LOCUS       NM_010615               4844 bp    mRNA    linear   ROD 06-JUN-2024
DEFINITION  Mus musculus kinesin family member 11 (Kif11), mRNA.
ACCESSION   NM_010615 XM_129251
VERSION     NM_010615.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4844)
  AUTHORS   Miao,J., Yao,H., Liu,J., Huang,Z., Shi,C., Lu,X., Jiang,J., Ren,R.,
            Wang,C., Pan,Y., Wang,T. and Jin,H.
  TITLE     Inhibition of KIF11 ameliorates osteoclastogenesis via regulating
            mTORC1-mediated NF-kappaB signaling
  JOURNAL   Biochem Pharmacol 217, 115817 (2023)
   PUBMED   37757917
  REMARK    GeneRIF: Inhibition of KIF11 ameliorates osteoclastogenesis via
            regulating mTORC1-mediated NF-kappaB signaling.
REFERENCE   2  (bases 1 to 4844)
  AUTHORS   Chen,D., Wang,J., Li,Y., Xu,C., Fanzheng,M., Zhang,P. and Liu,L.
  TITLE     LncRNA NEAT1 suppresses cellular senescence in hepatocellular
            carcinoma via KIF11-dependent repression of CDKN2A
  JOURNAL   Clin Transl Med 13 (9), e1418 (2023)
   PUBMED   37752791
  REMARK    GeneRIF: LncRNA NEAT1 suppresses cellular senescence in
            hepatocellular carcinoma via KIF11-dependent repression of CDKN2A.
REFERENCE   3  (bases 1 to 4844)
  AUTHORS   Fang,Q., Li,Q., Qi,Y., Pan,Z., Feng,T. and Xin,W.
  TITLE     ASPM promotes migration and invasion of anaplastic thyroid
            carcinoma by stabilizing KIF11
  JOURNAL   Cell Biol Int 47 (7), 1209-1221 (2023)
   PUBMED   36883909
  REMARK    GeneRIF: ASPM promotes migration and invasion of anaplastic thyroid
            carcinoma by stabilizing KIF11.
REFERENCE   4  (bases 1 to 4844)
  AUTHORS   He,S., Gillies,J.P., Zang,J.L., Cordoba-Beldad,C.M., Yamamoto,I.,
            Fujiwara,Y., Grantham,J., DeSantis,M.E. and Shibuya,H.
  TITLE     Distinct dynein complexes defined by DYNLRB1 and DYNLRB2 regulate
            mitotic and male meiotic spindle bipolarity
  JOURNAL   Nat Commun 14 (1), 1715 (2023)
   PUBMED   36973253
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4844)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4844)
  AUTHORS   Hansen,G.M. and Justice,M.J.
  TITLE     Activation of Hex and mEg5 by retroviral insertion may contribute
            to mouse B-cell leukemia
  JOURNAL   Oncogene 18 (47), 6531-6539 (1999)
   PUBMED   10597256
REFERENCE   7  (bases 1 to 4844)
  AUTHORS   Ferhat,L., Cook,C., Kuriyama,R. and Baas,P.W.
  TITLE     The nuclear/mitotic apparatus protein NuMA is a component of the
            somatodendritic microtubule arrays of the neuron
  JOURNAL   J Neurocytol 27 (12), 887-899 (1998)
   PUBMED   10659681
REFERENCE   8  (bases 1 to 4844)
  AUTHORS   Ferhat,L., Cook,C., Chauviere,M., Harper,M., Kress,M., Lyons,G.E.
            and Baas,P.W.
  TITLE     Expression of the mitotic motor protein Eg5 in postmitotic neurons:
            implications for neuronal development
  JOURNAL   J Neurosci 18 (19), 7822-7835 (1998)
   PUBMED   9742151
REFERENCE   9  (bases 1 to 4844)
  AUTHORS   Nakagawa,T., Tanaka,Y., Matsuoka,E., Kondo,S., Okada,Y., Noda,Y.,
            Kanai,Y. and Hirokawa,N.
  TITLE     Identification and classification of 16 new kinesin superfamily
            (KIF) proteins in mouse genome
  JOURNAL   Proc Natl Acad Sci U S A 94 (18), 9654-9659 (1997)
   PUBMED   9275178
  REMARK    Erratum:[Proc Natl Acad Sci U S A 1999 Mar 30;96(7):4214]
REFERENCE   10 (bases 1 to 4844)
  AUTHORS   Winter,H., Siry,P., Tobiasch,E. and Schweizer,J.
  TITLE     Sequence and expression of murine type I hair keratins mHa2 and
            mHa3
  JOURNAL   Exp Cell Res 212 (2), 190-200 (1994)
   PUBMED   7514534
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY097786.1, BC060670.1 and CJ206639.1.
            
            On Jul 21, 2018 this sequence version replaced NM_010615.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC060670.1, AK147754.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN00849383
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-21                BY097786.1         2-22
            22-4840             BC060670.1         1-4819
            4841-4844           CJ206639.1         398-401
FEATURES             Location/Qualifiers
     source          1..4844
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 32.27 cM"
     gene            1..4844
                     /gene="Kif11"
                     /gene_synonym="Eg5; Kif8; Kifl1; Knsl1"
                     /note="kinesin family member 11"
                     /db_xref="GeneID:16551"
                     /db_xref="MGI:MGI:1098231"
     exon            1..286
                     /gene="Kif11"
                     /gene_synonym="Eg5; Kif8; Kifl1; Knsl1"
                     /inference="alignment:Splign:2.1.0"
     CDS             213..3371
                     /gene="Kif11"
                     /gene_synonym="Eg5; Kif8; Kifl1; Knsl1"
                     /note="kinesin-related motor protein Eg5; kinesin-like 1"
                     /codon_start=1
                     /product="kinesin-like protein KIF11"
                     /protein_id="NP_034745.1"
                     /db_xref="CCDS:CCDS29777.1"
                     /db_xref="GeneID:16551"
                     /db_xref="MGI:MGI:1098231"
                     /translation="MASQPSSLKKKEEKGRNIQVVVRCRPFNLAERKANAHSVVECDH
                     ARKEVSVRTAGLTDKTSKKTYTFDMVFGASTKQIDVYRSVVCPILDEVIMGYNCTIFA
                     YGQTGTGKTFTMEGERSPNEVYTWEEDPLAGIIPRTLHQIFEKLTDNGTEFSVKVSLL
                     EIYNEELFDLLSPSSDVSERLQMFDDPRNKRGVIIKGLEEITVHNKDEVYQILEKGAA
                     KRTTAATLMNAYSSRSHSVFSVTIHMKETTIDGEELVKIGKLNLVDLAGSENIGRSGA
                     VDKRAREAGNINQSLLTLGRVITALVERTPHIPYRESKLTRILQDSLGGRTRTSIIAT
                     ISPASFNLEETLSTLEYAHRAKNIMNKPEVNQKLTKKALIKEYTEEIERLKRDLAAAR
                     EKNGVYISEESFRAMNGKVTVQEEQIVELVEKIAVLEEELSKATELFMDSKNELDQCK
                     SDLQTKTQELETTQKHLQETKLQLVKEEYVSSALERTEKTLHDTASKLLNTVKETTRA
                     VSGLHSKLDRKRAIDEHNAEAQESFGKNLNSLFNNMEELIKDGSAKQKAMLDVHKTLF
                     GNLMSSSVSALDTITTTALESLVSIPENVSARVSQISDMILEEQSLAAQSKSVLQGLI
                     DELVTDLFTSLKTIVAPSVVSILNINKQLQHIFRASSTVAEKVEDQKREIDSFLSILC
                     NNLHELRENTVSSLVESQKLCGDLTEDLKTIKETHSQELCQLSSSWAERFCALEKKYE
                     NIQKPLNSIQENTELRSTDIINKTTVHSKKILAESDGLLQELRHFNQEGTQLVEESVG
                     HCSSLNSNLETVSQEITQKCGTLNTSTVHFSDQWASCLSKRKEELENLMEFVNGCCKA
                     SSSEITKKVREQSAAVANQHSSFVAQMTSDEESCKAGSLELDKTIKTGLTKLNCFLKQ
                     DLKLDIPTGMTPERKKYLYPTTLVRTEPREQLLDQLQKKQPPMMLNSSEASKETSQDM
                     DEEREALEQCTEELVSPETTEHPSADCSSSRGLPFFQRKKPHGKDKENRGLNPVEKYK
                     VEEASDLSISKSRLPLHTSINL"
     exon            287..419
                     /gene="Kif11"
                     /gene_synonym="Eg5; Kif8; Kifl1; Knsl1"
                     /inference="alignment:Splign:2.1.0"
     exon            420..517
                     /gene="Kif11"
                     /gene_synonym="Eg5; Kif8; Kifl1; Knsl1"
                     /inference="alignment:Splign:2.1.0"
     exon            518..596
                     /gene="Kif11"
                     /gene_synonym="Eg5; Kif8; Kifl1; Knsl1"
                     /inference="alignment:Splign:2.1.0"
     exon            597..782
                     /gene="Kif11"
                     /gene_synonym="Eg5; Kif8; Kifl1; Knsl1"
                     /inference="alignment:Splign:2.1.0"
     exon            783..907
                     /gene="Kif11"
                     /gene_synonym="Eg5; Kif8; Kifl1; Knsl1"
                     /inference="alignment:Splign:2.1.0"
     exon            908..998
                     /gene="Kif11"
                     /gene_synonym="Eg5; Kif8; Kifl1; Knsl1"
                     /inference="alignment:Splign:2.1.0"
     exon            999..1241
                     /gene="Kif11"
                     /gene_synonym="Eg5; Kif8; Kifl1; Knsl1"
                     /inference="alignment:Splign:2.1.0"
     exon            1242..1337
                     /gene="Kif11"
                     /gene_synonym="Eg5; Kif8; Kifl1; Knsl1"
                     /inference="alignment:Splign:2.1.0"
     exon            1338..1426
                     /gene="Kif11"
                     /gene_synonym="Eg5; Kif8; Kifl1; Knsl1"
                     /inference="alignment:Splign:2.1.0"
     exon            1427..1514
                     /gene="Kif11"
                     /gene_synonym="Eg5; Kif8; Kifl1; Knsl1"
                     /inference="alignment:Splign:2.1.0"
     exon            1515..1703
                     /gene="Kif11"
                     /gene_synonym="Eg5; Kif8; Kifl1; Knsl1"
                     /inference="alignment:Splign:2.1.0"
     exon            1704..1911
                     /gene="Kif11"
                     /gene_synonym="Eg5; Kif8; Kifl1; Knsl1"
                     /inference="alignment:Splign:2.1.0"
     exon            1912..2084
                     /gene="Kif11"
                     /gene_synonym="Eg5; Kif8; Kifl1; Knsl1"
                     /inference="alignment:Splign:2.1.0"
     exon            2085..2210
                     /gene="Kif11"
                     /gene_synonym="Eg5; Kif8; Kifl1; Knsl1"
                     /inference="alignment:Splign:2.1.0"
     exon            2211..2369
                     /gene="Kif11"
                     /gene_synonym="Eg5; Kif8; Kifl1; Knsl1"
                     /inference="alignment:Splign:2.1.0"
     exon            2370..2476
                     /gene="Kif11"
                     /gene_synonym="Eg5; Kif8; Kifl1; Knsl1"
                     /inference="alignment:Splign:2.1.0"
     exon            2477..2756
                     /gene="Kif11"
                     /gene_synonym="Eg5; Kif8; Kifl1; Knsl1"
                     /inference="alignment:Splign:2.1.0"
     exon            2757..2979
                     /gene="Kif11"
                     /gene_synonym="Eg5; Kif8; Kifl1; Knsl1"
                     /inference="alignment:Splign:2.1.0"
     exon            2980..3122
                     /gene="Kif11"
                     /gene_synonym="Eg5; Kif8; Kifl1; Knsl1"
                     /inference="alignment:Splign:2.1.0"
     exon            3123..3239
                     /gene="Kif11"
                     /gene_synonym="Eg5; Kif8; Kifl1; Knsl1"
                     /inference="alignment:Splign:2.1.0"
     exon            3240..4844
                     /gene="Kif11"
                     /gene_synonym="Eg5; Kif8; Kifl1; Knsl1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3634..3639
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Kif11"
                     /gene_synonym="Eg5; Kif8; Kifl1; Knsl1"
                     /note="hexamer: ATTAAA"
     polyA_site      3656
                     /gene="Kif11"
                     /gene_synonym="Eg5; Kif8; Kifl1; Knsl1"
     regulatory      4722..4727
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Kif11"
                     /gene_synonym="Eg5; Kif8; Kifl1; Knsl1"
                     /note="hexamer: CATAAA"
     polyA_site      4739
                     /gene="Kif11"
                     /gene_synonym="Eg5; Kif8; Kifl1; Knsl1"
     regulatory      4821..4826
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Kif11"
                     /gene_synonym="Eg5; Kif8; Kifl1; Knsl1"
                     /note="hexamer: ATTAAA"
     polyA_site      4840
                     /gene="Kif11"
                     /gene_synonym="Eg5; Kif8; Kifl1; Knsl1"
                     /note="major polyA site"
ORIGIN      
        1 atcgttgctg atttcggagc agaggaggag gttcgtcctg tccggctttt gcggggcggc
       61 ggccacggcc aagaggcctg cgtggacctc ggggacgccg agctgcgagt ctcggtcctc
      121 gtggccttgg cagcaccggg tgaggagagg ctgctcccgg ttctcactgt gtctgagtct
      181 ccgctaggcc ggcaggtttt ggctcgaccg tcatggcgtc ccagccgagt tctttgaaga
      241 agaaagagga aaagggcagg aacatccagg tggtggtgag atgcagacca tttaatctgg
      301 cagagcggaa agctaatgcc cactcagtag tggaatgtga ccatgcacgg aaagaagtca
      361 gtgtacggac tgcagggttg acggacaaga cctccaagaa aacatacacg tttgatatgg
      421 tgtttggagc atctacaaaa caaattgatg tttaccgaag tgttgtttgt ccaattctag
      481 atgaagttat tatgggctat aattgcacca tcttcgcata tggtcagact ggcactggaa
      541 aaacttttac aatggaaggt gaaaggtcac ctaatgaagt atatacctgg gaggaggatc
      601 ctctggctgg tataattcca cgcactcttc atcaaatttt tgagaaactt actgataatg
      661 gcactgagtt ttcagttaaa gtgtccctat tggaaatcta taatgaggag ctttttgatc
      721 ttcttagtcc atcttctgat gtttctgaaa ggctgcagat gtttgatgat ccccggaaca
      781 agagaggagt gataatcaaa ggcttagagg aaatcacagt acacaataaa gatgaagtct
      841 accaaatctt agagaaggga gcagcaaaaa ggacaactgc agcaaccttg atgaatgctt
      901 actctagtcg ttcacactca gttttttctg ttacgataca catgaaagaa acaacaattg
      961 atggagaaga gcttgttaaa attggaaagt tgaatttggt tgatcttgca ggaagtgaaa
     1021 atattgggcg ttctggagct gttgacaaga gggcccggga agctggaaat atcaaccaat
     1081 ccctcttgac tctgggaaga gttattactg ctcttgtgga aagaacacct catattcctt
     1141 atcgagaatc taaactaact agaatcctgc aagattctct tgggggacgt acaagaacat
     1201 ctataattgc aaccatttcc cctgcatctt tcaatcttga ggaaactctg agtacattgg
     1261 aatatgctca cagagcaaag aacataatga ataagcctga agttaatcaa aaactcacca
     1321 aaaaagctct tattaaggag tatacagaag agatagagcg tttgaagcga gatcttgcag
     1381 cagctcgtga gaaaaatgga gtgtacatct ctgaagaaag ttttagagcc atgaatggaa
     1441 aggtaactgt tcaggaggaa caaattgttg agttggttga aaaaatcgct gttcttgagg
     1501 aggagctcag taaggctaca gagttattta tggatagtaa gaacgaactt gaccagtgta
     1561 aatctgacct gcaaaccaag acacaggaac ttgaaaccac tcagaaacat ttgcaagaaa
     1621 caaaattaca actggttaaa gaggaatatg tctcttcagc cttggaaaga accgagaaga
     1681 cactgcatga cacggccagc aagttgctta acacggttaa agaaaccacc agggctgtat
     1741 ctggtctaca ttctaaactg gaccgcaaga gagcaatcga tgagcacaac gctgaagctc
     1801 aggagagctt tggcaaaaac ctcaacagtc tgtttaataa tatggaagaa ttgattaagg
     1861 atggcagtgc gaaacaaaag gccatgctag acgttcataa gacactgttt ggtaacctga
     1921 tgtcttctag tgtctctgca ttagacacca ttaccacgac agcacttgaa tctctcgtgt
     1981 ctattccaga aaatgtgtcc gctcgtgttt ctcagatttc tgatatgata ttggaagagc
     2041 aatcgttagc agcacaaagt aaaagtgttc tgcaaggatt gattgatgaa cttgtgaccg
     2101 accttttcac ttccctgaag accatcgtag cccctagtgt ggtttccatc ttgaacataa
     2161 ataagcagct acagcatatt ttcagggctt catcgacagt ggctgaaaag gtagaagatc
     2221 aaaaaagaga aatagacagt tttctcagca tattgtgtaa caatttacat gaactccgag
     2281 aaaacacagt ttcttccttg gttgaatcac aaaagctttg tggagaccta actgaagacc
     2341 tgaagacaat aaaggaaacc cattcacagg aactttgcca gttaagcagt agttgggcag
     2401 agagattctg tgctttggag aagaagtatg aaaacatcca gaaaccactg aacagtattc
     2461 aagaaaatac agagctgagg tctactgata taatcaataa aacaacagtt cacagtaaga
     2521 aaattcttgc tgaatctgat ggattattac aagaactcag acactttaac caagaaggca
     2581 cacagctggt tgaagagtct gtaggacact gcagttcact caacagcaac ctggagactg
     2641 tatcccaaga gatcacccag aagtgtggga ccctgaacac aagcacagtt catttctctg
     2701 atcagtgggc atcctgccta agcaagagaa aggaagaact tgagaattta atggagtttg
     2761 taaatggctg ttgtaaagct tcaagttcgg agatcactaa gaaagtaaga gaacagagcg
     2821 cagctgttgc gaaccagcac agctcctttg ttgctcagat gacttccgat gaagaaagct
     2881 gtaaagcagg aagcctggag cttgataaaa ctataaagac tgggttaaca aagctgaatt
     2941 gctttctgaa acaggatctg aaactagata tcccaacagg tatgacacca gagaggaaaa
     3001 aatatttata tccaacaaca cttgtgagaa ctgaaccacg agagcagctc cttgatcagc
     3061 tgcaaaagaa acaaccacca atgatgctaa acagctcaga agccagcaag gagaccagtc
     3121 aggacatgga tgaagagagg gaggctctgg agcagtgtac tgaggaactt gtaagtccag
     3181 agacaactga acatcccagt gcagattgct cttccagcag aggtcttcca tttttccagc
     3241 gaaaaaagcc acatggaaaa gacaaagaaa acagaggcct taacccggtg gagaagtata
     3301 aagtggaaga ggcctcggat ctctccatct ccaagagcag actgccgctt cacacctcca
     3361 taaacctcta gctgatctga ggcttagggt gtcatcttta aaatacaacc tgaaactcca
     3421 gagtctgaag ctatgtacag atgaaaaggg gactgctgtg tgagggcccc acagtaactg
     3481 tagttgaact gaaagtcttt tttataatcc ctgtagtcca aggatgtagt aagctgggta
     3541 tcatttggga tttacattga atatgtgtgt gtgtttctag ctttttatat aaagaagctc
     3601 ttctgtaaca agtaagtatt tttcttgtat ataattaaat accaaatata tggaaatcat
     3661 tgttccaggt ttagacttgt attggtgaat gccatctcct ttgctgtctg gccaaggctg
     3721 tttccctacc tctaaccagc cttttctagt ttgtcttcga ctcctgtctc ccttttcctg
     3781 tcacttaacc ttttgtagcc tacagaaagg tttctttagt atgagaaacg cagggtttta
     3841 cctggaactc ttctatctca ctgattaccc ttacaatcac tgtcaaaaca cctgaccctg
     3901 gaaggaccct tccttttggg tccttcattt gttctcgctg atatgcacac atctcattcc
     3961 ttcctgaggt ctgacacatc accagcctcc ctgtagtgtc ggctcctaat gcaggagacc
     4021 ttgaggcccc acttaaaagg tctttaagtc tcttagaaat gataagattg ttttcaaact
     4081 accaattatg actataactt ctattttgtt tatcttttaa aactttattc cttgtatata
     4141 ataaaaatgt atatatacat tccctctgtt gaaatattaa ccctcgctct ttcgctttga
     4201 caacgctgtt tctggaagtt ggccatttta agatgaacca gagcacctac ctaaaagtgt
     4261 atgcagagag taagtgtggt cacgtcaagt tcatgtatac ggttcagagt gatgtggttt
     4321 tggcacagtc tcactatgga gctcaggctg gctttggact cactatgcag caggacagtc
     4381 atccttccaa ggcctgggaa tacagacatc atcactgtgc ctgtttcaga aatagaactt
     4441 tggccaggcg tggtggcgca cgcctttaat cccagcactc gggaggcaga ggcaggcgga
     4501 tttctgagtt cgaggccagc ctgatctaca aagtgagtgc caggacagct agggctacag
     4561 agaaaccctg tctcaaaaaa acaaaagaaa tagaactttg taacaaagag ctaaccccta
     4621 atagaaaatt agaaaaaaat gctactttaa gaaatttatt ttcttgtact atttctccaa
     4681 ctcattgtag aaatagaaac gttattttaa taaaaataat gcataaattt ctctgcaaac
     4741 agatgccaac ctaatctgtg gatattatct aatttgcttt tggtaaatct ttaattggta
     4801 attgtttttg aattttttaa attaaattat tttaattttt tgtt
//
