LOCUS       NM_011317               3762 bp    mRNA    linear   ROD 24-SEP-2024
DEFINITION  Mus musculus KH domain containing, RNA binding, signal transduction
            associated 1 (Khdrbs1), transcript variant 1, mRNA.
ACCESSION   NM_011317 XR_106272 XR_106449 XR_107632
VERSION     NM_011317.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3762)
  AUTHORS   Cesari,E., Farini,D., Medici,V., Ehrmann,I., Guerra,M., Testa,E.,
            Naro,C., Geloso,M.C., Pagliarini,V., La Barbera,L., D'Amelio,M.,
            Orsini,T., Vecchioli,S.F., Tamagnone,L., Fort,P., Viscomi,M.T.,
            Elliott,D.J. and Sette,C.
  TITLE     Differential expression of paralog RNA binding proteins establishes
            a dynamic splicing program required for normal cerebral cortex
            development
  JOURNAL   Nucleic Acids Res 52 (8), 4167-4184 (2024)
   PUBMED   38324473
REFERENCE   2  (bases 1 to 3762)
  AUTHORS   Qiao,A., Ma,W., Jiang,Y., Han,C., Yan,B., Zhou,J. and Qin,G.
  TITLE     Hepatic Sam68 Regulates Systemic Glucose Homeostasis and Insulin
            Sensitivity
  JOURNAL   Int J Mol Sci 23 (19), 11469 (2022)
   PUBMED   36232770
  REMARK    GeneRIF: Hepatic Sam68 Regulates Systemic Glucose Homeostasis and
            Insulin Sensitivity.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3762)
  AUTHORS   Goodman,W.A., Basavarajappa,S.C., Liu,A.R., Rodriguez,F.D.S.,
            Mathes,T. and Ramakrishnan,P.
  TITLE     Sam68 contributes to intestinal inflammation in experimental and
            human colitis
  JOURNAL   Cell Mol Life Sci 78 (23), 7635-7648 (2021)
   PUBMED   34693458
  REMARK    GeneRIF: Sam68 contributes to intestinal inflammation in
            experimental and human colitis.
REFERENCE   4  (bases 1 to 3762)
  AUTHORS   Qiao,A., Ma,W., Deng,J., Zhou,J., Han,C., Zhang,E., Boriboun,C.,
            Xu,S., Zhang,C., Jie,C., Kim,J.A., Habegger,K.M., Qiu,H.,
            Zhao,T.C., Zhang,J. and Qin,G.
  TITLE     Ablation of Sam68 in adult mice increases thermogenesis and energy
            expenditure
  JOURNAL   FASEB J 35 (8), e21772 (2021)
   PUBMED   34252225
  REMARK    GeneRIF: Ablation of Sam68 in adult mice increases thermogenesis
            and energy expenditure.
REFERENCE   5  (bases 1 to 3762)
  AUTHORS   Qiao,A., Zhou,J., Xu,S., Ma,W., Boriboun,C., Kim,T., Yan,B.,
            Deng,J., Yang,L., Zhang,E., Song,Y., Ma,Y.C., Richard,S., Zhang,C.,
            Qiu,H., Habegger,K.M., Zhang,J. and Qin,G.
  TITLE     Sam68 promotes hepatic gluconeogenesis via CRTC2
  JOURNAL   Nat Commun 12 (1), 3340 (2021)
   PUBMED   34099657
  REMARK    GeneRIF: Sam68 promotes hepatic gluconeogenesis via CRTC2.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3762)
  AUTHORS   Chen,T., Damaj,B.B., Herrera,C., Lasko,P. and Richard,S.
  TITLE     Self-association of the single-KH-domain family members Sam68,
            GRP33, GLD-1, and Qk1: role of the KH domain
  JOURNAL   Mol Cell Biol 17 (10), 5707-5718 (1997)
   PUBMED   9315629
REFERENCE   7  (bases 1 to 3762)
  AUTHORS   Agger,R. and Freimuth,P.
  TITLE     Purification and cDNA sequence of a murine protein homologous to
            the human p62 tyrosine phosphoprotein that associates with the Ras
            GTPase-activating protein p120 GAP
  JOURNAL   Gene 158 (2), 307-308 (1995)
   PUBMED   7541765
REFERENCE   8  (bases 1 to 3762)
  AUTHORS   Taylor,S.J., Anafi,M., Pawson,T. and Shalloway,D.
  TITLE     Functional interaction between c-Src and its mitotic target, Sam 68
  JOURNAL   J Biol Chem 270 (17), 10120-10124 (1995)
   PUBMED   7537265
REFERENCE   9  (bases 1 to 3762)
  AUTHORS   Richard,S., Yu,D., Blumer,K.J., Hausladen,D., Olszowy,M.W.,
            Connelly,P.A. and Shaw,A.S.
  TITLE     Association of p62, a multifunctional SH2- and SH3-domain-binding
            protein, with src family tyrosine kinases, Grb2, and phospholipase
            C gamma-1
  JOURNAL   Mol Cell Biol 15 (1), 186-197 (1995)
   PUBMED   7799925
REFERENCE   10 (bases 1 to 3762)
  AUTHORS   Fumagalli,S., Totty,N.F., Hsuan,J.J. and Courtneidge,S.A.
  TITLE     A target for Src in mitosis
  JOURNAL   Nature 368 (6474), 871-874 (1994)
   PUBMED   7512695
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ055187.1, AK152084.1, AK044927.1 and BE986307.1.
            
            On or before Aug 28, 2011 this sequence version replaced
            XR_106272.1, XR_107632.1, XR_106449.1, NM_011317.3.
            
            Transcript Variant: This variant (1) encodes the functional
            protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK044927.1, AK152084.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164134, SAMN01164138
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-21                CJ055187.1         2-22
            22-2705             AK152084.1         1-2684
            2706-3745           AK044927.1         2704-3743
            3746-3762           BE986307.1         1-17                c
FEATURES             Location/Qualifiers
     source          1..3762
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 63.34 cM"
     gene            1..3762
                     /gene="Khdrbs1"
                     /gene_synonym="p62; p68; Sam68"
                     /note="KH domain containing, RNA binding, signal
                     transduction associated 1"
                     /db_xref="GeneID:20218"
                     /db_xref="MGI:MGI:893579"
     exon            1..525
                     /gene="Khdrbs1"
                     /gene_synonym="p62; p68; Sam68"
                     /inference="alignment:Splign:2.1.0"
     CDS             144..1475
                     /gene="Khdrbs1"
                     /gene_synonym="p62; p68; Sam68"
                     /note="src-associated in mitosis 68 kDa protein;
                     GAP-associated tyrosine phosphoprotein p62; p21 Ras
                     GTPase-activating protein-associated p62; src associated
                     in mitosis, 68 kDa"
                     /codon_start=1
                     /product="KH domain-containing, RNA-binding, signal
                     transduction-associated protein 1"
                     /protein_id="NP_035447.3"
                     /db_xref="CCDS:CCDS18703.1"
                     /db_xref="GeneID:20218"
                     /db_xref="MGI:MGI:893579"
                     /translation="MQRRDDPASRLTRSSGRSCSKDPSGAHPSVRLTPSRPSPLPHRP
                     RGGGGGPRGGARASPATQPPPLLPPSTPGPDATVVGSAPTPLLPPSATAAVKMEPENK
                     YLPELMAEKDSLDPSFTHAMQLLSVEIEKIQKGESKKDDEENYLDLFSHKNMKLKERV
                     LIPVKQYPKFNFVGKILGPQGNTIKRLQEETGAKISVLGKGSMRDKAKEEELRKGGDP
                     KYAHLNMDLHVFIEVFGPPCEAYALMAHAMEEVKKFLVPDMMDDICQEQFLELSYLNG
                     VPEPSRGRGVSVRGRGAAPPPPPVPRGRGVGPPRGALVRGTPVRGSITRGATVTRGVP
                     PPPTVRGAPTPRARTAGIQRIPLPPTPAPETYEDYGYDDTYAEQSYEGYEGYYSQSQG
                     ESEYYDYGHGELQDSYEAYGQDDWNGTRPSLKAPPARPVKGAYREHPYGRY"
     exon            526..650
                     /gene="Khdrbs1"
                     /gene_synonym="p62; p68; Sam68"
                     /inference="alignment:Splign:2.1.0"
     exon            651..767
                     /gene="Khdrbs1"
                     /gene_synonym="p62; p68; Sam68"
                     /inference="alignment:Splign:2.1.0"
     exon            768..914
                     /gene="Khdrbs1"
                     /gene_synonym="p62; p68; Sam68"
                     /inference="alignment:Splign:2.1.0"
     exon            915..1048
                     /gene="Khdrbs1"
                     /gene_synonym="p62; p68; Sam68"
                     /inference="alignment:Splign:2.1.0"
     exon            1049..1250
                     /gene="Khdrbs1"
                     /gene_synonym="p62; p68; Sam68"
                     /inference="alignment:Splign:2.1.0"
     exon            1251..1318
                     /gene="Khdrbs1"
                     /gene_synonym="p62; p68; Sam68"
                     /inference="alignment:Splign:2.1.0"
     exon            1319..1377
                     /gene="Khdrbs1"
                     /gene_synonym="p62; p68; Sam68"
                     /inference="alignment:Splign:2.1.0"
     exon            1378..3750
                     /gene="Khdrbs1"
                     /gene_synonym="p62; p68; Sam68"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2681..2686
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Khdrbs1"
                     /gene_synonym="p62; p68; Sam68"
                     /note="hexamer: AATAAA"
     polyA_site      2708
                     /gene="Khdrbs1"
                     /gene_synonym="p62; p68; Sam68"
                     /note="major polyA site"
ORIGIN      
        1 atttccggtg ctctctcgct gggtcgctcg ggtcggcttc ggtcgctgtc gctcctgttc
       61 ttccaccccc gccaaccgcc gctcgggcct cagctgccgc cgcgtcgctt cctcgctcgt
      121 tcgctcgcca cccatcatcc ccgatgcagc gccgggacga tcctgcctcg cgcctcaccc
      181 ggtcctcggg ccgcagctgc tccaaggacc cgtcaggtgc ccacccctcg gtgcgtctga
      241 ccccgtctcg gccgtcgccg cttcctcacc ggccccgggg agggggaggt gggcccagag
      301 gaggcgctcg ggcctcgccc gccacccagc cgccgccgct gctgcctccc tccacccctg
      361 gtcccgacgc gacggtggtg ggttccgcgc cgaccccgct gctgcccccg tcagccacag
      421 ccgcggtcaa gatggagccg gagaataagt acctgcctga actcatggcc gagaaggact
      481 cgctcgaccc gtccttcact cacgccatgc agctgctgtc cgtagaaatt gagaagattc
      541 agaagggaga gtcaaaaaaa gatgacgagg agaattattt ggatttattt tctcataaga
      601 acatgaagct gaaagaacgc gtgctgatac ctgtcaagca gtatccaaag ttcaattttg
      661 tggggaagat tcttggacca caaggaaata caatcaaaag actccaggaa gagactggtg
      721 caaagatctc tgtcttgggg aagggttcaa tgagagacaa agccaaggag gaagagttgc
      781 gcaagggtgg agaccccaaa tatgcccatt taaatatgga tctgcatgtc ttcattgaag
      841 tctttggacc cccgtgtgaa gcttatgctc ttatggccca tgctatggaa gaagtcaaga
      901 agttcctagt accagatatg atggatgata tctgtcagga gcagtttcta gaattgtcct
      961 acttgaacgg agtacctgaa ccctctcgtg gtcgtggggt atctgtgaga ggacgaggag
     1021 ctgcccctcc tcctccacct gttcccagag gacgtggtgt tggaccacct agaggagctt
     1081 tggttcgtgg aaccccagtg agaggctcca tcaccagagg tgccactgtg actcgaggag
     1141 tgccaccccc acctactgtg aggggtgctc caacaccaag agctcggaca gctgggattc
     1201 agagaatacc tttgcctccc acacctgcac cagaaacata cgaagattat ggatatgatg
     1261 atacatacgc agaacagagt tacgaaggct atgaaggcta ttacagccag agtcaagggg
     1321 agtcagagta ttatgactat ggacatgggg agctccaaga ttcttacgaa gcctacggac
     1381 aagatgactg gaatgggacc aggccatcac tgaaggctcc tccagctagg ccagtgaagg
     1441 gagcatacag agagcatcca tatggacgtt attaaaaaca aacaggaggg aaaaatatca
     1501 gttatgagca aagttgttac tgatttcttg tatcccagga ttcctgttgc tttacccaca
     1561 acagacaagt aattgtctaa gtgtttttct tcgtggtccc tttcttttcc ccacttcctc
     1621 cattcttaac tctgcattct ggcttctgta tgtagtattt taaaatgagt taaaatagat
     1681 ttaggaatat cgaattaatt ttttaagtgt gtagatgctt ttttttcttt gttgtttaaa
     1741 tataaacagt gtacctttta taataaaaaa aagttgagtt aaaaaaaaac cacaaacatg
     1801 ttagtttcaa aagtggcatt gcttgcttaa aggttctgaa ggcttgttaa ctttttctta
     1861 gttttgattt gaggcacccc gtaaagtcat agttgcagaa tcccaaacta ggctacattt
     1921 caaaattcag ggctgcttaa gatgtaaaac cacaatgtta acaacggcag tagtgccacc
     1981 atgtaaaagt gagctcagag gtctctaaaa catttccttt aaaagcacat ggctgttgaa
     2041 tcttaaggtt aaattttaat atgaaagctc ctcatgaatt aaatagttga tgcaattttt
     2101 aacgttaatt gacttaaaac aacaacaaaa ttaggtttgt aaaagtgact ttttcattat
     2161 gtgggttttg aaatctagcc ccagacatac agtgttgaga gatacttagt gggggagggg
     2221 tgggctctga ataagattga tggggagaga agctagccac ctaaatggaa tctgatggag
     2281 ttctttttag ccacaatctt ttcaataata gtactaaaaa tcaaattttc agtatttaaa
     2341 atgtcaagag tattttgtcc atctgagatt ctacactcca tgaaaaactc acttggacac
     2401 tggggccaaa agctgatgat gttcaataaa ttgaccattg tcagttttga gctgttccca
     2461 aggtagaagg cagttaagta tgtctcaaca ctagcatgat ataaaaaggg acactgcagc
     2521 tgaatgagaa aagaatcaaa atccactttg tacataagtt aaagtcctaa tggatttgta
     2581 ccgtcctccc attttgtttt cggaagatta aatgctacat gtgtaagtct gcctaaatag
     2641 gtagcttaaa cttatgtcaa aatgtctgca gcagtttgtc aataaagttt agtccttttt
     2701 taatcaaagt aaatgtgatg aattgtcatt tttgggggtg gacaataaaa tagttttctc
     2761 tttcacataa acttaaatta attctaaagt taatgggatt gttaaaagtt ggagacattt
     2821 ttaaaagtgg tggtggggat tttattttaa ggttaccaaa aaaaagttta tgagttgtta
     2881 agttttagtt taaaaagaac caaagctttt tcaccccctg gaagttgttg aaagcagttt
     2941 tatccagtcc tatcaaaaaa ttacagtttt tagagagaaa aacccaactg acacagatag
     3001 gtacttcaag tgccagccat cctgccttcc gtcttctgta gagcccctag gtggccttaa
     3061 agaatgacac caaatctctg tgctcagaca ttgactccac ctgtgttcag ataccacaat
     3121 tcagcaaagc ctgggtgccc aggagggtta cccttccaat cctagagatg cagtaacaat
     3181 tgagctggcc tggggaggag ctggcgccat agactggtcc tgaactccct cccacaagac
     3241 tgaaaacagt ggaattggtt gtcactatgt aaaaagtcac tcttaattcc cagggacctc
     3301 attcttttcc ctaagagcca cctaaactgc tcgggggtga aaaatcctct tgtgtgaagt
     3361 gccaagctgc ctgtagcagt gcatgatggg catttttctt ttctttttaa aacacaccaa
     3421 caaaaactgt atttatagat tgtgataaag tgtaaataac tgaattttcc accgtggttt
     3481 gaagtcagct ttcagggcat tatgtcttgt tttgatgaaa agagatcact ctataccccc
     3541 ctttttaaag gaaaattatc gcaagagaat caggatgtgt aaagctaaca tgcatcgcaa
     3601 aaagccaaag gtaacctaaa tgtctgattt taatagcaca tatttctctt ttatataaac
     3661 ggtgacagca acttgcataa acaattctct agttgttaat tttaatgtta aaactttgca
     3721 aaacttgttt aataaaaata gctgtaaaaa aaaaaaaaaa aa
//
