LOCUS       NM_027143               5926 bp    mRNA    linear   ROD 31-MAY-2024
DEFINITION  Mus musculus KH and NYN domain containing (Khnyn), transcript
            variant 1, mRNA.
ACCESSION   NM_027143
VERSION     NM_027143.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5926)
  AUTHORS   Anantharaman,V. and Aravind,L.
  TITLE     The NYN domains: novel predicted RNAses with a PIN domain-like fold
  JOURNAL   RNA Biol 3 (1), 18-27 (2006)
   PUBMED   17114934
REFERENCE   2  (bases 1 to 5926)
  AUTHORS   Nishimura,M., Yokoi,N., Miki,T., Horikawa,Y., Yoshioka,H.,
            Takeda,J., Ohara,O. and Seino,S.
  TITLE     Construction of a multi-functional cDNA library specific for mouse
            pancreatic islets and its application to microarray
  JOURNAL   DNA Res 11 (5), 315-323 (2004)
   PUBMED   15747579
REFERENCE   3  (bases 1 to 5926)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Aizawa,H., Yuasa,S.,
            Nakajima,D., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: II. The complete nucleotide sequences of 400 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 10 (1), 35-48 (2003)
   PUBMED   12693553
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC098877.3, AK122247.1 and
            BP757894.1.
            
            On Aug 4, 2016 this sequence version replaced NM_027143.2.
            
            Summary: This gene encodes a protein with a C-terminal RNA
            modifying domain that belongs to a family of ribonucleases typified
            by eukaryotic Nedd4-binding protein1 and the bacterial YacP-like
            nucleases (NYN). The NYN domain shares a common protein fold with
            two other groups of nucleases, the PilT N-terminal nuclease and
            FLAP nuclease superfamilies. In addition to the NYN domain, the
            protein encoded by this gene also contains an N-terminal K homology
            RNA-binding domain. Alternative splicing results in multiple
            transcript variants. [provided by RefSeq, Aug 2016].
            
            Transcript Variant: This variant (1) represents the shorter
            transcript and encodes the functional protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK136301.1, AK033704.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-201               AC098877.3         200756-200956
            202-419             AC098877.3         201588-201805
            420-1546            AC098877.3         202306-203432
            1547-1677           AC098877.3         203528-203658
            1678-1774           AC098877.3         203735-203831
            1775-1882           AC098877.3         209806-209913
            1883-1984           AC098877.3         210101-210202
            1985-3902           AC098877.3         210677-212594
            3903-5895           AK122247.1         3888-5880
            5896-5926           BP757894.1         1-31                c
FEATURES             Location/Qualifiers
     source          1..5926
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 28.19 cM"
     gene            1..5926
                     /gene="Khnyn"
                     /gene_synonym="6330555F21; 9130227C08Rik; Kiaa0323;
                     mKIAA0323"
                     /note="KH and NYN domain containing"
                     /db_xref="GeneID:219094"
                     /db_xref="MGI:MGI:2451333"
     exon            1..201
                     /gene="Khnyn"
                     /gene_synonym="6330555F21; 9130227C08Rik; Kiaa0323;
                     mKIAA0323"
                     /inference="alignment:Splign:2.1.0"
     exon            202..419
                     /gene="Khnyn"
                     /gene_synonym="6330555F21; 9130227C08Rik; Kiaa0323;
                     mKIAA0323"
                     /inference="alignment:Splign:2.1.0"
     CDS             219..2234
                     /gene="Khnyn"
                     /gene_synonym="6330555F21; 9130227C08Rik; Kiaa0323;
                     mKIAA0323"
                     /note="KH and NYN domain-containing protein"
                     /codon_start=1
                     /product="protein KHNYN"
                     /protein_id="NP_081419.1"
                     /db_xref="CCDS:CCDS27134.1"
                     /db_xref="GeneID:219094"
                     /db_xref="MGI:MGI:2451333"
                     /translation="MSTWGFASPTPDRFAVSAEAEDKVREQQTRLERIFNVGMSVLSK
                     DCPENPHIWLQLEGPKENVCRAKEYLKGLCSPELQSEIHYPPRLHCIFLGAHGFFLDC
                     LAWSTSAHLVPLLPGSLMISGLTEAFVMAQSRVEELVQRLSWDLQLQSCPGAPDNGGV
                     LRDFSALLQTREDAYTEALLRLPLAVQEELLSLVQEASRGQGPSREVGSSGLLSPQFQ
                     GVRAPLNEGREFVGTRVAGSGKSPAVRGQSHTVEKEERKQDAVRDMGSGRKELSGEEV
                     WEPGVAYRSQLAGGGAEEVAPLKGKASGKQEVPQQRGGFSVQGEPSGAHVPCQRAAPI
                     RGASLLQRLHNGSASPPRVPSPPPAPEPPWPCGDRDRDRDRGDRGDKQQAGARGRGSP
                     WKRGTRGGNLVTGTQRFQEALQDPFTLCLANVPGQPDLRHIVIDGSNVAMVHGLQHYF
                     SSRGIALAVQYFWDRGHRDITVFVPQWRFSKDSKVRESHFLQKLYSLSLLSLTPSRVM
                     DGKRISSYDDRFMVKLAEETDGIIVSNDQFRDLAEESDKWMAIIRERLLPFTFVGNLF
                     MVPDDPLGRNGPTLDEFLKKPVRKQGSSKTQQPSKGSTEQANQQQGKDADRSNGGIRK
                     TRETERLRRQLLEVFWGQDHKVDFILQREPYCRDINQLSEALLSLNF"
     exon            420..1546
                     /gene="Khnyn"
                     /gene_synonym="6330555F21; 9130227C08Rik; Kiaa0323;
                     mKIAA0323"
                     /inference="alignment:Splign:2.1.0"
     exon            1547..1677
                     /gene="Khnyn"
                     /gene_synonym="6330555F21; 9130227C08Rik; Kiaa0323;
                     mKIAA0323"
                     /inference="alignment:Splign:2.1.0"
     exon            1678..1774
                     /gene="Khnyn"
                     /gene_synonym="6330555F21; 9130227C08Rik; Kiaa0323;
                     mKIAA0323"
                     /inference="alignment:Splign:2.1.0"
     exon            1775..1882
                     /gene="Khnyn"
                     /gene_synonym="6330555F21; 9130227C08Rik; Kiaa0323;
                     mKIAA0323"
                     /inference="alignment:Splign:2.1.0"
     exon            1883..1984
                     /gene="Khnyn"
                     /gene_synonym="6330555F21; 9130227C08Rik; Kiaa0323;
                     mKIAA0323"
                     /inference="alignment:Splign:2.1.0"
     exon            1985..5902
                     /gene="Khnyn"
                     /gene_synonym="6330555F21; 9130227C08Rik; Kiaa0323;
                     mKIAA0323"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5878..5883
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Khnyn"
                     /gene_synonym="6330555F21; 9130227C08Rik; Kiaa0323;
                     mKIAA0323"
                     /note="hexamer: ATTAAA"
     polyA_site      5899
                     /gene="Khnyn"
                     /gene_synonym="6330555F21; 9130227C08Rik; Kiaa0323;
                     mKIAA0323"
                     /note="major polyA site"
ORIGIN      
        1 tggctccgcc ccgggccgga aagtgactcc aaagccacaa cgcgttgttg acgagagaag
       61 tctaggttgg gtgaaggatc cgagaaggcc ctcccagatt cgggctccca gccccaggcc
      121 cctggggcgc gggagaaacg cgggcccctc ctcccccgcc gcgggcacct agaggagcgg
      181 gcggaactcg cggctttggc ggactccagg tagaagccat gtctacttgg gggtttgcct
      241 ccccgactcc cgaccgcttt gcggtgtctg cggaggccga ggacaaggtt cgggagcagc
      301 agactcgctt ggagcgtatc ttcaacgtgg gaatgagcgt cctctccaaa gactgcccag
      361 agaatcctca tatctggttg cagcttgagg gccccaagga gaacgtctgc agagccaagg
      421 aatacctgaa ggggctctgc agcccagaac tacagagtga gatccactac ccacccagac
      481 tgcactgcat ctttctggga gcccacggtt tcttccttga ctgcctggcc tggagcacat
      541 ctgcccacct ggtgcctctg cttcctggct ctctgatgat cagtggccta accgaggcgt
      601 ttgtgatggc ccagagccgg gtggaggagt tagtgcaacg gctgagctgg gaccttcagc
      661 tacagtcttg tcccggagcc cctgacaatg gcggagtgct gagagacttc tctgccctgc
      721 tgcagactag ggaggatgcc tacacagagg ccctgctgcg gctgcccctg gccgtgcagg
      781 aggagctcct aagcctggtg caggaggcat ctagagggca gggtccatct cgtgaggtgg
      841 ggagctcagg cctgttgagt cctcagttcc agggagtcag ggctcccttg aatgaaggca
      901 gggaattcgt aggcaccaga gtggcagggt cgggaaagtc gccagcagta agaggacaaa
      961 gtcatactgt ggagaaggag gaaaggaaac aggatgctgt cagggacatg ggttcagggc
     1021 ggaaggagct gtctggggaa gaggtctggg agcctggagt ggcttacagg tcacagctag
     1081 caggtggagg agcagaggag gtggcaccct tgaagggaaa ggcctcgggg aaacaggagg
     1141 ttcctcagca aagaggaggg ttcagtgtgc agggtgaacc ttcaggtgcg catgtgccct
     1201 gtcagagggc agctccaatc cggggagcct ctctcctcca gcggctccac aatgggagcg
     1261 cctcacctcc gagagtgcct agccctccgc ccgcgccgga acccccatgg ccctgtggag
     1321 accgagaccg agatcgagat cggggagaca ggggagacaa gcagcaggct ggagctcgag
     1381 gccgagggtc tccgtggaag cgaggcactc gtgggggcaa cttggtgact ggcacgcagc
     1441 gtttccagga agccttacag gatcctttca ccctgtgcct tgccaatgtg cctggccagc
     1501 cagatctccg tcacattgtc attgatggca gcaacgtggc catggtgcac ggactccagc
     1561 attacttttc cagtcggggt attgctctcg ctgtacagta cttctgggac cgtggccacc
     1621 gtgacataac cgtctttgtg cctcagtggc gcttcagtaa agattccaag gtcagagaga
     1681 gtcacttcct gcagaagttg tattccctga gtctgctttc cctgacaccc tcacgagtca
     1741 tggatggcaa gaggatttct tcttatgatg acaggttcat ggtgaagctg gctgaagaaa
     1801 cggatgggat cattgtctcc aatgaccagt tccgggatct ggctgaggag tctgacaagt
     1861 ggatggcgat catcagagag cgcctgctgc ccttcacctt tgtggggaac ctcttcatgg
     1921 tcccagatga cccactggga cgaaatggcc ccaccctgga tgagttcctg aagaagccag
     1981 tcaggaagca gggttcttct aagactcagc agccctctaa aggctccaca gagcaggcta
     2041 atcagcagca ggggaaggac gcggacagga gcaatggtgg cattcggaag acccgggaga
     2101 cagagcggct gcggcgccag ctgctcgaag tgttttgggg tcaggaccac aaggtggact
     2161 tcatcctgca gcgggaaccg tactgccggg atattaacca gctttctgag gccctgctga
     2221 gtctcaactt ctgagccttt ctgccctgca tagctgctgc cctattagag tcagcctccc
     2281 ccagccccgc cccttctctt acagtccctc tgccgctcag accatgacct agacccactc
     2341 taagatggtg ctttggccag aggaagcacc agagaagaga atttgagtgt gggaatactc
     2401 tttgcctggg gtagtttgag gtcaggtcct taaaatgact caacctgagg aaggaccacg
     2461 aagccagctc ttaggaggtt ttgatcagac tcagcgcctc aactctgtct ttagagaggg
     2521 cttctgtaag atgtagaagc tgttccagga gactgcgcct gtggctttac taccaagttc
     2581 cttagttgga ggatagggta ggctggaggc gacaaaaagg ctaagctgag aaagaaagca
     2641 ccctctggct gctcctctga gtggtaggat aggctgagct ctaccctggc gtgtccggag
     2701 gaatactgac tcccagaggg gtcatagcgc tacgtgggct gttgcagtgg gctagttgag
     2761 aaccagaagg cagaggtggg caggcttcca gtctcagctg tgcctgcctg tgaccttgac
     2821 agagttgctt ggcctttact tatgtctaca catcaggcat aaagataacc gttgagggaa
     2881 atgagaacag agaaggctcc catgaggacc tgtacttggg tcatggctca ggcgtgtctg
     2941 cctgtggctg gctgttcagg ctccctagcc agaacttcac attcagagat gtccactgtc
     3001 cactccctcg atgttaacgc tgggctttca gtagaacatg ccctgtaaat ggctgcatcc
     3061 cttttcagca accttcgaaa ctcacgttat caaaataggc aagttagggt ggatggctgc
     3121 attacttaaa tactctcagg gctcctataa atggcagctg ctcagttgca tttcaagtgt
     3181 ttgtttacag attgacaagg ccctggttaa attttctttc tggtgttgag cctattcacc
     3241 aaactcacga tgtcatgttt ggcagtgaca gtgttagtgg gatctatcta atatttcctt
     3301 tatggaagac aggtttcttt cggcaagaca cactgctacc ttctgtgtat gggaagcgga
     3361 agctgaagca tcaggatcga gatacctgat tggttacaga cggactccat tgacctgtca
     3421 tgacaagctg tttacattct aactcccaca agtcattgct ctgtatctgt ttgaactctg
     3481 tctgtgccgg ggaatgtact gtctgcaagg tggcacactc cttacttgat tgtgttaagc
     3541 agtttttcct ctagtgtagt ctaacctgct tctctgtgac tttcactttc cccaggagta
     3601 atttagggct agtcaacttc ttagaggcca gagtcgggta gaggtataaa aaggtaaggc
     3661 aggtgccact gggttcatgt agcaagtccc tgaattagat gcctttctag ctctgactta
     3721 gtccaagtga catggagtta actatgtggc tctctgggtc ccagtgtctt tgtctgtttc
     3781 cttgggtgat tttcatttca caccagattg attaggtgtt ggggacaagt tgattagggg
     3841 aatgacaagg gagaagaaga gaatggtctg gactgggggc tggtagagct gccttttaag
     3901 cttaggattg gtgtcttctc ttttctcttg ccatgatggt gggtatgcag aaggctgggg
     3961 ttatcttccc ttccctgagt gccctggaag gctgagtgtt cctgagaaga tgagagacca
     4021 agcttataga gggacactga catcttactg cagtatgacg agccgggacc tgtacacgtt
     4081 tactatatta actcatggct gtttggtaaa tgctgaaggc tagcccacag ggcccttttc
     4141 ccacttttgc tggcatcctc tgaacaggtg tcagggtgac accagagctc actggagaca
     4201 gatctttata tgtatcgcct ttaatctgtc ataacctcat gtctcaccag ctcatttgga
     4261 aagagagact gagaaaggaa aagatgagga gagattgcat gttaaaacgt taagaaccca
     4321 gcttaggaga agagccatgt agggtaatag ttcttcagat aattctaggg gaatataagc
     4381 caaagagaca gcggaagcca gtgatctagc gatgtaatct atctttattg ccataactgt
     4441 agaacattgt ctacacagca tatatgagaa ccagggcaac aatgtaacac agaagccaca
     4501 gaagaagttg aagaggtgaa ggttagaatg agattatatt cttgaggctg gagtttctca
     4561 gataggggtg gatcaacgaa catgggaaga gagtggggtg agggggggca gagtctaaga
     4621 ccctgatgga ttctgatctc aatcaagtgc agggatcatc acctgaccca cttctcagag
     4681 tgcgggagca ggccccagct tctgccttgg ggctccttct ctgctcaggc tacaacatcc
     4741 ttcaaggcag ccctcagctc tgggaaggag tactggtagc cagtagccag tgtccgccga
     4801 gggaccactt tttgcccttc caacagcatg atggcacgtt ctccaaagac cgctcgtacc
     4861 acagtgctgg ggacaggtat gaaggctggg cggcccaggg cagcacccaa ggcctgggca
     4921 aactcagcat tggtagttgt agatgctgga gccactccat tcaggactcc ttggacgtgg
     4981 tttgcttcaa gggcatagtt cagaattcct gccaggtcac caatgtgtat ccaggggaag
     5041 aattggcgac ctgaaccgat ggggcctcct aggcccaggc ggaagggcag aagcatgtga
     5101 ctgatggcgc cacctccacg gcccagcaca acccctaaag tagagaggtg gtacatggag
     5161 gctgcttagc cttgaaaatt tgcactactc tgctttccct tctcccttat ggtcttcccg
     5221 tgtgcacgtg gagtgggcag cgttgagggc tgtgggtctt ttggggattt ttccctctgc
     5281 tagctaaagt aatagtgtcc tctccctgca agctcagccc aggaatcgtc catgttgcct
     5341 gattcccagg cccttggtcc tcacctgaac gtaccacgac ctggcgtgta gactctccag
     5401 gaagcctggc tgctgcttcc catttggtta ccaggttgga gaaaaagtca aaattccctc
     5461 ctgggctgtc ttcatcatac tccttagtca ggcttggctg gtagtaagct gtcatggaag
     5521 agcgtttgtt tgctctggcg gtccctggcc tgctgggccc tttgtagtgc aaggctcctt
     5581 agcctcagtc tcctctgccc tttgggtttc cacaggagaa gaaagaacca taactgtttc
     5641 ccccttgagc ttctctgtgt gtccatgcct gaacatctag cttttggctg tcaggctgtg
     5701 tccagaggcc gctagcttgt agtgggtagg gacagaaacg taggtgctaa gctgcttgaa
     5761 ctggaccatt cttgacatct gtgacttttt ttttttttgg caagttactt ctccgtatga
     5821 aaaaaatctg catcctcagt atgggagtaa ctgtacctac ctcataaagt tgtaaggatt
     5881 aaataatatg tatataatag taaaaaaaaa aaaaaaaaaa aaaaaa
//
