LOCUS       NM_010616               2275 bp    mRNA    linear   ROD 03-JUN-2024
DEFINITION  Mus musculus kinesin family member 12 (Kif12), transcript variant
            2, mRNA.
ACCESSION   NM_010616
VERSION     NM_010616.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2275)
  AUTHORS   Niborski,L.L., Paces-Fessy,M., Ricci,P., Bourgeois,A.,
            Magalhaes,P., Kuzma-Kuzniarska,M., Lesaulnier,C., Reczko,M.,
            Declercq,E., Zurbig,P., Doucet,A., Umbhauer,M. and Cereghini,S.
  TITLE     Hnf1b haploinsufficiency differentially affects developmental
            target genes in a new renal cysts and diabetes mouse model
  JOURNAL   Dis Model Mech 14 (5) (2021)
   PUBMED   33737325
REFERENCE   2  (bases 1 to 2275)
  AUTHORS   Timmermans,S. and Libert,C.
  TITLE     Overview of inactivating mutations in the protein-coding genome of
            the mouse reference strain C57BL/6J
  JOURNAL   JCI Insight 3 (13), 121758 (2018)
   PUBMED   29997285
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2275)
  AUTHORS   Jensen,N., Autzen,J.K. and Pedersen,L.
  TITLE     Slc20a2 is critical for maintaining a physiologic inorganic
            phosphate level in cerebrospinal fluid
  JOURNAL   Neurogenetics 17 (2), 125-130 (2016)
   PUBMED   26660102
REFERENCE   4  (bases 1 to 2275)
  AUTHORS   Mrug,M., Zhou,J., Yang,C., Aronow,B.J., Cui,X., Schoeb,T.R.,
            Siegal,G.P., Yoder,B.K. and Guay-Woodford,L.M.
  TITLE     Genetic and Informatic Analyses Implicate Kif12 as a Candidate Gene
            within the Mpkd2 Locus That Modulates Renal Cystic Disease Severity
            in the Cys1cpk Mouse
  JOURNAL   PLoS One 10 (8), e0135678 (2015)
   PUBMED   26295839
  REMARK    GeneRIF: Kif12 is a candidate gene within the major polycystic
            kidney disease modifier 2 locus that modulates renal cystic disease
            severity in the Cys1cpk mouse.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2275)
  AUTHORS   Yang,W., Tanaka,Y., Bundo,M. and Hirokawa,N.
  TITLE     Antioxidant signaling involving the microtubule motor KIF12 is an
            intracellular target of nutrition excess in beta cells
  JOURNAL   Dev Cell 31 (2), 202-214 (2014)
   PUBMED   25373778
  REMARK    GeneRIF: the microtubule motor KIF12 mediates an antioxidant
            cascade in beta cells as an intracellular target of excess fat
            intake or 'lipotoxicity.'
REFERENCE   6  (bases 1 to 2275)
  AUTHORS   Mrug,M., Li,R., Cui,X., Schoeb,T.R., Churchill,G.A. and
            Guay-Woodford,L.M.
  TITLE     Kinesin family member 12 is a candidate polycystic kidney disease
            modifier in the cpk mouse
  JOURNAL   J Am Soc Nephrol 16 (4), 905-916 (2005)
   PUBMED   15728779
  REMARK    GeneRIF: Positional candidate gene, Kif12, fulfills the major
            criteria for quantitative trait loci gene discovery established by
            the Complex Trait Consortium, and, thus, it is proposed that Kif12
            is a cpk modifier gene.
REFERENCE   7  (bases 1 to 2275)
  AUTHORS   Mburu,P., Mustapha,M., Varela,A., Weil,D., El-Amraoui,A.,
            Holme,R.H., Rump,A., Hardisty,R.E., Blanchard,S., Coimbra,R.S.,
            Perfettini,I., Parkinson,N., Mallon,A.M., Glenister,P.,
            Rogers,M.J., Paige,A.J., Moir,L., Clay,J., Rosenthal,A., Liu,X.Z.,
            Blanco,G., Steel,K.P., Petit,C. and Brown,S.D.
  TITLE     Defects in whirlin, a PDZ domain molecule involved in stereocilia
            elongation, cause deafness in the whirler mouse and families with
            DFNB31
  JOURNAL   Nat Genet 34 (4), 421-428 (2003)
   PUBMED   12833159
REFERENCE   8  (bases 1 to 2275)
  AUTHORS   Miki,H., Setou,M., Kaneshiro,K. and Hirokawa,N.
  TITLE     All kinesin superfamily protein, KIF, genes in mouse and human
  JOURNAL   Proc Natl Acad Sci U S A 98 (13), 7004-7011 (2001)
   PUBMED   11416179
  REMARK    Review article
REFERENCE   9  (bases 1 to 2275)
  AUTHORS   Nakagawa,T., Tanaka,Y., Matsuoka,E., Kondo,S., Okada,Y., Noda,Y.,
            Kanai,Y. and Hirokawa,N.
  TITLE     Identification and classification of 16 new kinesin superfamily
            (KIF) proteins in mouse genome
  JOURNAL   Proc Natl Acad Sci U S A 94 (18), 9654-9659 (1997)
   PUBMED   9275178
  REMARK    Erratum:[Proc Natl Acad Sci U S A 1999 Mar 30;96(7):4214]
REFERENCE   10 (bases 1 to 2275)
  AUTHORS   Winter,H., Siry,P., Tobiasch,E. and Schweizer,J.
  TITLE     Sequence and expression of murine type I hair keratins mHa2 and
            mHa3
  JOURNAL   Exp Cell Res 212 (2), 190-200 (1994)
   PUBMED   7514534
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK018598.1 and BP765257.1.
            
            On Dec 1, 2015 this sequence version replaced NM_010616.2.
            
            Transcript Variant: This variant (2) uses an alternate in-frame
            splice site in the 3' coding region compared to variant 1. The
            encoded isoform (2) is shorter than isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK018598.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2250              AK018598.1         3-2252
            2251-2275           BP765257.1         1-25                c
FEATURES             Location/Qualifiers
     source          1..2275
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 33.96 cM"
     gene            1..2275
                     /gene="Kif12"
                     /note="kinesin family member 12"
                     /db_xref="GeneID:16552"
                     /db_xref="MGI:MGI:1098232"
     exon            1..152
                     /gene="Kif12"
                     /inference="alignment:Splign:2.1.0"
     CDS             127..2055
                     /gene="Kif12"
                     /note="isoform 2 is encoded by transcript variant 2;
                     kinesin-like protein KIF12; kinesin 12; N-9 kinesin;
                     kinesin superfamily protein 12"
                     /codon_start=1
                     /product="kinesin-like protein KIF12 isoform 2"
                     /protein_id="NP_034746.1"
                     /db_xref="CCDS:CCDS18249.1"
                     /db_xref="GeneID:16552"
                     /db_xref="MGI:MGI:1098232"
                     /translation="MEERGSPDGDPARNLEQGPEGSETPIQVVLRVRPMSTVELRRGE
                     QSALHCSGTRTLQVSPDVAFRFGAVLDGARTQEDVFRACGVKRLGELALRGFSCTVFT
                     FGQTGSGKTYTLTGPPPQGEGVPVPPSLAGIMQRTFTWLLDRVQHLDSPVTLRASYLE
                     IYNEQVWDLLSLGSPRPLPVRWTKARGFYVEQLRVVEFGSLEALMELLQMGLSRRRSS
                     SHTLNQASSRSHALLTLHISRPTSQQVPPVDLGEPPVGGKLCFVDLAGSEKVAATGSQ
                     GQLMLEANSINRSLLALGHCISLLLDPQRKQNHIPFRDSKLTKLLADSLGGRGVTLMV
                     ACVSPSAQCLPETLSTLRYASRAQRITTRPQGPKSPGVKPPQQVENELLRLQEENRHL
                     RFQLDQMHTTAPGAHGARMAWAQRNLYGMLQEFMLENERLRKEMRQLRSSRDLARAEQ
                     RVLAQQVHDLERRLLSACPLPQQGSTPVCPCRMVPAASCHALPPLCYCHHFCPLCRVP
                     LAHWTCPRRECHMPQVLEPEAPGHISQSVWPPPWAPPPSPGSAKPPRERSQSDWTQTR
                     VLAEMLMGEEVVPSAPPLSAGPSNMPYGLRGGSGIPNLTPRLETLTQQINSSLHLSQR
                     QPQPSEDTQSPGQGLSSC"
     exon            153..218
                     /gene="Kif12"
                     /inference="alignment:Splign:2.1.0"
     exon            219..297
                     /gene="Kif12"
                     /inference="alignment:Splign:2.1.0"
     exon            298..410
                     /gene="Kif12"
                     /inference="alignment:Splign:2.1.0"
     exon            411..486
                     /gene="Kif12"
                     /inference="alignment:Splign:2.1.0"
     exon            487..621
                     /gene="Kif12"
                     /inference="alignment:Splign:2.1.0"
     exon            622..757
                     /gene="Kif12"
                     /inference="alignment:Splign:2.1.0"
     exon            758..849
                     /gene="Kif12"
                     /inference="alignment:Splign:2.1.0"
     exon            850..1006
                     /gene="Kif12"
                     /inference="alignment:Splign:2.1.0"
     exon            1007..1125
                     /gene="Kif12"
                     /inference="alignment:Splign:2.1.0"
     exon            1126..1230
                     /gene="Kif12"
                     /inference="alignment:Splign:2.1.0"
     exon            1231..1333
                     /gene="Kif12"
                     /inference="alignment:Splign:2.1.0"
     exon            1334..1424
                     /gene="Kif12"
                     /inference="alignment:Splign:2.1.0"
     exon            1425..1511
                     /gene="Kif12"
                     /inference="alignment:Splign:2.1.0"
     exon            1512..1596
                     /gene="Kif12"
                     /inference="alignment:Splign:2.1.0"
     exon            1597..1695
                     /gene="Kif12"
                     /inference="alignment:Splign:2.1.0"
     exon            1696..1796
                     /gene="Kif12"
                     /inference="alignment:Splign:2.1.0"
     exon            1797..1915
                     /gene="Kif12"
                     /inference="alignment:Splign:2.1.0"
     exon            1916..2257
                     /gene="Kif12"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2230..2235
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Kif12"
                     /note="hexamer: AATAAA"
     polyA_site      2253
                     /gene="Kif12"
                     /note="major polyA site"
ORIGIN      
        1 gtatttctgg atgactggct gtgggagact ggggagggag atggatataa ggtgtgtctg
       61 aacagtcatg ctgtggtgag ggtaaggcat attagaaagg gaaagaaatc ctgtccacta
      121 caagacatgg aggaacgtgg gtctcccgat ggagacccag cacggaacct ggagcaaggg
      181 ccagaaggat cagaaactcc cattcaagtg gtgctcaggg tgcgtcccat gagcacagtg
      241 gagctgcgtc gaggggagca gagtgcattg cactgttcgg ggaccaggac tctgcaggtg
      301 agccccgatg tggcgttccg ctttggcgcc gtactggacg gggcgcgcac gcaggaggac
      361 gtgttcagag cttgcggtgt gaagcgcctg ggtgagctgg cgctgcgcgg tttctcctgc
      421 acggtcttca cgtttggcca gactggttct gggaagacct acactctgac tggacctcct
      481 ccgcaggggg aaggggtgcc cgtcccccca agcctggctg gcatcatgca gaggaccttc
      541 acctggctat tagatcgcgt gcagcacctg gattccccgg tcaccctccg agcttcctac
      601 ctggagatct acaatgagca ggtttgggac ttgctgagtc tggggtctcc acggcctctg
      661 cctgttagat ggaccaaggc acgaggcttc tatgtggaac agcttcgggt ggtggagttt
      721 ggcagtctgg aggctttgat ggagctcctg cagatgggtc tcagccgtcg tcggagctcc
      781 tcacatacct tgaaccaggc ctccagcaga agccatgccc tgcttacact ccacatcagc
      841 cgcccaactt ctcagcaggt acctcctgtg gaccttgggg agccccctgt tggagggaag
      901 ctgtgctttg tggatcttgc aggcagtgag aaagtggcag ccacaggatc ccaagggcag
      961 ctgatgcttg aggccaatag catcaaccgc agcctattgg cattgggcca ctgcatctcc
     1021 ctgctgttgg acccacagag gaagcagaac cacattccct tccgggacag caagctcacc
     1081 aagttgctgg cagactcact tgggggccgt ggggtcacac tcatggttgc ctgcgtgtcc
     1141 ccttcagcgc agtgccttcc tgagactctc agcactctgc gatatgcaag ccgagctcag
     1201 cggatcacca cccggccaca gggtcccaag tcccctggag taaagccacc ccagcaagta
     1261 gagaacgagt tgctaaggct ccaagaggag aatcgtcacc tgcggttcca gctggatcag
     1321 atgcacacca cggcaccagg ggcccatgga gcccggatgg cctgggccca gagaaacctc
     1381 tatgggatgc tgcaggagtt tatgctggag aacgagaggc tcaggaagga aatgagacag
     1441 ctgaggagta gccgggacct ggcccgggca gagcagcgtg tcctggccca acaggtccat
     1501 gatctggaga ggcgcctcct ttcggcttgt ccccttcccc agcagggctc tacccctgtg
     1561 tgtccctgca ggatggttcc agctgcctcc tgccatgcac tgccacccct ctgttactgc
     1621 caccacttct gtcctctgtg ccgagtgccc ttggcccact ggacctgccc acggagagag
     1681 tgccacatgc cacaggtgct ggagcccgag gccccaggtc acatatctca gtctgtgtgg
     1741 cccccaccct gggcacctcc accaagccca ggctctgcca agcccccacg agagaggagc
     1801 cagagtgact ggacccagac acgagtcctg gcagagatgc tgatgggaga agaagtggta
     1861 ccctccgcac cacccctgtc tgcagggccc tcgaacatgc catatgggct aagaggagga
     1921 tctgggattc caaacctgac cccgaggctg gaaaccctca cacagcagat caacagctcc
     1981 ctgcacctca gccagagaca accacagcct agcgaggaca cacagagccc tggccaaggc
     2041 ctctcttctt gttaaagatt accagactgg ctgtacccat ggggcctcca tctctctgtc
     2101 tgtgaattgc aaagaaatta gctgctgggc agagctgggg gcaccttaag gaggtacagg
     2161 gaccctgacc ctagaccttg aacctgagtc tcggttcaca atatgctggc agcgggtggg
     2221 ggaaatctga ataaagagag gcatcagctc taacttaaaa aaaaaaaaaa aaaaa
//
