LOCUS       NM_010158               1911 bp    mRNA    linear   ROD 24-SEP-2024
DEFINITION  Mus musculus KH domain containing, RNA binding, signal transduction
            associated 3 (Khdrbs3), transcript variant 1, mRNA.
ACCESSION   NM_010158 XM_907337 XM_920359
VERSION     NM_010158.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1911)
  AUTHORS   Cesari,E., Farini,D., Medici,V., Ehrmann,I., Guerra,M., Testa,E.,
            Naro,C., Geloso,M.C., Pagliarini,V., La Barbera,L., D'Amelio,M.,
            Orsini,T., Vecchioli,S.F., Tamagnone,L., Fort,P., Viscomi,M.T.,
            Elliott,D.J. and Sette,C.
  TITLE     Differential expression of paralog RNA binding proteins establishes
            a dynamic splicing program required for normal cerebral cortex
            development
  JOURNAL   Nucleic Acids Res 52 (8), 4167-4184 (2024)
   PUBMED   38324473
REFERENCE   2  (bases 1 to 1911)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 1911)
  AUTHORS   Traunmuller,L., Schulz,J., Ortiz,R., Feng,H., Furlanis,E.,
            Gomez,A.M., Schreiner,D., Bischofberger,J., Zhang,C. and
            Scheiffele,P.
  TITLE     A cell-type-specific alternative splicing regulator shapes synapse
            properties in a trans-synaptic manner
  JOURNAL   Cell Rep 42 (3), 112173 (2023)
   PUBMED   36862556
REFERENCE   4  (bases 1 to 1911)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1911)
  AUTHORS   Farini,D., Cesari,E., Weatheritt,R.J., La Sala,G., Naro,C.,
            Pagliarini,V., Bonvissuto,D., Medici,V., Guerra,M., Di Pietro,C.,
            Rizzo,F.R., Musella,A., Carola,V., Centonze,D., Blencowe,B.J.,
            Marazziti,D. and Sette,C.
  TITLE     A Dynamic Splicing Program Ensures Proper Synaptic Connections in
            the Developing Cerebellum
  JOURNAL   Cell Rep 31 (9), 107703 (2020)
   PUBMED   32492419
REFERENCE   6  (bases 1 to 1911)
  AUTHORS   Cote,J., Boisvert,F.M., Boulanger,M.C., Bedford,M.T. and Richard,S.
  TITLE     Sam68 RNA binding protein is an in vivo substrate for protein
            arginine N-methyltransferase 1
  JOURNAL   Mol Biol Cell 14 (1), 274-287 (2003)
   PUBMED   12529443
REFERENCE   7  (bases 1 to 1911)
  AUTHORS   Venables,J.P. and Eperon,I.
  TITLE     The roles of RNA-binding proteins in spermatogenesis and male
            infertility
  JOURNAL   Curr Opin Genet Dev 9 (3), 346-354 (1999)
   PUBMED   10377282
  REMARK    Review article
REFERENCE   8  (bases 1 to 1911)
  AUTHORS   Venables,J.P., Vernet,C., Chew,S.L., Elliott,D.J., Cowmeadow,R.B.,
            Wu,J., Cooke,H.J., Artzt,K. and Eperon,I.C.
  TITLE     T-STAR/ETOILE: a novel relative of SAM68 that interacts with an
            RNA-binding protein implicated in spermatogenesis
  JOURNAL   Hum Mol Genet 8 (6), 959-969 (1999)
   PUBMED   10332027
REFERENCE   9  (bases 1 to 1911)
  AUTHORS   Di Fruscio,M., Chen,T. and Richard,S.
  TITLE     Characterization of Sam68-like mammalian proteins SLM-1 and SLM-2:
            SLM-1 is a Src substrate during mitosis
  JOURNAL   Proc Natl Acad Sci U S A 96 (6), 2710-2715 (1999)
   PUBMED   10077576
REFERENCE   10 (bases 1 to 1911)
  AUTHORS   Vernet,C. and Artzt,K.
  TITLE     STAR, a gene family involved in signal transduction and activation
            of RNA
  JOURNAL   Trends Genet 13 (12), 479-484 (1997)
   PUBMED   9433137
  REMARK    Review article
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC123936.4.
            
            On Aug 23, 2022 this sequence version replaced NM_010158.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC057577.1, AF079763.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849384, SAMN01164131
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-431               AC123936.4         183410-183840       c
            432-550             AC123936.4         117073-117191       c
            551-667             AC123936.4         98769-98885         c
            668-814             AC123936.4         94769-94915         c
            815-954             AC123936.4         87404-87543         c
            955-1150            AC123936.4         82333-82528         c
            1151-1233           AC123936.4         62782-62864         c
            1234-1292           AC123936.4         21051-21109         c
            1293-1911           AC123936.4         18724-19342         c
FEATURES             Location/Qualifiers
     source          1..1911
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 30.36 cM"
     gene            1..1911
                     /gene="Khdrbs3"
                     /gene_synonym="Etle; Salp; SLM-2; Slm2; T-STAR"
                     /note="KH domain containing, RNA binding, signal
                     transduction associated 3"
                     /db_xref="GeneID:13992"
                     /db_xref="MGI:MGI:1313312"
     exon            1..431
                     /gene="Khdrbs3"
                     /gene_synonym="Etle; Salp; SLM-2; Slm2; T-STAR"
                     /inference="alignment:Splign:2.1.0"
     CDS             344..1384
                     /gene="Khdrbs3"
                     /gene_synonym="Etle; Salp; SLM-2; Slm2; T-STAR"
                     /note="isoform 1 is encoded by transcript variant 1; KH
                     domain-containing, RNA-binding, signal
                     transduction-associated protein 3; RNA-binding protein
                     Etoile; sam68-like mammalian protein 2; etoile"
                     /codon_start=1
                     /product="KH domain-containing, RNA-binding, signal
                     transduction-associated protein 3 isoform 1"
                     /protein_id="NP_034288.2"
                     /db_xref="CCDS:CCDS27513.1"
                     /db_xref="GeneID:13992"
                     /db_xref="MGI:MGI:1313312"
                     /translation="MEEKYLPELMAEKDSLDPSFTHALRLVNREIEKFQKGEGKEEEK
                     YIDVVINKNMKLGQKVLIPVKQFPKFNFVGKLLGPRGNSLKRLQEETLTKMSILGKGS
                     MRDKAKEEELRKSGEAKYFHLNDDLHVLIEVFAPPAEAYARMGHALEEIKKFLIPDYN
                     DEIRQAQLQELTYLNGGSENADVPVVRGKSTLRTRGVTTPAITRGRGGVTARPVAVGV
                     PRGTPTPRGVLSTRGPVSRGRGLLTPRARGVPPTGYRPPPPPPTQETYGEYDYDDGYG
                     TAYDEQSYDSYDNSYSTPAQSAADYYDYGHGLSEDAYDSYGQEEWTNSRHKAPSARTA
                     KGVYRDQPYGRY"
     exon            432..550
                     /gene="Khdrbs3"
                     /gene_synonym="Etle; Salp; SLM-2; Slm2; T-STAR"
                     /inference="alignment:Splign:2.1.0"
     exon            551..667
                     /gene="Khdrbs3"
                     /gene_synonym="Etle; Salp; SLM-2; Slm2; T-STAR"
                     /inference="alignment:Splign:2.1.0"
     exon            668..814
                     /gene="Khdrbs3"
                     /gene_synonym="Etle; Salp; SLM-2; Slm2; T-STAR"
                     /inference="alignment:Splign:2.1.0"
     exon            815..954
                     /gene="Khdrbs3"
                     /gene_synonym="Etle; Salp; SLM-2; Slm2; T-STAR"
                     /inference="alignment:Splign:2.1.0"
     exon            955..1150
                     /gene="Khdrbs3"
                     /gene_synonym="Etle; Salp; SLM-2; Slm2; T-STAR"
                     /inference="alignment:Splign:2.1.0"
     exon            1151..1233
                     /gene="Khdrbs3"
                     /gene_synonym="Etle; Salp; SLM-2; Slm2; T-STAR"
                     /inference="alignment:Splign:2.1.0"
     exon            1234..1292
                     /gene="Khdrbs3"
                     /gene_synonym="Etle; Salp; SLM-2; Slm2; T-STAR"
                     /inference="alignment:Splign:2.1.0"
     exon            1293..1911
                     /gene="Khdrbs3"
                     /gene_synonym="Etle; Salp; SLM-2; Slm2; T-STAR"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1893..1898
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Khdrbs3"
                     /gene_synonym="Etle; Salp; SLM-2; Slm2; T-STAR"
                     /note="hexamer: AATAAA"
     polyA_site      1911
                     /gene="Khdrbs3"
                     /gene_synonym="Etle; Salp; SLM-2; Slm2; T-STAR"
                     /note="major polyA site"
ORIGIN      
        1 agagcgcgcg gggtggcgcg cggggcgggt cgtggcagag caaggcatcg tcgcagccgg
       61 cgagcaagac tggccagcgc tcctcggctt tccagcccgc tctcttcgct catcccgccg
      121 ccttgcagcc cgcggcccgc agcgcggtga tctggggctc cacggggccg ggctgagcgg
      181 ccgccgcccg ccccgagccg ccgccgccgc ccggccgccc gcccggctta gccgccgagg
      241 cgcctggcgg ggtccgcgcc gccgggggcg ggcggctcgg gctgcggggc ggctggcgcg
      301 cgcgcgccgc ggggcggaga agcgggcccg gcggccggcg agcatggagg agaagtacct
      361 gccggagctg atggcggaga aggactctct ggacccctcc ttcacgcacg ccctgcgctt
      421 ggtgaaccga gaaatagaaa agtttcaaaa gggagaaggc aaggaggaag agaagtacat
      481 tgacgtggtg ataaacaaga acatgaagct gggacagaag gtgctgattc ccgtgaagca
      541 gtttcccaag ttcaactttg tggggaagct tttgggtccg cgtggcaatt ccctgaagcg
      601 cttacaagaa gaaacgttga caaaaatgtc catccttggc aaaggttcca tgagagacaa
      661 ggcaaaggag gaagagctga ggaaaagtgg agaagcgaag tactttcacc tcaatgacga
      721 cctgcacgtg ctcattgaag tgttcgcacc cccagcagaa gcatatgccc ggatggggca
      781 cgccttggaa gagatcaaga aattcctgat ccctgactat aatgatgaaa tcaggcaagc
      841 acaactccag gagttaacat atttgaatgg aggttcagaa aatgcagatg tcccagtggt
      901 tcgagggaaa tctactttgc gtacgagagg tgtaactaca ccagcaataa ccaggggaag
      961 aggaggagtc acagccaggc ctgttgcagt tggggtacca cgtgggacac cgactccccg
     1021 aggagtcctt tccacccgag ggccagtgag ccggggaaga ggccttctca ctcccagagc
     1081 aagaggtgtc cccccaaccg gatacagacc tcccccgcca cccccaacac aggagaccta
     1141 tggagagtat gactatgacg atgggtacgg tactgcctat gatgagcaga gctatgactc
     1201 ctatgacaac agctacagca ccccagcaca aagtgcagct gattactacg attatgggca
     1261 tggactcagc gaggacgctt atgactccta tgggcaagag gaatggacta actcaagaca
     1321 taaggctcct tcggcgagga cggcgaaggg cgtctacaga gaccagccat atggcagata
     1381 ctgattgtac tgtctgatgt tgtgaaatag ccaatctcca ccgtcctgta tactgttcaa
     1441 agtaattttt ttctatgacc aatccctttt taaataaatc aaaatgctta aaatctgaat
     1501 ggatggaact taaagccact ttgttgaagc atccacttga cagggagaag aaggacatgt
     1561 aaaattttgt tatttgcagt ctgtatatga aaactaggtt atgaaaagga aaaaaataac
     1621 tttgattaac tagtgttaaa caaaaagata ggtttactaa atatgttaat ccattcttta
     1681 acataagtct cacctttcat cttaaaggtt tccatagaat ttagttattt tatctttcag
     1741 ccatatgcta gttttttttt ttctttcttt ctttcttgcc aacttgcgta aaaagggagc
     1801 cgattacaag tgcagacaat gtggtattct tttgtaactg agtcctgaaa tgttctgtag
     1861 tgttaggcaa agtctcctct tgcttgatac taaataaact tttgaaagaa a
//
