LOCUS       NM_001081378            7253 bp    mRNA    linear   ROD 08-AUG-2024
DEFINITION  Mus musculus kinase D-interacting substrate 220 (Kidins220),
            transcript variant 5, mRNA.
ACCESSION   NM_001081378 XM_902491
VERSION     NM_001081378.2
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 7253)
  AUTHORS   Herr,L.A., Fiala,G.J., Sagar, Schaffer,A.M., Hummel,J.F.,
            Zintchenko,M., Raute,K., Velasco Cardenas,R.M., Heizmann,B.,
            Ebert,K., Fehrenbach,K., Janowska,I., Chan,S., Tanriver,Y.,
            Minguet,S. and Schamel,W.W.
  TITLE     Kidins220 and Aiolos promote thymic iNKT cell development by
            reducing TCR signals
  JOURNAL   Sci Adv 10 (11), eadj2802 (2024)
   PUBMED   38489359
  REMARK    GeneRIF: Kidins220 and Aiolos promote thymic iNKT cell development
            by reducing TCR signals.
REFERENCE   2  (bases 1 to 7253)
  AUTHORS   Del Puerto,A., Lopez-Fonseca,C., Simon-Garcia,A., Marti-Prado,B.,
            Barrios-Munoz,A.L., Pose-Utrilla,J., Lopez-Menendez,C.,
            Alcover-Sanchez,B., Cesca,F., Schiavo,G., Campanero,M.R.,
            Farinas,I., Iglesias,T. and Porlan,E.
  TITLE     Kidins220 sets the threshold for survival of neural stem cells and
            progenitors to sustain adult neurogenesis
  JOURNAL   Cell Death Dis 14 (8), 500 (2023)
   PUBMED   37542079
  REMARK    GeneRIF: Kidins220 sets the threshold for survival of neural stem
            cells and progenitors to sustain adult neurogenesis.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 7253)
  AUTHORS   Sanchez-Sanchez,J., Vicente-Garcia,C., Canada-Garcia,D.,
            Martin-Zanca,D. and Arevalo,J.C.
  TITLE     ARMS/Kidins220 regulates nociception by controlling brain-derived
            neurotrophic factor secretion
  JOURNAL   Pain 164 (3), 563-576 (2023)
   PUBMED   35916735
  REMARK    GeneRIF: ARMS/Kidins220 regulates nociception by controlling
            brain-derived neurotrophic factor secretion.
REFERENCE   4  (bases 1 to 7253)
  AUTHORS   Jaudon,F., Albini,M., Ferroni,S., Benfenati,F. and Cesca,F.
  TITLE     A developmental stage- and Kidins220-dependent switch in astrocyte
            responsiveness to brain-derived neurotrophic factor
  JOURNAL   J Cell Sci 134 (16) (2021)
   PUBMED   34279618
  REMARK    GeneRIF: A developmental stage- and Kidins220-dependent switch in
            astrocyte responsiveness to brain-derived neurotrophic factor.
REFERENCE   5  (bases 1 to 7253)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 7253)
  AUTHORS   Higuero,A.M., Sanchez-Ruiloba,L., Doglio,L.E., Portillo,F.,
            Abad-Rodriguez,J., Dotti,C.G. and Iglesias,T.
  TITLE     Kidins220/ARMS modulates the activity of microtubule-regulating
            proteins and controls neuronal polarity and development
  JOURNAL   J Biol Chem 285 (2), 1343-1357 (2010)
   PUBMED   19903810
  REMARK    GeneRIF: Kidins220/ARMS is a key modulator of the activity of
            microtubule-regulating proteins known to actively regulate neuronal
            morphogenesis and suggest a mechanism by which it contributes to
            control neuronal development.
REFERENCE   7  (bases 1 to 7253)
  AUTHORS   Yokoyama,S., Ito,Y., Ueno-Kudoh,H., Shimizu,H., Uchibe,K.,
            Albini,S., Mitsuoka,K., Miyaki,S., Kiso,M., Nagai,A., Hikata,T.,
            Osada,T., Fukuda,N., Yamashita,S., Harada,D., Mezzano,V., Kasai,M.,
            Puri,P.L., Hayashizaki,Y., Okado,H., Hashimoto,M. and Asahara,H.
  TITLE     A systems approach reveals that the myogenesis genome network is
            regulated by the transcriptional repressor RP58
  JOURNAL   Dev Cell 17 (6), 836-848 (2009)
   PUBMED   20059953
REFERENCE   8  (bases 1 to 7253)
  AUTHORS   Wu,S.H., Arevalo,J.C., Sarti,F., Tessarollo,L., Gan,W.B. and
            Chao,M.V.
  TITLE     Ankyrin Repeat-rich Membrane Spanning/Kidins220 protein regulates
            dendritic branching and spine stability in vivo
  JOURNAL   Dev Neurobiol 69 (9), 547-557 (2009)
   PUBMED   19449316
  REMARK    GeneRIF: This study suggested that ARMS/Kidins220 is important for
            the growth of dendritic arbors and spine stability during an
            activity- and BDNF-dependent period of development.
REFERENCE   9  (bases 1 to 7253)
  AUTHORS   Ghazalpour,A., Doss,S., Zhang,B., Wang,S., Plaisier,C.,
            Castellanos,R., Brozell,A., Schadt,E.E., Drake,T.A., Lusis,A.J. and
            Horvath,S.
  TITLE     Integrating genetic and network analysis to characterize genes
            related to mouse weight
  JOURNAL   PLoS Genet 2 (8), e130 (2006)
   PUBMED   16934000
REFERENCE   10 (bases 1 to 7253)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Aizawa,H., Yuasa,S.,
            Nakajima,D., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: II. The complete nucleotide sequences of 400 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 10 (1), 35-48 (2003)
   PUBMED   12693553
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC159307.2 and CT010478.15.
            
            On Mar 15, 2023 this sequence version replaced NM_001081378.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN00849390,
                              SAMN01164131 [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-138               AC159307.2         37583-37720         c
            139-279             AC159307.2         30268-30408         c
            280-378             AC159307.2         25643-25741         c
            379-477             AC159307.2         24015-24113         c
            478-576             AC159307.2         22809-22907         c
            577-675             AC159307.2         21871-21969         c
            676-774             AC159307.2         20337-20435         c
            775-972             AC159307.2         17636-17833         c
            973-1071            AC159307.2         15315-15413         c
            1072-1170           AC159307.2         13841-13939         c
            1171-1269           AC159307.2         13286-13384         c
            1270-1447           AC159307.2         10895-11072         c
            1448-1612           AC159307.2         9492-9656           c
            1613-1792           AC159307.2         8522-8701           c
            1793-1958           AC159307.2         7427-7592           c
            1959-2110           AC159307.2         4435-4586           c
            2111-2400           AC159307.2         3953-4242           c
            2401-2541           AC159307.2         2433-2573           c
            2542-2785           AC159307.2         1507-1750           c
            2786-2874           AC159307.2         1057-1145           c
            2875-3019           CT010478.15        22196-22340
            3020-3182           CT010478.15        25789-25951
            3183-3361           CT010478.15        45353-45531
            3362-3588           CT010478.15        47223-47449
            3589-3702           CT010478.15        49355-49468
            3703-3759           CT010478.15        50145-50201
            3760-3792           CT010478.15        55102-55134
            3793-3825           CT010478.15        56793-56825
            3826-3957           CT010478.15        59994-60125
            3958-4056           CT010478.15        61696-61794
            4057-4293           CT010478.15        62697-62933
            4294-7253           CT010478.15        65481-68440
FEATURES             Location/Qualifiers
     source          1..7253
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 8.54 cM"
     gene            1..7253
                     /gene="Kidins220"
                     /gene_synonym="3110039L19Rik; C330002I19Rik; mKIAA1250"
                     /note="kinase D-interacting substrate 220"
                     /db_xref="GeneID:77480"
                     /db_xref="MGI:MGI:1924730"
     exon            1..138
                     /gene="Kidins220"
                     /gene_synonym="3110039L19Rik; C330002I19Rik; mKIAA1250"
                     /inference="alignment:Splign:2.1.0"
     exon            139..279
                     /gene="Kidins220"
                     /gene_synonym="3110039L19Rik; C330002I19Rik; mKIAA1250"
                     /inference="alignment:Splign:2.1.0"
     CDS             172..5553
                     /gene="Kidins220"
                     /gene_synonym="3110039L19Rik; C330002I19Rik; mKIAA1250"
                     /note="isoform 5 is encoded by transcript variant 5;
                     kinase D-interacting substrate of 220 kDa"
                     /codon_start=1
                     /product="kinase D-interacting substrate of 220 kDa
                     isoform 5"
                     /protein_id="NP_001074847.1"
                     /db_xref="CCDS:CCDS36424.1"
                     /db_xref="GeneID:77480"
                     /db_xref="MGI:MGI:1924730"
                     /translation="MSVLISQSVINYVEEENIPALKALLEKCKDVDERNECGQTPLMI
                     AAEQGNVEIVKELIKNGANCNLEDLDNWTALISASKEGHIHIVEELLKCGANLEHRDM
                     GGWTALMWACYKGRTDVVELLLSHGANPSVTGLYSVYPIIWAAGRGHADIVHLLLQNG
                     AKVNCSDKYGTTPLVWAARKGHLECVKHLLAMGADVDQEGANSMTALIVAVKGGYTQS
                     VKEILKRNPNVNLTDKDGNTALMIASKEGHIEIVQDLLDAGTYVNIPDRSGDTVLIGA
                     VRGGHVEIVRALLQKYADIDIRGQDNKTALYWAVEKGNATMVRDILQCNPDTEICTKD
                     GETPLIKATKMRNIEVVELLLDKGARVSAVDKKGDTPLHVAIRGRSRRLAELLLRNPK
                     DGRLLYRPNKAGETPYNIDCSHQKSILTQIFGARHLSPTETDGDMLGYDLYSSALADI
                     LSEPTMQPPICVGLYAQWGSGKSFLLKKLEDEMKTFAGQQIEPLFQFSWLIVFLILLL
                     CGGLGLVFAFTVDTNLAIAVSLSFLALLYIFFIVIYFGGRQEGESWNWAWALSTRLAR
                     HIGYLELLFKLMFVNPPELPEQTTKALPVRFLFTDYNRLSSVGGETSLAEMIATLSDA
                     CEREFGFLATRLFRVFKTEDSQGKKKWKKTCCLPSFIIFLFIVGCIIAGITLLAIFRV
                     DPKHLTVNAILISIASIVGLAFVLNCRTWWQVLDSLLNSQRKRLHSAASKLHKLKSEG
                     FMKVLKCEVELMARMAKTIDSFTQNQTRLVVIIDGLDACEQDKVLQMLDTVRVLFSKG
                     PFIAIFASDPHIIIKAINQNLNSVLRDSNINGHDYMRNIVHLPVFLNSRGLSNARKFL
                     VTSATNGDISCSEATGVQEDADRRVSQNSLGEMTKLGSKTALNRRDTYRRRQMQRTIT
                     RQMSFDLTKLLVTEDWFSDISPQTMRRLLNIVSVTGRLLRANQITFNWDRLASWINLT
                     EQWPYRTSWLILYLGETEGIPDQMTLKTIYERISKNIPTTKDVEPLLEIDGDIRNFEV
                     FLSSRTPVLVARDVKTFLPCTVNLDPKLREIIADVRAAREQINIGGLAYPPLPLHEAP
                     PRPPSGYSQPASVCSSSASFNGPFPGGVVSPQPHSSYYSGLSGPQHPFYNRPFFAPYL
                     YTPRYYPGGSQHLISRSSVKTSLPRDQNNGLEVIKEDAAEGLPSPTASSREKSWTRKQ
                     LMELCDSGFNKQRQASVPATGTSLLLSSMTVDIVCEKLRQIEGLDQGMLPQYCTTIKK
                     ANINGRVLAQCNIDELKKEMAMNFGDWHLFRSMVLEMRSVENQVVPEDPRFLNENSSA
                     PVAHGESARRTSHSELPHTELSSQTPYTLNFSFEELNTLGLDEGAPRHSNLSWQSQTR
                     RTPSLSSLNSQDSSIEISKLTDKVQAEYRDAYREYIAQMSQLEGGTGSSTISGRSSPH
                     STYYIGQSSSGGSIHSNLEQERGKENELKQEEGRKSFLMKRGDVLDYSSSGVSTNEAS
                     PLDPITEEDEKSDQSGSKLLPGKKSSERPSLFQTDLKLKGSGLRYQKLPSDEDESGTE
                     ESDNTPLLKDDKDKKAEGKAERVAKSPEHSVEPIRTFIKAKEYLSDALLDKKDSSDSG
                     VRSNESSPNHSLHNEAADDSQLEKANLIELEDEGHSGKRGMPHSLSGLQDPVIARMSI
                     CSEDKKSPSECSLIASSPEESWPSCQKAYNLNRTPSTVTLNNNTAPTNRANQNFDEIE
                     GVRETSQVILRPGPSPNPTAVQNENLKSMAHKRSQRSSYTRLSKDASELHAASSDSTG
                     FGEERESIL"
     exon            280..378
                     /gene="Kidins220"
                     /gene_synonym="3110039L19Rik; C330002I19Rik; mKIAA1250"
                     /inference="alignment:Splign:2.1.0"
     exon            379..477
                     /gene="Kidins220"
                     /gene_synonym="3110039L19Rik; C330002I19Rik; mKIAA1250"
                     /inference="alignment:Splign:2.1.0"
     exon            478..576
                     /gene="Kidins220"
                     /gene_synonym="3110039L19Rik; C330002I19Rik; mKIAA1250"
                     /inference="alignment:Splign:2.1.0"
     exon            577..675
                     /gene="Kidins220"
                     /gene_synonym="3110039L19Rik; C330002I19Rik; mKIAA1250"
                     /inference="alignment:Splign:2.1.0"
     exon            676..774
                     /gene="Kidins220"
                     /gene_synonym="3110039L19Rik; C330002I19Rik; mKIAA1250"
                     /inference="alignment:Splign:2.1.0"
     exon            775..972
                     /gene="Kidins220"
                     /gene_synonym="3110039L19Rik; C330002I19Rik; mKIAA1250"
                     /inference="alignment:Splign:2.1.0"
     exon            973..1071
                     /gene="Kidins220"
                     /gene_synonym="3110039L19Rik; C330002I19Rik; mKIAA1250"
                     /inference="alignment:Splign:2.1.0"
     exon            1072..1170
                     /gene="Kidins220"
                     /gene_synonym="3110039L19Rik; C330002I19Rik; mKIAA1250"
                     /inference="alignment:Splign:2.1.0"
     exon            1171..1269
                     /gene="Kidins220"
                     /gene_synonym="3110039L19Rik; C330002I19Rik; mKIAA1250"
                     /inference="alignment:Splign:2.1.0"
     exon            1270..1447
                     /gene="Kidins220"
                     /gene_synonym="3110039L19Rik; C330002I19Rik; mKIAA1250"
                     /inference="alignment:Splign:2.1.0"
     exon            1448..1612
                     /gene="Kidins220"
                     /gene_synonym="3110039L19Rik; C330002I19Rik; mKIAA1250"
                     /inference="alignment:Splign:2.1.0"
     exon            1613..1792
                     /gene="Kidins220"
                     /gene_synonym="3110039L19Rik; C330002I19Rik; mKIAA1250"
                     /inference="alignment:Splign:2.1.0"
     exon            1793..1958
                     /gene="Kidins220"
                     /gene_synonym="3110039L19Rik; C330002I19Rik; mKIAA1250"
                     /inference="alignment:Splign:2.1.0"
     exon            1959..2110
                     /gene="Kidins220"
                     /gene_synonym="3110039L19Rik; C330002I19Rik; mKIAA1250"
                     /inference="alignment:Splign:2.1.0"
     exon            2111..2400
                     /gene="Kidins220"
                     /gene_synonym="3110039L19Rik; C330002I19Rik; mKIAA1250"
                     /inference="alignment:Splign:2.1.0"
     exon            2401..2541
                     /gene="Kidins220"
                     /gene_synonym="3110039L19Rik; C330002I19Rik; mKIAA1250"
                     /inference="alignment:Splign:2.1.0"
     exon            2542..2785
                     /gene="Kidins220"
                     /gene_synonym="3110039L19Rik; C330002I19Rik; mKIAA1250"
                     /inference="alignment:Splign:2.1.0"
     exon            2786..2874
                     /gene="Kidins220"
                     /gene_synonym="3110039L19Rik; C330002I19Rik; mKIAA1250"
                     /inference="alignment:Splign:2.1.0"
     exon            2875..3019
                     /gene="Kidins220"
                     /gene_synonym="3110039L19Rik; C330002I19Rik; mKIAA1250"
                     /inference="alignment:Splign:2.1.0"
     exon            3020..3182
                     /gene="Kidins220"
                     /gene_synonym="3110039L19Rik; C330002I19Rik; mKIAA1250"
                     /inference="alignment:Splign:2.1.0"
     exon            3183..3361
                     /gene="Kidins220"
                     /gene_synonym="3110039L19Rik; C330002I19Rik; mKIAA1250"
                     /inference="alignment:Splign:2.1.0"
     exon            3362..3588
                     /gene="Kidins220"
                     /gene_synonym="3110039L19Rik; C330002I19Rik; mKIAA1250"
                     /inference="alignment:Splign:2.1.0"
     exon            3589..3702
                     /gene="Kidins220"
                     /gene_synonym="3110039L19Rik; C330002I19Rik; mKIAA1250"
                     /inference="alignment:Splign:2.1.0"
     exon            3703..3759
                     /gene="Kidins220"
                     /gene_synonym="3110039L19Rik; C330002I19Rik; mKIAA1250"
                     /inference="alignment:Splign:2.1.0"
     exon            3760..3792
                     /gene="Kidins220"
                     /gene_synonym="3110039L19Rik; C330002I19Rik; mKIAA1250"
                     /inference="alignment:Splign:2.1.0"
     exon            3793..3825
                     /gene="Kidins220"
                     /gene_synonym="3110039L19Rik; C330002I19Rik; mKIAA1250"
                     /inference="alignment:Splign:2.1.0"
     exon            3826..3957
                     /gene="Kidins220"
                     /gene_synonym="3110039L19Rik; C330002I19Rik; mKIAA1250"
                     /inference="alignment:Splign:2.1.0"
     exon            3958..4056
                     /gene="Kidins220"
                     /gene_synonym="3110039L19Rik; C330002I19Rik; mKIAA1250"
                     /inference="alignment:Splign:2.1.0"
     exon            4057..4293
                     /gene="Kidins220"
                     /gene_synonym="3110039L19Rik; C330002I19Rik; mKIAA1250"
                     /inference="alignment:Splign:2.1.0"
     exon            4294..7253
                     /gene="Kidins220"
                     /gene_synonym="3110039L19Rik; C330002I19Rik; mKIAA1250"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7166..7171
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Kidins220"
                     /gene_synonym="3110039L19Rik; C330002I19Rik; mKIAA1250"
                     /note="hexamer: AATAAA"
     polyA_site      7184
                     /gene="Kidins220"
                     /gene_synonym="3110039L19Rik; C330002I19Rik; mKIAA1250"
                     /note="major polyA site"
     regulatory      7235..7240
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Kidins220"
                     /gene_synonym="3110039L19Rik; C330002I19Rik; mKIAA1250"
                     /note="hexamer: ATTAAA"
     polyA_site      7253
                     /gene="Kidins220"
                     /gene_synonym="3110039L19Rik; C330002I19Rik; mKIAA1250"
ORIGIN      
        1 agttcctgac tcctaggaag atggccgccg ggcgtggtgc gggcatagct gtgtgctctt
       61 ggcgtcttgt cctctgacaa ggtctgcggc gctgttctgc agagctgagg gcgccgtctt
      121 cggccaggcc gtgacacggt gaattaaagt cggctataga tttctgtgaa aatgtcggtt
      181 cttatatcac agagtgtgat aaattatgtg gaagaagaga atattcctgc tctgaaagcc
      241 cttcttgaga agtgcaaaga tgtagatgag aggaacgagt gtggccagac gccactgatg
      301 atagctgctg aacagggcaa tgtggaaata gtgaaagaac tcattaagaa tggagccaac
      361 tgcaacctgg aagacctgga taactggact gcgcttatat cagcatctaa agaggggcac
      421 atccacattg tggaagagct gctgaagtgt ggggccaatc tggagcaccg tgacatgggg
      481 ggatggacag ctctcatgtg ggcgtgctac aaaggcagga cggatgttgt ggagttgctt
      541 ctttctcatg gtgccaaccc aagtgtcact ggtttgtaca gtgtctaccc aatcatctgg
      601 gcagcgggca gaggccacgc cgacatagtg catcttctgc tgcagaatgg tgcgaaagtc
      661 aattgctctg ataagtatgg aacaactcct ttggtgtggg ctgcccgaaa gggtcatttg
      721 gaatgtgtga agcatttgtt ggccatggga gctgatgttg atcaagaagg agctaattcg
      781 atgactgcac tgattgtggc agtgaaaggg ggctacacac agtcagtgaa ggagattctg
      841 aaaaggaatc caaacgtgaa cctgactgat aaggacggaa acacagccct gatgattgcg
      901 tcgaaggagg gacatataga aattgtgcag gacctgttgg acgccggaac atacgtgaac
      961 atacctgaca ggagtgggga tactgtattg attggcgctg tgagaggtgg tcatgttgaa
     1021 attgttcgag cacttctcca aaaatacgct gatatagaca ttagagggca ggacaataag
     1081 actgcactgt attgggctgt tgagaaaggc aatgcgacaa tggtgagaga tatcctgcag
     1141 tgcaatcctg atacggaaat atgcacgaag gatggcgaga caccactaat aaaggccacc
     1201 aagatgagaa atattgaagt ggtggagctg ctgctggata agggggctag ggtgtctgct
     1261 gtggacaaga aaggtgacac tcccctgcac gttgccatcc gagggaggag ccggagactg
     1321 gcagaacttc ttttacggaa ccccaaagat ggacggttac tttacaggcc caacaaagca
     1381 ggcgagactc cctacaacat tgactgcagc caccagaaaa gcattttaac tcaaatattt
     1441 ggagccagac acttgtctcc tacggaaaca gacggtgaca tgcttggtta cgatttgtat
     1501 agcagcgccc tggcagatat tctcagtgag cccaccatgc agccacccat ctgtgtgggc
     1561 ttgtatgcac agtggggaag tgggaagtcc ttcttactca agaaactaga agatgaaatg
     1621 aagacgtttg cagggcagca gattgagccc cttttccagt tctcgtggct catcgtgttc
     1681 ctcatcctgc tgctgtgtgg ggggctcggc ctggtgtttg ctttcacagt tgatacaaac
     1741 ctcgccatag cggtttcatt gagtttccta gctctcttat acatattctt catcgtcatt
     1801 tacttcggtg gacggcagga aggagagagt tggaactggg cctgggctct cagcaccaga
     1861 ctggcaaggc acattgggta cctggagctc ctcttcaagc tgatgtttgt gaacccaccc
     1921 gaactaccag agcaaacgac aaaggctttg cctgtgaggt ttctgtttac agattacaat
     1981 agactctcca gtgttggggg agagacttcc ttggctgaaa tgatcgcgac cctctcagat
     2041 gcttgtgaga gagaattcgg ctttctggct acccggctgt ttcgagtatt taagactgaa
     2101 gattctcagg gtaaaaagaa atggaaaaaa acatgctgtc tcccgtcttt tataatcttt
     2161 ctttttattg ttggctgcat tattgctgga attactcttt tggctatatt ccgagttgac
     2221 ccaaaacatc tgacagtgaa tgctatcctc atatccattg catctatcgt ggggttggcc
     2281 tttgtgctga actgtcgaac atggtggcaa gtgctggact ctctcctgaa ttctcagaga
     2341 aaacgcctcc atagtgctgc ctccaaatta cataagctga aaagtgaagg attcatgaaa
     2401 gtcctgaagt gtgaggtgga gctgatggcc aggatggcca agaccatcga cagcttcacg
     2461 cagaatcaga cgaggctggt ggttatcatt gacggcctgg acgcctgtga gcaagataaa
     2521 gtgctgcaga tgctggacac tgtccgagtt ctgttttcaa agggcccttt tattgccatt
     2581 tttgcaagtg atccacatat tattataaag gccatcaacc agaacctgaa tagtgtgctt
     2641 cgtgattcaa atataaatgg acatgactat atgcgcaata tagttcattt accagttttc
     2701 cttaatagtc gtgggcttag caatgcaaga aaatttcttg taacttcagc aacaaatggg
     2761 gacatttcgt gctcagaagc aacaggagtg caggaggatg ctgacagaag agtttcacag
     2821 aacagccttg gggagatgac aaagcttggt agcaaaacgg ccctcaacag aagggatact
     2881 taccgcagaa ggcagatgca gagaaccatc acgaggcaga tgtcctttga tctcacaaag
     2941 ctgctggtta ctgaggattg gttcagtgac atcagtccac aaaccatgag acggttactc
     3001 aatattgttt cggtgacagg gcggctacta agagccaatc agattacttt caactgggac
     3061 aggctagcca gctggatcaa ccttactgag cagtggccat accggacgtc ctggctcata
     3121 ctatatctgg gagagactga aggtattcct gaccagatga cgctaaagac catctatgag
     3181 agaatatcaa agaatatccc aacaactaaa gatgttgagc cacttcttga aattgatgga
     3241 gatataagaa attttgaagt gtttttgtct tcaaggactc cagttcttgt ggctcgagat
     3301 gtaaagacct ttttgccatg cacggtaaac ctggatccca aactacggga gatcattgca
     3361 gatgttcgag ctgcaagaga acagatcaac ataggaggcc ttgcgtatcc cccgctccct
     3421 ctgcacgaag cccctcctcg gcctccttct gggtacagtc agcctgcatc tgtctgctcc
     3481 tcctcagcat ctttcaatgg gccgttccca ggcggcgttg tgtccccaca gccccacagc
     3541 agctactaca gcggcctgtc gggaccccag caccctttct acaacaggcc attctttgcc
     3601 ccataccttt acacgccaag gtattaccct ggcggttccc aacatctcat ctcacgttca
     3661 tcagtaaaaa cgagtttgcc cagagatcag aacaatggcc tagaggtaat caaggaggat
     3721 gctgctgagg gccttccttc acccacagcc tcctcgaggg agaagagctg gacaagaaag
     3781 cagctgatgg agctgtgtga ctctgggttt aacaaacaga gacaggcatc cgtccctgcc
     3841 acaggcacct ctctgttact gagttcaatg actgtggata tcgtgtgtga gaaactgaga
     3901 cagatagaag ggctggacca gggcatgctg cctcagtatt gcacaaccat caaaaaggca
     3961 aacataaatg gccgggtatt ggctcagtgt aatattgatg agctgaagaa agagatggct
     4021 atgaactttg gagactggca tctttttaga agcatggtct tagaaatgag aagtgtggaa
     4081 aaccaggtgg tccccgaaga cccacgtttt ctcaatgaaa actccagtgc ccccgttgct
     4141 catggggaat ctgctcgccg cacttctcac agtgaactgc cccacacgga gctttccagc
     4201 cagactccct acaccctgaa cttcagcttt gaagaactga acacgcttgg cctagacgag
     4261 ggagccccac ggcacagtaa tctgagttgg cagtcacaaa ctcgcagaac cccaagtctc
     4321 tcgagtctca attcccagga ctccagtatt gaaatttcaa agcttactga taaggtgcag
     4381 gccgagtata gagatgccta tagagagtac attgctcaga tgtcccagtt agaagggggc
     4441 acagggtcgt caacaataag cggcagatct tctccacaca gcacatacta cataggtcag
     4501 agttcttcag ggggctccat tcattctaat ctagaacaag aaagggggaa ggagaatgag
     4561 ctaaagcagg aggaggggcg gaagtcattt ttaatgaaga ggggggatgt cctagattac
     4621 tcctcatcag gggtgtccac taatgaggcc tcacccctgg accccattac tgaggaagat
     4681 gagaaatccg accagtcagg tagtaagctg ctcccaggca agaagtcttc agaacggcct
     4741 agtctcttcc agacagactt gaagcttaag ggaagtggtc tgcgctacca gaaactgccc
     4801 agtgatgaag atgagtctgg gacagaagag tcagataata ccccactgct caaagatgat
     4861 aaggataaaa aggccgaagg caaagcagag agagtggcta agtctccaga gcacagcgtc
     4921 gagcctatca gaacattcat caaagcaaaa gagtatttgt cggacgccct cctcgacaag
     4981 aaagattcct ccgattcggg agtgaggtcc aatgagagtt ctcccaacca ctctctccac
     5041 aatgaggcag cggatgactc ccagctggaa aaggcgaatc tcatcgagct tgaagatgag
     5101 ggccacagtg ggaagcgagg gatgccacac agtctgagtg gcctgcaaga tcctgtcata
     5161 gctcggatgt ccatttgctc ggaagacaag aaaagcccct ctgagtgcag cctgatcgct
     5221 agcagccctg aagaaagctg gccttcgtgc cagaaggcct acaatctaaa ccgaacaccc
     5281 agcactgtga ctctgaacaa caacactgcg cccaccaaca gagccaatca gaactttgat
     5341 gagatagagg gagtcaggga aacatcccag gtcattttga ggcctgggcc cagtcccaac
     5401 ccaactgctg tgcagaatga aaacctgaag agcatggcgc acaagcgaag ccagcgctcc
     5461 agttacacca ggctctcgaa agatgcgtct gagctgcatg cagcctcctc agatagcacg
     5521 ggctttgggg aagagagaga aagcattctc tgaggaagag agaagtgaag tagcgttgtc
     5581 ctacctgagg acaagagtgt cataagcttt gagttgaccc atcctcatta ctcatcgtgt
     5641 ttatgcatca cagacacctg ataggtggca ggcactgggg aagcagacgg gaaagcctga
     5701 caggacggtc accagtcatc tccattgtca ccgtcaccac aggcacttta acgtctcact
     5761 accactgctg tgccctttcc tgacgcacag ctctgcagag atgagatcag gctgaataca
     5821 gagagaggtc ggaaatgtat ttaaattgaa agggcttaag tcacaaggaa ataaacccag
     5881 agatctcctt tataaactat tcatgtaaca tttgagggga gatatagtat tagatgaagc
     5941 agaaaccaat ttcactggta gtgtttaatc ttggtgcaga tttataggtt ttagagtagc
     6001 ccagaaacta aaagtgaata cctagcaaat ggatagccag tgttctgtat aagaatcatt
     6061 gcttttaaga ggtcttaaaa tttaagtaga aaatacatac taaagagggc gtaaaagttg
     6121 atgattaagt gagttagcag agcccaaagc agtggcctgg gccatggtga gtcgttagca
     6181 gaggagttgg aggagggcag tgtattcctg ggatactctt tccaacccag ccctggcttc
     6241 cgacaccacc cacctgtgcc ctcaaaacca tcttagtctg ttctgcagct actaagtaat
     6301 gctcatggct aaagaaaagt tagtggtact ggtgatgaaa cgcaggacct cacagatcta
     6361 agtcctctag tgactagcta cgtccccagc cccaagtgct aggcctttcc ttcctccaga
     6421 gatttgggaa gacattaaag gagttagtga cggtggtact agacaaatga cagtatttag
     6481 tttgctaaca ttaaatcact gcctctgtac tgcaattatt taacgtatct gttcctaaat
     6541 cagcatttta gttctgggga ggggggtgga ttataaaaat ggaggcatgg ttttaaaaag
     6601 gaatttgaaa gcatacaaca aagcaagaat agaggcggag ctggtgtgac cttgacactt
     6661 ttattattct tagcagagct aggagaatga ccacatacat ttaggctaga ggtgtgcctg
     6721 tcttcatcct gcattgaaac tgtttgtcat ttgatcatag tgtgtttacg tagatcagct
     6781 ctagtggtgt gtcctgagcc atgggtagaa ttgtagatgg taaggttgca ggcttagtgc
     6841 tcagtgagat gtccatcact gactggacct gtgtggttca cttgacactg tgctcatagc
     6901 tgctccgtgt cccactgcct tgctgtttga gtgtaattga gcattttcat gaagtgcata
     6961 tgttgcatga tctttaacag gtatttttaa acattaaaaa cagcacgatg ttactgacat
     7021 tatgcaatat catgtgatgg gtacttgaga ggcagtttgg tttctttcca ggtgagtagt
     7081 tatagctcac ggtcatggga gccctttatt cacactgtct gtgaagttaa tgctggagtg
     7141 ccaagtgcac acggggacta ggaacaataa agagttgcat gccattctga ctcacggagt
     7201 tttattcact atagcaatga caattcccat tctgattaaa aattaaaaca tga
//
