LOCUS       NM_032540               2524 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Mus musculus Kell blood group (Kel), mRNA.
ACCESSION   NM_032540
VERSION     NM_032540.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2524)
  AUTHORS   Gibb,D.R., Liu,J., Santhanakrishnan,M., Natarajan,P., Madrid,D.J.,
            Patel,S., Eisenbarth,S.C., Tormey,C.A., Stowell,S.R., Iwasaki,A.
            and Hendrickson,J.E.
  TITLE     B cells require Type 1 interferon to produce alloantibodies to
            transfused KEL-expressing red blood cells in mice
  JOURNAL   Transfusion 57 (11), 2595-2608 (2017)
   PUBMED   28836263
  REMARK    GeneRIF: B cells require signaling from IFN-alpha/beta to produce
            alloantibodies to the human KEL glycoprotein in mice
REFERENCE   2  (bases 1 to 2524)
  AUTHORS   Maruyama,T., Dougan,S.K., Truttmann,M.C., Bilate,A.M., Ingram,J.R.
            and Ploegh,H.L.
  TITLE     Increasing the efficiency of precise genome editing with
            CRISPR-Cas9 by inhibition of nonhomologous end joining
  JOURNAL   Nat Biotechnol 33 (5), 538-542 (2015)
   PUBMED   25798939
  REMARK    Erratum:[Nat Biotechnol. 2016 Feb;34(2):210. doi:
            10.1038/nbt0216-210c.. PMID: 26849523]
REFERENCE   3  (bases 1 to 2524)
  AUTHORS   Zhu,X., Cho,E.S., Sha,Q., Peng,J., Oksov,Y., Kam,S.Y., Ho,M.,
            Walker,R.H. and Lee,S.
  TITLE     Giant axon formation in mice lacking Kell, XK, or Kell and XK:
            animal models of McLeod neuroacanthocytosis syndrome
  JOURNAL   Am J Pathol 184 (3), 800-807 (2014)
   PUBMED   24405768
REFERENCE   4  (bases 1 to 2524)
  AUTHORS   Rivera,A., Kam,S.Y., Ho,M., Romero,J.R. and Lee,S.
  TITLE     Ablation of the Kell/Xk complex alters erythrocyte divalent cation
            homeostasis
  JOURNAL   Blood Cells Mol Dis 50 (2), 80-85 (2013)
   PUBMED   23122227
  REMARK    GeneRIF: Absence of Kell was accompanied by changes in erythrocyte
            K(+), Mg(2+), Na(+) & Ca(2+) transport associated with changes in
            mean cellular volume & corpuscular hemoglobin concentration mean.
            Kel loss increased Mg(2+) permeability.
            Erratum:[Blood Cells Mol Dis. 2014 Jan;52(1):52]
REFERENCE   5  (bases 1 to 2524)
  AUTHORS   Zhu,X., Rivera,A., Golub,M.S., Peng,J., Sha,Q., Wu,X., Song,X.,
            Kumarathasan,P., Ho,M., Redman,C.M. and Lee,S.
  TITLE     Changes in red cell ion transport, reduced intratumoral
            neovascularization, and some mild motor function abnormalities
            accompany targeted disruption of the Mouse Kell gene (Kel)
  JOURNAL   Am J Hematol 84 (8), 492-498 (2009)
   PUBMED   19544475
  REMARK    GeneRIF: The targeted disruption of Kel in mouse enabled us to
            identify phenotypes that would not be easily detected in humans
            lacking Kell glycoprotein.
REFERENCE   6  (bases 1 to 2524)
  AUTHORS   Osawa,M., Horiuchi,H., Tian,W. and Kaneko,M.
  TITLE     Divergent evolution of the prolactin-inducible protein gene and
            related genes in the mouse genome
  JOURNAL   Gene 325, 179-186 (2004)
   PUBMED   14697523
REFERENCE   7  (bases 1 to 2524)
  AUTHORS   Lee,S., Russo,D.C., Pu,J., Ho,M. and Redman,C.M.
  TITLE     The mouse Kell blood group gene (Kel): cDNA sequence, genomic
            organization, expression, and enzymatic function
  JOURNAL   Immunogenetics 52 (1-2), 53-62 (2000)
   PUBMED   11132157
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY234859.1, AK028430.1 and AI894156.1.
            
            On Nov 15, 2007 this sequence version replaced NM_032540.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF252870.1, AK028430.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164135, SAMN01164140
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-82                BY234859.1         2-83
            83-2492             AK028430.1         57-2466
            2493-2524           AI894156.1         1-32                c
FEATURES             Location/Qualifiers
     source          1..2524
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 19.86 cM"
     gene            1..2524
                     /gene="Kel"
                     /gene_synonym="CD238; Ece3"
                     /note="Kell blood group"
                     /db_xref="GeneID:23925"
                     /db_xref="MGI:MGI:1346053"
     exon            1..169
                     /gene="Kel"
                     /gene_synonym="CD238; Ece3"
                     /inference="alignment:Splign:2.1.0"
     exon            170..281
                     /gene="Kel"
                     /gene_synonym="CD238; Ece3"
                     /inference="alignment:Splign:2.1.0"
     CDS             258..2399
                     /gene="Kel"
                     /gene_synonym="CD238; Ece3"
                     /note="Kell blood group, metallo-endopeptidase; Kel blood
                     group protein; Kell protein"
                     /codon_start=1
                     /product="kell blood group glycoprotein homolog"
                     /protein_id="NP_115929.3"
                     /db_xref="CCDS:CCDS20055.1"
                     /db_xref="GeneID:23925"
                     /db_xref="MGI:MGI:1346053"
                     /translation="MGPPWSQESSPEERLPTEWSRQLTRARWVLLAVLLCGLLLGSSM
                     LWFYIFRNCGPCPCETPVCMELLDHYLASGNRSVAPCTDFFSFACEKANGTSDSFQAL
                     TEENKSRLWRLLEAPGSWHLGSGEEKAFQFYNSCMDTDAIEASGSGPLIQIIEELGGW
                     NITGNWTSLDFNQNLRLLMSQYGHFPFFRAYLRPHPAPPHTPIIQIDQPEFDILLQQE
                     QEQKVYAQILREYVTYLNRLGTLLGSNPQEAQQHASWSIVFTSRLFQFLRPQQQQQAQ
                     DKLFHVVTIDELQEMAPAIDWLSCLQAIFTPMSLNSSQTLVVHDLDYLRNMSQLVEEG
                     LLNHRESIQSYMILGLVDTLSPALDTKFQEARRELIQELRKLKERPPLPAYPRWMKCV
                     EQTGAFFEPTLAALFVREAFGPSIQSAAMELFAEIKDAVIIRLKKLSWISEETQKEAL
                     NKLAQLQVEMGAPKRAVKPDIATQEYNDIQLGPSFLQSFLSCVRSLRARNVQSFLQPF
                     PYHRWQKSPWEVNAYYSISDHMVVFPAGLLQPPFFHPGYPRAVNFGAAGSIMAHELLH
                     IFYQLLLPGGCPACDTHVLQEALLCLERHYAAFPLPSISSFNGSHTLLENAADIGGVA
                     IAFQAYSKRIVEHTGELTLPNLDLSPYQLFFRSYAQVMCRGLSSQDPQDPHSPPSLRV
                     HGPLSNTPDFAKHFHCPRGTLLNPSARCKLW"
     exon            282..423
                     /gene="Kel"
                     /gene_synonym="CD238; Ece3"
                     /inference="alignment:Splign:2.1.0"
     exon            424..600
                     /gene="Kel"
                     /gene_synonym="CD238; Ece3"
                     /inference="alignment:Splign:2.1.0"
     exon            601..725
                     /gene="Kel"
                     /gene_synonym="CD238; Ece3"
                     /inference="alignment:Splign:2.1.0"
     exon            726..872
                     /gene="Kel"
                     /gene_synonym="CD238; Ece3"
                     /inference="alignment:Splign:2.1.0"
     exon            873..935
                     /gene="Kel"
                     /gene_synonym="CD238; Ece3"
                     /inference="alignment:Splign:2.1.0"
     exon            936..1124
                     /gene="Kel"
                     /gene_synonym="CD238; Ece3"
                     /inference="alignment:Splign:2.1.0"
     exon            1125..1273
                     /gene="Kel"
                     /gene_synonym="CD238; Ece3"
                     /inference="alignment:Splign:2.1.0"
     exon            1274..1403
                     /gene="Kel"
                     /gene_synonym="CD238; Ece3"
                     /inference="alignment:Splign:2.1.0"
     exon            1404..1514
                     /gene="Kel"
                     /gene_synonym="CD238; Ece3"
                     /inference="alignment:Splign:2.1.0"
     exon            1515..1613
                     /gene="Kel"
                     /gene_synonym="CD238; Ece3"
                     /inference="alignment:Splign:2.1.0"
     exon            1614..1691
                     /gene="Kel"
                     /gene_synonym="CD238; Ece3"
                     /inference="alignment:Splign:2.1.0"
     exon            1692..1792
                     /gene="Kel"
                     /gene_synonym="CD238; Ece3"
                     /inference="alignment:Splign:2.1.0"
     exon            1793..1903
                     /gene="Kel"
                     /gene_synonym="CD238; Ece3"
                     /inference="alignment:Splign:2.1.0"
     exon            1904..1971
                     /gene="Kel"
                     /gene_synonym="CD238; Ece3"
                     /inference="alignment:Splign:2.1.0"
     exon            1972..2141
                     /gene="Kel"
                     /gene_synonym="CD238; Ece3"
                     /inference="alignment:Splign:2.1.0"
     exon            2142..2237
                     /gene="Kel"
                     /gene_synonym="CD238; Ece3"
                     /inference="alignment:Splign:2.1.0"
     exon            2238..2516
                     /gene="Kel"
                     /gene_synonym="CD238; Ece3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2465..2470
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Kel"
                     /gene_synonym="CD238; Ece3"
                     /note="putative"
ORIGIN      
        1 agaggccaac agtacacatt tggggacaga gagagtggaa gagttgcccc ttctccaggg
       61 ccactgggac taggggcaaa agggaggtca ttttctgaat gctttagata cagcagctga
      121 aacaaaacca gagaggattc tgggagccag agaggagcag agacagatga ttctttgccc
      181 tcctccttcc tctagtcact tcaggaggag aaggacaaaa agggggaaag ctgaggggac
      241 agagccagag cagcacaatg ggacctccct ggagccagga gagttctcca gaagagaggc
      301 ttcccactga atggagcaga cagttgacaa gagccagatg ggtgctgcta gctgtcctgc
      361 tctgtggcct gctccttggt tcttctatgc tttggtttta catcttccgg aactgtggtc
      421 cttgtccatg tgagacacct gtgtgtatgg agctcctgga ccattacctg gcctctggaa
      481 acagaagcgt ggccccctgc actgactttt tcagctttgc ctgtgaaaaa gccaatggga
      541 ccagtgactc tttccaagca cttacagaag agaacaagag ccgactgtgg agactgttgg
      601 aggccccagg gtcctggcac ctaggatctg gagaggagaa agccttccaa ttttataact
      661 cctgcatgga cacagatgcc attgaagctt cagggtctgg tccactcata caaattattg
      721 aagagcttgg aggctggaac atcactggca actggacgtc cttggacttc aaccaaaatc
      781 tgaggcttct gatgagtcag tatggccact ttccattctt ccgagcctat ctacgacctc
      841 atccagcccc tccacataca ccaatcatcc agatagacca gccggagttt gacattcttc
      901 tccagcaaga gcaggaacag aaggtctatg ctcagatcct acgggaatat gtgacatacc
      961 tgaataggct gggaacatta ctggggagta acccacagga agcacaacag catgcctcct
     1021 ggtccatcgt ctttacctcc cggctgttcc agtttctgag gccacagcag cagcagcagg
     1081 cacaggacaa gctctttcat gtggttacta ttgacgaact gcaggaaatg gccccagcca
     1141 tcgactggtt atcctgttta caagcaatat tcacaccgat gtcactgaat tcctcccaga
     1201 ccctcgtggt ccatgaccta gactacttga gaaacatgtc acaacttgta gaagaagggc
     1261 tgctgaatca cagggagagt atacagagct acatgatctt ggggctggtg gatacccttt
     1321 caccagcact ggacactaaa ttccaggagg cacgcagaga actgatccag gaactacgga
     1381 aactgaaaga acgaccaccc ctgccagcct accctcgatg gatgaagtgt gtggaacaga
     1441 cgggagcctt ctttgagcct actctggcag ctctgtttgt tcgtgaagct tttggcccaa
     1501 gcattcaaag tgctgccatg gaattatttg ctgagataaa ggatgctgtc atcatacgcc
     1561 tcaaaaagct ttcctggata agtgaggaga cccagaaaga ggccttgaac aagcttgccc
     1621 aactgcaggt ggagatgggg gcaccaaaac gggccgtgaa gcctgacata gccacacagg
     1681 aatataatga tatacaactt ggtcctagtt tccttcaatc tttcctgagc tgtgtacgat
     1741 ccctccgggc cagaaatgtc cagagcttct tgcagccctt tccctaccac agatggcaga
     1801 aatctccctg ggaggtcaat gcttactatt caatatctga ccatatggtg gtcttccctg
     1861 ctggtcttct ccaacctcca ttcttccacc ctggctaccc cagagctgtg aactttggcg
     1921 ctgctggcag catcatggcc catgaattgt tgcatatctt ctaccaactc ttactccctg
     1981 ggggctgccc agcctgtgac acccatgtcc tacaagaagc acttctatgc ctggagcgcc
     2041 attatgctgc cttccctttg cctagcatat cctcgttcaa tggttctcac acactcctgg
     2101 aaaatgctgc agacatagga ggcgtagcca ttgcattcca ggcatatagc aagaggatag
     2161 tagagcacac tggggagttg accctgccca acctggatct tagcccctat caacttttct
     2221 tccgaagcta tgcccaggta atgtgtaggg ggctgagctc acaagaccct caggaccctc
     2281 acagtcctcc aagccttcga gtccatgggc ccctgagcaa tactccagat tttgccaaac
     2341 attttcattg tccacgtggg acccttctga atccctctgc ccgctgcaag ctctggtaaa
     2401 acttggctac caaagagact gatgtaaatg catgggctgc ttgtgagtcc atccttgaag
     2461 tcaaaataaa tctctctctt ctttctgttc ccaaataaaa gcgtgtattt agctttaaaa
     2521 aaaa
//
