LOCUS       NM_008438               1950 bp    mRNA    linear   ROD 13-AUG-2024
DEFINITION  Mus musculus keratocan (Kera), mRNA.
ACCESSION   NM_008438
VERSION     NM_008438.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1950)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1950)
  AUTHORS   Acosta,A.C., Sun,M., Zafrullah,N., Avila,M.Y., Margo,C.E. and
            Espana,E.M.
  TITLE     Stromal matrix directs corneal fibroblasts to re-express keratocan
            after injury and transplantation
  JOURNAL   Dis Model Mech 16 (9) (2023)
   PUBMED   37702214
  REMARK    GeneRIF: Stromal matrix directs corneal fibroblasts to re-express
            keratocan after injury and transplantation.
REFERENCE   3  (bases 1 to 1950)
  AUTHORS   Qiu,T., Huteckova,B., Seppala,M., Cobourne,M.T., Chen,Z.,
            Hovorakova,M., Buchtova,M. and Tucker,A.S.
  TITLE     Molecular profiling of the vestibular lamina highlights a key role
            for Hedgehog signalling
  JOURNAL   Development 150 (7) (2023)
   PUBMED   36971701
REFERENCE   4  (bases 1 to 1950)
  AUTHORS   Liu,H., Xu,J., Lan,Y., Lim,H.W. and Jiang,R.
  TITLE     The Scleraxis Transcription Factor Directly Regulates Multiple
            Distinct Molecular and Cellular Processes During Early Tendon Cell
            Differentiation
  JOURNAL   Front Cell Dev Biol 9, 654397 (2021)
   PUBMED   34150754
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1950)
  AUTHORS   Ogando,D.G., Shyam,R., Kim,E.T., Wang,Y.C., Liu,C.Y. and
            Bonanno,J.A.
  TITLE     Inducible Slc4a11 Knockout Triggers Corneal Edema Through
            Perturbation of Corneal Endothelial Pump
  JOURNAL   Invest Ophthalmol Vis Sci 62 (7), 28 (2021)
   PUBMED   34190974
REFERENCE   6  (bases 1 to 1950)
  AUTHORS   Matsushima,N., Ohyanagi,T., Tanaka,T. and Kretsinger,R.H.
  TITLE     Super-motifs and evolution of tandem leucine-rich repeats within
            the small proteoglycans--biglycan, decorin, lumican, fibromodulin,
            PRELP, keratocan, osteoadherin, epiphycan, and osteoglycin
  JOURNAL   Proteins 38 (2), 210-225 (2000)
   PUBMED   10656267
REFERENCE   7  (bases 1 to 1950)
  AUTHORS   Pressman,C.L., Chen,H. and Johnson,R.L.
  TITLE     LMX1B, a LIM homeodomain class transcription factor, is necessary
            for normal development of multiple tissues in the anterior segment
            of the murine eye
  JOURNAL   Genesis 26 (1), 15-25 (2000)
   PUBMED   10660670
REFERENCE   8  (bases 1 to 1950)
  AUTHORS   Liu,C.Y., Shiraishi,A., Kao,C.W., Converse,R.L., Funderburgh,J.L.,
            Corpuz,L.M., Conrad,G.W. and Kao,W.W.
  TITLE     The cloning of mouse keratocan cDNA and genomic DNA and the
            characterization of its expression during eye development
  JOURNAL   J Biol Chem 273 (35), 22584-22588 (1998)
   PUBMED   9712886
REFERENCE   9  (bases 1 to 1950)
  AUTHORS   Funderburgh,J.L., Perchellet,A.L., Swiergiel,J., Conrad,G.W. and
            Justice,M.J.
  TITLE     Keratocan (Kera), a corneal keratan sulfate proteoglycan, maps to
            the distal end of mouse chromosome 10
  JOURNAL   Genomics 52 (1), 110-111 (1998)
   PUBMED   10348636
REFERENCE   10 (bases 1 to 1950)
  AUTHORS   Dunlevy,J.R., Chakravarti,S., Gyalzen,P., Vergnes,J.P. and
            Hassell,J.R.
  TITLE     Cloning and chromosomal localization of mouse keratocan, a corneal
            keratan sulfate proteoglycan
  JOURNAL   Mamm Genome 9 (4), 316-319 (1998)
   PUBMED   9530631
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC159710.9.
            
            On Apr 27, 2007 this sequence version replaced NM_008438.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF022256.1, AK086197.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN01164133
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-173               AC159710.9         141979-142151
            174-1070            AC159710.9         143547-144443
            1071-1950           AC159710.9         147583-148462
FEATURES             Location/Qualifiers
     source          1..1950
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 50.34 cM"
     gene            1..1950
                     /gene="Kera"
                     /gene_synonym="CNA2; KTN; SLRR2B"
                     /note="keratocan"
                     /db_xref="GeneID:16545"
                     /db_xref="MGI:MGI:1202398"
     exon            1..173
                     /gene="Kera"
                     /gene_synonym="CNA2; KTN; SLRR2B"
                     /inference="alignment:Splign:2.1.0"
     exon            174..1070
                     /gene="Kera"
                     /gene_synonym="CNA2; KTN; SLRR2B"
                     /inference="alignment:Splign:2.1.0"
     CDS             182..1237
                     /gene="Kera"
                     /gene_synonym="CNA2; KTN; SLRR2B"
                     /note="keratan sulfate proteoglycan keratocan"
                     /codon_start=1
                     /product="keratocan precursor"
                     /protein_id="NP_032464.1"
                     /db_xref="CCDS:CCDS36044.1"
                     /db_xref="GeneID:16545"
                     /db_xref="MGI:MGI:1202398"
                     /translation="MATPNCLILWVLLIADTVWTQSVRQAYEIQDPEDWDVHDDFYCP
                     RECFCPPSFPTALYCENRGLTEIPPIPSRIWYLYLENNLIESIPEKPFENATQLRWIN
                     LNKNKITNYGIEKGALSQLKKLLFLFLEDNELEEVPSPLPRSLEQLQLARNKVSRIPQ
                     GTFSNLENLTLLDLQHNKLLDNAFQRDTFKGLKNLMQLNMAKNALRNMPPRLPANTMQ
                     LFLDNNSIEGIPENYFNVIPKVAFLRLNHNKLSDAGLPSRGFDVSSILDLQLSYNQLT
                     NFPRINANLQHLHLDHNKIKNVNMSVICPTTLRAEQDAFIHGPQLSYLRLDGNEIKPP
                     IPIDLVACFKLLQAFII"
     exon            1071..1950
                     /gene="Kera"
                     /gene_synonym="CNA2; KTN; SLRR2B"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 acatcaaaag ctcttcttgg tgaccagtca tcctactttt catttttttt cagactggag
       61 atttaatagc ataaagtcaa aacatttttt ttctttttgt tatcccccat caacttattt
      121 tagctaacct aacaccagcc acaggactca acggtatatt cctggaaagc aaggtgctgt
      181 aatggcaacc ccaaactgtt taatactctg ggtgttactc atagcagata ctgtgtggac
      241 acagagtgtg agacaggcct atgaaataca ggacccagag gactgggatg tccacgacga
      301 cttctattgt cccagagaat gcttctgtcc tcccagtttc cctactgcct tatactgtga
      361 gaacagaggt ctcacagaaa tccctcctat tccttcaagg atctggtacc tctacctgga
      421 aaacaacctg attgaatcca taccagagaa gccctttgag aatgccaccc agctgagatg
      481 gatcaattta aacaagaaca aaataaccaa ctacgggatt gagaaggggg ccctgagcca
      541 gctaaagaaa cttcttttcc tgtttcttga agacaatgag ctagaggagg taccttctcc
      601 attgccaaga agtttggaac aattacaatt agctagaaac aaagtatcca gaatccctca
      661 ggggaccttc agtaatctgg aaaacctgac ccttcttgat ctgcagcata acaaactatt
      721 agacaacgcc tttcaaagag atactttcaa gggccttaag aacctcatgc agttaaatat
      781 ggcgaagaat gccctgagga acatgccccc aagattacca gccaacacca tgcaactctt
      841 tctagacaac aactccattg aaggaatacc tgaaaattat ttcaatgtga ttcctaaggt
      901 ggctttcctg aggctcaacc acaacaaact atcagatgca ggtctcccgt cgaggggttt
      961 tgatgtgtca tccattctgg atcttcaact gtcttacaac cagctcacaa actttccccg
     1021 aatcaatgct aacctgcagc accttcacct tgatcacaac aaaattaaaa atgtgaacat
     1081 gtctgtaata tgtcccacca cactgcgtgc agaacaggat gccttcattc acggaccaca
     1141 actgagctac ctgcgtctgg atgggaatga aatcaagcca ccgatcccga tagatttggt
     1201 ggcttgcttc aagcttcttc aggctttcat aatataagac agaacccaaa ctggtttaag
     1261 ggtagatgta tgtggtatga gattttgatt gttacttcta ggtcctagac cacacttgca
     1321 attgttctta cccaccattt tcatatgtgc agcttgttct ttctgtttga ggatgctctg
     1381 gtcagtgaca cacaggggcc acgtgtatta gtttgctttc ttctgattaa caaaacagac
     1441 acagagttga aaaagctcct caactcaaag gtatttttat ctccttgcag ctactaatag
     1501 ccaatgtttt tttttttact gttacacatt caaaataatt tacttgcata tgaccaaatt
     1561 tatgagtact ggtagtgcag actccccata agcaccacaa tgagctagca ggaggaagct
     1621 ctgaaaatag gaataaatga aatattcctc tgtcatcatt ataatgagcc cactagtcaa
     1681 aagctttcta aaaagagaca cctggttatt agaatgaaac aataaagcaa gagagagagg
     1741 ttcaggtccc ttggagcgaa acaataaagc agtaaaaggt ggtggttcac tatcatttct
     1801 tacatatctt ttcttagatc ttatatatta tctccagtaa ctgattcctt aaatattgca
     1861 gttattataa catagcatgc aaactatcca gctcttattt tgattatgat ttgggggatt
     1921 tttctaaata aaactattga atattttcta
//
