   4  (residues 1 to 1387)
  AUTHORS   Zou,Y.J., Shan,M.M., Wan,X., Liu,J.C., Zhang,K.H., Ju,J.Q.,
            Xing,C.H. and Sun,S.C.
  TITLE     Kinesin KIF15 regulates tubulin acetylation and spindle assembly
            checkpoint in mouse oocyte meiosis
  JOURNAL   Cell Mol Life Sci 79 (8), 422 (2022)
   PUBMED   35835966
  REMARK    GeneRIF: Kinesin KIF15 regulates tubulin acetylation and spindle
            assembly checkpoint in mouse oocyte meiosis.
            Publication Status: Online-Only
REFERENCE   5  (residues 1 to 1387)
  AUTHORS   Naiman,N., Fujioka,K., Fujino,M., Valerius,M.T., Potter,S.S.,
            McMahon,A.P. and Kobayashi,A.
  TITLE     Repression of Interstitial Identity in Nephron Progenitor Cells by
            Pax2 Establishes the Nephron-Interstitium Boundary during Kidney
            Development
  JOURNAL   Dev Cell 41 (4), 349-365 (2017)
   PUBMED   28535371
REFERENCE   6  (residues 1 to 1387)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   7  (residues 1 to 1387)
  AUTHORS   Buster,D.W., Baird,D.H., Yu,W., Solowska,J.M., Chauviere,M.,
            Mazurek,A., Kress,M. and Baas,P.W.
  TITLE     Expression of the mitotic kinesin Kif15 in postmitotic neurons:
            implications for neuronal migration and development
  JOURNAL   J Neurocytol 32 (1), 79-96 (2003)
   PUBMED   14618103
  REMARK    GeneRIF: Kif15 opposes the capacity of other motors to generate
            independent microtubule movements within key regions of developing
            neurons.
REFERENCE   8  (residues 1 to 1387)
  AUTHORS   Miki,H., Setou,M., Kaneshiro,K. and Hirokawa,N.
  TITLE     All kinesin superfamily protein, KIF, genes in mouse and human
  JOURNAL   Proc Natl Acad Sci U S A 98 (13), 7004-7011 (2001)
   PUBMED   11416179
  REMARK    Review article
REFERENCE   9  (residues 1 to 1387)
  AUTHORS   Nakagawa,T., Tanaka,Y., Matsuoka,E., Kondo,S., Okada,Y., Noda,Y.,
            Kanai,Y. and Hirokawa,N.
  TITLE     Identification and classification of 16 new kinesin superfamily
            (KIF) proteins in mouse genome
  JOURNAL   Proc Natl Acad Sci U S A 94 (18), 9654-9659 (1997)
   PUBMED   9275178
  REMARK    Erratum:[Proc Natl Acad Sci U S A 1999 Mar 30;96(7):4214]
REFERENCE   10 (residues 1 to 1387)
  AUTHORS   Winter,H., Siry,P., Tobiasch,E. and Schweizer,J.
  TITLE     Sequence and expression of murine type I hair keratins mHa2 and
            mHa3
  JOURNAL   Exp Cell Res 212 (2), 190-200 (1994)
   PUBMED   7514534
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC060710.1.
            
            On Jan 1, 2004 this sequence version replaced XP_135231.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC060710.1, AJ560623.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849384, SAMN01164133
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1387
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 73.31 cM"
     Protein         1..1387
                     /product="kinesin-like protein KIF15"
                     /note="kinesin-like 7; kinesin-like protein 2;
                     kinesin-like protein 7; kinesin 15; N-10 kinesin"
                     /calculated_mol_wt=159990
     Region          1..23
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6P9L6.1)"
     Region          25..373
                     /region_name="KISc_KLP2_like"
                     /note="Kinesin motor domain, KIF15-like subgroup; cd01373"
                     /db_xref="CDD:276824"
     Site            order(34,109,112,114..117,265)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:276824"
     Site            order(316,319,322)
                     /site_type="other"
                     /note="microtubule interaction site [polypeptide binding]"
                     /db_xref="CDD:276824"
     Region          520..1339
                     /region_name="SMC_prok_B"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; TIGR02168"
                     /db_xref="CDD:274008"
     Site            568
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9NS87; propagated from
                     UniProtKB/Swiss-Prot (Q6P9L6.1)"
     Site            1009
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:Q9NS87; propagated from
                     UniProtKB/Swiss-Prot (Q6P9L6.1)"
     Site            1141
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9NS87; propagated from
                     UniProtKB/Swiss-Prot (Q6P9L6.1)"
     Site            1169
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9NS87; propagated from
                     UniProtKB/Swiss-Prot (Q6P9L6.1)"
     CDS             1..1387
                     /gene="Kif15"
                     /gene_synonym="3110023M17Rik; 3930402I10Rik;
                     b2b1117.1aClo; b2b1117.1Clo; D330038N01; HKLP2; Knsl7"
                     /coded_by="NM_010620.1:54..4217"
                     /db_xref="CCDS:CCDS23651.1"
                     /db_xref="GeneID:209737"
                     /db_xref="MGI:MGI:1098258"
ORIGIN      
        1 mapgckselr nvtnshsnqp snegdaikvf vrirpaeega rsadgeqsfc lsvlsqttlr
       61 lhsnpdpktf vfdyvagmdt tqesvfstva ksivescmsg yngtifaygq tgsgktftmm
      121 gpsdsdnfsh nlrgiiprsf eylfslidre kekagagksf lckcsfievy neqiydllds
      181 asvglylreh ikkgvfvvga veqavtsaae tyqvlsrgwr nrrvastsmn ressrshavf
      241 titiesmeks setvnirtsl lnlvdlagse rqkdthaegm rlkeagninr slsclgqvit
      301 alvdvgngkq rhicyrdskl tfllrdslgg naktaiianv hpgsrcfget lstlnfaqra
      361 kliknkavvn edtqgnvsql qaevkrlkeq lsqftsgqit pesllardke ktnyieyfle
      421 amlffkkseq ekksliekit qledltlkke kfiqsnkmiv kfredqimrl erlhkegrgs
      481 flpeeqdrll selrdevqtl rehvehhprl akyamenhsl reenrrlkll apvkraheid
      541 aqsiarleka faevsstetn dkglqgfspk alkessfftn teklkaqllq iqtelnnskq
      601 eyeefkeltr kkqlelesel qslqkanlnl enlleatkvc krqevsqlnk lhaetlkiit
      661 tptkayqlcs rlvpksspev gsfgflctes ssrldndiln epvppemseq aleavseelr
      721 tvqeqlsvlq vkldeeerkn lklqqnvdkl ehhstqmqel fssersdwtk qqqehvtqls
      781 dlekqlqdaq tkneflkcev hdlrivlnsa dkelslvkle ystfkenhek elsqlserhv
      841 qvqlqldnar lenekllesq aclqdsydnl qevmkfeidq lsknlqnckq enetlksdlh
      901 nlvelfeaek ernnklslqf eedkensske ilkvletvrq ekqkemakce kqmakiqkle
      961 esllatenvi ssleksresd kelvtnlmnq iqelrisige ksetiatlkq elqdinckyn
     1021 asladkeesk elirrqevdi lelketlrlr ilsedierdm lcedlahate qlnmlteask
     1081 khsgllqsaq eeltrkeali qelqhklnqe keeveqkkne fslkmrqleh vmgsateypq
     1141 spktpphfqa hlaklletqe qeiedgrask tslqhlvtkl nedrevknae ilrmkdqlce
     1201 menlrlesqq lreknwllqr qlddvkrqqe sgdqshpdsq qlkneheeii kerlaknkli
     1261 eemlkmktnl eevqsalhsk ekachrmsee iertrtlesr afqekeqlrs kleemyeere
     1321 rtflememlk kqleflaeen gklvghqnlh qkiqyvvrlk kenirlteet eklraenlfl
     1381 kekkkef
//
