LOCUS       NM_010613               4001 bp    mRNA    linear   ROD 03-SEP-2024
DEFINITION  Mus musculus KH-type splicing regulatory protein (Khsrp), mRNA.
ACCESSION   NM_010613 XM_128746
VERSION     NM_010613.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4001)
  AUTHORS   Li,M., Fang,Q., Xiao,P., Yin,Z., Mei,G., Wang,C., Xiang,Y.,
            Zhao,X., Qu,L., Xu,T., Zhang,J., Liu,K., Li,X., Dong,H., Xiao,R.
            and Zhou,R.
  TITLE     KHSRP ameliorates acute liver failure by regulating pre-mRNA
            splicing through its interaction with SF3B1
  JOURNAL   Cell Death Dis 15 (8), 618 (2024)
   PUBMED   39187547
  REMARK    GeneRIF: KHSRP ameliorates acute liver failure by regulating
            pre-mRNA splicing through its interaction with SF3B1.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4001)
  AUTHORS   Barssotti,L., Soares,G.M., Marconato-Junior,E., Lourenconi
            Alves,B., Oliveira,K.M., Carneiro,E.M., Boschero,A.C. and
            Barbosa,H.C.L.
  TITLE     KSRP improves pancreatic beta cell function and survival
  JOURNAL   Sci Rep 14 (1), 6136 (2024)
   PUBMED   38480757
  REMARK    GeneRIF: KSRP improves pancreatic beta cell function and survival.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4001)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (bases 1 to 4001)
  AUTHORS   Olguin,S.L., Patel,P., Buchanan,C.N., Dell'Orco,M., Gardiner,A.S.,
            Cole,R., Vaughn,L.S., Sundararajan,A., Mudge,J., Allan,A.M.,
            Ortinski,P., Brigman,J.L., Twiss,J.L. and Perrone-Bizzozero,N.I.
  TITLE     KHSRP loss increases neuronal growth and synaptic transmission and
            alters memory consolidation through RNA stabilization
  JOURNAL   Commun Biol 5 (1), 672 (2022)
   PUBMED   35798971
  REMARK    GeneRIF: KHSRP loss increases neuronal growth and synaptic
            transmission and alters memory consolidation through RNA
            stabilization.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4001)
  AUTHORS   Schmidtke,L., Meineck,M., Saurin,S., Otten,S., Gather,F.,
            Schrick,K., Kafer,R., Roth,W., Kleinert,H., Weinmann-Menke,J. and
            Pautz,A.
  TITLE     Knockout of the KH-Type Splicing Regulatory Protein Drives
            Glomerulonephritis in MRL-Faslpr Mice
  JOURNAL   Cells 10 (11), 3167 (2021)
   PUBMED   34831390
  REMARK    GeneRIF: Knockout of the KH-Type Splicing Regulatory Protein Drives
            Glomerulonephritis in MRL-Fas(lpr) Mice.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4001)
  AUTHORS   Briata,P., Forcales,S.V., Ponassi,M., Corte,G., Chen,C.Y.,
            Karin,M., Puri,P.L. and Gherzi,R.
  TITLE     p38-dependent phosphorylation of the mRNA decay-promoting factor
            KSRP controls the stability of select myogenic transcripts
  JOURNAL   Mol Cell 20 (6), 891-903 (2005)
   PUBMED   16364914
  REMARK    GeneRIF: Results uncover an unanticipated role for KSRP in
            establishing a biochemical link between differentiation-activated
            p38 signaling and turnover of myogenic mRNAs.
REFERENCE   7  (bases 1 to 4001)
  AUTHORS   Hall,M.P., Huang,S. and Black,D.L.
  TITLE     Differentiation-induced colocalization of the KH-type splicing
            regulatory protein with polypyrimidine tract binding protein and
            the c-src pre-mRNA
  JOURNAL   Mol Biol Cell 15 (2), 774-786 (2004)
   PUBMED   14657238
REFERENCE   8  (bases 1 to 4001)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   9  (bases 1 to 4001)
  AUTHORS   Wertz,K. and Herrmann,B.G.
  TITLE     Large-scale screen for genes involved in gonad development
  JOURNAL   Mech Dev 98 (1-2), 51-70 (2000)
   PUBMED   11044607
REFERENCE   10 (bases 1 to 4001)
  AUTHORS   Ring,H.Z., Vameghi-Meyers,V., Nikolic,J.M., Min,H., Black,D.L. and
            Francke,U.
  TITLE     Mapping of the KHSRP gene to a region of conserved synteny on human
            chromosome 19p13.3 and mouse chromosome 17
  JOURNAL   Genomics 56 (3), 350-352 (1999)
   PUBMED   10087204
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB645370.1, CB247078.1, BC108414.1 and BB258658.1.
            
            On Dec 28, 2007 this sequence version replaced NM_010613.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK077415.1, SRR13948564.4710559.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-475               BB645370.1         2-476
            476-699             CB247078.1         49-272
            700-3997            BC108414.1         1-3298
            3998-4001           BB258658.1         281-284
FEATURES             Location/Qualifiers
     source          1..4001
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 29.63 cM"
     gene            1..4001
                     /gene="Khsrp"
                     /gene_synonym="6330409F21Rik; Fbp2; Fubp2; Ksrp"
                     /note="KH-type splicing regulatory protein"
                     /db_xref="GeneID:16549"
                     /db_xref="MGI:MGI:1336214"
     exon            1..360
                     /gene="Khsrp"
                     /gene_synonym="6330409F21Rik; Fbp2; Fubp2; Ksrp"
                     /inference="alignment:Splign:2.1.0"
     exon            361..457
                     /gene="Khsrp"
                     /gene_synonym="6330409F21Rik; Fbp2; Fubp2; Ksrp"
                     /inference="alignment:Splign:2.1.0"
     exon            458..496
                     /gene="Khsrp"
                     /gene_synonym="6330409F21Rik; Fbp2; Fubp2; Ksrp"
                     /inference="alignment:Splign:2.1.0"
     exon            497..536
                     /gene="Khsrp"
                     /gene_synonym="6330409F21Rik; Fbp2; Fubp2; Ksrp"
                     /inference="alignment:Splign:2.1.0"
     exon            537..586
                     /gene="Khsrp"
                     /gene_synonym="6330409F21Rik; Fbp2; Fubp2; Ksrp"
                     /inference="alignment:Splign:2.1.0"
     exon            587..658
                     /gene="Khsrp"
                     /gene_synonym="6330409F21Rik; Fbp2; Fubp2; Ksrp"
                     /inference="alignment:Splign:2.1.0"
     exon            659..716
                     /gene="Khsrp"
                     /gene_synonym="6330409F21Rik; Fbp2; Fubp2; Ksrp"
                     /inference="alignment:Splign:2.1.0"
     exon            717..891
                     /gene="Khsrp"
                     /gene_synonym="6330409F21Rik; Fbp2; Fubp2; Ksrp"
                     /inference="alignment:Splign:2.1.0"
     exon            892..990
                     /gene="Khsrp"
                     /gene_synonym="6330409F21Rik; Fbp2; Fubp2; Ksrp"
                     /inference="alignment:Splign:2.1.0"
     exon            991..1089
                     /gene="Khsrp"
                     /gene_synonym="6330409F21Rik; Fbp2; Fubp2; Ksrp"
                     /inference="alignment:Splign:2.1.0"
     exon            1090..1192
                     /gene="Khsrp"
                     /gene_synonym="6330409F21Rik; Fbp2; Fubp2; Ksrp"
                     /inference="alignment:Splign:2.1.0"
     exon            1193..1438
                     /gene="Khsrp"
                     /gene_synonym="6330409F21Rik; Fbp2; Fubp2; Ksrp"
                     /inference="alignment:Splign:2.1.0"
     exon            1439..1599
                     /gene="Khsrp"
                     /gene_synonym="6330409F21Rik; Fbp2; Fubp2; Ksrp"
                     /inference="alignment:Splign:2.1.0"
     exon            1600..1709
                     /gene="Khsrp"
                     /gene_synonym="6330409F21Rik; Fbp2; Fubp2; Ksrp"
                     /inference="alignment:Splign:2.1.0"
     exon            1710..1798
                     /gene="Khsrp"
                     /gene_synonym="6330409F21Rik; Fbp2; Fubp2; Ksrp"
                     /inference="alignment:Splign:2.1.0"
     exon            1799..1999
                     /gene="Khsrp"
                     /gene_synonym="6330409F21Rik; Fbp2; Fubp2; Ksrp"
                     /inference="alignment:Splign:2.1.0"
     exon            2000..2077
                     /gene="Khsrp"
                     /gene_synonym="6330409F21Rik; Fbp2; Fubp2; Ksrp"
                     /inference="alignment:Splign:2.1.0"
     exon            2078..3999
                     /gene="Khsrp"
                     /gene_synonym="6330409F21Rik; Fbp2; Fubp2; Ksrp"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3978..3983
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Khsrp"
                     /gene_synonym="6330409F21Rik; Fbp2; Fubp2; Ksrp"
                     /note="hexamer: AATAAA"
     polyA_site      3997
                     /gene="Khsrp"
                     /gene_synonym="6330409F21Rik; Fbp2; Fubp2; Ksrp"
                     /note="major polyA site"
ORIGIN      
        1 atcgtgctcc gcggccgtgt ggagcgaggc cttgttcccg cgttgagccg ccgccgcctc
       61 cgcctcctca gcttgaagcc tccgcaccaa gcccgtcccc gccgcgccat gtcggactac
      121 aacaccggag gtcccccgcc cggcccgccg cctcccgctg gcggcggagg gggagccgcg
      181 ggtgcgggag gaggccctcc gccgggcccg ccgggcgcgg gagaccgggg cggcggaggc
      241 cctggcggcg gcggcccggg tggaggaggc gcgtccgggg gcccctcaca gcctcccggt
      301 ggcggcggcc ctgggatccg caaggacgcc ttcgccgacg ccgtgcagcg ggcccgccag
      361 attgcagcca aaatcggagg tgatgctgct accaccgtga ataacaacac tcctgatttt
      421 ggctttgggg gccaaaagag acagctggaa gatggagacc agccagacag caagaaactg
      481 gcttcccagg gagactcgat tggttctcaa ctgggaccca tccatcctcc ccccaggacc
      541 tcaatgacag aagagtatag ggttccggat ggcatggtgg gcttgattat tggcagaggt
      601 ggtgagcaga taaacaaaat ccagcaggac tcaggctgca aagttcagat ctcaccagat
      661 agtggtggcc tccctgagcg cagcgtgtct ctgactggag cacctgagtc tgtccaaaag
      721 gcaaagatga tgctggatga catcgtgtct cggggccgtg gtggcccccc aggacagttt
      781 cacgacaacg ccaatggggg tcagaatggc acagtgcagg agatcatgat ccctgctggc
      841 aaggctggcc tggtcattgg taaaggtgga gagaccatca agcagctgca ggagcgggct
      901 ggggtgaaga tgattttaat tcaggatggc tcccagaaca caaatgtgga caagccactg
      961 cggattatcg gggacccata caaagtacag caagcctgtg agatggtgat ggacatcctg
     1021 cgagaacgtg accaaggtgg ctttggggac cgcaatgaat acggatctcg agttggtgga
     1081 ggcattgatg tgcctgtacc caggcattca gttggtgtag tcattggccg gagtggagag
     1141 atgatcaaga agatccagaa tgatgccggt gtgcgcatcc agttcaagca agatgatggg
     1201 accggccctg agaagattgc tcacatcatg gggcctccag atcggtgtga acacgcagcc
     1261 cggatcatca atgacctcct ccagagtctt cggagtgggc ccccgggtcc tccaggggcc
     1321 cctggcatgc cccctggggg caggggccgg ggccgaggcc aaggcaactg gggccctcct
     1381 ggaggggaga tgactttctc cattcctacc cataagtgtg ggctggtcat tggccgaggc
     1441 ggggagaatg tgaaggccat taaccagcag acaggcgcct ttgtggaaat atctcggcag
     1501 ctgccaccca atggggaccc caatttcaag ttgtttgtga tccggggatc gccccagcag
     1561 attgaccatg caaagcagct cattgaggag aagatagagg gtcccctctg cccagttgga
     1621 ccaggccctg ggggaccagg ccctgctgga cccatggggc ctttcaaccc tggacccttc
     1681 aaccaggggc ctccaggggc acccccacat gctggtggtc cccctcctca ccagtacccg
     1741 cctcagggct ggggcaatac ctacccccag tggcagccac ctgcccctca cgacccaaac
     1801 aaagctgctg cagcggctac agatcctaat gctgcctggg ctgcctacta ctctcactac
     1861 taccagcaac ccccaggtcc tgtgccaggc cctgccccag cccctgcagc cccacctgca
     1921 cagggggaac ccccccagcc tccacccact ggccaatcag actacaccaa ggcttgggaa
     1981 gagtattaca aaaaaattgg ccagcagccc cagcagcctg gggcaccccc acagcaggac
     2041 tacaccaagg cctgggagga gtactacaag aagcaagcac aagtggccac tggtgggggt
     2101 cctggagcac cccctggctc ccagcctgat tacagtgctg cctgggctga gtattacaga
     2161 cagcaggctg cttactacgg acagacccca ggccctggtg gcccacagcc acctcccacc
     2221 cagcagggac agcagcaggc aagtgggaac tgccaccctc ctcctcctcc tttctccttc
     2281 caacccccgg ccaccgtcca tcctgcctta gtgggtagcg ccggaaaccc tttcccctgc
     2341 ggggtgtgcc cttgatgcca gcctcgggct cgtggccaga gtctcccaga gcctcgcagc
     2401 cccgccgctg ggaagcgctc gatgggtgca gaggcttacg gaagaggctc ctccagtagc
     2461 cactgtcgtg cgacgttgtc gggtgctggg ggcaccggcc gcaaaggtgg aactctgaac
     2521 tgctggggtg tcccgggtgg gggcaggatg tggggactgt gctgggtgcc acaccggttg
     2581 ctgaacctgc tcgctcaaaa tctggccact tgggaagaaa atgtctattt ttttccccct
     2641 tctcagcatc actattttgg gttttgttct ttttttattc ttttttcatg tccaagtaac
     2701 tgtgtgttgc aggcggccct ggctctgctg ggatgaaggg gagcccactg aggggactgg
     2761 gccctccctg cctggcaagg ccatctcttg tgtgcttgcc tctgtgtccc ggtcttgtct
     2821 gtgaagtggg catgacgatc gttgccacct tccaacctac ctcacagggg tgttgtgggg
     2881 acaccatgat ctgaatgttg tgacgccgag ctgccgcctc cctcctctgt ccccctcccc
     2941 cctggcaact tctcccctgt gtgccctctt ccacacctct ggcttctgct gcagacttct
     3001 cctcctcttc ctcttcctcc tgcttctcct ccaccaagga gcagtctggc cagtggagtc
     3061 cccaagacag acagtcacgg ccccctgctt agcctgtggg ggcttgggcc cggcctcttg
     3121 gcccactgcc tggagttgta gcctcctgta gccaggccgc cctcctgcca tgaccattcc
     3181 tgtctctccc tctctgcagg caaatgaagc aaatggatat gaacttcatc tgtgaaaata
     3241 tttttttttc tccatttttg ttccatttgg gggcttcttt tattggtttc tatatttgat
     3301 tggtttggcg agagagcagc ggctgcctag gggctgggga tccccttcat gccgaggcgc
     3361 tccctctctc actctgtgtg tctcatcttt ttcctttcca aaattgggat ccttcatgtt
     3421 gagccagcct tagaaaatag caagaattta acctctgccc cgccccccaa aaaagtttaa
     3481 aaattaaatc acaaagagca gaacaaaacc tataaaatga tatatgtata gaaatatata
     3541 aatctctatt ccccagcctc cgagcccacc ctctgaggga agcggttcac tatctcccta
     3601 ctgtctgggg ccctattctt gtttttaata aactttttaa aaggaaagaa acagtcacta
     3661 ttgctatctc tttttttctt ttttttttct ttttcttttt tctttttctt tttttttttt
     3721 ttttttagtt agagttggaa cattccttgg accaggtgtg ggtttcacag gcccctcctg
     3781 ccctgcccat ctctctctgt ctctctttct ccctgccccc gctcttccct ggctcctcct
     3841 tatacccacc ccaaccccag gactggcctg gtacgttgtc atctgttgaa gatgagataa
     3901 actgagaaaa aaatgagaac aaaacaaaaa aattgtatgg cagtttttac tttttatcgc
     3961 tcgtttttaa cttcacaaat aaatggtatc aaaaacctca a
//
