LOCUS       NP_081419                671 aa            linear   ROD 28-APR-2025
DEFINITION  protein KHNYN [Mus musculus].
ACCESSION   NP_081419
VERSION     NP_081419.1
DBSOURCE    REFSEQ: accession NM_027143.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 671)
  AUTHORS   Anantharaman,V. and Aravind,L.
  TITLE     The NYN domains: novel predicted RNAses with a PIN domain-like fold
  JOURNAL   RNA Biol 3 (1), 18-27 (2006)
   PUBMED   17114934
REFERENCE   2  (residues 1 to 671)
  AUTHORS   Nishimura,M., Yokoi,N., Miki,T., Horikawa,Y., Yoshioka,H.,
            Takeda,J., Ohara,O. and Seino,S.
  TITLE     Construction of a multi-functional cDNA library specific for mouse
            pancreatic islets and its application to microarray
  JOURNAL   DNA Res 11 (5), 315-323 (2004)
   PUBMED   15747579
REFERENCE   3  (residues 1 to 671)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Aizawa,H., Yuasa,S.,
            Nakajima,D., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: II. The complete nucleotide sequences of 400 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 10 (1), 35-48 (2003)
   PUBMED   12693553
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC098877.3, AK122247.1 and
            BP757894.1.
            
            Summary: This gene encodes a protein with a C-terminal RNA
            modifying domain that belongs to a family of ribonucleases typified
            by eukaryotic Nedd4-binding protein1 and the bacterial YacP-like
            nucleases (NYN). The NYN domain shares a common protein fold with
            two other groups of nucleases, the PilT N-terminal nuclease and
            FLAP nuclease superfamilies. In addition to the NYN domain, the
            protein encoded by this gene also contains an N-terminal K homology
            RNA-binding domain. Alternative splicing results in multiple
            transcript variants. [provided by RefSeq, Aug 2016].
            
            Transcript Variant: This variant (1) represents the shorter
            transcript and encodes the functional protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK136301.1, AK033704.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..671
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 28.19 cM"
     Protein         1..671
                     /product="protein KHNYN"
                     /note="KH and NYN domain-containing protein"
                     /calculated_mol_wt=74434
     Region          12..74
                     /region_name="KH-I_N4BP1_like_rpt1"
                     /note="first type I K homology (KH) RNA-binding domain
                     found in the family of NEDD4-binding protein 1 (N4BP1);
                     cd09032"
                     /db_xref="CDD:411808"
     Region          76..141
                     /region_name="KH-I_NYNRIN_like"
                     /note="type I K homology (KH) RNA-binding domain found in
                     the subfamily of NYN domain and retroviral integrase
                     catalytic domain-containing protein (NYNRIN); cd22477"
                     /db_xref="CDD:411905"
     Site            order(87,89..91,93..97,100..101,104..105,110..113)
                     /site_type="other"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]"
                     /db_xref="CDD:411905"
     Region          234..274
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q80U38.2)"
     Region          294..327
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q80U38.2)"
     Region          344..402
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q80U38.2)"
     Site            355
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:O15037; propagated from
                     UniProtKB/Swiss-Prot (Q80U38.2)"
     Region          429..582
                     /region_name="RNase_Zc3h12a"
                     /note="Zc3h12a-like Ribonuclease NYN domain; pfam11977"
                     /db_xref="CDD:403256"
     Region          577..626
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q80U38.2)"
     CDS             1..671
                     /gene="Khnyn"
                     /gene_synonym="6330555F21; 9130227C08Rik; Kiaa0323;
                     mKIAA0323"
                     /coded_by="NM_027143.3:219..2234"
                     /db_xref="CCDS:CCDS27134.1"
                     /db_xref="GeneID:219094"
                     /db_xref="MGI:MGI:2451333"
ORIGIN      
        1 mstwgfaspt pdrfavsaea edkvreqqtr lerifnvgms vlskdcpenp hiwlqlegpk
       61 envcrakeyl kglcspelqs eihypprlhc iflgahgffl dclawstsah lvpllpgslm
      121 isglteafvm aqsrveelvq rlswdlqlqs cpgapdnggv lrdfsallqt redayteall
      181 rlplavqeel lslvqeasrg qgpsrevgss gllspqfqgv raplnegref vgtrvagsgk
      241 spavrgqsht vekeerkqda vrdmgsgrke lsgeevwepg vayrsqlagg gaeevaplkg
      301 kasgkqevpq qrggfsvqge psgahvpcqr aapirgasll qrlhngsasp prvpspppap
      361 eppwpcgdrd rdrdrgdrgd kqqagargrg spwkrgtrgg nlvtgtqrfq ealqdpftlc
      421 lanvpgqpdl rhividgsnv amvhglqhyf ssrgialavq yfwdrghrdi tvfvpqwrfs
      481 kdskvreshf lqklyslsll sltpsrvmdg krissyddrf mvklaeetdg iivsndqfrd
      541 laeesdkwma iirerllpft fvgnlfmvpd dplgrngptl deflkkpvrk qgssktqqps
      601 kgsteqanqq qgkdadrsng girktreter lrrqllevfw gqdhkvdfil qrepycrdin
      661 qlseallsln f
//
