LOCUS       NM_001081177            8915 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus kinesin family member 13B (Kif13b), mRNA.
ACCESSION   NM_001081177 XM_283218
VERSION     NM_001081177.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 8915)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 8915)
  AUTHORS   Helmer,P. and Vallee,R.B.
  TITLE     A two-kinesin mechanism controls neurogenesis in the developing
            brain
  JOURNAL   Commun Biol 6 (1), 1219 (2023)
   PUBMED   38040957
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 8915)
  AUTHORS   Waters,S.B., Dominguez,J.R., Cho,H.D., Sarich,N.A., Malik,A.B. and
            Yamada,K.H.
  TITLE     KIF13B-mediated VEGFR2 trafficking is essential for vascular
            leakage and metastasis in vivo
  JOURNAL   Life Sci Alliance 5 (1), e202101170 (2021)
   PUBMED   34670814
  REMARK    GeneRIF: KIF13B-mediated VEGFR2 trafficking is essential for
            vascular leakage and metastasis in vivo.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 8915)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 8915)
  AUTHORS   Waters,S.B., Zhou,C., Nguyen,T., Zelkha,R., Lee,H., Kazlauskas,A.,
            Rosenblatt,M.I., Malik,A.B. and Yamada,K.H.
  TITLE     VEGFR2 Trafficking by KIF13B Is a Novel Therapeutic Target for Wet
            Age-Related Macular Degeneration
  JOURNAL   Invest Ophthalmol Vis Sci 62 (2), 5 (2021)
   PUBMED   33533881
REFERENCE   6  (bases 1 to 8915)
  AUTHORS   Okazaki,N., F-Kikuno,R., Ohara,R., Inamoto,S., Koseki,H.,
            Hiraoka,S., Saga,Y., Seino,S., Nishimura,M., Kaisho,T., Hoshino,K.,
            Kitamura,H., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: IV. The complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 11 (3), 205-218 (2004)
   PUBMED   15368895
REFERENCE   7  (bases 1 to 8915)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   8  (bases 1 to 8915)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
REFERENCE   9  (bases 1 to 8915)
  AUTHORS   Miki,H., Setou,M., Kaneshiro,K. and Hirokawa,N.
  TITLE     All kinesin superfamily protein, KIF, genes in mouse and human
  JOURNAL   Proc Natl Acad Sci U S A 98 (13), 7004-7011 (2001)
   PUBMED   11416179
  REMARK    Review article
REFERENCE   10 (bases 1 to 8915)
  AUTHORS   Nakagawa,T., Tanaka,Y., Matsuoka,E., Kondo,S., Okada,Y., Noda,Y.,
            Kanai,Y. and Hirokawa,N.
  TITLE     Identification and classification of 16 new kinesin superfamily
            (KIF) proteins in mouse genome
  JOURNAL   Proc Natl Acad Sci U S A 94 (18), 9654-9659 (1997)
   PUBMED   9275178
  REMARK    Erratum:[Proc Natl Acad Sci U S A 1999 Mar 30;96(7):4214]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC105979.13 and AC132602.2.
            
            On Sep 14, 2022 this sequence version replaced NM_001081177.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: partial sample support SAMN00849380, SAMN00849381
                              [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-116               AC105979.13        44146-44261         c
            117-210             AC105979.13        27085-27178         c
            211-223             AC132602.2         137223-137235       c
            224-284             AC132602.2         131593-131653       c
            285-377             AC132602.2         130247-130339       c
            378-558             AC132602.2         128073-128253       c
            559-646             AC132602.2         123333-123420       c
            647-781             AC132602.2         120893-121027       c
            782-894             AC132602.2         118541-118653       c
            895-1006            AC132602.2         117403-117514       c
            1007-1219           AC132602.2         109367-109579       c
            1220-1330           AC132602.2         108122-108232       c
            1331-1465           AC132602.2         107086-107220       c
            1466-1596           AC132602.2         103290-103420       c
            1597-1683           AC132602.2         100765-100851       c
            1684-1874           AC132602.2         99238-99428         c
            1875-2085           AC132602.2         98588-98798         c
            2086-2248           AC132602.2         97119-97281         c
            2249-2395           AC132602.2         95368-95514         c
            2396-2545           AC132602.2         94072-94221         c
            2546-2674           AC132602.2         93631-93759         c
            2675-2845           AC132602.2         88143-88313         c
            2846-3003           AC132602.2         87019-87176         c
            3004-3136           AC132602.2         84926-85058         c
            3137-3283           AC132602.2         80578-80724         c
            3284-3313           AC132602.2         79987-80016         c
            3314-3413           AC132602.2         78274-78373         c
            3414-3540           AC132602.2         77988-78114         c
            3541-3596           AC132602.2         77252-77307         c
            3597-3718           AC132602.2         75064-75185         c
            3719-3895           AC132602.2         72640-72816         c
            3896-3988           AC132602.2         69398-69490         c
            3989-4141           AC132602.2         66261-66413         c
            4142-4219           AC132602.2         65959-66036         c
            4220-4273           AC132602.2         63332-63385         c
            4274-4385           AC132602.2         57208-57319         c
            4386-4519           AC132602.2         56029-56162         c
            4520-4621           AC132602.2         45281-45382         c
            4622-5327           AC132602.2         41997-42702         c
            5328-8915           AC132602.2         36109-39696         c
FEATURES             Location/Qualifiers
     source          1..8915
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 33.77 cM"
     gene            1..8915
                     /gene="Kif13b"
                     /gene_synonym="5330429L19Rik; 6030414C01; C130021D12Rik;
                     GAKIN"
                     /note="kinesin family member 13B"
                     /db_xref="GeneID:16554"
                     /db_xref="MGI:MGI:1098265"
     exon            1..116
                     /gene="Kif13b"
                     /gene_synonym="5330429L19Rik; 6030414C01; C130021D12Rik;
                     GAKIN"
                     /inference="alignment:Splign:2.1.0"
     CDS             62..5593
                     /gene="Kif13b"
                     /gene_synonym="5330429L19Rik; 6030414C01; C130021D12Rik;
                     GAKIN"
                     /note="kinesin 13B; N-3 kinesin"
                     /codon_start=1
                     /product="kinesin-like protein KIF13B"
                     /protein_id="NP_001074646.1"
                     /db_xref="CCDS:CCDS36954.1"
                     /db_xref="GeneID:16554"
                     /db_xref="MGI:MGI:1098265"
                     /translation="MGDSKVKVAVRVRPMNRREIDLHTKCVVDVEANKVILNPVNTNL
                     SKGDARGQPKIFAYDHCFWSMDESVREKYAGQEDVFKCLGENILQNAFDGYNACIFAY
                     GQTGSGKSYTMMGTADQPGLIPRLCSGLFERTQKEENEEQSFKVEVSYMEIYNEKVRD
                     LLDPKGSRQTLKVREHSVLGPYVDGLSKLAVTSYKDIESLMSEGNKSRTVAATNMNEE
                     SSRSHAVFKITLTHTLYDVKSGTSGEKVGKLSLVDLAGSERATKTGAAGDRLKEGSNI
                     NKSLTTLGLVISALADQGAGKNKNKFVPYRDSVLTWLLKDSLGGNSKTAMVATVSPAA
                     DNYDETLSTLRYADRAKHIVNHAVVNEDPNARIIRDLREEVEKLREQLTKAEAMKSPE
                     LKDRLEESEKLIQEMTVTWEEKLRKTEEIAQERQKQLESLGISLQTSGIKVGDDKCFL
                     VNLNADPALNELLVYYLKEHTLIGSANSQDIQLCGMGILPEHGIIDITPEGQVVLTPQ
                     KNTRTFVNGSSVSSPIQLHHGDRILWGNNHFFRLNLPKKKKKAEREDEDREASLKNDS
                     SSEQLDADGDSSSEVSSEINFNFEYAQMEVTMKALGSNDPMQSILSSLEQQHEEEKRS
                     ALERQRLMYEHELEQLRRRLSPERQNCRGVDRLSFHSPSAQQRLKQWAEEREATLNNS
                     LMRLREQIVKANLLVREASYIAEELDKRTEYKVTLQIPTSSLDANRKRGSLLSEPAIQ
                     VRRKGKGKQIWSLEKLENRLLDMRDLYQEWKECEEDSPVSRSYFKRADPFYDEQENHS
                     LIGVANVFLETLFYDVKLQYAVPIINQKGEVAGRLHVEVMRLSGAIGERIAGGDDPTE
                     VSSEKEAQENRLVCMVKILQATGLPQHLCHFVFCKYDFWDQQEPVTVAPEVDTSSSPT
                     SKQPQCMVVFDHCSEFSVNITEDFIEYLSEGALAIEVYGHKMNDPRKNPALWDLGIIQ
                     AKTRSLRDRWSEVTRKLEFWVQILEQNENGDYCPVEVIAAKDVPTGGIFQLRQGQSRR
                     VQVEVKSVQESGTLPLMEECILSVGIGCVKVRPLRSPKIHENVHEEEEDMDSYQDRDL
                     ERLRRKWLNALTKRQEYLDQQLQKLVSKHDKTEDDADREAQLLEMRLTLTEERNAVMV
                     PSAGSGIPGAPAEWTPVPGMETHIPVIFLDLNADDFSSQDNLDDPEAGWDATLTGEEE
                     EEFFELQIVKQHDGEVKAEASWDSAVHSCPQLSKGTPADERVFLILRVTVQLSHPADM
                     QLVLRKRICVHVHGRQGFAQSLLKKMSHRSSIPGCGVTFEIVSNIPEDAQGVEEREAL
                     ARMAANVENPASADSEAYIEKYLRSVLAVENLLTLDRLRQEVAVKEQLTGKGKLSRRS
                     ISSPSMNRLSGSRQELSPSHSLGSNKGRWESQQDVSQTLVSRGIAPGPPALSVSPQNN
                     QSPDPGLGGVAASYLNPVKSLVPQMPKLLKSLFPVRDDRRGRHSSPLAHQPVPRILVQ
                     PTFSDTWATRTEEVSHQVGAAPLAEVMAAPAVKICDKPVKVSSPPSPMVVTQPPEGQD
                     GPPSPLSEASSGYFSHSVSSATLSETLTLGLDTTGLGSQTPGSPPALCQVTPEPELAF
                     LSCTQSHPPAPEEAHVPAAPTQSTELEVPRAPLLSEPASAVPTSPFRIRKVRTSELKS
                     FTGMLGGASSGAEEDPLASEDPSNARGQTLGRLEVTSDSEDASEVPEWLREGEYVVVG
                     TNKTGIVRYIGPTDFQEGTWIGVELDLPAGKNDGSIGGKQYFRCNPGYGLLVRPSRVR
                     RAVGTGRRRSSGLQPQGAPEVRRSATISGSATNLASLTAALAKGDRSYKNPENRKSWA
                     S"
     exon            117..210
                     /gene="Kif13b"
                     /gene_synonym="5330429L19Rik; 6030414C01; C130021D12Rik;
                     GAKIN"
                     /inference="alignment:Splign:2.1.0"
     exon            211..223
                     /gene="Kif13b"
                     /gene_synonym="5330429L19Rik; 6030414C01; C130021D12Rik;
                     GAKIN"
                     /inference="alignment:Splign:2.1.0"
     exon            224..284
                     /gene="Kif13b"
                     /gene_synonym="5330429L19Rik; 6030414C01; C130021D12Rik;
                     GAKIN"
                     /inference="alignment:Splign:2.1.0"
     exon            285..377
                     /gene="Kif13b"
                     /gene_synonym="5330429L19Rik; 6030414C01; C130021D12Rik;
                     GAKIN"
                     /inference="alignment:Splign:2.1.0"
     exon            378..558
                     /gene="Kif13b"
                     /gene_synonym="5330429L19Rik; 6030414C01; C130021D12Rik;
                     GAKIN"
                     /inference="alignment:Splign:2.1.0"
     exon            559..646
                     /gene="Kif13b"
                     /gene_synonym="5330429L19Rik; 6030414C01; C130021D12Rik;
                     GAKIN"
                     /inference="alignment:Splign:2.1.0"
     exon            647..781
                     /gene="Kif13b"
                     /gene_synonym="5330429L19Rik; 6030414C01; C130021D12Rik;
                     GAKIN"
                     /inference="alignment:Splign:2.1.0"
     exon            782..894
                     /gene="Kif13b"
                     /gene_synonym="5330429L19Rik; 6030414C01; C130021D12Rik;
                     GAKIN"
                     /inference="alignment:Splign:2.1.0"
     exon            895..1006
                     /gene="Kif13b"
                     /gene_synonym="5330429L19Rik; 6030414C01; C130021D12Rik;
                     GAKIN"
                     /inference="alignment:Splign:2.1.0"
     exon            1007..1219
                     /gene="Kif13b"
                     /gene_synonym="5330429L19Rik; 6030414C01; C130021D12Rik;
                     GAKIN"
                     /inference="alignment:Splign:2.1.0"
     exon            1220..1330
                     /gene="Kif13b"
                     /gene_synonym="5330429L19Rik; 6030414C01; C130021D12Rik;
                     GAKIN"
                     /inference="alignment:Splign:2.1.0"
     exon            1331..1465
                     /gene="Kif13b"
                     /gene_synonym="5330429L19Rik; 6030414C01; C130021D12Rik;
                     GAKIN"
                     /inference="alignment:Splign:2.1.0"
     exon            1466..1596
                     /gene="Kif13b"
                     /gene_synonym="5330429L19Rik; 6030414C01; C130021D12Rik;
                     GAKIN"
                     /inference="alignment:Splign:2.1.0"
     exon            1597..1683
                     /gene="Kif13b"
                     /gene_synonym="5330429L19Rik; 6030414C01; C130021D12Rik;
                     GAKIN"
                     /inference="alignment:Splign:2.1.0"
     exon            1684..1874
                     /gene="Kif13b"
                     /gene_synonym="5330429L19Rik; 6030414C01; C130021D12Rik;
                     GAKIN"
                     /inference="alignment:Splign:2.1.0"
     exon            1875..2085
                     /gene="Kif13b"
                     /gene_synonym="5330429L19Rik; 6030414C01; C130021D12Rik;
                     GAKIN"
                     /inference="alignment:Splign:2.1.0"
     exon            2086..2248
                     /gene="Kif13b"
                     /gene_synonym="5330429L19Rik; 6030414C01; C130021D12Rik;
                     GAKIN"
                     /inference="alignment:Splign:2.1.0"
     exon            2249..2395
                     /gene="Kif13b"
                     /gene_synonym="5330429L19Rik; 6030414C01; C130021D12Rik;
                     GAKIN"
                     /inference="alignment:Splign:2.1.0"
     exon            2396..2545
                     /gene="Kif13b"
                     /gene_synonym="5330429L19Rik; 6030414C01; C130021D12Rik;
                     GAKIN"
                     /inference="alignment:Splign:2.1.0"
     exon            2546..2674
                     /gene="Kif13b"
                     /gene_synonym="5330429L19Rik; 6030414C01; C130021D12Rik;
                     GAKIN"
                     /inference="alignment:Splign:2.1.0"
     exon            2675..2845
                     /gene="Kif13b"
                     /gene_synonym="5330429L19Rik; 6030414C01; C130021D12Rik;
                     GAKIN"
                     /inference="alignment:Splign:2.1.0"
     exon            2846..3003
                     /gene="Kif13b"
                     /gene_synonym="5330429L19Rik; 6030414C01; C130021D12Rik;
                     GAKIN"
                     /inference="alignment:Splign:2.1.0"
     exon            3004..3136
                     /gene="Kif13b"
                     /gene_synonym="5330429L19Rik; 6030414C01; C130021D12Rik;
                     GAKIN"
                     /inference="alignment:Splign:2.1.0"
     exon            3137..3283
                     /gene="Kif13b"
                     /gene_synonym="5330429L19Rik; 6030414C01; C130021D12Rik;
                     GAKIN"
                     /inference="alignment:Splign:2.1.0"
     exon            3284..3313
                     /gene="Kif13b"
                     /gene_synonym="5330429L19Rik; 6030414C01; C130021D12Rik;
                     GAKIN"
                     /inference="alignment:Splign:2.1.0"
     exon            3314..3413
                     /gene="Kif13b"
                     /gene_synonym="5330429L19Rik; 6030414C01; C130021D12Rik;
                     GAKIN"
                     /inference="alignment:Splign:2.1.0"
     exon            3414..3540
                     /gene="Kif13b"
                     /gene_synonym="5330429L19Rik; 6030414C01; C130021D12Rik;
                     GAKIN"
                     /inference="alignment:Splign:2.1.0"
     exon            3541..3596
                     /gene="Kif13b"
                     /gene_synonym="5330429L19Rik; 6030414C01; C130021D12Rik;
                     GAKIN"
                     /inference="alignment:Splign:2.1.0"
     exon            3597..3718
                     /gene="Kif13b"
                     /gene_synonym="5330429L19Rik; 6030414C01; C130021D12Rik;
                     GAKIN"
                     /inference="alignment:Splign:2.1.0"
     exon            3719..3895
                     /gene="Kif13b"
                     /gene_synonym="5330429L19Rik; 6030414C01; C130021D12Rik;
                     GAKIN"
                     /inference="alignment:Splign:2.1.0"
     exon            3896..3988
                     /gene="Kif13b"
                     /gene_synonym="5330429L19Rik; 6030414C01; C130021D12Rik;
                     GAKIN"
                     /inference="alignment:Splign:2.1.0"
     exon            3989..4141
                     /gene="Kif13b"
                     /gene_synonym="5330429L19Rik; 6030414C01; C130021D12Rik;
                     GAKIN"
                     /inference="alignment:Splign:2.1.0"
     exon            4142..4219
                     /gene="Kif13b"
                     /gene_synonym="5330429L19Rik; 6030414C01; C130021D12Rik;
                     GAKIN"
                     /inference="alignment:Splign:2.1.0"
     exon            4220..4273
                     /gene="Kif13b"
                     /gene_synonym="5330429L19Rik; 6030414C01; C130021D12Rik;
                     GAKIN"
                     /inference="alignment:Splign:2.1.0"
     exon            4274..4385
                     /gene="Kif13b"
                     /gene_synonym="5330429L19Rik; 6030414C01; C130021D12Rik;
                     GAKIN"
                     /inference="alignment:Splign:2.1.0"
     exon            4386..4519
                     /gene="Kif13b"
                     /gene_synonym="5330429L19Rik; 6030414C01; C130021D12Rik;
                     GAKIN"
                     /inference="alignment:Splign:2.1.0"
     exon            4520..4621
                     /gene="Kif13b"
                     /gene_synonym="5330429L19Rik; 6030414C01; C130021D12Rik;
                     GAKIN"
                     /inference="alignment:Splign:2.1.0"
     exon            4622..5327
                     /gene="Kif13b"
                     /gene_synonym="5330429L19Rik; 6030414C01; C130021D12Rik;
                     GAKIN"
                     /inference="alignment:Splign:2.1.0"
     exon            5328..8915
                     /gene="Kif13b"
                     /gene_synonym="5330429L19Rik; 6030414C01; C130021D12Rik;
                     GAKIN"
                     /inference="alignment:Splign:2.1.0"
     regulatory      8890..8895
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Kif13b"
                     /gene_synonym="5330429L19Rik; 6030414C01; C130021D12Rik;
                     GAKIN"
                     /note="hexamer: AATAAA"
     polyA_site      8915
                     /gene="Kif13b"
                     /gene_synonym="5330429L19Rik; 6030414C01; C130021D12Rik;
                     GAKIN"
                     /note="major polyA site"
ORIGIN      
        1 ggagagtttg tccggtggcc gaggtagacg gaggtgcagt gagaaccccg gcggtagcac
       61 gatgggagac tccaaagtga aagtggcggt acgggtccgg ccaatgaacc gacgagaaat
      121 tgacttacat accaaatgtg tggtggatgt tgaagcgaac aaagttattc tgaatcctgt
      181 aaatacaaat ctttccaaag gagatgcccg gggccagcca aagatctttg cttatgatca
      241 ctgtttctgg tccatggatg aatctgtccg agagaagtat gcaggtcaag aagatgtttt
      301 caagtgcctt ggggagaaca ttcttcagaa tgcatttgat ggctacaacg cctgtatctt
      361 tgcttatggg cagacagggt ctggaaagtc ttacaccatg atgggcactg ctgaccaacc
      421 tggattaatc ccaaggctct gtagtggact ctttgaacga acccagaaag aggaaaatga
      481 agaacagagt tttaaagtcg aagtgtcgta catggaaatt tataatgaaa aagtccgaga
      541 ccttcttgac cccaaaggaa gccgtcagac gttgaaagtg agagagcaca gtgtgttggg
      601 accctacgtg gatggacttt ctaaactggc tgtcacaagc tacaaggata ttgagtctct
      661 gatgtctgag ggcaacaagt ctcggacagt tgctgcaacc aacatgaacg aggaaagtag
      721 ccgttcccat gcagtcttca aaatcaccct gacacatact ctgtatgatg tgaagtctgg
      781 gacatctgga gagaaagtgg gcaagctgag cttagtggat ttagctggca gtgaacgagc
      841 cacgaaaacc ggagctgcgg gcgacaggct gaaggagggc agcaacatca acaagtccct
      901 cacaaccctg ggtctggtta tctctgccct agctgatcag ggtgctggca aaaacaaaaa
      961 taaatttgtt ccctatcggg actcagttct cacatggctg ctcaaggaca gtctgggagg
     1021 taatagcaag actgccatgg tggccactgt gagccccgct gcagataact atgacgaaac
     1081 cctctcaacc ctgaggtacg cagatcgagc aaagcacatc gtcaaccatg ctgtggtgaa
     1141 tgaggatccg aatgctcgga ttatccgaga tctgcgggag gaggtggaga agctccggga
     1201 gcagctgacc aaggcagagg caatgaaatc tccagagctg aaagatcgtc tggaagaatc
     1261 ggagaaactc atccaggaaa tgactgtgac ctgggaggag aaactaagga aaactgagga
     1321 gattgcgcag gagcggcaaa agcagcttga gagccttggc atatctcttc agacttctgg
     1381 aatcaaggtt ggggatgaca agtgcttcct ggttaacctg aatgctgacc cagctctgaa
     1441 tgaactcctg gtgtactact taaaggagca cacgctgata gggtcggcca attctcagga
     1501 catccagctc tgcgggatgg gcatcctccc tgagcacggc atcatagaca tcacgcccga
     1561 gggccaggtt gtgctgactc ctcagaagaa caccagaaca tttgtcaatg ggtcttctgt
     1621 ctccagcccc atccagctgc accatgggga caggatactg tggggaaaca accatttctt
     1681 cagactcaat ctgccaaaaa agaaaaagaa agcagagcga gaggacgagg accgtgaggc
     1741 atccctgaaa aacgacagta gttctgagca gctggatgcc gacggcgact cctccagtga
     1801 ggtgtccagc gagatcaact tcaactttga gtatgcacag atggaggtga ccatgaaggc
     1861 tctgggcagc aatgacccaa tgcagtccat actgagcagc ctagaacagc agcatgagga
     1921 ggagaagcgg tctgctctgg agcgccagag gctcatgtac gaacacgaac tggaacagct
     1981 tcgaagaagg ctgtctcctg agaggcagaa ctgccgcggt gtggaccggc tctccttcca
     2041 ctcgcccagt gcccagcagc gcttgaaaca gtgggctgaa gagagagaag caacattgaa
     2101 taacagcttg atgaggctga gggagcagat tgtaaaggcc aacctgctgg ttcgggaagc
     2161 tagttacatc gcagaagagt tggataaaag aaccgagtat aaagttaccc tccagattcc
     2221 aacctccagt ctggatgcca ataggaagcg aggctctctc ctcagtgaac ctgccatcca
     2281 ggtgagaaga aagggcaaag gaaagcagat ttggtctttg gaaaagctgg aaaacaggct
     2341 tttggatatg agagacctct accaggagtg gaaggagtgt gaagaagaca gcccggttag
     2401 ccggtcctac ttcaagcgtg ctgacccatt ctatgatgag caggaaaacc atagtctcat
     2461 cggtgtggcc aatgtcttcc tggagaccct gttttatgac gtgaagttac agtatgctgt
     2521 gccgatcatc aaccagaagg gagaggtggc aggccggctg cacgtggagg tgatgcgact
     2581 cagtggggct attggggaga ggattgcagg aggagacgat cctacagagg tcagctctga
     2641 aaaggaagcc caggagaaca ggctggtctg catggttaaa atactccaag ccacagggtt
     2701 gccgcagcat ctgtgtcact ttgtcttctg caaatatgac ttctgggatc agcaggagcc
     2761 agtgaccgtt gcccctgaag tggatacgtc ttcgtctccc accagcaagc agccacagtg
     2821 tatggttgtg ttcgatcact gcagtgagtt cagtgttaac atcacagaag acttcattga
     2881 atatctctca gaaggggccc tagccattga agtatatgga cataaaatga atgatccccg
     2941 gaaaaaccca gccctgtggg acttggggat catccaagca aaaacaagga gtcttcggga
     3001 caggtggagt gaagtcacca gaaagttgga attctgggtt cagatcttgg aacagaatga
     3061 gaatggtgat tactgtccgg tggaagtaat tgctgcaaaa gatgtcccca caggagggat
     3121 cttccagctc cgacaggggc agtctcggcg agttcaagtt gaagtgaagt ctgtgcagga
     3181 gtcaggaact ttaccactga tggaagagtg catattgtca gttggcattg ggtgtgtgaa
     3241 agttaggcca ctccggtccc ctaagatcca cgagaatgtc catgaggaag aggaggacat
     3301 ggacagctac caggataggg atttagagcg gcttcgtaga aaatggctca atgcattaac
     3361 caaacgtcaa gaatacttgg atcaacaact gcagaagctt gtcagtaaac atgacaaaac
     3421 tgaggatgat gctgaccgag aggcacagct cctggagatg cggctgacgc tcacagagga
     3481 aagaaatgca gtgatggtgc cttctgctgg gagtggcatt ccaggggccc ctgcagaatg
     3541 gaccccagtg cctgggatgg agacccacat tcctgttata tttcttgact taaatgcgga
     3601 tgatttcagc tctcaggata atctcgatga cccagaagca ggatgggatg ctaccctgac
     3661 tggggaagag gaggaggagt tctttgagct gcagattgtg aaacaacacg atggagaggt
     3721 gaaggcagag gcctcctggg actctgcagt gcacagctgt cctcaactca gtaagggcac
     3781 acctgctgac gagcgagtgt tcctcatcct gcgagtgact gtccagctca gccatcctgc
     3841 cgacatgcag ctggtcctac gcaagaggat ttgtgtccat gttcatgggc gccagggctt
     3901 tgctcaaagt ctcctcaaaa agatgtctca ccggagctct attcctggct gtggagtgac
     3961 ctttgaaatc gtctccaata ttccagagga tgcccaggga gtggaggagc gagaggcact
     4021 ggcaaggatg gcagctaacg tggaaaaccc agcatctgct gactccgagg cctatattga
     4081 gaagtacttg aggagtgtgc tggccgtgga aaacctcctg actttagatc gcctgcgtca
     4141 ggaagtggcc gtgaaggagc agctgacggg gaaggggaag ctgagccgaa ggagtatcag
     4201 ctcccccagc atgaacagat tgtcaggaag ccggcaggag cttagcccat cccacagtct
     4261 aggcagcaac aagggccggt gggaaagtca acaggatgtg tcccaaacac tagtttccag
     4321 aggaatagct ccaggccctc cagctctctc tgtttcgccc caaaataacc agtctcctga
     4381 tcctggactg ggaggcgtgg cagcctctta cttgaaccca gtgaagtccc tggtgccaca
     4441 gatgccaaag ctgctgaagt ctctcttccc tgttcgggat gacagaaggg ggagacactc
     4501 atctcccctt gcacaccagc ccgtgccccg aatcttggtg cagcctacct tctcagatac
     4561 ctgggcaaca aggacagagg aggtgagtca ccaggttggg gctgccccac ttgcagaggt
     4621 gatggcggcc cctgcagtaa agatctgtga caaacctgtc aaagtgtctt cccctccatc
     4681 tcccatggtg gttactcagc ccccagaagg acaggatgga ccacccagcc ctttgagtga
     4741 agcttcaagt ggctacttct ctcacagtgt ctcttctgcc accctgtcag aaacactcac
     4801 cttaggcctg gacaccacag gcctcggcag ccagacgcct gggtcccccc ctgccctgtg
     4861 tcaggtcacc ccagagcctg agctggcttt cctctcctgc acacaaagcc atcctcctgc
     4921 cccagaggag gcccacgtac ctgcagctcc tactcaaagc acagagctgg aggttcccag
     4981 agcacctctt ctttctgaac ccgcgtctgc tgtacccacg tccccattca gaatccggaa
     5041 agtgcggacc tcagagctta agtccttcac aggcatgctg ggtggtgcct cctccggagc
     5101 agaggaggac cccctggctt cagaagaccc cagcaatgct aggggacaga ctctggggag
     5161 gctagaagta acatctgact ctgaggatgc cagcgaagtc cctgagtggc tcagagaggg
     5221 agagtatgtt gttgtgggca ccaacaagac gggcattgta cggtatattg gaccaactga
     5281 tttccaggag ggaacatgga ttggtgtgga gctggatctg cctgcaggaa agaatgatgg
     5341 ctccattggt gggaaacagt atttcaggtg caaccctggc tatgggctgc tggtgaggcc
     5401 cagccgggtc cgcagggctg tgggcactgg gcgcaggcgc agttcagggc tccagcctca
     5461 gggagcccca gaggtccgca gaagtgctac catctcgggc tctgccacca acctggcttc
     5521 actgacagct gcactggcca agggagacag gagttacaag aatcctgaga accggaagtc
     5581 ctgggccagc taagatgcac ctcccttgtg gactcgaaca ggaaggggga gacctggctc
     5641 ctccatggga gcagggccat gaatgctttt tgcacgacgc agggatgctg gacaatctgg
     5701 ttccctgttc cctctgggaa gctggaagct ggatttcctt cctctgcttg gcagtggcag
     5761 aggcccctta gctatgctcc cctggttagg ggtggaaggt tccaggagcc cagagactcg
     5821 tgggatggag ccagcccagc tcctccctgc ctgcttgagg atgggggagg gggttcccag
     5881 ccagatgtgt tgggctcccc tttccttatt ctgctgactt cactaatgtc ttaatttaag
     5941 caatgatcct aactggtgac ttgccctcac agactggact tcccctgcct gggcccagca
     6001 cgcacactac cctctccgtg caccggagat tatcagcctc ccctgggcca cacctcatcc
     6061 tgctgcacgg ctggctcaca gggtttctaa gaggcatctt tgtgggtgtc ccggtgtctt
     6121 tacattcaaa atcttttctg ctggccattc atttcctaac aggatgcttg aactatattt
     6181 atttaattta tttttccaaa agttaaaata cttcacaatc cacaatcgct gtctatccca
     6241 acatgcctgc ctgtgctttc tggcctctgg ctggccagag ctgcagcctc tatcttggat
     6301 ggtggttgct ggaagtggca gccatcaaat gaaaccagct gcccttgtgt tacttgattg
     6361 gagacaccat ggctttactg accctggtgg gaaggctgac ccagggttgg cacggatcga
     6421 gccttcagta ccttgtctgg atctgccagg cttcagggag ctggaaaatg ttttgactct
     6481 gcctgtgcct ggggccagca gctggccagg caggtagtga gggcagaacc atctccattt
     6541 ccttctgtgg atctgggctg gagtcatggt atatcccagg gcattaccaa ccacctgttt
     6601 gctgagacgt gcatggcctt tgagtcccag agtgttggtg gagggctcag tgggtagatc
     6661 agagtcacct agtccctgtt gtcccaggcc ctgccctgcc ttccacctca ggctgtatca
     6721 gtacacaggt tatccttggc agtttgtttg aagtttgact ctcagattct cgaagaacca
     6781 cagctaacag gtgtctgtag aggaattggt tctgtgagga cttaagcctt ttaaaggaag
     6841 tagctcctgc caggtagctt ctcagaaccc ctcagcctcc tctggccatt gtggcctgtg
     6901 ctagtattgc tgacactcag tctggactgt ctgcattgtc tgattagccc agtataaact
     6961 tcactaccat ctgcttgccc aaaccctgac cagaggctgc ttagagcgct aggaggatgg
     7021 gtggccttcc tggcacaggt gcagactctg cctgcacccc agcctgggag tcaagtgtca
     7081 ctccacttgt caccacaatc tgccaggaga gacctgcctc tgttccattc ttgaatagca
     7141 cagatttctg gagctgccag ctagaggcag gcaccaattc agtaactcct ctccctcagc
     7201 tggcatcttg ggatacgcac caggtgagtt agcagtgcca gtcctgcctg gccactctat
     7261 ggaagcccac agtgcttctg actgtgttct agtgagagct tttctcctgt cagcatccac
     7321 agtgtcccct agagagcagt gtcccggagt cccatcctct aggatggcca tgcaatggct
     7381 gctagggaga gaagtccctg aggatgtaat gccagtcgtg ttaatgctgt gggaagggac
     7441 attgtgccac ctgtcactcg gatggtgtaa aacgggagaa agttactatt gacttcatct
     7501 cgctatccgg agttctcagg aagtcctgag gatctcactt ggccagctgt catcccgtgg
     7561 ttctgggacc actgtctctc tcccagcacc cccttccctt ccctccctgc tcattggatc
     7621 tgaggttccc tagcctttct atttccaggc tgcctaagaa atccccctgc ctctgaaagt
     7681 aataccattt ccacagagcc ttgcaggata ctcttcatgt gaagcgctcc agcttcacag
     7741 gcaactggcc aaagcacatg ggtcctccag tggctggagg gtgttttgtg agggcagtct
     7801 gtctgtctgc acagaaggct ctgctctcat gcacttggtg ctcaatgtgg atgggatctt
     7861 ttgggatctc atggcacaca tagcaagtgt gctagaagtt tatcctcatg ggtgttcctt
     7921 atgagttgtt cctgtggccg agaggaccct gtgttcctgt ctgctttgag ggcagggagg
     7981 tgaccttggg aaagctggca ctttcgggtg ggtccgaaga gatggggctc aggtgcttgc
     8041 tggtcttctg ggtttgctga gcacatattg cactctgacc ttcatgttgc ctgtgggccg
     8101 gatgaagaca gtgagctgtg ttcttcctgg gctctcatgc cagaagaggc tagacaggcc
     8161 agctgtagct tcagctctcc actgactgcc ttttggagca gactaacact aacttgcagc
     8221 tggaaacgtg atgtataggg gctgtggttg ttaaaatgtc aggtagtgga gggtaggtgg
     8281 tgggtgtggg gttaggtgcc catgtataag ggcagagggc cagtgtttct gggctgtgtt
     8341 tagtggcatg tcccctgagg agttgcacat ggtgtttcca tgttttcagt tttctcaacc
     8401 acttatcatg ccttaggggt tctgtgtggg aagcaggtga gtgacccatg tagcatttac
     8461 ctgtctgtcc aagctgcctt tgctacgtgt tgcccatgga tggtgacttg aagcttctag
     8521 tgcctcaagg cccaggccac ctcaggtcag agaccatagg gccatctcta gtgccttcct
     8581 tgggaccagt gtctagcctg tgcttctagt cccagacact gcccaaaaca tcttagtcta
     8641 tatgctgcct tccttttgtg ctgtggacaa aaattgggaa aagcacggct gtgtggattg
     8701 tgtaaatatg agctcatatc tgtgatgttg attccaggaa tccagtgatt tggtacatgt
     8761 taaatgggaa ttaaaaatcc aaagaccctg taatgaatag taaagatgat gatttatgtt
     8821 gtatgaggaa ccaaactatt gtaattttgt accatacata cctttccatc aagtgaccaa
     8881 cagcttctaa ataaatccag gtgatttctt gctta
//
