LOCUS       NM_025890               1686 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Mus musculus KH domain containing 3, subcortical maternal complex
            member (Khdc3), transcript variant 1, mRNA.
ACCESSION   NM_025890
VERSION     NM_025890.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1686)
  AUTHORS   Meng,T.G., Guo,J.N., Zhu,L., Yin,Y., Wang,F., Han,Z.M., Lei,L.,
            Ma,X.S., Xue,Y., Yue,W., Nie,X.Q., Zhao,Z.H., Zhang,H.Y., Sun,S.M.,
            Ouyang,Y.C., Hou,Y., Schatten,H., Ju,Z., Ou,X.H., Wang,Z.B.,
            Wong,C.C.L., Li,Z. and Sun,Q.Y.
  TITLE     NLRP14 Safeguards Calcium Homeostasis via Regulating the K27
            Ubiquitination of Nclx in Oocyte-to-Embryo Transition
  JOURNAL   Adv Sci (Weinh) 10 (27), e2301940 (2023)
   PUBMED   37493331
REFERENCE   2  (bases 1 to 1686)
  AUTHORS   Georges,R.O., Sepulveda,H., Angel,J.C., Johnson,E., Palomino,S.,
            Nowak,R.B., Desai,A., Lopez-Moyado,I.F. and Rao,A.
  TITLE     Acute deletion of TET enzymes results in aneuploidy in mouse
            embryonic stem cells through decreased expression of Khdc3
  JOURNAL   Nat Commun 13 (1), 6230 (2022)
   PUBMED   36266342
  REMARK    GeneRIF: Acute deletion of TET enzymes results in aneuploidy in
            mouse embryonic stem cells through decreased expression of Khdc3.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1686)
  AUTHORS   Niu,W. and Spradling,A.C.
  TITLE     Mouse oocytes develop in cysts with the help of nurse cells
  JOURNAL   Cell 185 (14), 2576-2590 (2022)
   PUBMED   35623357
REFERENCE   4  (bases 1 to 1686)
  AUTHORS   Li,J., Shang,Y., Wang,L., Zhao,B., Sun,C., Li,J., Liu,S., Li,C.,
            Tang,M., Meng,F.L. and Zheng,P.
  TITLE     Genome integrity and neurogenesis of postnatal hippocampal neural
            stem/progenitor cells require a unique regulator Filia
  JOURNAL   Sci Adv 6 (44) (2020)
   PUBMED   33115731
  REMARK    GeneRIF: Genome integrity and neurogenesis of postnatal hippocampal
            neural stem/progenitor cells require a unique regulator Filia.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1686)
  AUTHORS   Kanzaki,S., Tamura,S., Ito,T., Wakabayashi,M., Saito,K., Kato,S.,
            Ohta,Y., Sekita,Y. and Kimura,T.
  TITLE     Involvement of Nlrp9a/b/c in mouse preimplantation development
  JOURNAL   Reproduction 160 (2), 181-191 (2020)
   PUBMED   32413845
REFERENCE   6  (bases 1 to 1686)
  AUTHORS   Zheng,P. and Dean,J.
  TITLE     Role of Filia, a maternal effect gene, in maintaining euploidy
            during cleavage-stage mouse embryogenesis
  JOURNAL   Proc Natl Acad Sci U S A 106 (18), 7473-7478 (2009)
   PUBMED   19376971
  REMARK    GeneRIF: Filia is central to integrating the spatiotemporal
            localization of regulators that helps ensure euploidy and
            high-quality cell cycle progression in preimplantation mouse
            development.
REFERENCE   7  (bases 1 to 1686)
  AUTHORS   Li,L., Baibakov,B. and Dean,J.
  TITLE     A subcortical maternal complex essential for preimplantation mouse
            embryogenesis
  JOURNAL   Dev Cell 15 (3), 416-425 (2008)
   PUBMED   18804437
  REMARK    GeneRIF: Results describe a subcortical maternal complex,
            containing Mater, Floped, TLE6, and Filia, that is essential for
            preimplantation mouse embryogenesis.
REFERENCE   8  (bases 1 to 1686)
  AUTHORS   Ohsugi,M., Zheng,P., Baibakov,B., Li,L. and Dean,J.
  TITLE     Maternally derived FILIA-MATER complex localizes asymmetrically in
            cleavage-stage mouse embryos
  JOURNAL   Development 135 (2), 259-269 (2008)
   PUBMED   18057100
  REMARK    GeneRIF: The plasticity of the FILIA-MATER complex localization may
            reflect the regulative nature of preimplantation mouse development.
REFERENCE   9  (bases 1 to 1686)
  AUTHORS   Pierre,A., Gautier,M., Callebaut,I., Bontoux,M., Jeanpierre,E.,
            Pontarotti,P. and Monget,P.
  TITLE     Atypical structure and phylogenomic evolution of the new eutherian
            oocyte- and embryo-expressed KHDC1/DPPA5/ECAT1/OOEP gene family
  JOURNAL   Genomics 90 (5), 583-594 (2007)
   PUBMED   17913455
  REMARK    GeneRIF: This paper states that the ECAT1 gene is absent in
            rodents.
REFERENCE   10 (bases 1 to 1686)
  AUTHORS   Mitsui,K., Tokuzawa,Y., Itoh,H., Segawa,K., Murakami,M.,
            Takahashi,K., Maruyama,M., Maeda,M. and Yamanaka,S.
  TITLE     The homeoprotein Nanog is required for maintenance of pluripotency
            in mouse epiblast and ES cells
  JOURNAL   Cell 113 (5), 631-642 (2003)
   PUBMED   12787504
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK145595.1, AK010377.1 and BY756270.1.
            
            On Jan 12, 2008 this sequence version replaced NM_025890.2.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK166731.1, BC137808.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849383
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-458               AK145595.1         1-458
            459-1643            AK010377.1         396-1580
            1644-1686           BY756270.1         656-698
FEATURES             Location/Qualifiers
     source          1..1686
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 40.08 cM"
     gene            1..1686
                     /gene="Khdc3"
                     /gene_synonym="2410004A20Rik; FILIA; OEEP48"
                     /note="KH domain containing 3, subcortical maternal
                     complex member"
                     /db_xref="GeneID:66991"
                     /db_xref="MGI:MGI:1914241"
     exon            1..278
                     /gene="Khdc3"
                     /gene_synonym="2410004A20Rik; FILIA; OEEP48"
                     /inference="alignment:Splign:2.1.0"
     CDS             113..1435
                     /gene="Khdc3"
                     /gene_synonym="2410004A20Rik; FILIA; OEEP48"
                     /note="isoform 1 is encoded by transcript variant 1;
                     protein Filia; KH domain-containing protein 3"
                     /codon_start=1
                     /product="KH domain-containing protein 3 isoform 1"
                     /protein_id="NP_080166.1"
                     /db_xref="CCDS:CCDS23336.1"
                     /db_xref="GeneID:66991"
                     /db_xref="MGI:MGI:1914241"
                     /translation="MASLKRFQTLVPLDHKQGTLFEIIGEPKLPKWFHVECLEDPKRL
                     YVEPRLLEIMFGKDGEHIPHLESMLHTLIHVNVWGPERRAEIWIFGPPPFRRDVDRML
                     TDLAHYCRMKLMEIEALEAGVERRRMAAHKAATQPAPVKVREAAPRPASVKVPETATQ
                     PAPVKVREAAPQPAPVQEVREAAPQQASVQEEVREAATEQAPVQEVREAATEQAPVQE
                     VSEAATEQAPVQEVNEAATEQASVQAVREAATRPAPGKVRKAATQPAPVQVCQEATQL
                     APVKVREAATQPASGKVREAATQLAPVKVRKAATQLAPVKVHEAATQPAPGKVSDAAT
                     QSASVQVREAATQLSPVEATDTSQLAQVKADEAFAQHTSGEAHQVANGQSPIEVCETA
                     TGQHSLDVSRALSQKCPEVFEWETQSCLDGSYVIVQPPRDAWESFIIL"
     exon            279..458
                     /gene="Khdc3"
                     /gene_synonym="2410004A20Rik; FILIA; OEEP48"
                     /inference="alignment:Splign:2.1.0"
     exon            459..1686
                     /gene="Khdc3"
                     /gene_synonym="2410004A20Rik; FILIA; OEEP48"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1664..1669
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Khdc3"
                     /gene_synonym="2410004A20Rik; FILIA; OEEP48"
                     /note="hexamer: AATAAA"
     polyA_site      1681
                     /gene="Khdc3"
                     /gene_synonym="2410004A20Rik; FILIA; OEEP48"
                     /note="major polyA site"
ORIGIN      
        1 acttgagtgg gaaggggcca gtgaacagcc cttgaaatag agctctgagg tcagtctttg
       61 agttcactga tcttgagttt gcataggctt cctgcggtga aacgggtaca ctatggcctc
      121 tctgaagagg tttcagacgc tcgtgcccct ggatcacaaa caaggtacct tatttgaaat
      181 tattggagag cccaagttgc ccaagtggtt ccatgtcgaa tgcctggaag atccaaaaag
      241 actgtacgtg gaacctcggc tactggaaat catgtttggt aaggatggag agcacatccc
      301 acatcttgaa tctatgttgc acaccctgat acatgtgaac gtgtggggcc ctgaaaggcg
      361 agctgagatt tggatattcg gaccgccgcc tttccgaagg gacgttgacc ggatgctcac
      421 tgatctggct cactattgcc gcatgaaact gatggaaata gaggctctgg aggctggagt
      481 tgagcgtcgt cgtatggcgg cccataaggc tgccacccag cctgctcccg tgaaggtccg
      541 cgaggctgcc cctcggcccg cttccgtgaa ggtccctgag acggccaccc agcctgctcc
      601 cgtgaaggtc cgcgaggctg cccctcagcc cgctccggtg caggaggtcc gcgaggctgc
      661 ccctcagcag gcttccgtgc aggaggaggt ccgcgaggct gccaccgagc aggctcccgt
      721 gcaggaggtc cgcgaggctg ccaccgagca ggctcccgtg caggaggtca gcgaggctgc
      781 caccgagcag gctcccgtgc aggaggtcaa cgaggctgcc accgagcagg cttccgtgca
      841 ggcggtccgc gaggctgcca cccggccggc tcccgggaag gtccgcaagg cggccaccca
      901 gccggctccg gtgcaggttt gccaggaggc cacccagttg gctcccgtga aggtccgcga
      961 ggcggccacc cagccggctt ccgggaaggt ccgcgaggcg gccacccagt tggctcctgt
     1021 gaaggtccgc aaggcagcca cccagttggc tcctgtgaag gtccacgagg cggccaccca
     1081 gccggctccg gggaaggtca gcgatgctgc cacgcagtcg gcttcggtgc aggttcgtga
     1141 ggctgccacg cagctgtctc ccgtggaggc cactgatact agccagttgg ctcaggtgaa
     1201 ggctgatgaa gcctttgccc agcacacttc aggggaggcc caccaggttg ccaatgggca
     1261 gtctcccatt gaagtctgtg agactgccac cgggcagcat tctctagatg tctctagggc
     1321 cttgtcccag aagtgtcctg aggtttttga gtgggagacc cagagttgtt tggatggcag
     1381 ctatgtcata gttcagcctc caagggatgc ctgggaatca tttatcatat tataaatgca
     1441 tctctggtgt gagccaggat agatggtaca cgtctgcaaa tccagaacct aaaggcaggg
     1501 gttagcttgg gctgagtaag gcaatgatct taaacctcag cctgcctaag actcccttca
     1561 tctttctttc tggtttttgc cctaggaatc gggaagaaca gagtagagct gtttttgttt
     1621 ccccattgtg ttaaatgttt gcaaacacaa tttaaagtat tctaataaaa aaaaaattgc
     1681 attccc
//
